CN102764414B - Method for preparing Xiaoqinglong mixture - Google Patents
Method for preparing Xiaoqinglong mixture Download PDFInfo
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Abstract
The invention discloses a preparation method of a Xiaoqinglong mixture. The preparation method comprises the following steps of: adding Asarum Herb and cassia twig into water, distilling, and extracting a volatile oil; adding water into Chinese magnoliavine and honey-fried licorice root, and decocting; adding 6-10 times of ethanol with the concentration of 50-80% into ephedra stem for reflux extraction; adding ethanol into white peony root for reflux extraction; and percolating prepared pinellia tuber and dried ginger by using ethanol with the concentration of 50-80% as a solvent.
Description
Technical field
The present invention relates to Chinese medicine composition of a kind of dissipating fluid-retention relieving cough and asthma that induces sweat and preparation method thereof, belong to formulation art.
Background technology
Little Green Dragon mixture comes from the Eastern Han Dynasty and cures the XIAOQINGLONG TANG in holy Zhang Zhongjing < < Treatise on Febrile Diseases > >, through extract refining forming by modern science and technology, there is the dissipating fluid-retention of inducing sweat, the effect of relieving cough and asthma.The 40th of < < Treatise on Febrile Diseases > >: " typhoid fever exterior syndrome being not relieved, pathogenic water stagnating in the epigastrium are retched, or cough, or choke, or breathe heavily, XIAOQINGLONG TANG master it." the 41st: " typhoid fever pathogenic water stagnating in the epigastrium, cough with slight asthma, fever without thirst.Take soup person yearningly, this " expelling of cold leading to recovery from illness also, XIAOQINGLONG TANG master it." XIAOQINGLONG TANG cures mainly sun cold in both the exterior and interior, the name day Green Dragon, the justice of getting the refreshing incubative pathogen of east wood.The emerging cloud of dragon rises rain and falls the salty henry of product thing.Ta China existing thousand one-hundred-year histories among the people and clinical, for affection of exogenous wind-cold, the drink of inside cutting off the water, fever with aversion to cold, lossless, the diseases such as thin sputum of breathing with cough, determined curative effect, steady quality.Clinical diagnosis is acute bronchitis, pneumonia, chronic bronchitis, acute attack and bronchiectasis secondary infection acute attack, and the disease such as cough, abundant expectoration due to flu, doctor trained in Western medicine adopts relieving the exterior syndrome by diaphoresis mostly, anti-inflammation, the agent of relieving cough and asthma, in the hope of quick-acting, is hindered liquid but this method easily consumes the moon, cause deficiency of YIN endogenous dryness, use little Green Dragon mixture to avoid these deficiencies.
Prior art discloses prescription and the preparation technology thereof of little Green Dragon mixture
Herba Ephedrae 125g Ramulus Cinnamomi 125g Radix Paeoniae Alba 125g Rhizoma Zingiberis 125g
Herba Asari 62g Radix Glycyrrhizae (processed with honey) 125g Rhizoma Pinelliae Preparatum 188g Fructus Schisandrae Chinensis 125g
Above eight tastes, Herba Asari, Ramulus Cinnamomi distillating extracting oil, the another device of aqueous solution after distillation is collected; Medicinal residues and the Radix Paeoniae Alba, Herba Ephedrae, Fructus Schisandrae Chinensis, Radix Glycyrrhizae Preparata decoct with water twice, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filtered, and the aqueous solution after filtrate and distillation merges, and is concentrated into about 1000ml.Rhizoma Pinelliae Preparatum, Rhizoma Zingiberis make solvent with 70% ethanol, flood and carry out percolation after 24 hours, collect percolate and reclaim ethanol and be concentrated in right amount, merge with above-mentioned medicinal liquid, standing, filter, filtrate is concentrated into 1000ml, the volatile oil that adds sodium benzoate 3g and Herba Asari, Ramulus Cinnamomi, stirs evenly, and obtains.
Herba Ephedrae has the effect of diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema, is the monarch drug in the party.The flavour of a drug such as above-mentioned preparation method epheday intermedia, Radix Glycyrrhizae decoct with water together, and main effective ingredient in Herba Ephedrae is ephedrine, in Radix Glycyrrhizae, contain glycyrrhizic acid, glycyrrhizic acid and Herba Ephedrae Ephedrine can generate precipitation in water extraction process, the content of this two tastes medicine is reduced, thereby the effect of its relieving cough and asthma also decrease.
Summary of the invention
The preparation method that the object of the present invention is to provide a kind of little Green Dragon mixture, overcomes the deficiencies in the prior art, makes the dissipating fluid-retention that induces sweat of product, and the effect of relieving cough and asthma is stronger.
The object of the invention is to be achieved through the following technical solutions:
A preparation method for little Green Dragon mixture, the method comprises the steps:
1) choose following crude drug:
Herba Ephedrae 100-150g Ramulus Cinnamomi 100-150g Radix Paeoniae Alba 100-150g
Rhizoma Zingiberis 100-150g Herba Asari 50-70g Radix Glycyrrhizae 100-150g Rhizoma Pinelliae Preparatum 160-220g Fructus Schisandrae Chinensis 100-150g;
2) Herba Asari, Ramulus Cinnamomi add 8～12 times of amount distillating extracting oils of water, and the another device of aqueous solution after distillation is collected; Medicinal residues and Fructus Schisandrae Chinensis, Radix Glycyrrhizae Preparata add 6～10 times of amounts of water and decoct twice, and 1～3 hour for the first time, 1～3 hour for the second time, collecting decoction, filtered filtrate for later use;
3) Herba Ephedrae adds 6～10 times of the ethanol amount reflux, extract, 1～3 time that concentration is 50～80% (volume ratios), each 0.5～4 hour, gets ethanol extract standby;
4) Radix Paeoniae Alba adds 4～8 times of the ethanol amount reflux, extract, 1～3 time that concentration is 50～80% (volume ratios), each 0.5～3 hour, gets ethanol extract standby;
5) Rhizoma Pinelliae Preparatum, Rhizoma Zingiberis make solvent with 50～80% ethanol, flood and carry out percolation after 24 hours, collect percolate standby;
6) combining step 3), step 4) and step 5) ethanol extract, reclaim ethanol, obtain extractum;
7) get step 6) extractum and the step 2 of gained) filtrate merge, standing, filter, filtrate is concentrated, adds Herba Asari, Ramulus Cinnamomi Volatile oil and conventional adjuvant, stirs evenly, and obtains.
A little Green Dragon mixture, by the following method preparation:
Choose following crude drug:
Herba Ephedrae 100-150g Ramulus Cinnamomi 100-150g Radix Paeoniae Alba 100-150g
Rhizoma Zingiberis 100-150g Herba Asari 50-70g Radix Glycyrrhizae 100-150g Rhizoma Pinelliae Preparatum 160-220g Fructus Schisandrae Chinensis 100-150g
The preparation method of the little Green Dragon mixture of the present invention, comprises the steps:
1) Herba Asari, Ramulus Cinnamomi add 8～12 times of amount distillating extracting oils of water, and the another device of aqueous solution after distillation is collected; Medicinal residues and Fructus Schisandrae Chinensis, Radix Glycyrrhizae Preparata add 6～10 times of amounts of water and decoct twice, and 1～3 hour for the first time, 1～3 hour for the second time, collecting decoction, filtered filtrate for later use;
2) Herba Ephedrae adds 6～10 times of the ethanol amount reflux, extract, 1～3 time that concentration is 50～80% (volume ratios), each 0.5～4 hour, gets ethanol extract standby;
3) Radix Paeoniae Alba adds 4～8 times of the ethanol amount reflux, extract, 1～3 time that concentration is 50～80% (volume ratios), each 0.5～3 hour, gets ethanol extract standby;
4) Rhizoma Pinelliae Preparatum, Rhizoma Zingiberis make solvent with 50～80% ethanol, flood and carry out percolation after 24 hours, collect percolate standby;
5) combining step 2), step 3) and step 4) ethanol extract, reclaim ethanol;
6) get step 5) extractum and the step 1 of gained) filtrate merge, standing, filter, filtrate is concentrated into 1000ml, adds the volatile oil of sodium benzoate 3g and Herba Asari, Ramulus Cinnamomi, stirs evenly, and obtains.
The preparation method of the little Green Dragon mixture of the present invention is preferably:
Choose following crude drug:
Herba Ephedrae 125g Ramulus Cinnamomi 125g Radix Paeoniae Alba 125g Rhizoma Zingiberis 125g
Herba Asari 62g Radix Glycyrrhizae (processed with honey) 125g Rhizoma Pinelliae Preparatum 188g Fructus Schisandrae Chinensis 125g
The preparation method of the little Green Dragon mixture of the present invention, comprises the steps:
1) Herba Asari, Ramulus Cinnamomi add 10 times of amount distillating extracting oils of water, and the another device of aqueous solution after distillation is collected; Medicinal residues and Fructus Schisandrae Chinensis, Radix Glycyrrhizae Preparata add 8 times of amounts of water for the first time, decoct 2 hours, add for the second time 6 times of amounts of water and decoct 1.5 hours, and collecting decoction, filters filtrate for later use;
2) Herba Ephedrae adds 6 times of the ethanol amount reflux, extract, 3 times that concentration is 70% (volume ratio), each 2 hours, merges ethanol extract standby;
3) Radix Paeoniae Alba adds 7 times of the ethanol amount reflux, extract, 2 times of 60% (volume ratio), each 2 hours, merges ethanol extract standby;
4) Rhizoma Pinelliae Preparatum, Rhizoma Zingiberis make solvent with 70% ethanol, flood and carry out percolation after 24 hours, collect percolate standby;
5) combining step 2), step 3) and step 4) ethanol extract, reclaim ethanol;
6) get step 5) extractum and the step 1 of gained) filtrate merge, standing, filter, filtrate is concentrated into 1000ml, adds the volatile oil of sodium benzoate 3g and Herba Asari, Ramulus Cinnamomi, stirs evenly, and obtains.
Above-mentioned times of amount refers to that quality doubly measures.
Experimental example 1 preparation process technical research
1 Processing Technology of Ephedra sinica engineering test
1.1 materials and instrument
Herba Ephedrae: be purchased from Anguo Yadong pharmaceutcal corporation, Ltd
Ephedrine hydrochloride reference substance: be purchased from Nat'l Pharmaceutical & Biological Products Control Institute
Detecting instrument: the SPD-10ATvp of Shimadzu company type high performance liquid chromatograph
1.2 extracting method prerun comparisons
1.2.1 decocting method is got Herba Ephedrae decoction pieces, decocts with water 2 times, adds for the first time 8 times of amounts of water and decocts 2 hours, adds for the second time 6 times of amounts of water and decocts 1.5 hours, and medicinal liquid filters, and merging filtrate, is concentrated into relative density 1.10～1.15;
1.2.2 ethanol refluxing process is got Herba Ephedrae decoction pieces, adds alcohol reflux 2 times, adds for the first time 8 times of amount reflux, extract, of ethanol 2 hours, adds for the second time 6 times of amount reflux, extract, of ethanol 1.5 hours, and medicinal liquid filters, and reclaims ethanol, is concentrated into relative density 1.10～1.15;
Above-mentioned two kinds of methods are extract obtained, measure respectively content, the results are shown in Table 1.
Table 1 Herba Ephedrae extracting method comparative result table
Table 1 explanation alcohol reflux thing Determination of ephedrine hydrochloride is apparently higher than decocting method.1.2.3 the preferred alcohol reflux, extract, Determination of ephedrine hydrochloride of extraction process condition is higher, thereby selects alcohol reflux method to carry out preferably extraction process condition.Affect alcohol reflux because have concentration of alcohol, return time, extraction time, 4 factors of ethanol consumption, 3 levels of each selecting factors, by L
9(3
4) orthogonal table carries out orthogonal test, factor level table is in Table 2, and orthogonal experiments table is in Table 3, and analysis of variance table is in Table 4.
Table 2 Herba Ephedrae ethanol extraction technique
The arrangement of table 3 orthogonal test and result
Table 4 analysis of variance table
Interpretation of result shows: the factor size that affects ephedrine hydrochloride is followed successively by A > B > C > D, and A, B two factors have significance (P < 0.05), be that concentration of alcohol and return time are for affecting the principal element of ephedrine hydrochloride, consider Cost Problems, select A
3b
2, concentration of alcohol 70%, and return time is 2 hours; And C, D factor affect without significance ephedrine hydrochloride, extraction time and ethanol consumption are less on Determination of ephedrine hydrochloride impact, according to interpretation of result, have selected C
3d
2, extracting 3 times, ethanol consumption is 6 times of amounts.
2 Radix Paeoniae Alba extraction process technology tests
2.2 materials and instrument
White Peony Root: be purchased from Anguo Yadong pharmaceutcal corporation, Ltd
Peoniflorin reference substance: be purchased from Nat'l Pharmaceutical & Biological Products Control Institute
Detecting instrument: the SPD-10ATvp of Shimadzu company type high performance liquid chromatograph
2.2 extracting method prerun comparisons
2.2.1 decocting method is got Radix Paeoniae Alba decoction pieces, decocts with water 2 times, adds for the first time 8 times of amounts of water and decocts 2 hours, adds for the second time 6 times of amounts of water and decocts 1.5 hours, and medicinal liquid filters, and merging filtrate, is concentrated into relative density 1.10～1.15;
2.2.2 ethanol refluxing process is got Radix Paeoniae Alba decoction pieces, adds alcohol reflux 2 times, adds for the first time 8 times of amount reflux, extract, of water 2 hours, adds for the second time 6 times of amount reflux, extract, of water 1.5 hours, and medicinal liquid filters, and reclaims ethanol, is concentrated into relative density 1.10～1.15;
Above-mentioned two kinds of methods are extract obtained, measure respectively content, the results are shown in Table 1.
Table 5 Radix Paeoniae Alba extracting method comparative result table
Table 5 explanation alcohol reflux thing paeoniflorin content is apparently higher than decocting method.
2.2.3 the preferred alcohol reflux, extract, paeoniflorin content of extraction process condition is higher, thereby selects alcohol reflux method to carry out preferably extraction process condition.Affect alcohol reflux because have concentration of alcohol, return time, extraction time, 4 factors of ethanol consumption, 3 levels of each selecting factors, by L
9(3
4) orthogonal table carries out orthogonal test, factor level table is in Table 6, and orthogonal experiments table is in Table 7, and analysis of variance table is in Table 8.
Table 6 Radix Paeoniae Alba ethanol extraction technique
The arrangement of table 7 orthogonal test and result
Table 8 analysis of variance table
Interpretation of result shows: the factor size that affects peoniflorin is followed successively by C > A > B > D, and factor C has significance (P < 0.05), be that return time is the principal element that affects ephedrine hydrochloride, select C
2, return time is 2 hours, and factor A, B, D affect without significance peoniflorin, and concentration of alcohol, extraction time and ethanol consumption are less on paeoniflorin content impact, according to interpretation of result, have selected A
2b
1d
2, extracting 2 times, 60% ethanol consumption is 7 times of amounts.
Experimental example 2 pharmacodynamics tests
1 test material
1.1 Experimental agents:
Of the present invention group: by embodiment 1, prepared;
Matched group: Herba Asari, Ramulus Cinnamomi distillating extracting oil, the another device of aqueous solution after distillation is collected; Medicinal residues and the Radix Paeoniae Alba, Herba Ephedrae, Fructus Schisandrae Chinensis, Radix Glycyrrhizae Preparata decoct with water twice, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filtered, and the aqueous solution after filtrate and distillation merges, and is concentrated into about 1000ml.Rhizoma Pinelliae Preparatum, Rhizoma Zingiberis make solvent with 70% ethanol, flood and carry out percolation after 24 hours, collect percolate and reclaim ethanol and be concentrated in right amount, merge with above-mentioned medicinal liquid, standing, filter, filtrate is concentrated into 1000ml, the volatile oil that adds sodium benzoate 3g and Herba Asari, Ramulus Cinnamomi, stirs evenly, and obtains.
1.2 animal NIH mice and Cavia porcelluss, body weight is 18～22g and 200～250g (purchased from Chinese Medical Sciences University's zoopery center) respectively
2 methods and result
2.1 antiasthmatic effect tests are tested and are got 200～250g Cavia porcellus the previous day, by only putting in spray tank, with 5313～6616kPa pressure, spraying into 1mg/mL histamine phosphate 1mL enters in device case, Cavia porcellus is after sucking above medicinal liquid, through certain incubation period, produce asthma reaction, be generally no more than 150s, surpass 150s person and can think insensitive, will not select.Animal one is had a convulsion, and pulls open chamber door and takes out animal, in order to avoid animal dies because being choked to death.By 30 of the qualified Cavia porcelluss of preliminary election, be divided at random 3 groups next day, and group and dosage are in Table 1.Each administration group is gastric infusion according to dosage, matched group gives equal-volume distilled water, 30min after administration, the similarity condition histamine phosphate of spraying respectively while putting into respectively sprayer unit by preliminary election, record starts as incubation period, to the results are shown in Table 9 to time that symptom occurs (using twitch, falling is as the criterion) from spraying.
The antiasthmatic effect of table 9 pair Cavia porcellus
Note: * compares * P < 0.05, * * P < 0.01 with blank group; △ compares P < 0.05 with medicine matched group
Result shows, of the present invention group and medicine matched group cause Experimental Asthma In Guinea-pigs to histamine phosphate all antiasthmatic effect, relatively have significant differences (P < 0.01) with blank group, of the present invention group relatively has significant difference (P < 0.05) with medicine matched group.
42 of NIH mices are got in 2.2 antitussive action tests, and male and female half and half, are divided into 3 groups at random, and group and dosage are in Table 10.Administration group is gastric infusion according to dosage, and matched group gives equal-volume distilled water, and 1h after administration puts into 250mL wide mouthed bottle by mice, injects quantitative sulfur dioxide gas, observes mouse cough incubation period, calculates cough-relieving rate, the results are shown in Table 10.Cough-relieving rate (%)=medication group cough response time/matched group cough response time * 100%
The antitussive action of table 10 pair mice
Note: * compares * P < 0.05, * * P < 0.01 with blank group; △ compares P < 0.05 with medicine matched group
Result shows, of the present invention group and medicine matched group cause mouse cough to sulfur dioxide all antitussive action, relatively have significant differences (P < 0.01) with blank group, of the present invention group relatively has significant difference (P < 0.05) with medicine matched group.
36 of NIH mices are got in 2.3 impacts that capillary permeability is increased, and male and female half and half are divided into 3 groups at random, and group and dosage are with 2.2.Administration group gastric infusion every day 1 time, matched group gavage equal-volume heats up in a steamer water, continuously 3d.1h after last administration, time each treated animal tail vein injection 0.1% azovan blue 10ml/kg, except Normal group, all the other respectively organize mice lumbar injection 0.6% glacial acetic acid 20ml/kg immediately, after 20 minutes, put to death mice, cut off abdominal cavity, use normal saline flushing abdominal cavity, collect cleaning mixture 5m l.At 723 type spectrophotometers, in 590nm wavelength place, measure absorption value, calculate azovan blue content.The results are shown in Table 11.
The impact of table 11 on mice capillary permeability
Note: * compares * P < 0.05, * * P < 0.01 with blank group; △ compares P < 0.05 with medicine matched group
Result shows, of the present invention group and medicine matched group all have the effect of increasing capillary permeability, of the present invention group relatively has significant differences (P < 0.01) with blank group, relatively has significant difference (P < 0.05) with medicine matched group.
Following embodiment can realize the effect of above-mentioned experimental example
The specific embodiment
Embodiment 1:
Crude drug:
Herba Ephedrae 125g Ramulus Cinnamomi 125g Radix Paeoniae Alba 125g Rhizoma Zingiberis 125g
Herba Asari 62g Radix Glycyrrhizae (processed with honey) 125g Rhizoma Pinelliae Preparatum 188g taste 125g
Preparation technology:
1) Herba Asari, Ramulus Cinnamomi add 10 times of amount distillating extracting oils of water, and the another device of aqueous solution after distillation is collected; Medicinal residues and Fructus Schisandrae Chinensis, Radix Glycyrrhizae Preparata add 8 times of amounts of water for the first time, decoct 2 hours, add for the second time 6 times of amounts of water and decoct 1.5 hours, and collecting decoction, filters filtrate for later use;
2) Herba Ephedrae adds 6 times of the ethanol amount reflux, extract, 3 times that concentration is 70% (volume ratio), each 1 hour, merges ethanol extract standby;
3) Radix Paeoniae Alba adds 7 times of the ethanol amount reflux, extract, 2 times of 65% (volume ratio), each 2 hours, merges ethanol extract standby;
4) Rhizoma Pinelliae Preparatum, Rhizoma Zingiberis make solvent with 70% ethanol, flood and carry out percolation after 24 hours, collect percolate standby;
5) combining step 2), step 3) and step 4) ethanol extract, reclaim ethanol;
6) get step 5) extractum and the step 1 of gained) filtrate merge, standing, filter, filtrate is concentrated into 1000ml, adds the volatile oil of sodium benzoate 3g and Herba Asari, Ramulus Cinnamomi, stirs evenly, and obtains.
Embodiment 2:
Crude drug:
Herba Ephedrae 135g Ramulus Cinnamomi 115g Radix Paeoniae Alba 125g Rhizoma Zingiberis 135g
Herba Asari 62g Radix Glycyrrhizae (processed with honey) 115g Rhizoma Pinelliae Preparatum 188g taste 125g
Preparation technology:
1) Herba Asari, Ramulus Cinnamomi add 9 times of amount distillating extracting oils of water, and the another device of aqueous solution after distillation is collected; Medicinal residues and Fructus Schisandrae Chinensis, Radix Glycyrrhizae Preparata add 8 times of amounts of water for the first time, decoct 2 hours, add for the second time 6 times of amounts of water and decoct 1.5 hours, and collecting decoction, filters filtrate for later use;
2) Herba Ephedrae adds 6 times of the ethanol amount reflux, extract, 3 times that concentration is 60% (volume ratio), each 1 hour, merges ethanol extract standby;
3) Radix Paeoniae Alba adds 7 times of the ethanol amount reflux, extract, 2 times of 60% (volume ratio), each 2 hours, merges ethanol extract standby;
4) Rhizoma Pinelliae Preparatum, Rhizoma Zingiberis make solvent with 70% ethanol, flood and carry out percolation after 24 hours, collect percolate standby;
5) combining step 2), step 3) and step 4) ethanol extract, reclaim ethanol;
6) get step 5) extractum and the step 1 of gained) filtrate merge, standing, filter, filtrate is concentrated into 1000ml, adds the volatile oil of sodium benzoate 3g and Herba Asari, Ramulus Cinnamomi, stirs evenly, and obtains.
Claims (1)
1. a preparation method for little Green Dragon mixture, is characterized in that the method comprises the steps:
Crude drug:
Herba Ephedrae 125g Ramulus Cinnamomi 125g Radix Paeoniae Alba 125g Rhizoma Zingiberis 125g
Herba Asari 62g Radix Glycyrrhizae (processed with honey) 125g Rhizoma Pinelliae Preparatum 188g Fructus Schisandrae Chinensis 125g
Preparation technology:
1) Herba Asari, Ramulus Cinnamomi add 10 times of amount distillating extracting oils of water, and the another device of aqueous solution after distillation is collected; Medicinal residues and Fructus Schisandrae Chinensis, Radix Glycyrrhizae Preparata add 8 times of amounts of water for the first time, decoct 2 hours, add for the second time 6 times of amounts of water and decoct 1.5 hours, and collecting decoction, filters filtrate for later use;
2) Herba Ephedrae adds 6 times of the ethanol amount reflux, extract, 3 times that concentration is 70% (volume ratio), each 1 hour, merges ethanol extract standby;
3) Radix Paeoniae Alba adds 7 times of the ethanol amount reflux, extract, 2 times of 65% (volume ratio), each 2 hours, merges ethanol extract standby;
4) Rhizoma Pinelliae Preparatum, Rhizoma Zingiberis make solvent with 70% ethanol, flood and carry out percolation after 24 hours, collect percolate standby;
5) combining step 2), step 3) and step 4) ethanol extract, reclaim ethanol;
6) get step 5) extractum and the step 1 of gained) filtrate merge, standing, filter, filtrate is concentrated into 1000ml, adds the volatile oil of sodium benzoate 3g and Herba Asari, Ramulus Cinnamomi, stirs evenly, and obtains.
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| CN105999216A (en) * | 2016-07-07 | 2016-10-12 | 安徽精诚本草中药饮片有限公司 | Candied ephedra decoction pieces for eliminating cold to stop wheezing and preparation method thereof |
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| CN1626141A (en) * | 2003-12-11 | 2005-06-15 | 天津天士力制药股份有限公司 | Medication for relieving cough and asthma |
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| CN1626141A (en) * | 2003-12-11 | 2005-06-15 | 天津天士力制药股份有限公司 | Medication for relieving cough and asthma |
Non-Patent Citations (3)
| Title |
|---|
| 国家药典委员会.小青龙合剂.《中华人民共和国药典 2010年版 一部》.2010,第504-505页. * |
| 正交设计法优选小青龙贴膏乙醇回流提取工艺;潘玲,台小华,韩建伟,董克;《中国医院药学杂志》;20090331;第29卷(第5期);367-370 * |
| 潘玲,台小华,韩建伟,董克.正交设计法优选小青龙贴膏乙醇回流提取工艺.《中国医院药学杂志》.2009,第29卷(第5期),367-370. * |
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