CN101537056B - Method for preparing Chinese medicinal preparation for treating external respiration infection of children - Google Patents
Method for preparing Chinese medicinal preparation for treating external respiration infection of children Download PDFInfo
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Abstract
The invention relates to a method for preparing a Chinese medicinal preparation for treating external respiration infection of children. In the method, the pharmic and pharmacological tests are combined to systematically control parameters of the preparation process, and by the tests, we found that the separate decoction of Chinese ephedra and baikal skullcap root better facilitates the extraction of active components. The preparation prepared by the method has the characteristics of high efficiency and stability in pharmacological effect.
Description
Technical field
The present invention relates to a kind of preparation method for the treatment of the Chinese medicine preparation of external respiration infection of children, belong to technical field of Chinese medicines.
Background technology
The infantile heat-clearing and antitussive oral liquid comes from 348 pages of the Pharmacopoeias of the People's Republic of China (version was an one in 2005), and its prescription and method for making are respectively:
[prescription] Herba Ephedrae 90g Semen Armeniacae Amarum (stir-fry) 120g Gypsum Fibrosum 270g Radix Glycyrrhizae 90g
Radix Scutellariae 180g Radix Isatidis 180g Rhizoma Menispermi 90g
[method for making] above seven flavors, Herba Ephedrae, Gypsum Fibrosum decoct with water half an hour, add the five tastes such as Semen Armeniacae Amarum again, decoct secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression is concentrated into about 600ml, leaves standstill 24 hours, filters, filtrate adds Mel 200g, sucrose 100g and sodium benzoate 3g, boils to make dissolving, adds water to total amount 1000ml, stir evenly, cold preservation 24～48 hours filters, embedding, sterilization, promptly.
This preparation technology is more coarse, and exists some unreasonable parts, curative effect to be difficult to guarantee, so be necessary this preparation technology is further studied, makes it specific, scientific more, and this also is one of direction of the modernization of Chinese medicine.
Summary of the invention
The object of the invention is to provide a kind of Chinese medicine preparation and preparation method thereof.
For realizing above goal of the invention, the technical solution used in the present invention is as follows:
A kind of preparation method for the treatment of the Chinese medicine preparation of external respiration infection of children, said preparation be by the crude drug of following weight ratio,
Herba Ephedrae 90g Semen Armeniacae Amarum (stir-fry) 120g Gypsum Fibrosum 270g Radix Glycyrrhizae 90g
Radix Scutellariae 180g Radix Isatidis 180g Rhizoma Menispermi 90g
Carry out according to the following steps:
More than seven flavors, Herba Ephedrae decocts with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression is concentrated into relative density 1.15～1.20, and Radix Scutellariae decocts with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression concentrates, and to relative density 1.15～1.20, Gypsum Fibrosum decocts with water half an hour, add four flavors such as Semen Armeniacae Amarum again, decoct secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression is concentrated into relative density 1.15～1.20, leaves standstill 24 hours, filters, filtrate adds Mel 200g, sucrose 100g and sodium benzoate 3g, boil and make dissolving, add water to total amount 1000ml, stir evenly, 2～6 ℃ of cold preservation 24～48 hours, filter, embedding, 105 ℃ of moist heat sterilizations 20 minutes are promptly.
The preparation of this Chinese medicine preparation can also be carried out according to the following steps:
More than seven the flavor, Herba Ephedrae decocts with water secondary, adding for the first time 8 times of amounts of water decocted 2 hours, adding for the second time 6 times of amounts of water decocted 1 hour, collecting decoction, filter, filtrate is injected the economic benefits and social benefits concentration tank, concentrating under reduced pressure, one effect heating clamber pressure is 0.04MPa, and two effect heating clamber pressure are 0.06MPa, are concentrated into relative density 1.15～1.20, Radix Scutellariae decocts with water secondary, add for the first time 8 times of amounts of water and decocted 2 hours, add 6 times of amounts of water for the second time and decocted collecting decoction 1 hour, filter, filtrate decompression concentrates, and an effect heating clamber pressure is 0.04MPa, and two effect heating clamber pressure are 0.06MPa, be concentrated into relative density 1.15～1.20, Gypsum Fibrosum adds 8 times of amounts of water and decocts half an hour, adds four flavors such as Semen Armeniacae Amarum again, decocts secondary, adding for the first time 8 times of amounts of water decocted 2 hours, add for the second time 6 times of amounts of water and decocted 1 hour, collecting decoction filters, filtrate decompression concentrates, one effect heating clamber pressure is 0.04MPa, and two effect heating clamber pressure are 0.06MPa, are concentrated into relative density 1.15～1.20, left standstill 24 hours, filter, filtrate adds Mel 200g, sucrose 100g and sodium benzoate 3g boil and make dissolving, add water to total amount 1000ml, stir evenly, 2～6 ℃ of cold preservation 24～48 hours filters, embedding, 105 ℃ of moist heat sterilizations 20 minutes are promptly.
This preparation method has drawn the production process control parameter of optimizing in conjunction with pharmacy and pharmacology test, and has fried in shallow oil the stripping that more helps effective ingredient by test discovery Herba Ephedrae and Radix Scutellariae branch, has improved ephedrine and content of baicalin.Effect such as above technical scheme can significantly improve this pharmaceutical composition heat clearing away, lung qi dispersing, relieving asthma.Make said preparation have curative effect height, stay-in-grade characteristics.
In order to make those skilled in the art understand content of the present invention better, the preparation method to Chinese medicine preparation of the present invention is described in detail below.
The specific embodiment
Following experimental example and embodiment further specify but are not limited to the present invention down.
Experimental example 1 Herba Ephedrae decocts determining of amount of water
Get every part of 90g of 3 parts of medical materials of Herba Ephedrae, decocted 2 hours for the first time, decocted 1 hour for the second time, divide 3 groups to test, 6 times of amounts of first group of amount of water, 4 times of amounts, 8 times of amounts of second group of amount of water, 6 times of amounts, 10 times of amounts of the 3rd group of amount of water, 8 times of amounts, collecting decoction filters, leave standstill, get supernatant and measure Determination of Ephedrine Hydrochloride.
According to high effective liquid chromatography for measuring, be filler with the octadecylsilane chemically bonded silica, be mobile phase (3:97) with acetonitrile-0.1% phosphoric acid solution (containing 0.1% triethylamine), the detection wavelength is 205nm.Number of theoretical plate calculates by ephedrine hydrochloride should be not less than 4000.It is an amount of to get the ephedrine hydrochloride reference substance, and accurate the title decides, and the hydrochloric acid solution that adds 0.1mol/L is made the solution that every 1ml contains 45 μ g, promptly.Accurate amount gained supernatant 5ml adds water 10ml and strong ammonia solution 0.5ml, with 5 (30ml of ether extraction, 30ml, 20ml, 20ml, 20ml), merge ether solution, add ethanol solution hydrochloride (1 → 20) 2ml, mixing, low temperature reclaim solvent to doing, and residue adds ethanol 5ml makes dissolving, be transferred in the 25ml measuring bottle, add the 0.1mol/L hydrochloric acid solution and be diluted to scale, shake up, promptly.Accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing inject chromatograph of liquid, measure, and the results are shown in following table.
Table 1: Herba Ephedrae decocts determining of amount of water
With ephedrine hydrochloride content is index, second group as can be seen (8 times of amounts of amount of water, 6 times of amounts), the 3rd group (10 times of amounts of amount of water, 8 times of amounts), paste-forming rate is more or less the same, for energy savings and shortening production time, so second group of test parameters adopted in decision in big the production.Promptly decoct with water twice, 2 hours for the first time, amount of water was 8 times, and 1 hour for the second time, amount of water was 6 times of amounts.
Experimental example 2 Radix Scutellariaes decoct determining of amount of water
Get every part of 180g of 3 parts of medical materials of Radix Scutellariae, decocted 2 hours for the first time, decocted 1 hour for the second time, divide 3 groups to test, 6 times of amounts of first group of amount of water, 4 times of amounts, 8 times of amounts of second group of amount of water, 6 times of amounts, 10 times of amounts of the 3rd group of amount of water, 8 times of amounts, collecting decoction, filter, leave standstill, get supernatant and determine content of baicalin, the results are shown in Table 2:
Table 2: Herba Ephedrae decocts determining of amount of water
With the content of baicalin is index, second group as can be seen (8 times of amounts of amount of water, 6 times of amounts), the 3rd group (10 times of amounts of amount of water, 8 times of amounts), paste-forming rate is more or less the same, for energy savings and shortening production time, so second group of test parameters adopted in decision in big the production.Promptly decoct with water twice, 2 hours for the first time, amount of water was 8 times, and 1 hour for the second time, amount of water was 6 times of amounts.
Experimental example 3 Herba Ephedraes and Radix Scutellariae are fried in shallow oil altogether and are divided the influence of frying in shallow oil the stripping composition
Get Herba Ephedrae 90g, Radix Scutellariae 180g fries in shallow oil altogether, adding for the first time 8 times of water gagings decocted 2 hours, adding 6 times of water gagings for the 2nd time decocted 1 hour, collecting decoction filters, and leaves standstill, get supernatant and determine ephedrine hydrochloride, content of baicalin, the result of Comprehensive Experiment example 1,2, analysis Herba Ephedrae and Radix Scutellariae are fried in shallow oil altogether and are divided the influence of frying in shallow oil the stripping composition, see Table 3:
Table 3: Herba Ephedrae and Radix Scutellariae are fried in shallow oil altogether and are divided the influence of frying in shallow oil the stripping composition
By above-mentioned experimental result as can be seen, frying in shallow oil gained effective ingredient ephedrine hydrochloride and baicalin under Herba Ephedrae and Radix Scutellariae the same terms altogether all is starkly lower than branch and fries in shallow oil.So the present invention separately decocts this two flavors crude drug.
Experimental example 4 Semen Armeniacae Amarums (stir-fry), Radix Glycyrrhizae, Radix Isatidis, Rhizoma Menispermi decoct determining of amount of water
Get Semen Armeniacae Amarum (stir-fry) 120g, Radix Glycyrrhizae 90g, Radix Isatidis 180g, Rhizoma Menispermi 90g, three parts, decoct with water and decocted 2 hours for the first time, decocted 1 hour for the second time, divide 3 groups to test, 8 times of amounts of first group of amount of water, 6 times of amounts, 10 times of amounts of second group of amount of water, 8 times of amounts, 10 times of amounts of the 3rd group of amount of water, 10 times of amounts, collecting decoction filters, leave standstill, getting supernatant concentration, to become relative density be 1.20 clear paste (60 ℃), is index to go out the clear paste amount, determines amount of water.The results are shown in Table 4:
Table 4: Semen Armeniacae Amarum (stir-fry), Radix Glycyrrhizae, Radix Isatidis, Rhizoma Menispermi decoct determining of amount of water
To go out the clear paste amount is index, second group as can be seen (10 times of amounts of amount of water, 8 times of amounts), the 3rd group (10 times of amounts of amount of water, 10 times of amounts), paste-forming rate is more or less the same, for energy savings and shortening production time, so second group of test parameters adopted in decision in big the production.Promptly decoct with water twice, 2 hours for the first time, amount of water was 8 times, and 1 hour for the second time, amount of water was 6 times.
The investigation of experimental example 5 concentration technologies
Press experimental example 1,2,4 and extract three batch samples, the gained extracting solution is injected the economic benefits and social benefits concentration tank carry out concentration technology research, divides and carry out concentrating under reduced pressure with following parameters three times, for the first time, one imitates: vacuum 0.02MPa, two effect: vacuum 0.04MPa; For the second time, one imitates: vacuum 0.04MPa, and two imitate: vacuum 0.06MPa; One imitate for the third time: vacuum 0.06MPa, two imitate: vacuum 0.08MPa.Result of the test sees Table 5.
The investigation of table 5 concentration technology
By above experiment as can be seen, in order to save concentration time, guarantee concentrated effect, determine that it is an effect: vacuum 0.04MPa that the economic benefits and social benefits concentration tank concentrates parameter, two imitate: vacuum 0.06MPa.
The investigation of experimental example 6 sterilising conditions
After the liquid medicine filling that makes by above-mentioned technology,, investigate pH value before and after the outward appearance, sterilization of sample, content, aseptic assurance level indexs such as (SAL) respectively at 105 ℃ of following flowing steam sterilizations 20,30,45min.The results are shown in Table 6.
Table 6 sterilising conditions is to the influence of medicinal liquid
Conclusion: through investigating this product solution through 105 ℃ of following flowing steam sterilizations 20,30,45min, the content of the outward appearance before and after the sterilization, pH value, index components has no significant change, and sterilization effect has all reached 2005 editions pharmacopeia regulations.In order to economize on resources, be 105 ℃ of following flowing steam sterilization 20min so select the sterilising conditions of this product solution.
The research of test example 7 pharmacodynamics tests
1 experiment material
1.1 medicine
Be subjected to reagent thing group I: according to the pharmaceutical preparation of the present invention of embodiment 2 preparations;
Be subjected to reagent thing group II:
[prescription] Herba Ephedrae 90g Semen Armeniacae Amarum (stir-fry) 120g Gypsum Fibrosum 270g Radix Glycyrrhizae 90g
Radix Scutellariae 180g Radix Isatidis 180g Rhizoma Menispermi 90g
[method for making] above seven flavors, Herba Ephedrae and Gypsum Fibrosum decoct with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression is concentrated into relative density 1.15～1.20, and all the other five tastes decoct with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction, filter, filtrate decompression is concentrated into relative density 1.15～1.20, leaves standstill 24 hours, filters, filtrate adds Mel 200g, sucrose 100g and sodium benzoate 3g, boil and make dissolving, add water to total amount 1000ml, stir evenly, 2～6 ℃ of cold preservation 24～48 hours, filter, embedding, 105 ℃ of moist heat sterilizations 20 minutes are promptly.
Positive drug group: infantile heat-clearing and antitussive oral liquid (specification: 10ml/ props up), the accurate word Z20033069 of traditional Chinese medicines, Shantou metal and stone pharmacy head factory;
Ammonium chloride is analytical pure;
According to train of thought orchid, 5-hydroxy tryptamine Fluka import packing, Shanghai chemical reagent purchasing and supply station packing factory.
1.2 animal Wistar rat, ICR mice and SD rat, Cavia porcellus, rabbit ♀ ♂ all uses.
2 methods and result
Get 30 of Wistar rats, body weight 200～250g, male and female half and half, 10 every group 2.1 suppress the effect of capillary permeability.Be divided into 4 groups at random, respectively administration normal saline, positive drug, be subjected to reagent thing group I, be subjected to reagent thing group II, each is organized behind ig administration or saline 30min, and at the 5-hydroxy tryptamine 0.1ml of rat back center line left side subcutaneous injection 1 μ g/ml, iv1% is according to the blue 4ml/kg of the train of thought immediately.Put to death animal behind the 15min, the painted skin in back is cut and shredded put into 3ml normal saline-acetone (3: 7) mixed liquor, place 24h, get supernatant, with 721 spectrophotometers (610nm) photometry density.The results are shown in Table 7.
Table 7 suppresses the effect of capillary permeability
| Group | Dosage | Optical density value (x ± s) |
| The normal saline group | - | 0.1233±0.0526 |
| The positive drug group | 2.7ml/kg | 0.0747±0.0224 |
| Be subjected to reagent thing group I | 2.7ml/kg | 0.0470±0.0218**# |
| Be subjected to reagent thing group II | 2.7ml/kg | 0.0653±0.0314* |
Annotate: n=10, compare * * P＜0.01, * P＜0.05 with the positive drug group; Compare #P＜0.05 with being subjected to reagent thing group II.
Be subjected to reagent thing group I, II that capillary permeability due to the 5-hydroxy tryptamine is all had inhibitory action, be subjected to the inhibitory action of reagent thing group I significantly to be better than the positive control medicine and to be subjected to reagent thing group II.
2.2 influence 30 of extracting male Wistar rats to what carrageenin caused rat paw edema, body weight 140～160g, grouping and administration are the same, 1h after the administration, in the subcutaneous injection 1% carrageenin 0.1ml/ of the right sufficient sole of the foot of rat only.Cause scorching back 1～6h and measure sufficient sole of the foot volume respectively, calculate swelling value (causing the sufficient sole of the foot difference in volume in scorching front and back).The results are shown in Table 8.
Table 8 pair carrageenin causes the influence of rat paw edema
Annotate: n=10, compare * * P＜0.01, * P＜0.05 with the positive drug group; Compare #P＜0.05 with being subjected to reagent thing group II.
Being subjected to reagent thing group that carrageenin is caused rat paw edema all has inhibitory action, is subjected to the inhibitory action of reagent thing group I to be better than being subjected to reagent thing group II.
2.3 to influence (capillary glass-tube method) the SD rat of rat expectoration amount, ♀ ♂ half and half, body weight 200～250g is divided into 5 groups at random, 10 every group, is respectively normal saline matched group, ammonium chloride, positive drug group, is subjected to reagent thing group I, is subjected to reagent thing group II.Insert the normal sputum secretory volume in the 2h before the administration of capillary glass tube record, each group gives relative medicine with the 1mL/100g duodenum respectively then, continues the sputum secretory volume in the 2h after the record administration.Draw the effect of reducing phlegm that sputum length is estimated medicine with capillary tube.The results are shown in Table 9.
The influence of table 9 pair rat expectoration amount
Annotate: n=10, compare * * P＜0.01, * P＜0.05 with the positive drug group; Compare #P＜0.05 with being subjected to reagent thing group II.
The result shows that pharmaceutical composition of the present invention, ammonium chloride and infantile heat-clearing and antitussive oral liquid all can significantly increase the expectoration amount of rat, and be better than by the effect of reagent thing group I to be subjected to reagent thing group II.
2.4 to strong aqua ammonia draw cough influence the ICR mice, ♀ ♂ half and half, body weight 20～24g is divided into 4 groups at random, 10 every group, is respectively normal saline matched group, positive drug group, is subjected to reagent thing group I, is subjected to reagent thing group II, ig administration, one day twice, continuous 5 times.The reference literature method is observed cough latent period (spraying finished to the time that begins to occur coughing) and the interior cough number of times of 3min behind 27% the strong aqua ammonia that mice feeds atomizing behind last administration 45min.The results are shown in Table 10.
Table 10 pair strong aqua ammonia draws the influence of coughing
| Group | Dosage | Cough latent period (s) | Cough number of times in the 30min |
| The saline control group | Equal-volume | 45.8±8.6 | ?75.3±6.6 |
| The positive drug group | 2.7ml/kg | 48.1±10.2 | ?70.0±7.5 |
| Be subjected to reagent thing group I | 2.7ml/kg | 77.8±9.7*# | ?46.1±5.8*# |
| Be subjected to reagent thing group II | 2.7ml/kg | 56.82±8.6 | ?54.2±7.5 |
Annotate: n=10, compare * * P＜0.01, * P＜0.05 with the positive drug group; Compare #P＜0.05 with being subjected to reagent thing group II.
This experimental result shows, is subjected to reagent thing group the significant prolongation cough latent period also to reduce the cough number of times; Be subjected to reagent thing group I and to be subjected to reagent thing group II relatively strong aqua ammonia to be drawn the inhibitory action of coughing better.
2.5 drawing Cavia porcellus, the present invention breathes heavily preclinical influence
Cavia porcellus is put in people's special glass case, and constant voltage sprays into 1%Ach (acetylcholine) and 0.5%Hist capacity mixed liquors such as (histamine) in case.Spray time 20S, spouting liquid 6ml.Finishing rapid breathing time fall of twitching to occur to Cavia porcellus with spraying breathes heavily incubation period as drawing.Select body weight 180 ± 20g Cavia porcellus, before the experiment 1d reject responsive person (draw breathe heavily the incubation period＞120S).Get 40 of qualified Cavia porcelluss next day, press table 4 grouping ig administration, 40min opens to draw as spraying and breathes heavily behind the medicine.The results are shown in Table 11.
Table 11 the present invention draws Cavia porcellus and breathes heavily preclinical influence (X ± S)
Annotate: n=10, compare * * P＜0.01, * P＜0.05 with the positive drug group; Compare #P＜0.05 with being subjected to reagent thing group II.
This experimental result shows that medicine of the present invention can the significant prolongation cough latent period also reduce the cough number of times; It is better that medicine of the present invention and positive control medicine relatively draw the inhibitory action of coughing to strong aqua ammonia.
2.6 the analgesic experiment of rabbit
Select rabbit for use, body weight 1.5～2.0Kg, male and female half and half.Choose body temperature between 38.5～39.5 ℃, and basal body temperature changes less than 32 of 0.5 ℃ qualified rabbit for three days on end, is divided into 4 groups at random, 8 every group, promptly blank group, positive drug matched group, be subjected to reagent thing group I, be subjected to reagent thing group II.Gavage different pharmaceutical respectively, behind the administration 30min, auricular vein injection antityphoid vaccine 1ml/Kg begins to measure the anus temperature behind the 30min respectively, and every 0.5h surveys 1 time, surveys 4h continuously.See Table 12.
The influence of fever in rabbits body temperature due to the table 12 pair antityphoid vaccine (n=8,, x ± s)
| *# |
| Be subjected to reagent thing group II | 39.4± 0.47 | 0.66 ± 0.21 | 1.11± 0.14 | 1.06± 0.22 | 0.33 ± 0.14* | 0.25± 0.16* | 0.18± 0.08* | 0.16± 0.30* | 0.11± 0.22 |
Annotate: n=8, compare * * P＜0.01, * P＜0.05 with the positive drug group; Compare #P＜0.05 with being subjected to reagent thing group II.30min after the vaccinate, each is organized rabbit body temperature and all significantly rises, the 1h peaking, the result shows and is subjected to reagent thing group I, rabbit body temperature is risen by reagent thing group II and positive control medicine inhibitory action is all arranged that the inhibitory action of reagent thing group I is better than being subjected to reagent thing group II.
Drawn by experimental example 7, Herba Ephedrae and Radix Scutellariae separately extract effect such as can significantly improve this pharmaceutical composition heat clearing away, lung qi dispersing, relieving asthma.
Following embodiment all can realize the described effect of above-mentioned experimental example
Embodiment 1.
Herba Ephedrae 90g Semen Armeniacae Amarum (stir-fry) 120g Gypsum Fibrosum 270g Radix Glycyrrhizae 90g
Radix Scutellariae 180g Radix Isatidis 180g Rhizoma Menispermi 90g
More than seven flavors, Herba Ephedrae decocts with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression is concentrated into relative density 1.15～1.20, and Radix Scutellariae decocts with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression concentrates, and to relative density 1.15～1.20, Gypsum Fibrosum decocts with water half an hour, add four flavors such as Semen Armeniacae Amarum again, decoct secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression is concentrated into relative density 1.15～1.20, leaves standstill 24 hours, filters, filtrate adds Mel 200g, sucrose 100g and sodium benzoate 3g, boil and make dissolving, add water to total amount 1000ml, stir evenly, 2～6 ℃ of cold preservation 24～48 hours, filter, embedding, 105 ℃ of moist heat sterilizations 20 minutes are promptly.
Embodiment 2.
Herba Ephedrae 90g Semen Armeniacae Amarum (stir-fry) 120g Gypsum Fibrosum 270g Radix Glycyrrhizae 90g
Radix Scutellariae 180g Radix Isatidis 180g Rhizoma Menispermi 90g
More than seven the flavor, Herba Ephedrae decocts with water secondary, adding for the first time 8 times of amounts of water decocted 2 hours, adding for the second time 6 times of amounts of water decocted 1 hour, collecting decoction, filter, filtrate is injected the economic benefits and social benefits concentration tank, concentrating under reduced pressure, one effect heating clamber pressure is 0.04MPa, and two effect heating clamber pressure are 0.06MPa, are concentrated into relative density 1.15～1.20, Radix Scutellariae decocts with water secondary, add for the first time 8 times of amounts of water and decocted 2 hours, add 6 times of amounts of water for the second time and decocted collecting decoction 1 hour, filter, filtrate decompression concentrates, and an effect heating clamber pressure is 0.04MPa, and two effect heating clamber pressure are 0.06MPa, be concentrated into relative density 1.15～1.20, Gypsum Fibrosum adds 8 times of amounts of water and decocts half an hour, adds four flavors such as Semen Armeniacae Amarum again, decocts secondary, adding for the first time 8 times of amounts of water decocted 2 hours, add for the second time 6 times of amounts of water and decocted 1 hour, collecting decoction filters, filtrate decompression concentrates, one effect heating clamber pressure is 0.04MPa, and two effect heating clamber pressure are 0.06MPa, are concentrated into relative density 1.15～1.20, left standstill 24 hours, filter, filtrate adds Mel 200g, sucrose 100g and sodium benzoate 3g boil and make dissolving, add water to total amount 1000ml, stir evenly, 2～6 ℃ of cold preservation 24～48 hours filters, embedding, 105 ℃ of moist heat sterilizations 20 minutes are promptly.
Embodiment 3.
Herba Ephedrae 90g Semen Armeniacae Amarum (stir-fry) 120g Gypsum Fibrosum 270g Radix Glycyrrhizae 90g
Radix Scutellariae 180g Radix Isatidis 180g Rhizoma Menispermi 90g
More than seven flavors, Herba Ephedrae decocts with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression is concentrated into relative density 1.15, and Radix Scutellariae decocts with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression concentrates, and to relative density 1.15, Gypsum Fibrosum decocts with water half an hour, add four flavors such as Semen Armeniacae Amarum again, decoct secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression is concentrated into relative density 1.15, leaves standstill 24 hours, filters, filtrate adds Mel 200g, sucrose 100g and sodium benzoate 3g, boil and make dissolving, add water to total amount 1000ml, stir evenly, 2 ℃ of cold preservation 24 hours, filter, embedding, 105 ℃ of moist heat sterilizations 20 minutes are promptly.
Embodiment 4.
Herba Ephedrae 90g Semen Armeniacae Amarum (stir-fry) 120g Gypsum Fibrosum 270g Radix Glycyrrhizae 90g
Radix Scutellariae 180g Radix Isatidis 180g Rhizoma Menispermi 90g
More than seven flavors, Herba Ephedrae decocts with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression is concentrated into relative density 1.20, and Radix Scutellariae decocts with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression concentrates, and to relative density 1.20, Gypsum Fibrosum decocts with water half an hour, add four flavors such as Semen Armeniacae Amarum again, decoct secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression is concentrated into relative density 1.20, leaves standstill 24 hours, filters, filtrate adds Mel 200g, sucrose 100g and sodium benzoate 3g, boil and make dissolving, add water to total amount 1000ml, stir evenly, 6 ℃ of cold preservation 24～48 hours, filter, embedding, 105 ℃ of moist heat sterilizations 20 minutes are promptly.
Embodiment 5.
Herba Ephedrae 90g Semen Armeniacae Amarum (stir-fry) 120g Gypsum Fibrosum 270g Radix Glycyrrhizae 90g
Radix Scutellariae 180g Radix Isatidis 180g Rhizoma Menispermi 90g
More than seven flavors, Herba Ephedrae decocts with water secondary, adds for the first time 8 times of amounts of water and decocts 2 hours, adding for the second time 6 times of amounts of water decocted 1 hour, collecting decoction filters, and filtrate is injected the economic benefits and social benefits concentration tank, concentrating under reduced pressure, one effect heating clamber pressure is 0.04MPa, and two effect heating clamber pressure are 0.06MPa, are concentrated into relative density 1.15, Radix Scutellariae decocts with water secondary, add for the first time 8 times of amounts of water and decocted 2 hours, add 6 times of amounts of water for the second time and decocted collecting decoction 1 hour, filter, filtrate decompression concentrates, and an effect heating clamber pressure is 0.04MPa, and two effect heating clamber pressure are 0.06MPa, be concentrated into relative density 1.15, Gypsum Fibrosum adds 8 times of amounts of water and decocts half an hour, adds four flavors such as Semen Armeniacae Amarum again, decocts secondary, adding for the first time 8 times of amounts of water decocted 2 hours, add for the second time 6 times of amounts of water and decocted 1 hour, collecting decoction filters, filtrate decompression concentrates, one effect heating clamber pressure is 0.04MPa, and two effect heating clamber pressure are 0.06MPa, are concentrated into relative density 1.15, left standstill 24 hours, filter, filtrate adds Mel 200g, sucrose 100g and sodium benzoate 3g boil and make dissolving, add water to total amount 1000ml, stir evenly, 2 ℃ of cold preservation 24 hours filters, embedding, 105 ℃ of moist heat sterilizations 20 minutes are promptly.
Embodiment 6.
Herba Ephedrae 90g Semen Armeniacae Amarum (stir-fry) 120g Gypsum Fibrosum 270g Radix Glycyrrhizae 90g
Radix Scutellariae 180g Radix Isatidis 180g Rhizoma Menispermi 90g
More than seven flavors, Herba Ephedrae decocts with water secondary, adds for the first time 8 times of amounts of water and decocts 2 hours, adding for the second time 6 times of amounts of water decocted 1 hour, collecting decoction filters, and filtrate is injected the economic benefits and social benefits concentration tank, concentrating under reduced pressure, one effect heating clamber pressure is 0.04MPa, and two effect heating clamber pressure are 0.06MPa, are concentrated into relative density 1.15～1.20, Radix Scutellariae decocts with water secondary, add for the first time 8 times of amounts of water and decocted 2 hours, add 6 times of amounts of water for the second time and decocted collecting decoction 1 hour, filter, filtrate decompression concentrates, and an effect heating clamber pressure is 0.04MPa, and two effect heating clamber pressure are 0.06MPa, be concentrated into relative density 1.20, Gypsum Fibrosum adds 8 times of amounts of water and decocts half an hour, adds four flavors such as Semen Armeniacae Amarum again, decocts secondary, adding for the first time 8 times of amounts of water decocted 2 hours, add for the second time 6 times of amounts of water and decocted 1 hour, collecting decoction filters, filtrate decompression concentrates, one effect heating clamber pressure is 0.04MPa, and two effect heating clamber pressure are 0.06MPa, are concentrated into relative density 1.20, left standstill 24 hours, filter, filtrate adds Mel 200g, sucrose 100g and sodium benzoate 3g boil and make dissolving, add water to total amount 1000ml, stir evenly, 6 ℃ of cold preservation 48 hours filters, embedding, 105 ℃ of moist heat sterilizations 20 minutes are promptly.
Claims (2)
1. preparation method for the treatment of the Chinese medicine preparation of external respiration infection of children, said preparation is made by the crude drug of following weight ratio,
Herba Ephedrae 90g Semen Armeniacae Amarum (parched) 120g Gypsum Fibrosum 270g Radix Glycyrrhizae 90g
Radix Scutellariae 180g Radix Isatidis 180g Rhizoma Menispermi 90g
It is characterized in that carrying out according to the following steps:
More than seven flavors, Herba Ephedrae decocts with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression is concentrated into relative density 1.15～1.20, and Radix Scutellariae decocts with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression concentrates, and to relative density 1.15～1.20, Gypsum Fibrosum decocts with water half an hour, add four flavors such as Semen Armeniacae Amarum again, decoct secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, filtrate decompression is concentrated into relative density 1.15～1.20, leaves standstill 24 hours, filters, filtrate adds Mel 200g, sucrose 100g and sodium benzoate 3g, boil and make dissolving, add water to total amount 1000ml, stir evenly, 2～6 ℃ of cold preservation 24～48 hours, filter, embedding, 105 ℃ of moist heat sterilizations 20 minutes are promptly.
2. the preparation method of Chinese medicine preparation as claimed in claim 1 is characterized in that carrying out according to the following steps:
More than seven the flavor, Herba Ephedrae decocts with water secondary, adding for the first time 8 times of amounts of water decocted 2 hours, adding for the second time 6 times of amounts of water decocted 1 hour, collecting decoction, filter, filtrate is injected the economic benefits and social benefits concentration tank, concentrating under reduced pressure, one effect heating clamber pressure is 0.04MPa, and two effect heating clamber pressure are 0.06MPa, are concentrated into relative density 1.15～1.20, Radix Scutellariae decocts with water secondary, add for the first time 8 times of amounts of water and decocted 2 hours, add 6 times of amounts of water for the second time and decocted collecting decoction 1 hour, filter, filtrate decompression concentrates, and an effect heating clamber pressure is 0.04MPa, and two effect heating clamber pressure are 0.06MPa, be concentrated into relative density 1.15～1.20, Gypsum Fibrosum adds 8 times of amounts of water and decocts half an hour, adds four flavors such as Semen Armeniacae Amarum again, decocts secondary, adding for the first time 8 times of amounts of water decocted 2 hours, add for the second time 6 times of amounts of water and decocted 1 hour, collecting decoction filters, filtrate decompression concentrates, one effect heating clamber pressure is 0.04MPa, and two effect heating clamber pressure are 0.06MPa, are concentrated into relative density 1.15～1.20, left standstill 24 hours, filter, filtrate adds Mel 200g, sucrose 100g and sodium benzoate 3g boil and make dissolving, add water to total amount 1000ml, stir evenly, 2～6 ℃ of cold preservation 24～48 hours filters, embedding, 105 ℃ of moist heat sterilizations 20 minutes are promptly.
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| CN102125614B (en) * | 2010-01-15 | 2013-06-26 | 北京亚东生物制药有限公司 | Preparation method of traditional Chinese medicine composition for treating common cold of children |
| CN101780214B (en) * | 2010-03-30 | 2012-02-01 | 海南新中正制药有限公司 | Method for preparing granules for curing infantile lung pathogenic heat and cough and asthma |
| CN102579632A (en) * | 2012-04-09 | 2012-07-18 | 河南百年康鑫药业有限公司 | Preparation method of concentrated heat-clearing and cough-relieving oral solution for children |
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| CN1939449A (en) * | 2005-09-30 | 2007-04-04 | 江西本草天工科技有限责任公司 | Infantile heat-clearing and antitussive dispersing tablets |
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