CN103038223A - 作为金属螯合剂的脱氮杂去铁硫辛类似物 - Google Patents
作为金属螯合剂的脱氮杂去铁硫辛类似物 Download PDFInfo
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- CN103038223A CN103038223A CN2011800290386A CN201180029038A CN103038223A CN 103038223 A CN103038223 A CN 103038223A CN 2011800290386 A CN2011800290386 A CN 2011800290386A CN 201180029038 A CN201180029038 A CN 201180029038A CN 103038223 A CN103038223 A CN 103038223A
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- compound
- alkyl
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- hydrogen
- iron
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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Applications Claiming Priority (3)
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| US33113810P | 2010-05-04 | 2010-05-04 | |
| US61/331,138 | 2010-05-04 | ||
| PCT/US2011/035211 WO2011140232A2 (en) | 2010-05-04 | 2011-05-04 | Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents |
Publications (1)
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| CN103038223A true CN103038223A (zh) | 2013-04-10 |
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| EP (1) | EP2566854A4 (https=) |
| JP (1) | JP2013525495A (https=) |
| CN (1) | CN103038223A (https=) |
| AU (1) | AU2011248158A1 (https=) |
| BR (1) | BR112012028321A2 (https=) |
| CA (1) | CA2798082A1 (https=) |
| NZ (1) | NZ603774A (https=) |
| WO (1) | WO2011140232A2 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107708693A (zh) * | 2015-04-27 | 2018-02-16 | 佛罗里达大学研究基金会 | 代谢程序化的金属螯合剂及其用途 |
| CN109862892A (zh) * | 2016-08-05 | 2019-06-07 | 阿布费罗制药股份有限公司 | 用于治疗金属介导的病症的给药方案 |
| CN118561711A (zh) * | 2024-07-31 | 2024-08-30 | 爱斯特（成都）生物制药股份有限公司 | 一种制备n-[8-(2-羟基苯甲酰基)氨基]辛酸及其盐的方法 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR201910900T4 (tr) | 2005-04-04 | 2019-08-21 | Univ Florida | Desferritiyokin polieter analogları. |
| WO2008115433A1 (en) | 2007-03-15 | 2008-09-25 | University Of Florida | Desferrithiocin polyether analogues |
| MY163516A (en) * | 2008-07-14 | 2017-09-15 | Ferrokin Biosciences Inc | Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
| EP2459544A4 (en) * | 2009-07-27 | 2012-12-05 | Ferrokin Biosciences Inc | DESDAADESFERROTHIOCIN POLYETHERAL ANALOGUE PROGRUGS USING METAL CHLORIDE |
| US8993606B2 (en) | 2011-12-09 | 2015-03-31 | Ferrokin Biosciences, Inc. | Oral formulations for treating metal overload |
| EP3620161A1 (en) | 2011-12-16 | 2020-03-11 | University of Florida Research Foundation, Inc. | Uses of 4'-desferrithiocin analogs |
| EP2928469A4 (en) * | 2012-12-07 | 2016-11-02 | Ferrokin Biosciences Inc | POLYMORPHIC FORMS OF DESAZADESFERRITHIOCIN ANALOGS |
| EP2953899A4 (en) * | 2013-02-11 | 2016-10-12 | Yeda Res & Dev | LANTHANID CLUSTER AND METHOD OF USE THEREOF |
| JP2016513652A (ja) | 2013-03-15 | 2016-05-16 | フェロキン バイオサイエンシーズ， インコーポレイテッド | デスアザデスフェリチオシン類似体の多形形態 |
| AU2014352780A1 (en) * | 2013-11-22 | 2016-06-09 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogs and uses thereof |
| TWI791362B (zh) | 2021-12-27 | 2023-02-01 | 財團法人工業技術研究院 | 有機金屬錯合物、包含其之觸媒組合物、以及聚烯烴的製備方法 |
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| WO2008130395A2 (en) * | 2006-12-12 | 2008-10-30 | University Of Florida | Desferrithiocin analogue actinide decorporation agents |
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| WO2011028255A2 (en) | 2009-08-25 | 2011-03-10 | University Of Florida Research Foundation, Inc. | Desferrithiocin polyether analogues and uses thereof |
-
2011
- 2011-05-04 EP EP11778269.8A patent/EP2566854A4/en not_active Withdrawn
- 2011-05-04 BR BR112012028321A patent/BR112012028321A2/pt not_active IP Right Cessation
- 2011-05-04 NZ NZ603774A patent/NZ603774A/en not_active IP Right Cessation
- 2011-05-04 CA CA2798082A patent/CA2798082A1/en not_active Abandoned
- 2011-05-04 US US13/695,376 patent/US20130053387A1/en not_active Abandoned
- 2011-05-04 AU AU2011248158A patent/AU2011248158A1/en not_active Abandoned
- 2011-05-04 US US13/100,705 patent/US9045440B2/en not_active Expired - Fee Related
- 2011-05-04 CN CN2011800290386A patent/CN103038223A/zh active Pending
- 2011-05-04 WO PCT/US2011/035211 patent/WO2011140232A2/en not_active Ceased
- 2011-05-04 JP JP2013509223A patent/JP2013525495A/ja active Pending
-
2015
- 2015-05-27 US US14/722,422 patent/US20150259306A1/en not_active Abandoned
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| US4457936A (en) * | 1980-01-29 | 1984-07-03 | Hoechst Aktiengesellschaft | Use of hydroxyphenyl-thiazole-, -thiazoline- and -thiazolidine-carboxylic acids, for influencing the collagen metabolism |
| US20030022923A1 (en) * | 2001-03-01 | 2003-01-30 | Medinox, Inc. | Methods for treatment of sickle cell anemia |
| US20060211746A1 (en) * | 2003-09-09 | 2006-09-21 | Bergeron Raymond J Jr | Desferrithiocin derivatives and methods of use thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107708693A (zh) * | 2015-04-27 | 2018-02-16 | 佛罗里达大学研究基金会 | 代谢程序化的金属螯合剂及其用途 |
| CN109862892A (zh) * | 2016-08-05 | 2019-06-07 | 阿布费罗制药股份有限公司 | 用于治疗金属介导的病症的给药方案 |
| CN118561711A (zh) * | 2024-07-31 | 2024-08-30 | 爱斯特（成都）生物制药股份有限公司 | 一种制备n-[8-(2-羟基苯甲酰基)氨基]辛酸及其盐的方法 |
| CN118561711B (zh) * | 2024-07-31 | 2024-11-22 | 爱斯特（成都）生物制药股份有限公司 | 一种制备n-[8-(2-羟基苯甲酰基)氨基]辛酸及其盐的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013525495A (ja) | 2013-06-20 |
| EP2566854A4 (en) | 2013-11-06 |
| US20110275636A1 (en) | 2011-11-10 |
| CA2798082A1 (en) | 2011-11-10 |
| EP2566854A2 (en) | 2013-03-13 |
| BR112012028321A2 (pt) | 2017-03-21 |
| US9045440B2 (en) | 2015-06-02 |
| WO2011140232A3 (en) | 2012-02-23 |
| NZ603774A (en) | 2014-11-28 |
| US20150259306A1 (en) | 2015-09-17 |
| AU2011248158A1 (en) | 2012-12-20 |
| US20130053387A1 (en) | 2013-02-28 |
| WO2011140232A2 (en) | 2011-11-10 |
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