CN103005228B - Preparation method and application of additive for preventing diarrhea of piglet and promoting growth - Google Patents
Preparation method and application of additive for preventing diarrhea of piglet and promoting growth Download PDFInfo
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- CN103005228B CN103005228B CN 201310013723 CN201310013723A CN103005228B CN 103005228 B CN103005228 B CN 103005228B CN 201310013723 CN201310013723 CN 201310013723 CN 201310013723 A CN201310013723 A CN 201310013723A CN 103005228 B CN103005228 B CN 103005228B
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- 239000000654 additive Substances 0.000 title claims abstract description 30
- 230000000996 additive effect Effects 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 206010012735 Diarrhoea Diseases 0.000 title abstract description 9
- 230000001737 promoting effect Effects 0.000 title abstract 2
- 229940088594 vitamin Drugs 0.000 claims abstract description 42
- 229930003231 vitamin Natural products 0.000 claims abstract description 42
- 235000013343 vitamin Nutrition 0.000 claims abstract description 42
- 239000011782 vitamin Substances 0.000 claims abstract description 42
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 42
- 241000361919 Metaphire sieboldi Species 0.000 claims abstract description 41
- 239000011265 semifinished product Substances 0.000 claims abstract description 32
- 239000000284 extract Substances 0.000 claims abstract description 31
- 230000002255 enzymatic effect Effects 0.000 claims abstract description 25
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 22
- 239000008101 lactose Substances 0.000 claims abstract description 21
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 9
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 30
- 239000000047 product Substances 0.000 claims description 26
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 20
- 241000894006 Bacteria Species 0.000 claims description 16
- 239000004310 lactic acid Substances 0.000 claims description 15
- 235000014655 lactic acid Nutrition 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 15
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 10
- 229930003427 Vitamin E Natural products 0.000 claims description 10
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 10
- 235000019165 vitamin E Nutrition 0.000 claims description 10
- 229940046009 vitamin E Drugs 0.000 claims description 10
- 239000011709 vitamin E Substances 0.000 claims description 10
- 239000002994 raw material Substances 0.000 claims description 9
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 238000004108 freeze drying Methods 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 239000000376 reactant Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 7
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 7
- 241000482268 Zea mays subsp. mays Species 0.000 claims description 7
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 7
- 235000019155 vitamin A Nutrition 0.000 claims description 7
- 239000011719 vitamin A Substances 0.000 claims description 7
- 229940045997 vitamin a Drugs 0.000 claims description 7
- 229930003316 Vitamin D Natural products 0.000 claims description 6
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 6
- 241001233061 earthworms Species 0.000 claims description 6
- 235000019166 vitamin D Nutrition 0.000 claims description 6
- 239000011710 vitamin D Substances 0.000 claims description 6
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 6
- 229940046008 vitamin d Drugs 0.000 claims description 6
- 240000008042 Zea mays Species 0.000 abstract description 6
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract description 6
- 235000005822 corn Nutrition 0.000 abstract description 6
- 238000011161 development Methods 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 241000186660 Lactobacillus Species 0.000 abstract 3
- 229940039696 lactobacillus Drugs 0.000 abstract 3
- 239000012467 final product Substances 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 8
- 241000282887 Suidae Species 0.000 description 7
- 210000000936 intestine Anatomy 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000009360 aquaculture Methods 0.000 description 2
- 244000144974 aquaculture Species 0.000 description 2
- 235000014590 basal diet Nutrition 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000003031 feeding effect Effects 0.000 description 1
- 230000007413 intestinal health Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 235000021238 nutrient digestion Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a preparation method and application of an additive for preventing diarrhea of a piglet and promoting growth. The additive is mainly prepared from earthworm enzymatic extract, vitamin semi-finished product, lactose, lactobacillus, and extruded corn. The preparation method comprises the steps of preparing the earthworm enzymatic extract, preparing the vitamin semi-finished product, and evenly mixing the earthworm enzymatic extract, the vitamin semi-finished product, the lactose, the lactobacillus and the extruded corn according to the mass ratio of (8-10): 0.5: (5-8): 0.2: 10 to obtain the final product. The additive is suitable for the piglet before and after ablactation and added to complete batch; and the adding ratio is 1-1.5% of complete batch. According to thepreparation method, the earthworm enzymatic extract, the vitamin semi-finished product, the lactose, the lactobacillus and the extruded corn which are partitioned scientifically are organically combined to play a good role in diarrhea and slow growth caused before and after ablactation; the diarrhea morbidity of the piglet can be obviously reduced; growth and development of the piglet are obviously facilitated, and a good foundation is established for improvement of pig production efficiency.
Description
Technical field
The present invention relates to a kind of aquaculture with preparation method and the application of additive, particularly relate to a kind of be used to preventing newborn piglet white scour, somatotrophic additive producing method and application thereof.
Background technology
In recent years, the pig industry development rapidly, but because newborn weaned piglet, reload during the disease incidence such as diarrhea high, in case newborn piglet white scour occurs, can only adopt passively the method for perfusion to treat newborn piglet white scour, result for the treatment of is not good enough passively by force owing to newborn piglet white scour rapid onset infectiousness, causes the newborn piglet death rate high, and survival rate is low.Directly affect the economic benefit of aquaculture.How to improve newborn piglet survival ratio by technological means, be the problem of the person of raising pigs, researcher's research always.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, one provides a kind of preparation method who utilizes the material reasonable preparation productions such as earthworm enzymatic hydrolyzed extract, vitamin, lactose, lactic acid bacteria and popcorn to prevent newborn piglet white scour, somatotrophic additive, and two provide the application of a kind of newborn piglet white scour, somatotrophic additive.
The purpose that realizes foregoing invention adopts technical scheme:
A kind of preparation method who prevents newborn piglet white scour, somatotrophic additive, the raw material that consists of additive mainly is comprised of earthworm enzymatic hydrolyzed extract, vitamin semi-finished product, lactose, lactic acid bacteria and popcorn, and its preparation method is:
The preparation of described earthworm enzymatic hydrolyzed extract: dried earthworms is mixed in the 1:3-5 ratio with water, reaction is 36-48 hour under 40 ℃ of-50 ℃ of conditions, with reactant under 4 ℃ of conditions the centrifugal 10-15 of 1500r/min minute, products therefrom was the earthworm enzymatic hydrolyzed extract after the freeze drying of liquid part;
The preparation vitamin semi-finished product: vitamin semi-finished product is the mixture of vitamin A, vitamin D, vitamin E, and the component and the parts by weight that consist of vitamin semi-finished product are: 5 ~ 10 parts of vitamin A 3-5 parts, vitamin D 2-4 part, vitamin E mix and make vitamin semi-finished product;
With earthworm enzymolysis product extract, vitamin semi-finished product, lactose, lactic acid bacteria and popcorn in mass ratio the ratio of 8-10:0.5:5-8:0.2:10 mix and be final products.
As preferred version, prepare the earthworm enzymatic hydrolyzed extract take bright earthworm as raw material, its method is that bright earthworm is mixed in the 1:0.5-1 ratio with water, reaction is 45 hours under 45 ℃ of conditions, with reactant under 4 ℃ of conditions the centrifugal 10-15 of 1500r/min minute, products therefrom was the earthworm enzymatic hydrolyzed extract after the freeze drying of liquid part.
As preferred version, the component of described vitamin semi-finished product and parts by weight are: 8 parts of 4 parts of vitamin As, 3 parts of vitamin Ds, vitamin E mix and make vitamin semi-finished product.
As preferred version, described lactose content is greater than 50% product.
As preferred version, the viable count of described lactic acid bacteria is greater than 4 * 10
9Cfu/g.
A kind of application that prevents newborn piglet white scour, somatotrophic additive, the newborn piglet before and after being applicable to wean.
As preferred version, described additive adds the full price batch to, and the adding proportion of this additive is the 1-1.5% of full price batch.
Adopt technique scheme, contain abundant free amino acid, low molecular peptide, antibacterial peptide and chelating amino acids attitude trace element in the earthworm enzymatic hydrolyzed extract of the present invention, can establishment the growth of harmful bacteria in the breast intestine of young pigs, not newborn piglet growth provides comparatively sufficient, that absorption efficiency is high free amino acid and low molecular peptide, thereby can effectively prevent newborn piglet white scour and promote growth.The vitamin A. D. E of scientific matching can provide sufficient assurance for growing of each organ such as newborn intestine of young pigs mucous membrane, is conducive to reparation and the division of cell, promotes absorption and the utilization of calcium, phosphorus, thereby promotes newborn Piglet Development; Lactose has important effect as the early stage necessary nutrient of newborn Piglet Development aspect the newborn piglet growth, be the indispensable nutriment of newborn intestine of young pigs normal flora, and its tunning is conducive to newborn intestine of young pigs and grows.The interpolation of lactic acid bacteria can improve newborn intestine of young pigs flora environment, is conducive to intestinal health and nutrient digestion and absorbs, and then be conducive to newborn piglet growth and prevent the generation of diarrhea etc.The diarrhea that the combination of earthworm enzymolysis product extract, vitamin, lactose, lactic acid bacteria and the popcorn of scientific matching causes the wean front and back, poor growth etc. have good effect, can significantly reduce the newborn piglet white scour incidence of disease, significantly promote newborn Piglet Development, for the raising benefit of raising pigs has been established good basis.
The specific embodiment
The present invention will be further described below in conjunction with specific embodiment.
Embodiment 1
The present embodiment is a kind of preparation method who prevents newborn piglet white scour, somatotrophic additive, and the method is take earthworm enzymatic hydrolyzed extract, vitamin semi-finished product, lactose, lactic acid bacteria and expanded corn powder as raw material, and its preparation method is:
At first prepare the earthworm enzymatic hydrolyzed extract
Selecting dried earthworms or bright earthworm is raw material, dried earthworms is mixed in the ratio of 1:4 with water, reaction is 40 hours under 45 ℃ of conditions, and with reactant centrifugal 12 minutes of 1500r/min under 4 ℃ of conditions, products therefrom is the earthworm enzymatic hydrolyzed extract after the freeze drying of liquid part;
Selecting bright earthworm is that raw material prepares the earthworm enzymatic hydrolyzed extract, its method is that bright earthworm is mixed in the ratio of 1:0.8 with water, reaction is 45 hours under 45 ℃ of conditions, with reactant centrifugal 15 minutes of 1500r/min under 4 ℃ of conditions, products therefrom is the earthworm enzymatic hydrolyzed extract after the freeze drying of liquid part.
The preparation vitamin semi-finished product: vitamin semi-finished product is the mixture of vitamin A, vitamin D, vitamin E, and the component and the parts by weight that consist of vitamin semi-finished product are: 8 parts of 4 parts of vitamin As, 3 parts of vitamin Ds, vitamin E mix and make vitamin semi-finished product.
Adopt the lactose prod of lactose content 55%.
Lactic acid bacteria adopts viable count greater than 4 * 10
9The product of cfu/g.
With earthworm enzymolysis product extract, vitamin semi-finished product, lactose, lactic acid bacteria and expanded corn powder in mass ratio the ratio of 9:0.5:6:0.2:10 mix and be final products.
Embodiment 2
At first prepare the earthworm enzymatic hydrolyzed extract
Selecting dried earthworms or bright earthworm is raw material, dried earthworms is mixed in the ratio of 1:5 with water, reaction is 40 hours under 45 ℃ of conditions, and with reactant centrifugal 15 minutes of 1500r/min under 4 ℃ of conditions, products therefrom is the earthworm enzymatic hydrolyzed extract after the freeze drying of liquid part;
Selecting bright earthworm is that raw material prepares the earthworm enzymatic hydrolyzed extract, its method is that bright earthworm is mixed in the ratio of 1:1 with water, reaction is 45 hours under 45 ℃ of conditions, and with reactant centrifugal 15 minutes of 1500r/min under 4 ℃ of conditions, products therefrom is the earthworm enzymatic hydrolyzed extract after the freeze drying of liquid part.
The preparation vitamin semi-finished product: vitamin semi-finished product is the mixture of vitamin A, vitamin D, vitamin E, and the component and the parts by weight that consist of vitamin semi-finished product are: 10 parts of 5 parts of vitamin As, 4 parts of vitamin Ds, vitamin E mix and make vitamin semi-finished product.
Lactose employing lactose content is 60% product.
Lactic acid bacteria adopts viable count greater than 4 * 10
9The product of cfu/g.
With earthworm enzymolysis product extract, vitamin semi-finished product, lactose, lactic acid bacteria and expanded corn powder in mass ratio the ratio of 10:0.5:8:0.2:10 mix and be final products.
Embodiment 3
A kind of application that prevents newborn piglet white scour, somatotrophic additive, the newborn piglet before and after being applicable to wean.
Additive adds in the full price batch, and the adding proportion of this additive is the 1-1.5% of full price batch.Feeding effect reduces the newborn piglet white scour incidence of disease for can significantly preventing the generation of newborn piglet white scour, promotes newborn Piglet Development, and the speed of growth improves more than 8%.
Embodiment 4
Product feeding experiment effect embodiment
40 of 20 ages in days breasts piglets are chosen in test, are divided into two groups, the control group fed basal diet, test group add on the basal diet basis 1.5% prevent newborn piglet white scour, somatotrophic additive, test period 30 days.Testing index is daily gain and diarrhea rate.Result of the test shows: the average daily gain of duration of test test group breast piglet is 352 grams, and control group is 324 grams, compares with control group and has improved 8.36%, and newborn grice diarrhoea rate test group is 3.8%, and control group is 18.5%, compares and has reduced by 15 percentage points.
Claims (7)
1. preparation method who prevents newborn piglet white scour, somatotrophic additive, the raw material that consists of additive mainly is comprised of earthworm enzymatic hydrolyzed extract, vitamin semi-finished product, lactose, lactic acid bacteria and popcorn, it is characterized in that, and its preparation method is:
The preparation of described earthworm enzymatic hydrolyzed extract: dried earthworms is mixed in the 1:3-5 ratio with water, reaction is 36-48 hour under 40 ℃ of-50 ℃ of conditions, with reactant under 4 ℃ of conditions the centrifugal 10-15 of 1500r/min minute, products therefrom was the earthworm enzymatic hydrolyzed extract after the freeze drying of liquid part;
The preparation vitamin semi-finished product: vitamin semi-finished product is the mixture of vitamin A, vitamin D, vitamin E, and the component and the parts by weight that consist of vitamin semi-finished product are: 5 ~ 10 parts of vitamin A 3-5 parts, vitamin D 2-4 part, vitamin E mix and make vitamin semi-finished product;
With earthworm enzymolysis product extract, vitamin semi-finished product, lactose, lactic acid bacteria and popcorn in mass ratio the ratio of 8-10:0.5:5-8:0.2:10 mix and be final products.
2. the preparation method who prevents newborn piglet white scour, somatotrophic additive according to claim 1, it is characterized in that, prepare the earthworm enzymatic hydrolyzed extract take bright earthworm as raw material, its method is that bright earthworm is mixed in the 1:0.5-1 ratio with water, reaction is 45 hours under 45 ℃ of conditions, with reactant under 4 ℃ of conditions the centrifugal 10-15 of 1500r/min minute, products therefrom was the earthworm enzymatic hydrolyzed extract after the freeze drying of liquid part.
3. the preparation method who prevents newborn piglet white scour, somatotrophic additive according to claim 1, it is characterized in that, the component of described vitamin semi-finished product and parts by weight are: 8 parts of 4 parts of vitamin As, 3 parts of vitamin Ds, vitamin E mix and make vitamin semi-finished product.
4. the preparation method who prevents newborn piglet white scour, somatotrophic additive according to claim 1 is characterized in that, described lactose is lactose content greater than 50% product.
5. the preparation method who prevents newborn piglet white scour, somatotrophic additive according to claim 1 is characterized in that, the viable count of described lactic acid bacteria is greater than 4 * 10
9Cfu/g.
6. application that prevents newborn piglet white scour, somatotrophic additive, it is characterized in that, described additive be with earthworm enzymolysis product extract, vitamin semi-finished product, lactose, lactic acid bacteria and popcorn in mass ratio the ratio of 8-10:0.5:5-8:0.2:10 mix the final products that make, the newborn piglet before and after this product is applicable to wean.
7. the application that prevents newborn piglet white scour, somatotrophic additive according to claim 6, described additive adds the full price batch to, and the adding proportion of this additive is the 1-1.5% of full price batch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201310013723 CN103005228B (en) | 2013-01-15 | 2013-01-15 | Preparation method and application of additive for preventing diarrhea of piglet and promoting growth |
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|---|---|---|---|
| CN 201310013723 CN103005228B (en) | 2013-01-15 | 2013-01-15 | Preparation method and application of additive for preventing diarrhea of piglet and promoting growth |
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| CN103005228A CN103005228A (en) | 2013-04-03 |
| CN103005228B true CN103005228B (en) | 2013-10-23 |
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| CN109874937A (en) * | 2019-03-28 | 2019-06-14 | 北部湾大学 | The low brotein equilibrium nutrition selenium-rich zoology feed of store pig |
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| CN1640292A (en) * | 2004-12-17 | 2005-07-20 | 李成会 | Process for producing high fodder protein by treating low protein using earthworm |
| CN101243832A (en) * | 2008-03-21 | 2008-08-20 | 唐山师范学院 | Process technique of ecological nutrition feedstuff additive |
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Effective date of registration: 20180509 Address after: 438000 No. 19, No. 5 Heping Road, new industrial park, Hong'an Economic Development Zone, Huanggang, Hubei Patentee after: Hongan Zhengbang Aquaculture Co.,Ltd. Address before: No. 156, construction of North Road, Tangshan City, Hebei Province Patentee before: Tangshan Normal University |
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| CB03 | Change of inventor or designer information | ||
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Inventor after: Hu Binfa Inventor after: Li Chenghui Inventor after: Zhu Lianying Inventor after: Jia Jiuman Inventor before: Li Chenghui Inventor before: Zhu Lianying Inventor before: Jia Jiuman |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20131023 |