CN102973799B - Pill used for post-anesthesia nerve injury - Google Patents

Pill used for post-anesthesia nerve injury Download PDF

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CN102973799B
CN102973799B CN201210594534.2A CN201210594534A CN102973799B CN 102973799 B CN102973799 B CN 102973799B CN 201210594534 A CN201210594534 A CN 201210594534A CN 102973799 B CN102973799 B CN 102973799B
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CN102973799A (en
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林艳霞
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Abstract

The invention discloses a pill used for post-anesthesia nerve injury and belongs to the field of traditional Chinese medicines. The effective constituents of the pill comprise the following raw materials in parts by weight: 70-90 parts of astragalus mongholicus, 60-85 parts of white paeony root, 55-80 parts of cassia twig, 50-65 parts of teasel root, 45-65 parts of radices sileris, 45-60 parts of radix stephaniae tetrandrae, 40-60 parts of rhizoma alismatis, 40-55 parts of cassia bark, 35-50 parts of radix salviae miltiorrhizae, 30-45 parts of peach kernel, 25-40 parts of angelica, 20-35 parts of rhizoma polygonati, 14-25 parts of ligusticum wallichii, 10-20 parts of aconite root, 7-16 parts of talcum and 4-12 parts of fructus trichosanthis. According to the pill, the raw materials are reasonably mixed, the conception is novel, the selected monarch and ministerial materials complement each other, and the raw materials are prepared respectively according to the herbal properties for the occurrence mechanism of the nerve injury in the anesthetization process so as to achieve the effects of clearing away heat, promoting diuresis, soothing the liver, removing stasis, activating blood, dissipating mass and eliminating dampness with aromatics. Through clinic verification, the pill has the characteristics of good absorption effect and remarkable treatment effect, avoids toxic and side effects and clinic adverse reactions, and has a very good effect for promoting repair of the injury caused by instruments and the nerve injury caused by anesthetics in anesthesia.

Description

A kind of for anaesthetizing the pill of postoperative nerve injury
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to a kind of for anaesthetizing the pill of postoperative nerve injury.
Background technology
In medical treatment clinically, anesthesia refers to all or part of swound that makes body with medicine or additive method, often be applied to the aspects such as surgical operation, be while performing a surgical operation or be to ease the pain, ensure patient safety, create the method that good surgical condition is taked while carrying out diagnostic test operation.Enter the approach of human body according to anesthetis, clinically anesthesia is divided into inhalation anesthesia, intravenous anesthesia and basal anesthesia, execute art method and comprise intravertebral anesthesia, nerve block anesthesia, regional anesthesia, local infiltration anesthesia and topical anesthesia etc., ultimate principles of these anesthesia arts are consistent, utilize anesthetis Anesthetic Patients whole body or partial nerve and reach the effect of pain relieving.
Be limited to narcotic research level, and operating theater instruments in anaesthesia process stimulating, all there is complication in various degree in current anesthesia: one, and vagus reflex.Comprise oculocardiac reflex, carotid sinus reflex, vago-vagal reflex; Two, pulmonary embolism.Comprise thrombosis, especially common with the dark vein of shank and femoral vein thrombosis, aeroembolism, fat embolism, amniotic fluid bolt, cancer embolus etc.; Three, in art, hemodynamics acutely changes; Four, hypoxemia in art, main manifestations is that SPO2 declines; Five, art mesobronchus spasm; Six, arrhythmia in anesthesia; Seven, endotracheal tube stops up; Eight, middle hypothermia disease; Nine, acute lung edema; Ten, acute cerebral edema.The existence of these complication, has had a strong impact on operation and has carried out, and has reduced operation safety rate, and patient's life and health has been proposed to acid test.
In above-mentioned complication, especially to cause damage the most general to local nerve, become the focus in Anesthesia Department's nursing, but at present to anaesthetizing treatment and the nursing of postoperative nerve injury, unripe available scheme, can only expect patient self nervous system and immune slow reparation, the postoperative care cycle is long, nursing efficacy is not obvious, has increased great work difficulty to medical personnel, has restricted the development of anesthesia postoperative care.
Traditional Chinese medical theory thinks, the channel system that nerve system of human body and the traditional Chinese medical science are traditional is very close, and nervous system sustains damage, and except apparatus is invaded wound, is mainly to stop up channels, damp-heat accumulation, qi depression to blood stasis by heat to be caused, the therefore formation such as common thrombosis, aeroembolism.Prevention key forms, melts key, should start with from the base reason of causing a disease, and lets out clearly the heat of channels, dredging liver internal organs QI and blood, with the Chinese crude drug prescription compatibility of the clearing heat in YING system solution stasis of blood, eliminating turbid pathogen with aromatics, by nourishing the method for meridians, raising nervous system nutrition supply, promote the healing of injured nerve.
Summary of the invention
The invention provides a kind ofly for anaesthetizing the pill of postoperative nerve injury, there is effect of clearing away heat-damp and promoting diuresis, the soothing the liver solution stasis of blood, blood circulation promoting and dispersing pathogen accumulation, eliminating turbid pathogen with aromatics, cause the nerve of damage to have fabulous reparation effect to apparatus in anaesthesia process or anesthetis.
For achieving the above object, technical scheme of the present invention is implemented as follows:
For anaesthetizing a pill for postoperative nerve injury, raw material composition and the parts by weight of making described pill effective ingredient are:
50~65 parts of 55~80 parts of Radix Dipsacis of 60~85 parts of Ramulus Cinnamomi of 70~90 portions of Radix Paeoniae Albas of the Radix Astragali
40~55 parts of 40~60 portions of Cortex Cinnamomis of 45~60 portions of Rhizoma Alismatis of 45~65 parts of Radixs Stephaniae Tetrandrae of Radix Saposhnikoviae
20~35 parts of 25~40 parts of Rhizoma Polygonatis of 30~45 parts of Radix Angelicae Sinensis of 35~50 parts of Semen Persicaes of Radix Salviae Miltiorrhizae
4~12 parts of 7~16 parts of Fructus Trichosanthis of 10~20 parts of Talcums of 14~25 portions of Radix Aconitis of Rhizoma Chuanxiong.
Raw material composition and the parts by weight of making described pill effective ingredient are:
55~60 parts of 60~75 parts of Radix Dipsacis of 65~80 parts of Ramulus Cinnamomi of 75~85 portions of Radix Paeoniae Albas of the Radix Astragali
42~52 parts of 43~56 portions of Cortex Cinnamomis of 48~58 portions of Rhizoma Alismatis of 50~60 parts of Radixs Stephaniae Tetrandrae of Radix Saposhnikoviae
24~32 parts of 28~38 parts of Rhizoma Polygonatis of 34~42 parts of Radix Angelicae Sinensis of 38~48 parts of Semen Persicaes of Radix Salviae Miltiorrhizae
7~10 parts of 9~13 parts of Fructus Trichosanthis of 13~17 parts of Talcums of 18~22 portions of Radix Aconitis of Rhizoma Chuanxiong.
Raw material composition and the parts by weight of making described pill effective ingredient are:
58 parts of 68 parts of Radix Dipsacis of 72 parts of Ramulus Cinnamomi of 80 portions of Radix Paeoniae Albas of the Radix Astragali
47 parts of 50 portions of Cortex Cinnamomis of 53 portions of Rhizoma Alismatis of 55 parts of Radixs Stephaniae Tetrandrae of Radix Saposhnikoviae
28 parts of 33 parts of Rhizoma Polygonatis of 38 parts of Radix Angelicae Sinensis of 43 parts of Semen Persicaes of Radix Salviae Miltiorrhizae
9 parts of 11 parts of Fructus Trichosanthis of 15 parts of Talcums of 20 portions of Radix Aconitis of Rhizoma Chuanxiong.
For anaesthetizing the preparation method of pill for postoperative nerve injury, comprise following processing step:
(1) Semen Persicae, Rhizoma Chuanxiong are ground into powder after pulverizing, crossed 160 order fine powders, for subsequent use.
(2) Radix Salviae Miltiorrhizae is fried and is coke yellow to surface with slow fire, after cooling, grind into powder, cross 160 order fine powders, for subsequent use.
(3) after Rhizoma Alismatis is stir-fried for several times with slow fire, after surface sprinkling rice vinegar, continue to stir-fry sallow to surface, cool rear pulverizing and grind into powder, cross 160 order fine powders, for subsequent use.
(4) Talcum, Fructus Trichosanthis are wrapped with crocus cloth, put into container together with the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, Cortex Cinnamomi, Rhizoma Polygonati, Radix Aconiti, add the water of six times of amounts, soak after 12~14 hours, get immersion; In remaining medicinal residues, add again the water of four times of amounts, soak after 6~8 hours, get immersion; Merge twice gained immersion, evaporation and concentration is the ointment of relative density 1.10~1.15 under 60 DEG C of environment, for subsequent use.
(5) Radix Paeoniae Alba, Radix Dipsaci, Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis are put into container, add the shao-hsing rice wine of quintuple, boil rear continuation and soak after 4~6 hours, get immersion; In remaining medicinal residues, add again the shao-hsing rice wine of triplication, boil rear continuation and soak after 2~3 hours, get immersion; Merge twice gained immersion, evaporation and concentration is the ointment of relative density 1.15~1.20 under 60 DEG C of environment, for subsequent use.
(6) by the fine powder of step (1), step (2), step (3) gained, the ointment making with step (4), step (5) mixes, and stirs after adding refined honey, is prepared as the pill of 1.25g~1.50g/ grain with modern science technique.
The property of medicine of the present invention's Chinese medicine used is as follows:
The Radix Astragali: sweet in the mouth; Warm in nature.Enter the heart; Lung; Spleen; Kidney channel.Invigorating QI to consolidate the body surface resistance; Diuresis; Expelling pus and toxin by strengthening QI; Promoting tissue regeneration and ulcer healing.Cure mainly the cardiopalmus of breathing hard; Asthenia; Weak; Chronic diarrhea; Body is impractical swollen; Chronic nephritis; Carbuncle is difficult bursts; Or burst and do not hold back for a long time." Xinhua's book on Chinese herbal medicine outline " carries: " have the function of invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, granulation promoting." modern medicine study confirmation; Radix Astragali main component is Radix Astragali total flavones, Radix Astragali Mongolici total polysaccharide, Radix Astragali total saponins and aminoacid etc.; have diuretic antihypertensive, anti-inflammatory analgesic, heart tonifying, antioxidant radical generation and improve the multiple pharmacological effect such as body's immunity; can act on from many aspects body, improve the relevant blood vessel sexually transmitted disease (STD) change patients' such as cardiovascular, cerebrovascular, diabetes, nephropathy the function such as hemodynamics and vascular endothelial cell.
The Radix Paeoniae Alba: bitter in the mouth; Property is put down.Enter liver; Spleen channel.Nourishing blood to suppress the hyperactive liver, slow middle pain relieving; Yin fluid astringing is received antiperspirant.Cure mainly the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency." not Lu " carries: " clear and coherent blood vessels, slow in, dispelling malignant blood, expelling extravasated blood, the gas that anhydrates, sharp bladder, intestine and small intestine, subduing inflammation." modern medicine study confirms; the Radix Paeoniae Alba can regulate immunity; strengthen macrophage and leukocytic phagocytic function; regulate the immunologic function of T lymphocyte and body fluid; protect the liver, spasmolytic, analgesia, calmness, resist cool, cooling effect; suppress in addition in addition smooth muscle, the effect of enhancing anoxia enduring, antioxidation and resisting fatigue.
Ramulus Cinnamomi: acrid in the mouth; Sweet; Warm in nature.Enter bladder; The heart; Lung meridian.Expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.Cure mainly exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Amenorrhea dysmenorrhea; WEIJIA caking; The thoracic obstruction; Cardiopalmus; Phlegm retention; Dysuria." Changsha medicine solution " carries: " enter liver man and promoting the circulation of blood divides, determine meridians and reach Rong Yu.The kind ailment said due to cold or exposure of separating, adjusts wood gas most.The detrapping of sending up the lucid YANG, the punching of the turbid descending the moon is contrary, the anxious contraction of relaxing muscles and tendons feeling pulse; The heap soil or fertilizer over and around the roots resistance in profit joint.Enter liver and gall and loose suppressing, utmost point pain relieving Chu, the meridian dredging and to open numbness puckery, very dries cold.Only renal mass, more peace palpitation with fear." modern medicine study confirms, Ramulus Cinnamomi effectively blood vessel dilating, promote diaphoresis, that contained cinnamic aldehyde, natrium cinnamicum has is antipyretic, analgesia, calmness, anticonvulsant action, in addition Ramulus Cinnamomi antibacterial, antiviral effect in addition.
Radix Dipsaci: bitter in the mouth; Pungent; Slightly warm in nature.Return liver; Kidney channel.Invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Continuous injured; Only metrorrhagia.For back ache; Podomere flaccidity syndrome and arthralgia syndrome; Fall and flutter wound; Damage dish folding bone; Carbuncle skin ulcer is swollen." Standards of Diagnosis and Treatment " carry: " sweet temperature is supporing yang, pungent with dissipating blood stasis, has liver and kidney tonifying concurrently, strong bone strengthening, the merit of promoting blood circulation." modern medicine study confirmation, Radix Dipsaci contains multiple alkaloid and Trace Element Titanium, has the effect of vitamin antagonist E deficiency disease, carbuncle and ulcer is had to the effect of evacuation of pus, hemostasis, analgesia, promotion tissue regeneration.
Radix Saposhnikoviae: acrid in the mouth; Micro-sweet; Slightly warm in nature.Return lung; Bladder; Liver; Spleen channel.Deliver; Dispel the wind; Victory is wet; Pain relieving.Cure mainly headache; Giddy; Cold-damp stomachache; Have loose bowels; Rheumatic arthralgia; Spasm of the limbs; Tetanus; Conjunctival congestion; Skin infection; Hernia abdominal mass; Scabies; Rubella." Japan hanako materia medica " year: " wind as controlling 36, all labor of man are bad, invigorating middle warmer benefit god, blepharitis marginalis, arresting lacrimation and paralysis are slow, tonneau the five internal organs GUAN-pulse, five kinds of strain and seven kinds of impairment, thin damage night sweat, vexed body weight, energy tranquilizing the mind, even gaseous pulse." modern medicine study confirmation, anti-wind energy significantly improves the hypoxia-bearing capability of acute cerebral hypoxia, significantly suppresses the formation of external lipid peroxide of bringing out, and has antioxidant activity, and neurocyte is shielded.
Radix Stephaniae Tetrandrae: bitter in the mouth; Pungent; Cold in nature, flat.Return liver; Spleen; Kidney; Taiyang channel.Wind-expelling pain-stopping; Clearing away heat and promoting diuresis.Cure mainly damp and hot general pain; Rheumatic arthralgia; Lower limbs edema; Dysuria; Beriberi swells and ache." not Lu " carries: " treat edema, swelling due to wind, go bladder heat, typhoid fever cold and heat pathogen, apoplexy hands muscle spasm of the leg and foot, stopping leak, loose carbuncle is disliked knot, logical space between skin and muscles, sharp nine orifices." modern medicine study discovery; the contained mufangchine of Radix Stephaniae Tetrandrae has the central inhibitory actions such as calmness, antiinflammatory, analgesia and cooling, has anti-allergic effects widely, is the antagonist of Anaphylactic mediator; be also the blocker of Anaphylactic mediator; can strengthen the contractility of heart, and myocardial infarction is had to protective effect, can expand coronary vasodilator; reduce blood pressure; loose striped muscle, resisting pathogenic microbes, and significant antitumaous effect.
Rhizoma Alismatis: sweet in the mouth; Light; Cold in nature.Return kidney; Urinary bladder channel.Promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria.Cure mainly dysuria; The puckery pain of pyretic stranguria; Edema distension; Have loose bowels; Dizziness due to fluid-retention; Seminal emission." not Lu " carries: " tonifying deficiency five kinds of over strain, except the five internal organs feeling of fullness, plays cloudy gas, stopping leak essence, quenches one's thirst, drenches drop, cuts off the water by bladder, three warmers." modern medicine study confirmation, Rhizoma Alismatis has the cholesterol of reduction and atherosclerosis effect, improves liver lipid metabolism, reduces blood glucose, blood pressure, affects function of immune system, reduces serum hemolysin.
Cortex Cinnamomi: acrid in the mouth; Bitter; Hot in nature.Enter kidney; Spleen; The heart; Liver Channel.Mend fire supporing yang; Let the fire back to its origin; Dispersing cold for relieving pain; Warming the meridian and promoting blood circulation.Cure mainly insufficiency of kidney-YANG; Gate of vitality's fire; Aversion to cold and cold limbs; Soreness of the waist and knees; The dyspnea with rapid and short breath of losing heart; The all cards of edema oliguria; Floating YANG; Refusing yang; And heat in the upper and cold in the lower; Flushed complexion cold foot; Dizziness and tinnitus; Dispute is rotten broken; Spleen-kidney vacuity cold; Coldness and pain in the epigastrium lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Colic of cold type pain." property of medicine opinion " carries: " cure mainly nine types of precordial pain, kill three worms, main removing blood stasis, the tonneau moon closes, and controls weak foot, numbness, meciless, retention of placenta, except cough with dyspnea, stagnation of QI, gathers around numbness, and only cold air in abdomen, unbearably painful, main dysentery, nasal polyp.Herbicide wood poison." modern medicine study confirmation, Cortex Cinnamomi contains the compositions such as cinnamic aldehyde, cinnamyl acetate, acetoxyphenyl group the third cheese, has the effect of fragrant stomach invigorating, antipyretic-antalgic, anti-inflammation.
Radix Salviae Miltiorrhizae: bitter in the mouth; Cold nature; Nontoxic.Enter the heart; Liver Channel.Promoting blood flow to regulate menstruation; Stasis-dispelling and pain-killing; Removing heat from blood eliminating carbuncle; Relieving restlessness clears away heart-fire; Nourishing blood to tranquillize the mind.Cure mainly trusted subordinate's pathogen; Cold and heat gather; Ailment said due to cold or exposure is stayed heat." herbal classic " carries: " main trusted subordinate's pathogen, borborygmus are faint as leaked water, and cold and heat gather; Broken disease, except abdominal mass, is stopped stuffy sensation with restlessness, QI invigorating." modern medicine study confirms; Radix Salviae Miltiorrhizae can improve plasmin activity; extend hemorrhage, clotting time; anticoagulant; coronary artery dilating and peripheral blood vessel, increases myocardial flow, promotes reparation and the regeneration of tissue; promote the formation of fibroblast differentiation and collagen fiber, suppresses synthesizing of originality cholesterol in cell.
Semen Persicae: bitter in the mouth; Sweet; Property is put down.GUIXIN; Liver; Large intestine channel.Blood circulation promoting and blood stasis dispelling; Loosening bowel to relieve constipation; Relieving cough and asthma.Cure mainly amenorrhea; Dysmenorrhea; WEIJIA mass in the abdomen; Injury from falling down; Dryness of the intestine constipation." herbal classic is met former " carries: " Semen Persicae, the special medicine closing for blood stasis blood.Bitter to let out stagnant blood, sweetly control invasion of the blood-chamber by heat with tissue regeneration promoting blood, the stasis of blood amass lump in the abdomen, amenorrhea, malaria with splenomegaly, cardiac and abdominal pain, the blood agglomeration of the Liver Channel that also falls apart." modern medicine study confirmation, Semen Persicae alcohol extract can increase vein blood vessel flow, vasodilator; can increase femoral artery blood flow, reduces vascular resistance, and blood vessel wall is had to direct dilating effect; maintain body temperature and protection internal organs, suppress in addition in addition blood coagulation and haemolysis.
Radix Angelicae Sinensis: sweet in the mouth; Pungent; Warm in nature.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation; Menstruction regulating and pain relieving; Loosening bowel to relieve constipation.Cure mainly blood deficiency and yellow complexion; Dizzy cardiopalmus; Asthenia cold abdominalgia; Rheumatic arthralgia; Injury from falling down; Ulcer sores." book on Chinese herbal medicine is just " carries: " its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, can support nutrition blood, QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing unsuitable." modern medicine study confirmation, antibacterial, antiinflammation that Radix Angelicae Sinensis has, to chronic rheumatoid arthritis, acute attack has obvious inhibitory action.
Rhizoma Polygonati: sweet in the mouth; Property is put down.Enter spleen; Lung; Kidney channel.Nourishing YIN and moistening the lung; Invigorating the spleen and replenishing QI; Zishen fill fine.Cure mainly deficiency of YIN chronic cough; Xeropulmonary cough; Insufficiency of the spleen weak; Lack of appetite xerostomia; Quench one's thirst; Deficiency of the kidney soreness of the waist and knees; Tinnitus order is dark; Body weakness with emaciation is thin." book on Chinese herbal medicine meets former " carries: " alleviating distention in middle-JIAO QI invigorating, is in harmonious proportion five Tibetan, muscle sufficiency, and bone marrow is hard by force, is all the merit of nourishing YIN." modern medicine study confirmation; the blood sugar increasing that Rhizoma Polygonati causes epinephrine has significant inhibitory action; common pathomycete is had to inhibitory action in various degree; rising Liver Superoxide Dismutase Activity activity; reduce myocardium lipofuscin content and reduce; strengthen the tolerance to anoxia, also has in addition antiviral efficacy.
Rhizoma Chuanxiong: acrid in the mouth; Warm in nature.Return liver; Gallbladder; Pericardium channel.Blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.Zhu Zhi WEIJIA lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia." book on Chinese herbal medicine just " carries: " dispersing wind and cold, controls pain, and removing blood stasis with potent drugs holds, and promoting blood circulation is separated stagnation of QI, and by pain, evacuation of pus detumescence, stimulates the menstrual flow by blood." modern medicine scientific research discovery; Rhizoma Chuanxiong extracting solution has certain effect to suppressing leukaemia; preparation has certain antibacterial action; especially Bacillus typhi, Salmonella paratyphi, vibrio cholera, bacillus pyocyaneus and pathogenic dermatophytes etc. are all had to inhibitory action; contained ligustrazine, the ferulic acid of Rhizoma Chuanxiong received has blood circulation invigorating efficacies; expansible coronary artery, promote coronary flow, allevating angina pectoris, and thering is anti-thrombosis function, contained cnidium lactone has smooth muscle spasmolysis and suppresses the effects such as myenteron, uterine contraction.
Radix Aconiti: acrid in the mouth; Bitter; Hot in nature; Poisonous.GUIXIN; Liver; Kidney; Spleen channel.Expelling wind and removing dampness; Antalgic.For anemofrigid-damp arthralgia; Arthralgia; Trusted subordinate's cold type of pain; Colic of cold type is had a pain; Narcotic analgesic." pearl sac addendum Yaoxing Fu " carries: " the cold-evil of loose all wind; The cold type of pain of broken various masses." modern medicine study confirmation, the contained aconitine of Radix Aconiti has analgesic activity, and the outer used time can be benumbed the peripheral termination of nerve, produces local anesthesia effect, also has in addition analgesia, antiinflammation.
Talcum: sweet in the mouth; Light; Cold in nature; Nontoxic.Enter stomach; Urinary bladder channel.Relieving stranguria by diuresis; Clearing away summer-heat; Removing dampness sore; Cure mainly damp-heat in the urinary bladder; Summer-heat excessive thirst; Dysuria; Have loose bowels; Urine drenches puckery pain; Edema; Epistaxis." Amplification on Materia Medica addendum " carries: " dampness, diversion channel, real large intestine, relieving dyspepsia poison, row is stagnant, by blood coagulation, separates dry yearningly, and the key medicine of heart-fire, falls in tonifying the spleen and stomach." modern medicine study shows; Talcum has inhibitory action to Bacillus typhi, paratyphoid fever bacillus, meningococcus; external can be adsorbed a large amount of chemical irritants or poisonous substance; can protect the surface of inflammation or damaged tissue; the gastrointestinal mucosa except protection inflammation for oral administration and bring into play that town is told, anti-diarrhea effect, can also stop the absorption of poisonous substance in gastrointestinal tract.
Fructus Trichosanthis: sweet-bitter flavor; Cold in nature.Enter lung; Stomach warp.Lung moistening; Reduce phlegm; Eliminating stagnation; Intestine moistening.Cure mainly phlegm-heat cough; The thoracic obstruction; Blocked-up chest; Consumptive lung disease hemoptysis; Quench one's thirst; Jaundice; Constipation; Carbuncle from the beginning of." detailed outline " carries: " lung moistening is dry, pathogenic fire reducing, and the main thoracic obstruction, controls cough, and clearing away phlegm knot is logical hot and suffocating in the heart." modern medicine study confirms, Fructus Trichosanthis is containing triterpene saponin, fatty oil, several amino acids and alkaloid, have eliminate the phlegm, the effect of coronary artery dilator, increase coronary flow, anti-hypoxia, blood fat reducing, have good curative effect for the treatment of coronary heart disease clinically.
The present invention compared with prior art, has following beneficial effect:
Compatibility of the present invention is reasonable, theory novelty, selected medical material the monarch and his subjects help mutually, for the triggering mechanism of nerve damage in anaesthesia process, concoct respectively according to the property of medicine, ask effect of clearing away heat-damp and promoting diuresis, the soothing the liver solution stasis of blood, blood circulation promoting and dispersing pathogen accumulation, eliminating turbid pathogen with aromatics, through clinical verification, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, the nerve injury that in anesthesia art, apparatus damage and anesthetis cause is had to fabulous repairing accelerant effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Raw material composition and the weight of pill effective ingredient of the present invention are:
Radix Astragali 85g Radix Paeoniae Alba 80g Ramulus Cinnamomi 75g Radix Dipsaci 62g
Radix Saposhnikoviae 60g Radix Stephaniae Tetrandrae 57g Rhizoma Alismatis 55g Cortex Cinnamomi 52g
Radix Salviae Miltiorrhizae 47g Semen Persicae 42g Radix Angelicae Sinensis 37g Rhizoma Polygonati 32g
Rhizoma Chuanxiong 22g Radix Aconiti 17g Talcum 13g Fructus Trichosanthis 10g.
The processing step of pill preparation method of the present invention is:
(1) Semen Persicae, Rhizoma Chuanxiong are ground into powder after pulverizing, crossed 160 order fine powders, for subsequent use.
(2) Radix Salviae Miltiorrhizae is fried and is coke yellow to surface with slow fire, after cooling, grind into powder, cross 160 order fine powders, for subsequent use.
(3) after Rhizoma Alismatis is stir-fried for several times with slow fire, after surface sprinkling rice vinegar, continue to stir-fry sallow to surface, cool rear pulverizing and grind into powder, cross 160 order fine powders, for subsequent use.
(4) Talcum, Fructus Trichosanthis are wrapped with crocus cloth, put into container together with the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, Cortex Cinnamomi, Rhizoma Polygonati, Radix Aconiti, add the water of six times of amounts, soak after 12~14 hours, get immersion; In remaining medicinal residues, add again the water of four times of amounts, soak after 6~8 hours, get immersion; Merge twice gained immersion, evaporation and concentration is the ointment of relative density 1.10~1.15 under 60 DEG C of environment, for subsequent use.
(5) Radix Paeoniae Alba, Radix Dipsaci, Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis are put into container, add the shao-hsing rice wine of quintuple, boil rear continuation and soak after 4~6 hours, get immersion; In remaining medicinal residues, add again the shao-hsing rice wine of triplication, boil rear continuation and soak after 2~3 hours, get immersion; Merge twice gained immersion, evaporation and concentration is the ointment of relative density 1.15~1.20 under 60 DEG C of environment, for subsequent use.
(6) by the fine powder of step (1), step (2), step (3) gained, the ointment making with step (4), step (5) mixes, and stirs after adding refined honey, is prepared as the pill of 1.25g~1.50g/ grain with modern science technique.
Usage and dosage: adult every day 2 times, each 1~2, one hour ante cibum is on an empty stomach with warm water delivery service, patient with severe symptoms every day 3 times, each 2~3, take with warm yellow wine one hour ante cibum on an empty stomach, within 4 days, is a course for the treatment of, general 1~3 onset course for the treatment of.
Embodiment 2
Raw material composition and the weight of pill effective ingredient of the present invention are:
68 parts of Radix Dipsaci 58g of 72 parts of Ramulus Cinnamomi of the Radix Astragali 80g Radix Paeoniae Alba
47 parts of 50 portions of Cortex Cinnamomis of 53 portions of Rhizoma Alismatis of Radix Saposhnikoviae 55g Radix Stephaniae Tetrandrae
28 parts of 33 parts of Rhizoma Polygonatis of 38 parts of Radix Angelicae Sinensis of Radix Salviae Miltiorrhizae 43g Semen Persicae
9 parts of 11 parts of Fructus Trichosanthis of 15 parts of Talcums of Rhizoma Chuanxiong 20g Radix Aconiti.
Pill preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
Raw material composition and the parts by weight of pill effective ingredient of the present invention are:
Radix Astragali 75g Radix Paeoniae Alba 65g Ramulus Cinnamomi 60g Radix Dipsaci 55g
Radix Saposhnikoviae 52g Radix Stephaniae Tetrandrae 48g Rhizoma Alismatis 45g Cortex Cinnamomi 42g
Radix Salviae Miltiorrhizae 38g Semen Persicae 35g Radix Angelicae Sinensis 28g Rhizoma Polygonati 24g
Rhizoma Chuanxiong 17g Radix Aconiti 14g Talcum 9g Fructus Trichosanthis 6g.
Pill preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
Use the clinical care of surgery anesthesia follows the tracks of through my institute's 47 examples, report shows that pill of the present invention can significantly promote the reparation of postoperative injured nerve, particularly remarkable to the curative effect of apparatus nerve injury, the Probability of complication of anesthesia has reduced by 51%, average care cycle has shortened 3.7 days, is suitable for anaesthetizing clinical expansion completely and uses.

Claims (4)

1. for anaesthetizing a pill for postoperative nerve injury, it is characterized in that: raw material composition and the parts by weight of making described pill effective ingredient are:
50~65 parts of 55~80 parts of Radix Dipsacis of 60~85 parts of Ramulus Cinnamomi of 70~90 portions of Radix Paeoniae Albas of the Radix Astragali
40~55 parts of 40~60 portions of Cortex Cinnamomis of 45~60 portions of Rhizoma Alismatis of 45~65 parts of Radixs Stephaniae Tetrandrae of Radix Saposhnikoviae
20~35 parts of 25~40 parts of Rhizoma Polygonatis of 30~45 parts of Radix Angelicae Sinensis of 35~50 parts of Semen Persicaes of Radix Salviae Miltiorrhizae
4~12 parts of 7~16 parts of Fructus Trichosanthis of 10~20 parts of Talcums of 14~25 portions of Radix Aconitis of Rhizoma Chuanxiong.
2. according to claim 1 a kind of for anaesthetizing the pill of postoperative nerve injury, it is characterized in that: raw material composition and the parts by weight of making described pill effective ingredient are:
55~60 parts of 60~75 parts of Radix Dipsacis of 65~80 parts of Ramulus Cinnamomi of 75~85 portions of Radix Paeoniae Albas of the Radix Astragali
42~52 parts of 43~56 portions of Cortex Cinnamomis of 48~58 portions of Rhizoma Alismatis of 50~60 parts of Radixs Stephaniae Tetrandrae of Radix Saposhnikoviae
24~32 parts of 28~38 parts of Rhizoma Polygonatis of 34~42 parts of Radix Angelicae Sinensis of 38~48 parts of Semen Persicaes of Radix Salviae Miltiorrhizae
7~10 parts of 9~13 parts of Fructus Trichosanthis of 13~17 parts of Talcums of 18~22 portions of Radix Aconitis of Rhizoma Chuanxiong.
3. according to claim 1 a kind of for anaesthetizing the pill of postoperative nerve injury, it is characterized in that: raw material composition and the parts by weight of making described pill effective ingredient are:
58 parts of 68 parts of Radix Dipsacis of 72 parts of Ramulus Cinnamomi of 80 portions of Radix Paeoniae Albas of the Radix Astragali
47 parts of 50 portions of Cortex Cinnamomis of 53 portions of Rhizoma Alismatis of 55 parts of Radixs Stephaniae Tetrandrae of Radix Saposhnikoviae
28 parts of 33 parts of Rhizoma Polygonatis of 38 parts of Radix Angelicae Sinensis of 43 parts of Semen Persicaes of Radix Salviae Miltiorrhizae
9 parts of 11 parts of Fructus Trichosanthis of 15 parts of Talcums of 20 portions of Radix Aconitis of Rhizoma Chuanxiong.
As described in claim 1-3 any one for anaesthetizing the preparation method of pill for postoperative nerve injury, it is characterized in that: comprise following processing step:
(1) Semen Persicae, Rhizoma Chuanxiong are ground into powder after pulverizing, crossed 160 order fine powders, for subsequent use;
(2) Radix Salviae Miltiorrhizae is fried and is coke yellow to surface with slow fire, after cooling, grind into powder, cross 160 order fine powders, for subsequent use;
(3) after Rhizoma Alismatis is stir-fried for several times with slow fire, after surface sprinkling rice vinegar, continue to stir-fry sallow to surface, cool rear pulverizing and grind into powder, cross 160 order fine powders, for subsequent use;
(4) Talcum, Fructus Trichosanthis are wrapped with crocus cloth, put into container together with the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, Cortex Cinnamomi, Rhizoma Polygonati, Radix Aconiti, add the water of six times of amounts, soak after 12~14 hours, get immersion; Remaining
In medicinal residues, add again the water of four times of amounts, soak after 6~8 hours, get immersion; Merge twice gained immersion, evaporation and concentration is the ointment of relative density 1.10~1.15 under 60 DEG C of environment, for subsequent use;
(5) Radix Paeoniae Alba, Radix Dipsaci, Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis are put into container, add the shao-hsing rice wine of quintuple, boil rear continuation and soak after 4~6 hours, get immersion; In remaining medicinal residues, add again the shao-hsing rice wine of triplication, boil rear continuation and soak after 2~3 hours, get immersion; Merge twice gained immersion, evaporation and concentration is the ointment of relative density 1.15~1.20 under 60 DEG C of environment, for subsequent use;
(6) by the fine powder of step (1), step (2), step (3) gained, the ointment making with step (4), step (5) mixes, and stirs after adding refined honey, is prepared as the pill of 1.25g~1.50g/ grain with modern science technique.
CN201210594534.2A 2012-12-31 2012-12-31 Pill used for post-anesthesia nerve injury Expired - Fee Related CN102973799B (en)

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CN104758605A (en) * 2013-08-19 2015-07-08 庞尊钊 Preparation method for external-use drug for nerve injury
CN104706964A (en) * 2013-08-19 2015-06-17 王刚刚 Preparation method of mixed application for treating peripheral nerve injuries
CN104383495A (en) * 2014-11-15 2015-03-04 唐国永 Drug for treating neural injury caused by chemotherapy and preparation method of drug
CN104740213A (en) * 2015-04-23 2015-07-01 张思彦 Traditional Chinese medicine for treating epidural anesthesia nerve injury
CN106729127A (en) * 2017-04-12 2017-05-31 青岛大学附属医院 A kind of Chinese medicine composition for alleviating anesthesia postoperative nerve damage
CN108498605A (en) * 2017-11-10 2018-09-07 姜燕 A kind of pharmaceutical composition and its preparation method and application of anesthesia postoperative nerve nursing

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