CN104758605A - Preparation method for external-use drug for nerve injury - Google Patents
Preparation method for external-use drug for nerve injury Download PDFInfo
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Abstract
The invention discloses a preparation method for an external-use drug for nerve injury, and aims to solve the treatment problem after peripheral nerve injury. The preparation method is characterized by comprising the following steps: mixing 10-30 parts of fruits of bittersweet, 6-12 parts of harlequin glorybower leaves, 3-10 parts of delavay raspberry herb, 6-12 parts of erycibe obtusifolia benth, 3-10 parts of securinega suffruticosa, 6-12 parts of rhizoma polygonati, 6-12 parts of glossy privet fruits, 6-12 parts of white atractylodes rhizome, 6-12 parts of alate senna leaves, 1-5 parts of fetid viburnum fruit leaves, 3-10 parts of amblystegium serpens and 10-25 parts of strong gale, adding water to decoct, obtaining filtrate 30 minutes later, adding water into dregs of a decoction to continuously decoct for 20 minutes, then, obtaining filtrate, combining the filtrate obtained twice, concentrating, drying and crushing. According to the clinical experiment, the external-use drug for nerve injury has the characteristics of being good in curative effect and relatively high in safety, and is worthy of being clinically applied and popularized.
Description
Technical field
The present invention is that (application number: divisional application 2013103587978), relates to drug world is specifically related to a kind of medicine for the postoperative reparation of peripheral nerve injury in application for a patent for invention " a kind of medicine for the postoperative reparation of peripheral nerve injury ".
Background technology
Peripheral nerve injury (peripheral nerve injury) is common neurosurgery related disease, can occur separately, also can merge with other tissue injurys and occur.After peripheral nerve injury, by the motion in this innervation district, all will there is obstacle in sensation and nutrition.Clinical signs is Muscle paralysis, atrophoderma, feels to go down or disappear.Although Peripheral nerve repair technology there has been significant progress, as adopted histochemistry or SABC to carry out in meticulous microsurgical technique, art to move and sensory function Shu Dingwei etc., even but fresh, clean peripheral nerve rupture wound, the timely microsurgical technique of advanced person that adopts is repaired, usually also can not obtain holomorphosis, function also often can not be recovered completely; And to feel for a long time or the disappearance of moving will cause amyotrophy, arthrogryposis deformity etc.Therefore, how to promote the regeneration of peripheral nerve injury, recover its function to greatest extent, be the basis of CO2 laser weld and the focus of clinical research always.
The postoperative repair medicine of peripheral nerve injury of current Clinical practice has exogenous neurotrophic factor, adenylic acid Cycloxygenase activator and cyclic adenosine monophosphate, Protein kinase C, inflammatory factor, vitamin B complex etc.Nerve growth factor (nerve growth factor in its exogenous neurotrophic factor, NGF) curative effect is the most reliable, but also there is side effect in application NGF: sprouting of int normal neuronal aixs cylinder, can cause the untoward reaction such as chronic pain and abnormal neuron reflection to occur.Therefore exploration one class of still needing at present can promote neural growth fast, can ensure again the inexpensive drugs of regenerated nervous fibers function.
Chinese medicine after peripheral nerve injury prothesis is the based uplink gas promoting blood circulation to remove obstruction in the collateral being vigorate qi and replenish the blood then more, but actual clinical effect not obvious.Acupuncture effect is obviously better than Chinese medicine, but patient is difficult to adhere to.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the little medicine for the postoperative reparation of peripheral nerve injury of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of preparation method of nerve injury external used medicine, it is characterized in that: mixing and water adding is decocted by Herba Solani Lyrati 10 ~ 30 parts, Folium et Ramulus Clerodendri Trichotomi 6 ~ 12 parts, Rubus delavayi Franch. 3 ~ 10 parts, Caulis Erycibes 6 ~ 12 parts, Cacumen Securinegae Suffruticosae 3 ~ 10 parts, Rhizoma Polygonati 6 ~ 12 parts, Fructus Ligustri Lucidi 6 ~ 12 parts, the Rhizoma Atractylodis Macrocephalae 6 ~ 12 parts, Folium Cassiae Alatae 6 ~ 12 parts, 1 ~ 5 part, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 3 ~ 10 parts, nine layers of wind 10 ~ 25 parts, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and concentrate drying is pulverized and applied.
Chinese medicine of the present invention is prepared from by the raw material of following optimum weight part proportioning: Herba Solani Lyrati 20 parts, Folium et Ramulus Clerodendri Trichotomi 10 parts, Rubus delavayi Franch. 6 parts, Caulis Erycibes 10 parts, Cacumen Securinegae Suffruticosae 6 parts, Rhizoma Polygonati 10 parts, Fructus Ligustri Lucidi 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Folium Cassiae Alatae 10 parts, 2 parts, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 6 parts, nine layers of wind 20 parts.
Wherein said: Herba Solani Lyrati is the herb of plant of Solanaceae Herba Solani Lyrati Solanum lyratum Thunb..Sweet in the mouth; Bitter; Cold in nature.Return liver; Gallbladder; Kidney channel.Merit can clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.
Folium et Ramulus Clerodendri Trichotomi, is Verbena officinalis Ke Cheng paulownia platymiscium clerodendron trichotomum Clerodendron trichotomum Thunb., is used as medicine with root, stem, leaf.Taste bitter, sweet, flat.Merit can remove rheumatism, blood pressure lowering.
Rubus delavayi Franch. is the Herb of rosaceous plant SANYE Fructus Rubi corchorifolii Immaturus Rubus delavayi Franch..Sweet in the mouth; Micro-acid; Flat.GUIXIN; Liver Channel.Merit can heat-clearing and toxic substances removing; Dehumidifying dysentery relieving; Drive ascarid.
Caulis Erycibes is the dry rattan of convolvulaceous plant Caulis Erycibes Erycibe obtusfolia Benth. or erycibe schmidtii Craib Erycibe sch-midtii Craib.Acrid in the mouth, temperature.Return liver, spleen, stomach warp.Merit can expelling wind and removing dampness, reducing swelling and alleviating pain.
Cacumen Securinegae Suffruticosae is euphorbia plant Suffrutescent Securinega Twig Securinega suffruticosa(Pal1.) browse of Rehd. or root.Acrid in the mouth; Bitter; Slightly warm in nature.Return liver; Kidney; Spleen channel.Merit can expelling wind and activating blood circulation; The strong muscle of kidney tonifying.
Rhizoma Polygonati is the dry rhizome of liliaceous plant P. kingianum Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.Nature and flavor are sweet, flat.Return spleen, lung, kidney channel.Merit can boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.
Fructus Ligustri Lucidi is the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi Ligustrum lucidum Ait..Nature and flavor sweet, bitter, cold.Return liver, kidney channel.Merit can nourishing the liver and kidney, improving eyesight black hair.
The Rhizoma Atractylodis Macrocephalae is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor are bitter, sweet, temperature.Return spleen, stomach warp.Merit can invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.
Folium Cassiae Alatae, is pulse family Folium Cassiae Alatae Cassia alata L., is used as medicine with leaf.Nature and flavor are pungent, temperature.Merit can parasite killing, antipruritic.
Fructus Viburni Foetidi leaf is the leaf for Radix Ophiopogonis place's plant Caulis Viburni Dilatati Viburnum foetidrm Wall..Puckery; Property is put down.Merit can be detoxified; Symplectic bone.
Folium Salicis Babylonicae moss is Amblystegiaceae Folium Salicis Babylonicae moss Amblystegium serpens(Hedw.) plant of B.S.G..Nature and flavor are puckery; Flat.Merit can astringing to arrest bleeding.
Nine layers of wind are the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn.Nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Merit can be enriched blood, and invigorates blood circulation, dredging collateral.
Composition principle: peripheral nerve injury is much more general to be occurred with wound, and the Chinese medicine after current peripheral nerve injury prothesis is the based uplink gas promoting blood circulation to remove obstruction in the collateral of vigorate qi and replenish the blood more, but actual clinical effect not obvious.Inventor's clinical research for many years finds, peripheral nerve injury is except qi depression to blood stasis, peripheral nerve injury postoperative limbs channels is obstructed, stay poly-not loose relevant to body fluid, surely belong to the traditional Chinese medical science and be referred to as " phlegm stagnating in meridian ", accumulation of phlegm blocks, in network, QI and blood is not all right, also blood stasis can be caused, and " accumulation of blood is both of a specified duration, also can turn to expectorant water " (" treatise on blood trouble " rolls up five).So, because expectorant causes the stasis of blood, the long-pending stasis of blood is reduced phlegm, phlegm and blood stasis, and glue work is for suffering from, and then obstructed till passages through which vital energy circulates, four ends do not reach and produce the malnutrition in Substance P region.Therefore, the postoperative main pathological basis of peripheral nerve injury is be the accumulation of phlegm folder stasis of blood.Expectorant, the stasis of blood are pathological product, are again paathogenic factors; Both be the mark of disease, being also disease basis, is wherein major pathogenetic factor especially with accumulation of phlegm.Therefore it is treated, and should invigorate blood circulation, eliminate the phlegm, eliminating stagnation, dredging collateral are gone forward side by side, and can promote the postoperative local recovery of peripheral nerve injury.
Compared with prior art, the present invention has following characteristics.
1, Herba Solani Lyrati and Folium et Ramulus Clerodendri Trichotomi coordinate for monarch drug, wherein: Herba Solani Lyrati merit can clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, inventor's cell culture experiments proves: Herba Solani Lyrati decocting liquid has unique logical stagnant effect after being used for peripheral nerve injury prothesis, its mechanism of action may be that Herba Solani Lyrati can promote local growth associated protein (Growth associated protein-43, GAP-43) synthesis, and specific proteins GAP-43 is in the growth of nerve fiber, grow, the important roles such as the maintenance of axon regeneration and synaptic function, and participate in the adjustment of neurotransmitter regulator, grow again neural or can determine to grow along correct direction with inducing neural projection in regeneration, and there is no the side effect of sprouting of that int normal neuronal aixs cylinder of NGF, and Folium et Ramulus Clerodendri Trichotomi is by expelling wind and removing dampness, in conjunction with the logical stagnant effect of Herba Solani Lyrati, reach the effect eliminating the retardance of meridians accumulation of phlegm.We avoid using eliminating phlegm eliminating stagnation medicine, and its reason is that meridians stagnation of phlegm is different from visible phlegm, inventor's clinical experience gained: use such medicine, nerve conduction irritability, easily causes the untoward reaction such as chronic pain and abnormal neuron reflection.
2, Rubus delavayi Franch. heat-clearing and toxic substances removing dehumidifying, Caulis Erycibes expelling wind and removing dampness, reducing swelling and alleviating pain, auxiliary Herba Solani Lyrati and Folium et Ramulus Clerodendri Trichotomi dispel the phlegm-damp in meridians, remove wet retention of phlegm and amass this pathologic basis.
3, Rhizoma Polygonati boosting qi and nourishing yin, Fructus Ligustri Lucidi nourishing the liver and kidney, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI diuretic, carry out training from phlegm-damp upstream and downstream respectively and mend, help Herba Solani Lyrati processed, Folium et Ramulus Clerodendri Trichotomi, Rubus delavayi Franch., Caulis Erycibes, anti-its is got rid of evils too and just hinders.
4, nine layers of wind are enriched blood promoting blood circulation to remove obstruction in the collateral, the strong muscle of Cacumen Securinegae Suffruticosae expelling wind and activating blood circulation, kidney tonifying, and two taste blood system medicines, return liver, kidney channel, reinforcement and elimination in combination, and motionless blood of invigorating blood circulation, and have the strong muscle effect of dredging collateral.
5, inventor's experimentation shows: low dose of Fructus Viburni Foetidi leaf can increase neurocyte liveness effectively.
6, Folium Cassiae Alatae can reduce the local skin stimulation of we, is beneficial to Drug Percutaneous Absorption rate.
7, in one row falls apart dredging collateral medicine, add low dose of Folium Salicis Babylonicae moss, play assistant and make use, reduce side effect.
8, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Herba Solani Lyrati 20 parts, Folium et Ramulus Clerodendri Trichotomi 10 parts, Rubus delavayi Franch. 6 parts, Caulis Erycibes 10 parts, Cacumen Securinegae Suffruticosae 6 parts, Rhizoma Polygonati 10 parts, Fructus Ligustri Lucidi 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Folium Cassiae Alatae 10 parts, 2 parts, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 6 parts, nine layers of wind 20 parts.
The preparation method of embodiment 1 is: Herba Solani Lyrati, Folium et Ramulus Clerodendri Trichotomi, Rubus delavayi Franch., Caulis Erycibes, Cacumen Securinegae Suffruticosae, Rhizoma Polygonati, Fructus Ligustri Lucidi, the Rhizoma Atractylodis Macrocephalae, Folium Cassiae Alatae, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss, nine layers of wind mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and concentrate drying dresses after pulverizing.
Embodiment 2, crude drug weight proportion: Herba Solani Lyrati 10 parts, Folium et Ramulus Clerodendri Trichotomi 6 parts, Rubus delavayi Franch. 3 parts, Caulis Erycibes 6 parts, Cacumen Securinegae Suffruticosae 3 parts, Rhizoma Polygonati 6 parts, Fructus Ligustri Lucidi 6 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Folium Cassiae Alatae 6 parts, 1 part, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 3 parts, nine layers of wind 10 parts.
Embodiment 3, crude drug weight proportion: Herba Solani Lyrati 20 parts, Folium et Ramulus Clerodendri Trichotomi 10 parts, Rubus delavayi Franch. 6 parts, Caulis Erycibes 10 parts, Cacumen Securinegae Suffruticosae 6 parts, Rhizoma Polygonati 10 parts, Fructus Ligustri Lucidi 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Folium Cassiae Alatae 10 parts, 2 parts, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 6 parts, nine layers of wind 20 parts.
Embodiment 4, crude drug weight proportion: Herba Solani Lyrati 30 parts, Folium et Ramulus Clerodendri Trichotomi 12 parts, Rubus delavayi Franch. 10 parts, Caulis Erycibes 12 parts, Cacumen Securinegae Suffruticosae 10 parts, Rhizoma Polygonati 12 parts, Fructus Ligustri Lucidi 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Folium Cassiae Alatae 12 parts, 5 parts, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 10 parts, nine layers of wind 25 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Fructus Ligustri Lucidi, Folium et Ramulus Clerodendri Trichotomi, Cacumen Securinegae Suffruticosae coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) Herba Solani Lyrati, Rubus delavayi Franch., Caulis Erycibes, Rhizoma Polygonati, Folium Cassiae Alatae, the Rhizoma Atractylodis Macrocephalae, nine layers of wind are decocted with water 2 times, filter, merging filtrate, is concentrated into relative density 1.1, obtains Aqueous extracts;
(4) fine powder of the volatile oil of step 1 gained, step 2 gained is added the Aqueous extracts of step 3 gained, stir, be concentrated into relative density 1.36.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
The efficient combination of said medicine, coordinates mutually, invigorates blood circulation, eliminates the phlegm, dredging collateral, effectively reach the object promoting the reparation of peripheral nerve injury postoperative nerve, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: the wrist injury from sharp utensil that in March, 2011 ~ 2012 year December is accepted for medical treatment causes median nerve or injury of radial nerve 26 example, and all patients underwent emergency's surgical repair are neural.Wherein male 20 example, women 6 example, 18 ~ 45 years old age, average 22.3 years old.
1.1.2 divide into groups: be divided into matched group 8 example at random, dress group 8 example, unguentum group 10 is routine.Compare in sex, age, the state of an illness before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 operation method: patient is debridement in the rear 8h of wound, in art, the neural broken ends of fractured bone is all without obviously dampening, and the neural broken ends of fractured bone of row no-station pole canopy epineurial neurorrhaphy method is meticulous involutory.
1.2.2 postoperative administration mode: matched group takes conventional postoperative operation, below elbow cast holder is fixed and function is rebuilded, dress group adopts embodiment 1 gained medicament local to dress on the basis of matched group, unguentum group adopts embodiment 3 gained unguentum Local out dressing on the basis of matched group, dress group and unguentum group 7 days all after surgery beginning local applications, change dressings weekly once, after within postoperative 4 weeks, removing below elbow cast holder, every medication 6 days intervals expose 1 day, and total course for the treatment of is 16 weeks.
1.2.3 observation index and evaluation methodology: in check in postoperative 17 weeks, measure the 30g pressure sensation of skin in injured nerve domination region respectively, 2g sense of touch, the 5g pain sensation and 2 differentiate and feel that patient's numbers of <10 mm and percent and differentiate the numerical value contrast of feeling and make comparisons at 2.
2 results.
2.1 3 groups of equal primary healings of postoperative patient wound.
2.2 postoperative 17 weeks, three groups of pressure sensations, sense of touch, the pain sensation and 2 are differentiated and feel that the patients of >10mm compare, the results are shown in following table:
| Group | Number of cases | Pressure sensation (%) | Sense of touch | The pain sensation | Differentiate for 2 and feel |
| Matched group | 8 | 50% | 50% | 37.5% | 12.5% |
| Dress group | 8 | 100% | 100% | 87.5% | 50% |
| Unguentum group | 10 | 100% | 100% | 90% | 70% |
The present invention of result display application dresses or the patient of unguentum external application differentiates recovery feels in apparently higher than blank group (P<0.05) pressure sensation, sense of touch, the pain sensation and at 2.
2.3 3 groups of adverse reactions of patients incidence rates compare: three groups be occur any obvious adverse reaction record, dress group and unguentum group local skin there is not obvious red and swollen pruritus, the equal omnidistance completed treatment of all cases.
3. conclusion.
This result of study shows, and the present invention dresses or unguentum external application can accelerate the nervous tissue of repairing damage, improves nervous tissue and transmits and dysbolismus.And do not find in following up a case by regular visits to occur any untoward reaction in medication process, illustrate that the application of this clinical drug is safe.
Claims (1)
1. the preparation method of a nerve injury external used medicine, it is characterized in that: mixing and water adding is decocted by Herba Solani Lyrati 10 ~ 30 parts, Folium et Ramulus Clerodendri Trichotomi 6 ~ 12 parts, Rubus delavayi Franch. 3 ~ 10 parts, Caulis Erycibes 6 ~ 12 parts, Cacumen Securinegae Suffruticosae 3 ~ 10 parts, Rhizoma Polygonati 6 ~ 12 parts, Fructus Ligustri Lucidi 6 ~ 12 parts, the Rhizoma Atractylodis Macrocephalae 6 ~ 12 parts, Folium Cassiae Alatae 6 ~ 12 parts, 1 ~ 5 part, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 3 ~ 10 parts, nine layers of wind 10 ~ 25 parts, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and concentrate drying is pulverized.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310358797.8A CN103432385B (en) | 2013-08-19 | 2013-08-19 | Medicine for peripheral nerve injury postoperation recovery |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310358797.8A Division CN103432385B (en) | 2013-08-19 | 2013-08-19 | Medicine for peripheral nerve injury postoperation recovery |
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| CN104758605A true CN104758605A (en) | 2015-07-08 |
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| CN201510171462.4A Pending CN104758605A (en) | 2013-08-19 | 2013-08-19 | Preparation method for external-use drug for nerve injury |
| CN201310358797.8A Expired - Fee Related CN103432385B (en) | 2013-08-19 | 2013-08-19 | Medicine for peripheral nerve injury postoperation recovery |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973799A (en) * | 2012-12-31 | 2013-03-20 | 林艳霞 | Pill used for post-anesthesia nerve injury |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872343B (en) * | 2012-10-25 | 2014-04-09 | 薛伟伟 | Nursing hydropathic compress liquid for promoting recovery of nerve injury |
| CN103040976B (en) * | 2012-12-31 | 2014-01-15 | 刘建贞 | Medicine for promoting postoperative rehabilitation of facial nerve injury surgical anastomosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973799A (en) * | 2012-12-31 | 2013-03-20 | 林艳霞 | Pill used for post-anesthesia nerve injury |
Non-Patent Citations (3)
| Title |
|---|
| 国家中医药管理局《中华本草》编委会: "《中华本草》", 31 December 1999 * |
| 王爱国等: "神经营养类中药研究进展", 《实用中医药杂志》 * |
| 贾河先主编: "《中医方库》", 31 October 1994 * |
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| CN103432385A (en) | 2013-12-11 |
| CN103432385B (en) | 2015-04-22 |
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