CN104706964A - Preparation method of mixed application for treating peripheral nerve injuries - Google Patents
Preparation method of mixed application for treating peripheral nerve injuries Download PDFInfo
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- CN104706964A CN104706964A CN201510167730.5A CN201510167730A CN104706964A CN 104706964 A CN104706964 A CN 104706964A CN 201510167730 A CN201510167730 A CN 201510167730A CN 104706964 A CN104706964 A CN 104706964A
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Abstract
The invention discloses a preparation method of a mixed application for treating peripheral nerve injuries to solve treatment problems after a wrist nerve injury operation. The preparation method is characterized by comprising the following steps: mixing bittersweet herb, pseudobulb of appendiculate cremastra, herb of beach morningglory, paniculate spotflower herb, suffrutescent securinega twigs, mulberry seeds, Himalayan teasel roots, dried tangerine peels, leaves of ringworm senna, fragile blueberry leaves, amblystegium serpens and medicinal cyathula roots, adding water for decocting, taking out a filtrate after 30 minutes, adding water into dregs of a decoction to continuously decoct for 20 minutes, taking out a filtrate, combining the filtrates, concentrating, drying and crushing. A clinical experiment shows that the mixed application has the characteristics of good curative effect and relatively high safety after the operation for treating wrist nerve injuries, and is worthy of clinical application and popularization.
Description
Technical field
The present invention is that (application number: divisional application 2013103601509), relates to drug world is specifically related to a kind of peripheral nerve injury preparation method dressing agent to patent of invention " a kind of medicine for external use causing nerve injury for wrist wound ".
Background technology
Carpal nerve comprises median nerve, ulnar nerve and radial nerve, because these neural tables are shallow, easily hurt or dampens.After the nerve injury that wound is involved, by the motion in this innervation district, all will there is obstacle in sensation and nutrition.Clinical signs is Muscle paralysis, atrophoderma, feels to go down or disappear.Although Peripheral nerve repair technology there has been significant progress, as adopted histochemistry or SABC to carry out in meticulous microsurgical technique, art to move and sensory function Shu Dingwei etc., even but fresh, clean peripheral nerve rupture wound, the timely microsurgical technique of advanced person that adopts is repaired, usually also can not obtain holomorphosis, function also often can not be recovered completely; And to feel for a long time or the disappearance of moving will cause amyotrophy, arthrogryposis deformity etc.Therefore, how to promote the regeneration of peripheral nerve injury, recover its function to greatest extent, be the basis of CO2 laser weld and the focus of clinical research always.
The nerve injury medicine of current Clinical practice has exogenous neurotrophic factor, adenylic acid Cycloxygenase activator and cyclic adenosine monophosphate, Protein kinase C, inflammatory factor, vitamin B complex etc.Nerve growth factor (nerve growth factor in its exogenous neurotrophic factor, NGF) curative effect is the most reliable, but also there is side effect in application NGF: sprouting of int normal neuronal aixs cylinder, can cause the untoward reaction such as chronic pain and abnormal neuron reflection to occur.Therefore exploration one class of still needing at present can promote neural growth fast, can ensure again the inexpensive drugs of regenerated nervous fibers function.
The postoperative Chinese medicine of repairing of neural injury is the based uplink gas promoting blood circulation to remove obstruction in the collateral being vigorate qi and replenish the blood then more, but actual clinical effect not obvious.Acupuncture effect is obviously better than Chinese medicine, but patient is difficult to adhere to.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the little medicine for external use causing nerve injury for wrist wound of side effect.
The technical scheme that the present invention solves its technical problem is: the peripheral nerve injury preparation method dressing agent, it is characterized in that: Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones, Herba Ipomoeae Pes-Capraes, Herba Spilanthis Acmellae, Cacumen Securinegae Suffruticosae, Fructus Mori, Radix Dipsaci, Pericarpium Citri Reticulatae, Folium Cassiae Alatae, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss, nine layers of wind mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and concentrate drying is pulverized.
Chinese medicine of the present invention is prepared from by the raw material of following optimum weight part proportioning: Herba Solani Lyrati 20 parts, Pseudobulbus Cremastrae Seu Pleiones 10 parts, Herba Ipomoeae Pes-Capraes 6 parts, Herba Spilanthis Acmellae 10 parts, Cacumen Securinegae Suffruticosae 6 parts, Fructus Mori 10 parts, Radix Dipsaci 10 parts, Pericarpium Citri Reticulatae 10 parts, Folium Cassiae Alatae 10 parts, 2 parts, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 6 parts, nine layers of wind 20 parts.
Wherein said: Herba Solani Lyrati is the herb of plant of Solanaceae Herba Solani Lyrati Solanum lyratum Thunb..Sweet in the mouth; Bitter; Cold in nature.Return liver; Gallbladder; Kidney channel.Merit can clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.
Pseudobulbus Cremastrae Seu Pleiones is orchid Cremastra appendiculata Cremastra appendiculata (D.Don) Makino, pleione bulbocodioides Pleione bulbocodioides(Franch.) the dry pseudobulb of Rolfe or Pleione yunnanensis Pleione yunnanensis Rolfe.Nature and flavor are sweet, micro-pungent, cold.Enter liver, stomach warp.Merit can heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.
Herba Ipomoeae Pes-Capraes is the herb of Convolvulaceae morning glory two leaf Radix Ipomoeae Ipomoea pescarpae (L.) Sweet.Pungent, the micro-hardship of nature and flavor, wet.Merit can expelling wind and removing dampness, detumescence of drawing out pus by applying a plaster to the affected part.
Herba Spilanthis Acmellae is the herb of feverfew Herba Cancriniae lasiocarpae Spilanthes paniculata Wall.ex DC..Acrid in the mouth; Bitter; Slightly warm in nature; Mild toxicity.Merit can relieving cough and asthma; Detoxification and promoting urination; Reducing swelling and alleviating pain.
Cacumen Securinegae Suffruticosae is euphorbia plant Suffrutescent Securinega Twig Securinega suffruticosa(Pal1.) browse of Rehd. or root.Acrid in the mouth; Bitter; Slightly warm in nature.Return liver; Kidney; Spleen channel.Merit can expelling wind and activating blood circulation; The strong muscle of kidney tonifying.
Fructus Mori is the dry fruit ear of moraceae plants Mulberry Morus alba L..Nature and flavor are sweet, sour, cold.GUIXIN, liver, kidney channel.Merit can be enriched blood YIN nourishing, promotes the production of body fluid and moisturizes.
Radix Dipsaci is the dry root of Dipsacaceae herbaceos perennial Radix Dipsaci Himalayan Teasel Root.Bitter in the mouth is pungent; Slightly warm in nature.Return liver, kidney channel.Merit can invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Continuous injured; Only metrorrhagia.
Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor are bitter, pungent, temperature.Return lung, spleen channel.Merit can regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Folium Cassiae Alatae, is pulse family Folium Cassiae Alatae Cassia alata L., is used as medicine with leaf.Nature and flavor are pungent, temperature.Merit can parasite killing, antipruritic.
Fructus Viburni Foetidi leaf is the leaf of Radix Ophiopogonis place's plant Caulis Viburni Dilatati Viburnum foetidrm Wall..Puckery; Property is put down.Merit can be detoxified; Symplectic bone.
Folium Salicis Babylonicae moss is Amblystegiaceae Folium Salicis Babylonicae moss Amblystegium serpens(Hedw.) plant of B.S.G..Nature and flavor are puckery; Flat.Merit can astringing to arrest bleeding.
Nine layers of wind are the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn.Nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Merit can be enriched blood, and invigorates blood circulation, dredging collateral.
Composition principle: carpal nerve damage is much more general to be occurred with wound, the postoperative Chinese medicine of current carpal nerve injury repairing is the based uplink gas promoting blood circulation to remove obstruction in the collateral of vigorate qi and replenish the blood more, but actual clinical effect not obvious.Inventor's clinical research for many years finds, carpal nerve damage is except qi depression to blood stasis, it is obstructed that carpal nerve damages postoperative limbs channels, stay poly-not loose relevant to body fluid, surely belong to the traditional Chinese medical science and be referred to as " phlegm stagnating in meridian ", accumulation of phlegm blocks, in network, QI and blood is not all right, also blood stasis can be caused, and " accumulation of blood is both of a specified duration, also can turn to expectorant water " (" treatise on blood trouble " rolls up five).So, because expectorant causes the stasis of blood, the long-pending stasis of blood is reduced phlegm, phlegm and blood stasis, and glue work is for suffering from, and then obstructed till passages through which vital energy circulates, four ends do not reach and produce the malnutrition in Substance P region.Therefore, carpal nerve damages postoperative main pathological basis is be the accumulation of phlegm folder stasis of blood.Expectorant, the stasis of blood are pathological product, are again paathogenic factors; Both be the mark of disease, being also disease basis, is wherein major pathogenetic factor especially with accumulation of phlegm.Therefore it is treated, and should invigorate blood circulation, eliminate the phlegm, eliminating stagnation, dredging collateral are gone forward side by side, and can promote that carpal nerve damages postoperative local recovery.
Compared with prior art, the present invention has following characteristics.
1, Herba Solani Lyrati and Pseudobulbus Cremastrae Seu Pleiones coordinate for monarch drug, wherein: Herba Solani Lyrati merit can clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, inventor's cell culture experiments proves: Herba Solani Lyrati decocting liquid is used for wrist wound and causes the postoperative logical stagnant effect with uniqueness of repairing of neural injury, its mechanism of action may be that Herba Solani Lyrati can promote local growth associated protein (Growth associated protein-43, GAP-43) synthesis, and specific proteins GAP-43 is in the growth of nerve fiber, grow, the important roles such as the maintenance of axon regeneration and synaptic function, and participate in the adjustment of neurotransmitter regulator, grow again neural or can determine to grow along correct direction with inducing neural projection in regeneration, and there is no the side effect of sprouting of that int normal neuronal aixs cylinder of NGF, and Pseudobulbus Cremastrae Seu Pleiones dispersing strength is strong, the logical stagnant effect of Herba Solani Lyrati can be strengthened, reach the effect eliminating the retardance of meridians accumulation of phlegm.We avoid using eliminating phlegm eliminating stagnation medicine, and its reason is that meridians stagnation of phlegm is different from visible phlegm, inventor's clinical experience gained: use such medicine, nerve conduction irritability, easily causes the untoward reaction such as chronic pain and abnormal neuron reflection.
2, Herba Ipomoeae Pes-Capraes expelling wind, removing dampness and detumescence, Herba Spilanthis Acmellae expelling wind and removing dampness, reducing swelling and alleviating pain, auxiliary Herba Solani Lyrati and Pseudobulbus Cremastrae Seu Pleiones dispel the phlegm-damp in meridians, remove wet retention of phlegm and amass this pathologic basis.
3, Fructus Mori is enriched blood yin nourishing, Radix Dipsaci nourishing the liver and kidney, Pericarpium Citri Reticulatae invigorating the spleen and benefiting QI diuretic, carries out training respectively and mends, help Herba Solani Lyrati processed, Pseudobulbus Cremastrae Seu Pleiones, Herba Ipomoeae Pes-Capraes, Herba Spilanthis Acmellae from phlegm-damp upstream and downstream, prevents that it is got rid of evils too and just hinders.
4, nine layers of wind are enriched blood promoting blood circulation to remove obstruction in the collateral, the strong muscle of Cacumen Securinegae Suffruticosae expelling wind and activating blood circulation, kidney tonifying, and two taste blood system medicines, return liver, kidney channel, reinforcement and elimination in combination, and motionless blood of invigorating blood circulation, and have the strong muscle effect of dredging collateral.
5, inventor's experimentation shows: low dose of Fructus Viburni Foetidi leaf can increase neurocyte liveness effectively.
6, Folium Cassiae Alatae can reduce the local skin stimulation of we, is beneficial to Drug Percutaneous Absorption rate.
7, in one row falls apart dredging collateral medicine, add low dose of Folium Salicis Babylonicae moss, play assistant and make use, reduce side effect.
8, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Herba Solani Lyrati 20 parts, Pseudobulbus Cremastrae Seu Pleiones 10 parts, Herba Ipomoeae Pes-Capraes 6 parts, Herba Spilanthis Acmellae 10 parts, Cacumen Securinegae Suffruticosae 6 parts, Fructus Mori 10 parts, Radix Dipsaci 10 parts, Pericarpium Citri Reticulatae 10 parts, Folium Cassiae Alatae 10 parts, 2 parts, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 6 parts, nine layers of wind 20 parts.
The preparation method of embodiment 1 is: Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones, Herba Ipomoeae Pes-Capraes, Herba Spilanthis Acmellae, Cacumen Securinegae Suffruticosae, Fructus Mori, Radix Dipsaci, Pericarpium Citri Reticulatae, Folium Cassiae Alatae, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss, nine layers of wind mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and concentrate drying dresses after pulverizing.
Embodiment 2, crude drug weight proportion: Herba Solani Lyrati 10 parts, Pseudobulbus Cremastrae Seu Pleiones 6 parts, Herba Ipomoeae Pes-Capraes 3 parts, Herba Spilanthis Acmellae 6 parts, Cacumen Securinegae Suffruticosae 3 parts, Fructus Mori 6 parts, Radix Dipsaci 6 parts, Pericarpium Citri Reticulatae 6 parts, Folium Cassiae Alatae 6 parts, 1 part, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 3 parts, nine layers of wind 10 parts.
Embodiment 3, crude drug weight proportion: Herba Solani Lyrati 20 parts, Pseudobulbus Cremastrae Seu Pleiones 10 parts, Herba Ipomoeae Pes-Capraes 6 parts, Herba Spilanthis Acmellae 10 parts, Cacumen Securinegae Suffruticosae 6 parts, Fructus Mori 10 parts, Radix Dipsaci 10 parts, Pericarpium Citri Reticulatae 10 parts, Folium Cassiae Alatae 10 parts, 2 parts, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 6 parts, nine layers of wind 20 parts.
Embodiment 4, crude drug weight proportion: Herba Solani Lyrati 30 parts, Pseudobulbus Cremastrae Seu Pleiones 12 parts, Herba Ipomoeae Pes-Capraes 10 parts, Herba Spilanthis Acmellae 12 parts, Cacumen Securinegae Suffruticosae 10 parts, Fructus Mori 12 parts, Radix Dipsaci 12 parts, Pericarpium Citri Reticulatae 12 parts, Folium Cassiae Alatae 12 parts, 5 parts, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss 10 parts, nine layers of wind 25 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Radix Dipsaci, Pseudobulbus Cremastrae Seu Pleiones, Cacumen Securinegae Suffruticosae coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) Herba Solani Lyrati, Herba Ipomoeae Pes-Capraes, Herba Spilanthis Acmellae, Fructus Mori, Folium Cassiae Alatae, Pericarpium Citri Reticulatae, nine layers of wind are decocted with water 2 times, filter, merging filtrate, is concentrated into relative density 1.1, obtains Aqueous extracts;
(4) fine powder of the volatile oil of step 1 gained, step 2 gained is added the Aqueous extracts of step 3 gained, stir, be concentrated into relative density 1.36.
In prioritization scheme, described simmer down to concentrating under reduced pressure.
The efficient combination of said medicine, coordinates mutually, invigorates blood circulation, eliminates the phlegm, dredging collateral, effectively reach the object promoting the reparation of carpal nerve damage postoperative nerve, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: the wrist injury from sharp utensil that in March, 2011 ~ 2012 year December is accepted for medical treatment causes carpal nerve to damage 33 examples, wherein median nerve injury 20 example, injury of radial nerve 11 example, and radial nerve injury 9 example, all patients underwent emergency's surgical repair are neural.Wherein male 24 example, women 9 example, 16 ~ 51 years old age, average 25.4 years old.
1.1.2 divide into groups: be divided into matched group 11 example at random, dress group 12 example, unguentum group 10 is routine.Compare in sex, age, the state of an illness before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 operation method: patient is debridement in the rear 8h of wound, in art, the neural broken ends of fractured bone is all without obviously dampening, and the neural broken ends of fractured bone of row no-station pole canopy epineurial neurorrhaphy method is meticulous involutory.
1.2.2 postoperative administration mode: matched group takes conventional postoperative operation, below elbow cast holder is fixed and function is rebuilded, dress group adopts embodiment 1 gained medicament local to dress on the basis of matched group, unguentum group adopts embodiment 3 gained unguentum Local out dressing on the basis of matched group, dress group and unguentum group 7 days all after surgery beginning local applications, change dressings weekly once, after within postoperative 4 weeks, removing below elbow cast holder, every medication 6 days intervals expose 1 day, and total course for the treatment of is 16 weeks.
1.2.3 observation index and evaluation methodology: in check in postoperative 17 weeks, measures the 30g pressure sensation of skin in injured nerve domination region respectively, 2g sense of touch, the 5g pain sensation and 2 differentiates and feel that patient's numbers of <10 mm and percent and differentiate the numerical value contrast of feeling and make and comparing at 2.
2 results.
2.1 3 groups of equal primary healings of postoperative patient wound.
2.2 postoperative 17 weeks, three groups of pressure sensations, sense of touch, the pain sensation and 2 are differentiated and feel that the patients of >10mm compare, the results are shown in following table:
| Group | Number of cases | Pressure sensation (%) | Sense of touch | The pain sensation | Differentiate for 2 and feel |
| Matched group | 11 | 63.63% | 63.63% | 36.36% | 18.18% |
| Dress group | 12 | 100% | 100% | 66.67% | 50% |
| Unguentum group | 10 | 100% | 100% | 80% | 70% |
The present invention of result display application dresses or the patient of unguentum external application differentiates recovery feels in apparently higher than blank group (P<0.05) the pain sensation and at 2.
2.3 3 groups of adverse reactions of patients incidence rates compare: three groups all do not occur any obvious adverse reaction record, dress group and unguentum group local skin there is not obvious red and swollen pruritus, the equal omnidistance completed treatment of all cases.
3. conclusion.
This result of study shows, and the present invention dresses or unguentum external application can accelerate the nervous tissue of repairing damage, improves nervous tissue and transmits and dysbolismus.And do not find in following up a case by regular visits to occur any untoward reaction in medication process, illustrate that this medicine for external use clinical practice is safe.
Claims (1)
1. the peripheral nerve injury preparation method dressing agent, it is characterized in that: Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones, Herba Ipomoeae Pes-Capraes, Herba Spilanthis Acmellae, Cacumen Securinegae Suffruticosae, Fructus Mori, Radix Dipsaci, Pericarpium Citri Reticulatae, Folium Cassiae Alatae, Fructus Viburni Foetidi leaf, Folium Salicis Babylonicae moss, nine layers of wind mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and concentrate drying is pulverized.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510167730.5A CN104706964A (en) | 2013-08-19 | 2013-08-19 | Preparation method of mixed application for treating peripheral nerve injuries |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510167730.5A CN104706964A (en) | 2013-08-19 | 2013-08-19 | Preparation method of mixed application for treating peripheral nerve injuries |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310360150.9A Division CN103405650B (en) | 2013-08-19 | 2013-08-19 | External medicine for nerve injury caused by wrist traumas |
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| CN104706964A true CN104706964A (en) | 2015-06-17 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872343A (en) * | 2012-10-25 | 2013-01-16 | 薛伟伟 | Nursing hydropathic compress liquid for promoting recovery of nerve injury |
| CN102973799A (en) * | 2012-12-31 | 2013-03-20 | 林艳霞 | Pill used for post-anesthesia nerve injury |
-
2013
- 2013-08-19 CN CN201510167730.5A patent/CN104706964A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872343A (en) * | 2012-10-25 | 2013-01-16 | 薛伟伟 | Nursing hydropathic compress liquid for promoting recovery of nerve injury |
| CN102973799A (en) * | 2012-12-31 | 2013-03-20 | 林艳霞 | Pill used for post-anesthesia nerve injury |
Non-Patent Citations (1)
| Title |
|---|
| 魏少荫 等: "促进周围神经再生的中药及复方", 《中国中药杂志》 * |
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Application publication date: 20150617 |