CN102973685A - Anti-fatigue traditional Chinese medicine preparation and preparation method thereof - Google Patents
Anti-fatigue traditional Chinese medicine preparation and preparation method thereof Download PDFInfo
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Abstract
The invention provides an anti-fatigue traditional Chinese medicine compound preparation, which is composed of hawthorn, acanthopanax, ginseng, rhodiola rosea, schisandra chinensis, herba epimedii, chinese angelica, the root of kudzu vine, the root of red-rooted salvia, rhizoma anemarrhenae, dogwood, Chinese-date, flatstem milkvetch seed and prepared rhizoma polygonati and scientifically prepared into a traditional Chinese medicine preparation. The anti-fatigue traditional Chinese medicine preparation provided by the invention has the effects of increasing immunity, treating insufficiency of both the spleen and the kidney, insubstantiality, fatigue, anepithymia, waist and knee pain, insomnia and dreamful sleep and the like and is applied to people suffering from long-time insubstantiality and fatigue, anepithymia, rhythm of the restless, amnesia, insomnia and dreamful sleep, severe neurasthenia, climacteric syndrome and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition with resisting fatigue, also disclose simultaneously the preparation method of this medicine, belong to traditional Chinese medical science pharmaceutical technology and field of health care food.
Background technology
Along with the quickening of modern life rhythm, the aggravation of social competition, a lot of people are because of the excessive overdraw healths such as pressure of work, study, and fatigue becomes the health problem that perplexs a lot of people.
According to World Health Organization's investigation, the whole world has the people more than 35% to be in fatigue state approximately, and especially middle-aged male crowd fatigue state person is up to 60-75%.Brainstrust is pointed out, it is serious to continue overtired, long-term poor sleep consequence, both cause the diseases such as chronic pharyngolaryngitis, cervical region or axillary gland swell and ache, muscular soreness, multiple non-arthritis arthralgia, giddy, dizziness, headache, and finally caused immunity degradation; And after the immunity degradation, make again " fatigue syndrome " more outstanding and deterioration, thereby form a vicious cycle.
Anti-fatigue product in the market roughly can be divided into following a few class: the firstth, and makeup energy.Usually reach and keep the body normal physiological function, the purpose of relieving fatigue by replenishing the nutrition that consumes in the motion.The secondth, vitamin and the trace element of additional needed by human.The 3rd is that removing, the discharge of acceleration bodies intracellular metabolite material reach the resisting fatigue purpose by the function of the function, particularly blood circulation that improves biological organs.A lot of Chinese herbal and crude drugs preparationses all belong to this class.But fatigue occurs that composite factor often causes, and links also closely links to each other, and only is that to come resisting fatigue for some links wherein be incomplete.From the exploitation of present fatigue resistant health food, also trending towards to alleviating physical fatigue functions expanding in addition.
At present the home and abroad still lacks a kind of determined curative effect, safely and effectively Therapeutic Method and Chinese medicine composition.
Summary of the invention
The purpose of this invention is to provide a kind of compound Chinese medicinal preparation with resisting fatigue, have enhancing immunity, the effects such as treatment deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.It is weak to be applicable to long-term body void, and inappetence, the rhythm of the heart are not peaceful, forgetful, insomnia and dreamful sleep person and neurasthenia gravis and climacteric syndrome etc.
The invention also discloses the preparation method of this medicine, be applicable to suitability for industrialized production.
The present invention is theoretical according to the traditional Chinese medicine health care of China, and selected following Chinese crude drug extract is made Chinese medicine preparation: (by weight) through the scientific composition compatibility
The raw material of the preferred following weight proportion of Chinese medicine composition of the present invention is prepared from:
Fructus Crataegi 350-390 part Radix Et Caulis Acanthopanacis Senticosi 180-200 part Radix Ginseng 60-80 part
Radix Rhodiolae 60-80 part Fructus Schisandrae Chinensis 15-20 part Herba Epimedii 30-40 part.
The raw material of the preferred following weight proportion of Chinese medicine composition of the present invention is prepared from:
70 parts of 190 parts of Radix Ginsengs of 370 parts of Radix Et Caulis Acanthopanacis Senticosis of Fructus Crataegi
36 parts of 18 parts of Herba Epimedii of 70 parts of Fructus Schisandrae Chinensis of Radix Rhodiolae.
Chinese medicine composition of the present invention can be made various dosage forms by the conventional preparation method in this area, such as capsule, tablet, granule, pill etc.
The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:
Above Six-element, Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi decoct with water 3 times, and amount of water is respectively 10,8,6 times, decocting time is 3.5,2,1.5 hours, and collecting decoction filters, it is 1.15-1.18(80 ℃ that filtrate decompression is concentrated into relative density) fluid extract, let cool, stir, slowly add ethanol and make and contain alcohol amount and reach about 70%, leave standstill more than 12 hours, filter, get supernatant, precipitate 2 times with 70% washing with alcohol again, get supernatant, merge three times medicinal liquid, filter, for subsequent use.Radix Ginseng, Radix Rhodiolae, Fructus Schisandrae Chinensis, Herba Epimedii, with 70% alcohol reflux 3 times, the amount that adds 70% ethanol is respectively 10,8,6 times, return time was respectively 3,2,1 hours, and merge extractive liquid, filters, merge with front Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi medicinal liquid, the concentrating under reduced pressure Recycled ethanol gets thick paste, vacuum drying, pulverize, sieve, then make Chinese medicine preparation according to the conventional preparation method of Chinese medicine.Such as capsule, tablet, granule, pill etc.
For strengthening resisting fatigue effect of the present invention, according to the difference of degree of fatigue, we can also replenish Radix Angelicae Sinensis, Radix Puerariae, and Radix Salviae Miltiorrhizae, the Rhizoma Anemarrhenae, Fructus Corni, Fructus Jujubae, Semen Astragali Complanati, the eight flavor Chinese crude drugs such as Rhizoma Polygonati (processed) are write out a prescription as potentiation.
The raw material of the preferred following weight proportion of potentiation prescription Chinese medicine composition of the present invention is prepared from:
Fructus Crataegi 350-390 part Radix Et Caulis Acanthopanacis Senticosi 180-200 part Radix Ginseng 60-80 part
Radix Rhodiolae 60-80 part Fructus Schisandrae Chinensis 15-20 part Herba Epimedii 30-40 part
Radix Angelicae Sinensis 10-18 part Radix Puerariae 8-12 part Radix Salviae Miltiorrhizae 10-18 part
Rhizoma Anemarrhenae 10-18 part Fructus Corni 20-40 part Fructus Jujubae 45-55 part
Semen Astragali Complanati 25-35 part Rhizoma Polygonati (processed) 45-55 part.
The raw material of the preferred following weight proportion of potentiation prescription Chinese medicine composition of the present invention is prepared from:
70 parts of 190 parts of Radix Ginsengs of 370 parts of Radix Et Caulis Acanthopanacis Senticosis of Fructus Crataegi
36 parts of 18 parts of Herba Epimedii of 70 parts of Fructus Schisandrae Chinensis of Radix Rhodiolae
15 parts of 10 parts of Radix Salviae Miltiorrhizaes of 15 parts of Radix Puerariaes of Radix Angelicae Sinensis
50 parts in 30 portions of Fructus Jujubaes of 15 parts of Fructus Corni of the Rhizoma Anemarrhenae
50 parts of 30 parts of Rhizoma Polygonati (processed) of Semen Astragali Complanati.
Potentiation prescription Chinese medicine composition also can be made various dosage forms by the conventional preparation method in this area, such as capsule, tablet, granule, pill etc.
The preparation method of potentiation prescription Chinese medicine composition comprises the steps:
More than 14 the flavor, Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi decoct with water 3 times, amount of water is respectively 10,8,6 times, decocting time is 3.5,2,1.5 hours, and collecting decoction filters, it is 1.15-1.18(80 ℃ that filtrate decompression is concentrated into relative density) fluid extract, let cool, stir, slowly add ethanol and make and contain alcohol amount and reach about 70%, leave standstill more than 12 hours, filter, get supernatant, precipitate 2 times with 70% washing with alcohol again, get supernatant, merge three times medicinal liquid, filter, for subsequent use.Radix Ginseng, Radix Rhodiolae, Fructus Schisandrae Chinensis, Herba Epimedii, Radix Angelicae Sinensis, Radix Puerariae, Radix Salviae Miltiorrhizae, the Rhizoma Anemarrhenae, Fructus Corni, Fructus Jujubae, Semen Astragali Complanati, Rhizoma Polygonati (processed), with 70% alcohol reflux 3 times, the amount that adds 70% ethanol is respectively 10,8,6 times Deng 12 flavors, and return time was respectively 3,2,1 hours, merge extractive liquid,, filter, merge with front Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi medicinal liquid, the concentrating under reduced pressure Recycled ethanol gets thick paste, vacuum drying is pulverized, and sieves, and then makes Chinese medicine preparation according to the conventional preparation method of Chinese medicine.Such as capsule, tablet, granule, pill etc.
Health care: resisting fatigue.
The method consumption: ante cibum is oral, each 1.2 ~ 1.5g, every day 3 times.
Chinese medicine is thought: spleen governing muscles, and liver governing tendons, kidney governing bones, the three has close contacting with the generation of fatigue.Especially liver still can be regulated transformation and transportation of the spleen and stomach and harmonizing the functional activities of vital QI and feelings will by its catharsis effect." Plain Questions six joint the state of internal organs opinions " cloud: " the liver person, source of endurance (such as the raging labor of appointing), the residence of soul also, its China is at pawl, it fills at muscle, with hemopoietic gas.So ", when liver spleen kidney three dirty dysfunction, then can cause the generation of chronic fatigue syndrome, long-term fatigue and weak appears, neurolysis, work efficiency reduces, and can be with spiritual feelings will symptoms such as various pain, depression or irritated irritabilities.Thus, when diet is adjusted, should catch liver spleen kidney this pathogenesis of lacking of proper care, regulate the flow of vital energy the kidney invigorating as main take spleen invigorating.
In the present invention, Fructus Crataegi, Radix Ginseng are principal agent, and the Fructus Crataegi sour in the mouth is sweet, tepor.Enter spleen, stomach, Liver Channel.It is long-pending to help digestion, dissipating blood stasis blood, expelling tenia, promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.Radix Ginseng, strongly invigorating primordial QI, life lengthening, strengthening by means of tonics, promoting the production of body fluid to quench thirst, the mind calming and mentality promoting, heart tonifying take off admittedly; Radix Et Caulis Acanthopanacis Senticosi, Fructus Schisandrae Chinensis are accessory drugs, have the effect of replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, and Radix Et Caulis Acanthopanacis Senticosi has than Radix Ginseng and better adapts to the former state effect.Both compatibilities have complementary functions, and collaborative play altogether YIN nourishing, enrich blood, the hold concurrently effect of YIN nourishing of invigorate vital energy and yang.Simultaneously, enhancing body is to the resistivity of destructive stimulus factor, regulates pathological process, makes it be tending towards normalization, as when food or the adrenal gland's property hyperglycemia, the effect of blood sugar lowering is arranged, and when insulin hypoglycemia, blood glucose can raise again.Fructus Schisandrae Chinensis can strengthen central nervous system's process of excitation, also can strengthen process of inhibition, makes its mutual balance, improves corticocerebral regulating action; Can improve work ratio, lessen fatigue.Can regulate blood pressure, cardiac function enhancing.Can excited breathe, and eliminate the phlegm, antitussive effect.Can promote bile secretion, reduce hepatitis patient serum's glutamate pyruvate transaminase, hepatocyte is had certain protective role.Still can regulate gastric secretion, excited uterus, and promote vision, audition, improve the resolving ability of skin receptor.Radix Rhodiolae, have foster lung, heat clearing away, nourishing vigour, bring down a fever, the effect of sharp lung, cure mainly the diseases such as sexual disorder, diabetes, hypotension pneumonia, neural paralysis disease, tracheitis, be widely used in now resisting fatigue, the aspects such as defying age and raising mentality and physical function.It all has obvious dual regulation to improving muscle power and mental work efficient, is desirable analeptic.Herba Epimedii has kidney-replenishing, bone and muscle strengthening, the multiple efficacies such as wind-damp dispelling.It is soft to be used for the muscles and bones flaccidity, rheumatic arthralgia, numbness contracture.More than each medicine share, can work in coordination with and play a role, have obvious resisting fatigue, significantly the effect of alleviating physical fatigue.
In the potentiation prescription, Radix Angelicae Sinensis can be enriched blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation, can be used for all cards of blood deficiency.Radix Puerariae, the yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness ends temperature.Cold, the warm headache stiffness of the nape that can cure the wound, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels dysentery.Radix Salviae Miltiorrhizae, promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.The Rhizoma Anemarrhenae, the effect clearing away heat-fire promotes the production of body fluid and moisturizes.Be used for fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, the dryness of the intestine constipation.Fructus Corni, the function liver and kidney tonifying is restrained astringent or styptic treatment for spontaneous sweatingly, and controlling nocturnal emission with astringent drugs reducing urination leukorrhagia stopping only collapses, and hidroschesis also has the promoting the production of body fluid to quench thirst effect in addition.Be used for soreness of waist and knee joint, dizziness and tinnitus, forgetful emission and spermatorrhea, enuresis frequent micturition, the bleeding not during menses menoxenia, the profuse sweating collapse, interior-heat is quenched one's thirst.Fructus Jujubae, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.Be used for insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Semen Astragali Complanati, the temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination makes eye bright.Be used for lumbago due to renal deficiency, seminal emission premature ejaculation, nebulousurine leukorrhagia, dribbling urination, dizzy blurred vision.Rhizoma Polygonati (processed), nourishing kidney lung moistening, invigorating the spleen and replenishing QI.Above-mentioned each medicine interacts, can QI invigorating enrich blood, and the yang invigorating expelling pathogenic factors from muscles, promoting the production of body fluid to quench thirst, promoting blood flow to regulate menstruation, invigorating the spleen and replenishing QI can significantly improve functions of biological organs, regains one's strength fast and energy, share with each medicine of main formula of the present invention, further strengthens the effect of resisting fatigue.
Good effect of the present invention is: mainly being comprised of Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi etc. 14 flavor Chinese medicines, is pure Chinese medicinal preparation, the spleen invigorating the kidney invigorating of regulating the flow of vital energy, the effect with resisting fatigue.Fructus Crataegi, Radix Ginseng and Radix Et Caulis Acanthopanacis Senticosi extract are mixed and made into the compound formulation of resisting fatigue, than taking separately Radix Ginseng or Radix Et Caulis Acanthopanacis Senticosi outstanding superiority are arranged, have the invigorating YANG of consolidating, QI invigorating spermatogenesis, the effects such as blood circulation promoting and blood stasis dispelling.Independent long-term all side effect that Radix Ginseng or Radix Et Caulis Acanthopanacis Senticosi bring of taking have been overcome.
The specific embodiment
Further specify technical solution of the present invention below by specific embodiment
Embodiment 1
Fructus Crataegi 370g, Radix Et Caulis Acanthopanacis Senticosi 190g decoct with water 3 times, and amount of water is respectively 10,8,6 times, and decocting time is 3.5,2,1.5 hours, collecting decoction filters, and it is 1.15-1.18(80 ℃ that filtrate decompression is concentrated into relative density) fluid extract, let cool, stir, slowly add ethanol and make and contain the alcohol amount and reach about 70%, leave standstill more than 12 hours, filter, get supernatant, precipitate 2 times with 70% washing with alcohol again, get supernatant, merge three times medicinal liquid, filter, for subsequent use.Radix Ginseng 70g, Radix Rhodiolae 70g, Fructus Schisandrae Chinensis 18g, Herba Epimedii 36g, with 70% alcohol reflux 3 times, the amount that adds 70% ethanol is respectively 10,8,6 times, return time was respectively 3,2,1 hours, merge extractive liquid, filters, and merges with front Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi medicinal liquid, the concentrating under reduced pressure Recycled ethanol, get thick paste, vacuum drying is pulverized, sieve, then make Chinese medicine preparation according to the conventional preparation method of Chinese medicine.Such as capsule, tablet, granule, pill etc.
Embodiment 2
Fructus Crataegi 370g, Radix Et Caulis Acanthopanacis Senticosi 190g decoct with water 3 times, and amount of water is respectively 10,8,6 times, and decocting time is 3.5,2,1.5 hours, collecting decoction filters, and it is 1.15-1.18(80 ℃ that filtrate decompression is concentrated into relative density) fluid extract, let cool, stir, slowly add ethanol and make and contain the alcohol amount and reach about 70%, leave standstill more than 12 hours, filter, get supernatant, precipitate 2 times with 70% washing with alcohol again, get supernatant, merge three times medicinal liquid, filter, for subsequent use.Radix Ginseng 70g, Radix Rhodiolae 70g, Fructus Schisandrae Chinensis 18g, Herba Epimedii 36g, with 70% alcohol reflux 3 times, the amount that adds 70% ethanol is respectively 10,8,6 times, return time was respectively 3,2,1 hours, and merge extractive liquid, filters, merge with front Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi medicinal liquid, the concentrating under reduced pressure Recycled ethanol gets thick paste, vacuum drying, pulverize, cross 60 mesh sieves, encapsulated, make altogether 1000, other should meet People's Republic of China's version pharmacopeia in 2010 capsule item.
Embodiment 3
Fructus Crataegi 740g, Radix Et Caulis Acanthopanacis Senticosi 380g decoct with water 3 times, and amount of water is respectively 10,8,6 times, and decocting time is 3.5,2,1.5 hours, collecting decoction filters, and it is 1.15-1.18(80 ℃ that filtrate decompression is concentrated into relative density) fluid extract, let cool, stir, slowly add ethanol and make and contain the alcohol amount and reach about 70%, leave standstill more than 12 hours, filter, get supernatant, precipitate 2 times with 70% washing with alcohol again, get supernatant, merge three times medicinal liquid, filter, for subsequent use.Radix Ginseng 140g, Radix Rhodiolae 140g, Fructus Schisandrae Chinensis 36g, Herba Epimedii 72g, with 70% alcohol reflux 3 times, the amount that adds 70% ethanol is respectively 10,8,6 times, return time was respectively 3,2,1 hours, and merge extractive liquid, filters, merge with front Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi medicinal liquid, the concentrating under reduced pressure Recycled ethanol gets thick paste, vacuum drying, pulverize, sieve the granulation granulate, the granulation agent, other should meet People's Republic of China's version pharmacopeia in 2010 granule item.
Embodiment 4
Fructus Crataegi 370g, Radix Et Caulis Acanthopanacis Senticosi 190g decoct with water 3 times, and amount of water is respectively 10,8,6 times, and decocting time is 3.5,2,1.5 hours, collecting decoction filters, and it is 1.15-1.18(80 ℃ that filtrate decompression is concentrated into relative density) fluid extract, let cool, stir, slowly add ethanol and make and contain the alcohol amount and reach about 70%, leave standstill more than 12 hours, filter, get supernatant, precipitate 2 times with 70% washing with alcohol again, get supernatant, merge three times medicinal liquid, filter, for subsequent use.Radix Ginseng 70g, Radix Rhodiolae 70g, Fructus Schisandrae Chinensis 18g, Herba Epimedii 36g, Radix Angelicae Sinensis 15g, Radix Puerariae 10g, Radix Salviae Miltiorrhizae 15g, Rhizoma Anemarrhenae 15g, Fructus Corni 30g, Fructus Jujubae 50g, Semen Astragali Complanati 30g, Rhizoma Polygonati (processed) 50g, with 70% alcohol reflux 3 times, the amount that adds 70% ethanol is respectively 10,8,6 times, return time was respectively 3,2,1 hours, merge extractive liquid, filters, and merges with front Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi medicinal liquid, the concentrating under reduced pressure Recycled ethanol, get thick paste, vacuum drying is pulverized, sieve, then make Chinese medicine preparation according to the conventional preparation method of Chinese medicine.Such as capsule, tablet, granule, pill etc.
Embodiment 5
Fructus Crataegi 370g, Radix Et Caulis Acanthopanacis Senticosi 190g decoct with water 3 times, and amount of water is respectively 10,8,6 times, and decocting time is 3.5,2,1.5 hours, collecting decoction filters, and it is 1.15-1.18(80 ℃ that filtrate decompression is concentrated into relative density) fluid extract, let cool, stir, slowly add ethanol and make and contain the alcohol amount and reach about 70%, leave standstill more than 12 hours, filter, get supernatant, precipitate 2 times with 70% washing with alcohol again, get supernatant, merge three times medicinal liquid, filter, for subsequent use.Radix Ginseng 70g, Radix Rhodiolae 70g, Fructus Schisandrae Chinensis 18g, Herba Epimedii 36g, Radix Angelicae Sinensis 15g, Radix Puerariae 10g, Radix Salviae Miltiorrhizae 15g, Rhizoma Anemarrhenae 15g, Fructus Corni 30g, Fructus Jujubae 50g, Semen Astragali Complanati 30g, Rhizoma Polygonati (processed) 50g, with 70% alcohol reflux 3 times, the amount that adds 70% ethanol is respectively 10,8,6 times, return time is respectively 3,2,1 hour, merge extractive liquid,, filter, with the front Fructus Crataegi, the Radix Et Caulis Acanthopanacis Senticosi medicinal liquid merges, and the concentrating under reduced pressure Recycled ethanol gets thick paste, vacuum drying, pulverize, cross 60 mesh sieves, encapsulated, make altogether 1000, other should meet People's Republic of China's version pharmacopeia in 2010 capsule item.
Embodiment 6
Fructus Crataegi 740g, Radix Et Caulis Acanthopanacis Senticosi 380g decoct with water 3 times, and amount of water is respectively 10,8,6 times, and decocting time is 3.5,2,1.5 hours, collecting decoction filters, and it is 1.15-1.18(80 ℃ that filtrate decompression is concentrated into relative density) fluid extract, let cool, stir, slowly add ethanol and make and contain the alcohol amount and reach about 70%, leave standstill more than 12 hours, filter, get supernatant, precipitate 2 times with 70% washing with alcohol again, get supernatant, merge three times medicinal liquid, filter, for subsequent use.Radix Ginseng 140g, Radix Rhodiolae 140g, Fructus Schisandrae Chinensis 36g, Herba Epimedii 72g, Radix Angelicae Sinensis 30g, Radix Puerariae 20g, Radix Salviae Miltiorrhizae 30g, Rhizoma Anemarrhenae 30g, Fructus Corni 60g, Fructus Jujubae 100g, Semen Astragali Complanati 60g, Rhizoma Polygonati (processed) 100g, with 70% alcohol reflux 3 times, the amount that adds 70% ethanol is respectively 10,8,6 times, return time is respectively 3,2,1 hour, merge extractive liquid,, filter, with the front Fructus Crataegi, the Radix Et Caulis Acanthopanacis Senticosi medicinal liquid merges, and the concentrating under reduced pressure Recycled ethanol gets thick paste, vacuum drying, pulverize, sieve the granulation granulate, the granulation agent, other should meet People's Republic of China's version pharmacopeia in 2010 granule item.
Below example is further set forth the beneficial effect of medicine of the present invention by experiment:
Test example 1
The national method of inspection to " resisting fatigue " function is the result's judgement in conjunction with two exercise tests and three biochemical indicators.Two exercise tests are the tests of climbing of mice burden swimming test and mice, and three indexs are blood lactic acid, serum urea nitrogen and hepatic glycogen.
For showing the therapeutic effect of Chinese medicine composition of the present invention, by zoopery several the indexs such as mice pole-climbing, swimming, serum urea nitrogen, blood lactic acid, hepatic glycogen are examined or check.
One, materials and methods
1. sample: the preparation that above-described embodiment Chinese medicine composition is made take content as given the test agent, is mixed with the enema of desired concn, positive control sample: Ginseng decoction with distilled water.
2. animal and grouping: male mice in kunming, a minute Normal group gavage gives distilled water and embodiment 2, embodiment 3, embodiment 5, embodiment 6 and positive controls, and gavage gives drug substance contents concentration respectively, 0.3g/ml, 7.5g/kg body weight.Positive controls: Ginseng decoction: by crude drug 0.25ml/10g body weight.
3. instrument and reagent:
Instrument: swimming trunk, spectrophotometer, water-bath, stopwatch, electronic scale;
Reagent: serum urea is measured test kit, hepatic glycogen is measured test kit, full blood lactic mensuration test kit
4. method:
By Ministry of Health of the People's Republic of China " function of health food is learned assessment process and method of inspection standard ", the prescriptive procedure of alleviating Loaned swimming test in the physical functional check method, serum urea mensuration (diacetyl monoxime method), hepatic glycogen mensuration (anthrone method) and blood Plasma lactate is carried out.Gavage capacity 25ml/kgbw/d, every day 1 time, continuous 30 days.
Two, result
Treat with Chinese medicine composition of the present invention, the results are shown in Table 1:
The resisting fatigue experimental result
Annotate: each embodiment sample and matched group be a:0.01＜p＜0.05 relatively; Aa:p＜0.01
Three, conclusion
Each group of administration and positive controls and matched group be pole-climbing time and all to some extent increases of swimming time relatively, serum urea nitrogen descends, illustrate that tested material can reduce the degree of fatigue when animal is quiet to exert oneself and the degree of animal movement fatigue, has the effect of the tired serum urea content with reducing the rear mice that moves of minimizing; Each test group hepatic glycogen content slightly increases to increase with the mouse movement time and is directly proportional; Serum lactic acid content and positive controls no significant difference are respectively organized in administration, compare with matched group slightly to descend, and illustrate that the blood lactic acid rising to the rear mice that moves has certain inhibitory action.Pharmaceutical composition of the present invention has significantly been strengthened the effect of QI invigorating resisting fatigue, and the preferably effect of alleviating physical fatigue is arranged.Wherein embodiment 5, embodiment 6 are potentiation prescription sample, and test effect has obtained remarkable enhancing, illustrates that this prescription has further strengthened anti-fatigue effect.
Claims (6)
1. compound Chinese medicinal preparation with resisting fatigue it is characterized in that being made by ratio of weight and the number of copies by following medicine:
Fructus Crataegi 350-390, Radix Et Caulis Acanthopanacis Senticosi 180-200, Radix Ginseng 60-80, Radix Rhodiolae 60-80, Fructus Schisandrae Chinensis 15-20, Herba Epimedii 30-40.
2. the compound Chinese medicinal preparation with resisting fatigue claimed in claim 1 it is characterized in that being made by ratio of weight and the number of copies by following medicine:
Fructus Crataegi 370, Radix Et Caulis Acanthopanacis Senticosi 190, Radix Ginseng 70, Radix Rhodiolae 70, Fructus Schisandrae Chinensis 18, Herba Epimedii 36.
3. the compound Chinese medicinal preparation with resisting fatigue claimed in claim 1 it is characterized in that being made by ratio of weight and the number of copies by following medicine:
Fructus Crataegi 350-390, Radix Et Caulis Acanthopanacis Senticosi 180-200, Radix Ginseng 60-80, Radix Rhodiolae 60-80, Fructus Schisandrae Chinensis 15-20, Herba Epimedii 30-40, Radix Angelicae Sinensis 10-18, Radix Puerariae 8-12, Radix Salviae Miltiorrhizae 10-18, Rhizoma Anemarrhenae 10-18, Fructus Corni 20-40, Fructus Jujubae 45-55, Semen Astragali Complanati 25-35, Rhizoma Polygonati (processed) 45-55.
4. the compound Chinese medicinal preparation with resisting fatigue claimed in claim 2 it is characterized in that being made by ratio of weight and the number of copies by following medicine:
Fructus Crataegi 370, Radix Et Caulis Acanthopanacis Senticosi 190, Radix Ginseng 70, Radix Rhodiolae 70, Fructus Schisandrae Chinensis 18, Herba Epimedii 36, Radix Angelicae Sinensis 15, Radix Puerariae 10, Radix Salviae Miltiorrhizae 15, the Rhizoma Anemarrhenae 15, Fructus Corni 30, Fructus Jujubae 50, Semen Astragali Complanati 30, Rhizoma Polygonati (processed) 50.
5. the preparation method with compound Chinese medicinal preparation of resisting fatigue claimed in claim 1 may further comprise the steps:
Above Six-element, Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi decoct with water 3 times, and amount of water is respectively 10,8,6 times, decocting time is 3.5,2,1.5 hours, and collecting decoction filters, it is 1.15-1.18(80 ℃ that filtrate decompression is concentrated into relative density) fluid extract, let cool, stir, slowly add ethanol and make and contain alcohol amount and reach about 70%, leave standstill more than 12 hours, filter, get supernatant, precipitate 2 times with 70% washing with alcohol again, get supernatant, merge three times medicinal liquid, filter, for subsequent use; Radix Ginseng, Radix Rhodiolae, Fructus Schisandrae Chinensis, Herba Epimedii, with 70% alcohol reflux 3 times, the amount that adds 70% ethanol is respectively 10,8,6 times, return time was respectively 3,2,1 hours, and merge extractive liquid, filters, merge with front Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi medicinal liquid, the concentrating under reduced pressure Recycled ethanol gets thick paste, vacuum drying, pulverize, sieve, then make Chinese medicine preparation according to the conventional preparation method of Chinese medicine.
6. the compound Chinese medicinal preparation with resisting fatigue claimed in claim 1 may further comprise the steps:
More than 14 the flavor, Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi decoct with water 3 times, amount of water is respectively 10,8,6 times, decocting time is 3.5,2,1.5 hours, and collecting decoction filters, it is 1.15-1.18(80 ℃ that filtrate decompression is concentrated into relative density) fluid extract, let cool, stir, slowly add ethanol and make and contain alcohol amount and reach about 70%, leave standstill more than 12 hours, filter, get supernatant, precipitate 2 times with 70% washing with alcohol again, get supernatant, merge three times medicinal liquid, filter, for subsequent use; Radix Ginseng, Radix Rhodiolae, Fructus Schisandrae Chinensis, Herba Epimedii, Radix Angelicae Sinensis, Radix Puerariae, Radix Salviae Miltiorrhizae, the Rhizoma Anemarrhenae, Fructus Corni, Fructus Jujubae, Semen Astragali Complanati, Rhizoma Polygonati (processed), with 70% alcohol reflux 3 times, the amount that adds 70% ethanol is respectively 10,8,6 times Deng 12 flavors, and return time was respectively 3,2,1 hours, merge extractive liquid,, filter, merge with front Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi medicinal liquid, the concentrating under reduced pressure Recycled ethanol gets thick paste, vacuum drying is pulverized, and sieves, and then makes Chinese medicine preparation according to the conventional preparation method of Chinese medicine.
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