CN102947458B - 用于丝状真菌中c4-二羧酸的改善的产生的方法 - Google Patents

用于丝状真菌中c4-二羧酸的改善的产生的方法 Download PDF

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Publication number
CN102947458B
CN102947458B CN201180030913.2A CN201180030913A CN102947458B CN 102947458 B CN102947458 B CN 102947458B CN 201180030913 A CN201180030913 A CN 201180030913A CN 102947458 B CN102947458 B CN 102947458B
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seq
sequence
host cell
dicarboxylic acid
transporter
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Chinese (zh)
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CN102947458A (zh
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S.卢特林格
D.亚维尔
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Novozymes Inc
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Novozymes Inc
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44Polycarboxylic acids
    • C12P7/46Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/38Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201180030913.2A 2010-06-21 2011-06-21 用于丝状真菌中c4-二羧酸的改善的产生的方法 Expired - Fee Related CN102947458B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35700710P 2010-06-21 2010-06-21
US61/357,007 2010-06-21
PCT/US2011/041301 WO2011163270A1 (en) 2010-06-21 2011-06-21 Methods for improved c4-dicarboxylic acid production in filamentous fungi

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CN102947458A CN102947458A (zh) 2013-02-27
CN102947458B true CN102947458B (zh) 2016-05-04

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CN201180030913.2A Expired - Fee Related CN102947458B (zh) 2010-06-21 2011-06-21 用于丝状真菌中c4-二羧酸的改善的产生的方法

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US (2) US8497103B2 (enExample)
EP (1) EP2582829B1 (enExample)
CN (1) CN102947458B (enExample)
BR (1) BR112012028031A2 (enExample)
IN (1) IN2013CN00459A (enExample)
WO (1) WO2011163270A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5833553B2 (ja) * 2009-09-01 2015-12-16 ノボザイムス,インコーポレイティド 糸状菌におけるリンゴ酸生成の改良方法
WO2014142647A1 (en) * 2013-03-14 2014-09-18 Wageningen Universiteit Fungals strains with improved citric acid and itaconic acid production
EP3161142A4 (en) * 2014-06-26 2018-05-16 Lygos, Inc. Recombinant host cells for the production of malonate
US10781462B2 (en) 2015-02-15 2020-09-22 Tianjin Institute Of Industrial Biotechnology, Chinese Academy Of Sciences Dibasic organic acid producing strain and preparation and application of same
CN106148209B (zh) * 2015-03-23 2020-11-20 中国科学院天津工业生物技术研究所 新的二元有机酸生产菌株及其制备和应用
CN106148208B (zh) * 2015-03-23 2020-12-18 中国科学院天津工业生物技术研究所 新的二元有机酸生产菌株及其制备和应用
JP6637712B2 (ja) * 2015-10-13 2020-01-29 花王株式会社 C4ジカルボン酸の製造方法
CN105754963A (zh) * 2016-05-19 2016-07-13 江南大学 一种提高延胡索酸产量的方法
CN109689871B (zh) * 2016-09-15 2022-07-01 花王株式会社 突变丝状菌和使用其制造c4二羧酸的方法
CN114806899B (zh) * 2022-04-14 2024-04-02 王玮 一种生产l-苹果酸的里氏木霉工程菌及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009011974A1 (en) * 2007-05-18 2009-01-22 Microbia Precision Engineering, Inc. Organic acid production by fungal cells
CN101365782A (zh) * 2005-11-21 2009-02-11 泰特&莱尔组分美国公司 重组酵母中的苹果酸生产

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1047002A (en) 1911-04-03 1912-12-10 James S Diehl Scissors.
US3063910A (en) 1960-02-03 1962-11-13 Kyowa Hakko Kogyo Kk Method of producing l-malic acid by fermentation
US5536661A (en) 1987-03-10 1996-07-16 Novo Nordisk A/S Process for the production of protein products in aspergillus
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
DE4343591A1 (de) 1993-12-21 1995-06-22 Evotec Biosystems Gmbh Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
EP0765394B1 (en) 1994-06-03 2001-10-04 Novo Nordisk Biotech, Inc. Purified myceliophthora laccases and nucleic acids encoding same
AU2705895A (en) 1994-06-30 1996-01-25 Novo Nordisk Biotech, Inc. Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein
US5766439A (en) 1996-10-10 1998-06-16 A. E. Staley Manufacturing Co. Production and recovery of organic acids
US7504490B1 (en) 1998-10-16 2009-03-17 Oscient Pharmaceuticals Corporation Nucleic acid and amino acid sequences relating to Apergillus fumigatus for diagnostics and therapeutics
WO2000024883A1 (en) 1998-10-26 2000-05-04 Novozymes A/S Constructing and screening a dna library of interest in filamentous fungal cells
CN100482801C (zh) 1999-03-22 2009-04-29 诺沃奇梅兹有限公司 用于在真菌细胞中表达基因的启动子
AU2005207970B2 (en) 2004-01-29 2011-04-28 Zeachem Inc. Recovery of organic acids
US20110045559A1 (en) 2007-05-18 2011-02-24 Aaron Adriaan Winkler Malic acid production in recombinant yeast
CN104818224A (zh) 2007-11-20 2015-08-05 帝斯曼知识产权资产管理有限公司 在真核细胞中生产琥珀酸
WO2009155382A1 (en) 2008-06-17 2009-12-23 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
CN107267561A (zh) 2008-07-08 2017-10-20 帝斯曼知识产权资产管理有限公司 通过在低pH下发酵生产二羧酸
WO2010111344A2 (en) 2009-03-24 2010-09-30 Microbia, Inc. Methods and microorganisms for production of c4-dicarboxylic acids
JP2012223091A (ja) 2009-08-25 2012-11-15 Ajinomoto Co Inc L−アミノ酸の製造法
JP5833553B2 (ja) 2009-09-01 2015-12-16 ノボザイムス,インコーポレイティド 糸状菌におけるリンゴ酸生成の改良方法
WO2011066304A2 (en) 2009-11-25 2011-06-03 Codexis, Inc. Engineered beta-class carbonic anhydrase polypeptides and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101365782A (zh) * 2005-11-21 2009-02-11 泰特&莱尔组分美国公司 重组酵母中的苹果酸生产
WO2009011974A1 (en) * 2007-05-18 2009-01-22 Microbia Precision Engineering, Inc. Organic acid production by fungal cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Aspergillus clavatus NRRL1 1099423829736 genomic scaffold,whole genome shotgun sequence,登录号:NW_001517111.1;Nierman W C;《Genbank》;20090202;全文 *
Aspergillus fumigatus Af293 chromosome 8,whole genome shotgun sequence,登录号:NC_007201.1;Nierman W C等;《Genbank》;20100414;全文 *
Sequence 41942 from patent US 7504490,登录号为ACQ09725.1;Weinstock K G等;《Genbank》;20090429;全文 *

Also Published As

Publication number Publication date
CN102947458A (zh) 2013-02-27
US8497103B2 (en) 2013-07-30
US20110312046A1 (en) 2011-12-22
US20130288321A1 (en) 2013-10-31
IN2013CN00459A (enExample) 2015-07-03
EP2582829A1 (en) 2013-04-24
EP2582829B1 (en) 2016-11-30
BR112012028031A2 (pt) 2019-09-24
WO2011163270A1 (en) 2011-12-29

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