BR112012028031A2 - célula hospedeira, e , métodos para produzir um ácido dicarboxílico c4 e para aumentar a produção de ácido dicarboxílico c4. - Google Patents
célula hospedeira, e , métodos para produzir um ácido dicarboxílico c4 e para aumentar a produção de ácido dicarboxílico c4.Info
- Publication number
- BR112012028031A2 BR112012028031A2 BR112012028031A BR112012028031A BR112012028031A2 BR 112012028031 A2 BR112012028031 A2 BR 112012028031A2 BR 112012028031 A BR112012028031 A BR 112012028031A BR 112012028031 A BR112012028031 A BR 112012028031A BR 112012028031 A2 BR112012028031 A2 BR 112012028031A2
- Authority
- BR
- Brazil
- Prior art keywords
- dicarboxylic acid
- production
- producing
- increasing
- methods
- Prior art date
Links
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- 102000016862 Dicarboxylic Acid Transporters Human genes 0.000 abstract 1
- 108010092943 Dicarboxylic Acid Transporters Proteins 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- 150000001991 dicarboxylic acids Chemical class 0.000 abstract 1
- -1 malic acid Chemical class 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35700710P | 2010-06-21 | 2010-06-21 | |
| PCT/US2011/041301 WO2011163270A1 (en) | 2010-06-21 | 2011-06-21 | Methods for improved c4-dicarboxylic acid production in filamentous fungi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012028031A2 true BR112012028031A2 (pt) | 2019-09-24 |
Family
ID=44504321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012028031A BR112012028031A2 (pt) | 2010-06-21 | 2011-06-21 | célula hospedeira, e , métodos para produzir um ácido dicarboxílico c4 e para aumentar a produção de ácido dicarboxílico c4. |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8497103B2 (enExample) |
| EP (1) | EP2582829B1 (enExample) |
| CN (1) | CN102947458B (enExample) |
| BR (1) | BR112012028031A2 (enExample) |
| IN (1) | IN2013CN00459A (enExample) |
| WO (1) | WO2011163270A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8741611B2 (en) * | 2009-09-01 | 2014-06-03 | Novozymes, Inc. | Methods for improving malic acid production in filamentous fungi |
| WO2014142647A1 (en) * | 2013-03-14 | 2014-09-18 | Wageningen Universiteit | Fungals strains with improved citric acid and itaconic acid production |
| EP3161142A4 (en) * | 2014-06-26 | 2018-05-16 | Lygos, Inc. | Recombinant host cells for the production of malonate |
| CN106148209B (zh) * | 2015-03-23 | 2020-11-20 | 中国科学院天津工业生物技术研究所 | 新的二元有机酸生产菌株及其制备和应用 |
| WO2016127920A1 (zh) * | 2015-02-15 | 2016-08-18 | 中国科学院天津工业生物技术研究所 | 新的二元有机酸生产菌株及其制备和应用 |
| CN106148208B (zh) * | 2015-03-23 | 2020-12-18 | 中国科学院天津工业生物技术研究所 | 新的二元有机酸生产菌株及其制备和应用 |
| JP6637712B2 (ja) * | 2015-10-13 | 2020-01-29 | 花王株式会社 | Ｃ４ジカルボン酸の製造方法 |
| CN105754963A (zh) * | 2016-05-19 | 2016-07-13 | 江南大学 | 一种提高延胡索酸产量的方法 |
| US20190194700A1 (en) * | 2016-09-15 | 2019-06-27 | Kao Corporation | Mutant Filamentous Fungus and Method for Producing C4 Dicarboxylic Acid Using Same |
| CN114806899B (zh) * | 2022-04-14 | 2024-04-02 | 王玮 | 一种生产l-苹果酸的里氏木霉工程菌及其应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1047002A (en) | 1911-04-03 | 1912-12-10 | James S Diehl | Scissors. |
| US3063910A (en) | 1960-02-03 | 1962-11-13 | Kyowa Hakko Kogyo Kk | Method of producing l-malic acid by fermentation |
| US5536661A (en) | 1987-03-10 | 1996-07-16 | Novo Nordisk A/S | Process for the production of protein products in aspergillus |
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| KR970703426A (ko) | 1994-06-03 | 1997-07-03 | 제임스 쉐한 | 정제된 Myceliophthora 락카제 및 그것을 암호화 하는 핵산(PURIFIED MYCELIOPHTHORA LACCASES AND NUCLEIC ACIDS ENCODING SAME) |
| AU2705895A (en) | 1994-06-30 | 1996-01-25 | Novo Nordisk Biotech, Inc. | Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein |
| US5766439A (en) | 1996-10-10 | 1998-06-16 | A. E. Staley Manufacturing Co. | Production and recovery of organic acids |
| US7504490B1 (en) | 1998-10-16 | 2009-03-17 | Oscient Pharmaceuticals Corporation | Nucleic acid and amino acid sequences relating to Apergillus fumigatus for diagnostics and therapeutics |
| AU6188599A (en) | 1998-10-26 | 2000-05-15 | Novozymes A/S | Constructing and screening a dna library of interest in filamentous fungal cells |
| CN1526820B (zh) | 1999-03-22 | 2010-05-26 | 诺沃奇梅兹有限公司 | 用于在真菌细胞中表达基因的启动子 |
| MX306561B (es) | 2004-01-29 | 2013-01-09 | Zeachem Inc | Recuperacion de acidos organicos. |
| US20080090273A1 (en) * | 2005-11-21 | 2008-04-17 | Aaron Adriaan Winkler | Malic Acid Production in Recombinant Yeast |
| US20110039327A1 (en) | 2007-05-18 | 2011-02-17 | Aaron Adriaan Winkler | Organic acid production by fungal cells |
| WO2008144626A1 (en) | 2007-05-18 | 2008-11-27 | Microbia Precision Engineering, Inc. | Malic acid production in recombinant yeast |
| BRPI0819275B8 (pt) | 2007-11-20 | 2022-07-19 | Dsm Ip Assets Bv | Célula eucariótica recombinante produtora de ácido succínico e processo para a preparação de ácido succínico |
| US8129154B2 (en) | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| EP3176265A1 (en) | 2008-07-08 | 2017-06-07 | DSM IP Assets B.V. | Dicarboxylic acid production by fermentation at low ph |
| WO2010111344A2 (en) | 2009-03-24 | 2010-09-30 | Microbia, Inc. | Methods and microorganisms for production of c4-dicarboxylic acids |
| JP2012223091A (ja) | 2009-08-25 | 2012-11-15 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| US8741611B2 (en) | 2009-09-01 | 2014-06-03 | Novozymes, Inc. | Methods for improving malic acid production in filamentous fungi |
| WO2011066304A2 (en) | 2009-11-25 | 2011-06-03 | Codexis, Inc. | Engineered beta-class carbonic anhydrase polypeptides and uses thereof |
-
2011
- 2011-06-21 BR BR112012028031A patent/BR112012028031A2/pt not_active IP Right Cessation
- 2011-06-21 WO PCT/US2011/041301 patent/WO2011163270A1/en not_active Ceased
- 2011-06-21 US US13/165,719 patent/US8497103B2/en not_active Expired - Fee Related
- 2011-06-21 EP EP11728507.2A patent/EP2582829B1/en not_active Not-in-force
- 2011-06-21 IN IN459CHN2013 patent/IN2013CN00459A/en unknown
- 2011-06-21 CN CN201180030913.2A patent/CN102947458B/zh not_active Expired - Fee Related
-
2013
- 2013-06-25 US US13/926,421 patent/US20130288321A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN102947458A (zh) | 2013-02-27 |
| US8497103B2 (en) | 2013-07-30 |
| IN2013CN00459A (enExample) | 2015-07-03 |
| US20110312046A1 (en) | 2011-12-22 |
| EP2582829A1 (en) | 2013-04-24 |
| US20130288321A1 (en) | 2013-10-31 |
| CN102947458B (zh) | 2016-05-04 |
| EP2582829B1 (en) | 2016-11-30 |
| WO2011163270A1 (en) | 2011-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |