CN102947438B - 用于细胞培养的装置和方法 - Google Patents

用于细胞培养的装置和方法 Download PDF

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Publication number
CN102947438B
CN102947438B CN201180023670.XA CN201180023670A CN102947438B CN 102947438 B CN102947438 B CN 102947438B CN 201180023670 A CN201180023670 A CN 201180023670A CN 102947438 B CN102947438 B CN 102947438B
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Prior art keywords
carrier
bioreactor
adjacent
bioreactors
area
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English (en)
Chinese (zh)
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CN102947438A (zh
Inventor
迪迪耶·卡勒兰嘉博
朱利安·卡登
何塞·安东尼奥·卡斯蒂略冈萨雷斯
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Pouratris Private Ltd
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Artelis SA
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Priority claimed from GBGB1007855.8A external-priority patent/GB201007855D0/en
Priority claimed from GBGB1007863.2A external-priority patent/GB201007863D0/en
Priority claimed from GBGB1007861.6A external-priority patent/GB201007861D0/en
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Publication of CN102947438A publication Critical patent/CN102947438A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C12M3/04—Tissue, human, animal or plant cell, or virus culture apparatus with means providing thin layers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/06—Plates; Walls; Drawers; Multilayer plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/14—Apparatus for enzymology or microbiology with means providing thin layers or with multi-level trays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/04—Flat or tray type, drawers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/22—Transparent or translucent parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201180023670.XA 2010-05-11 2011-05-11 用于细胞培养的装置和方法 Active CN102947438B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1007855.8A GB201007855D0 (en) 2010-05-11 2010-05-11 Bioreactor for the culture of cells
GBGB1007863.2A GB201007863D0 (en) 2010-05-11 2010-05-11 Bioreactor for cell culture
GBGB1007861.6A GB201007861D0 (en) 2010-05-11 2010-05-11 Dynamic bioreactor for cell culture
GB1007863.2 2010-05-11
GB1007855.8 2010-05-11
GB1007861.6 2010-05-11
PCT/EP2011/057621 WO2011141512A2 (en) 2010-05-11 2011-05-11 Apparatus and methods for cell culture

Publications (2)

Publication Number Publication Date
CN102947438A CN102947438A (zh) 2013-02-27
CN102947438B true CN102947438B (zh) 2017-01-18

Family

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Application Number Title Priority Date Filing Date
CN201180023670.XA Active CN102947438B (zh) 2010-05-11 2011-05-11 用于细胞培养的装置和方法

Country Status (9)

Country Link
US (3) US9399755B2 (enExample)
EP (1) EP2516618B1 (enExample)
JP (2) JP5988962B2 (enExample)
KR (1) KR20130109000A (enExample)
CN (1) CN102947438B (enExample)
AU (1) AU2011252063A1 (enExample)
BR (1) BR112012028786A2 (enExample)
SG (2) SG10201503666UA (enExample)
WO (1) WO2011141512A2 (enExample)

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JP5939650B2 (ja) * 2013-01-07 2016-06-22 賽宇細胞科技股▲ふん▼有限公司 充填ベッド培養装置のための大規模な細胞採取方法
CN103146578B (zh) * 2013-03-29 2014-11-05 东北农业大学 转基因细胞培养装置
KR20150117599A (ko) * 2014-04-09 2015-10-20 에스케이이노베이션 주식회사 바이오매스의 연속당화 반응기
EP3430119B1 (en) * 2016-03-14 2023-06-07 Omnibrx Biotechnologies Private Limited A bioreactor system and method thereof
EP3484997A4 (en) * 2016-07-12 2020-07-29 California Institute of Technology SUBSTRATES FOR HIGH-DENSITY CELL GROWTH AND METABOLITE EXCHANGE
JP6942448B2 (ja) * 2016-08-08 2021-09-29 株式会社カネカ 細胞培養容器、これを用いた細胞培養システム、および細胞培養方法
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BE1024733B1 (fr) * 2016-11-09 2018-06-14 Univercells Sa Matrice de croissance cellulaire
DE102017128489B4 (de) * 2017-09-26 2025-08-14 Elmos Semiconductor Se Selbsttestfähiges Bussystem und Verwendung dieser Selbsttestfähigkeit zur Vergabe von Busknotenadressen mit einer Erkennung der Vertauschung von Eingängen und Ausgängen
EP3493479B1 (de) * 2017-11-30 2020-12-02 Elmos Semiconductor SE Verfahren zum einspeisen von adressierungsströmen durch busknoten eines seriellen datenbussystems und busknoten für ein derartiges datenbussystem
US10367782B2 (en) * 2017-12-05 2019-07-30 Elmos Semiconductor Ag Serial bus auto-addressing
CN111801410A (zh) 2017-12-20 2020-10-20 尤尼沃尔塞尔斯技术股份公司 生物反应器及相关方法
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CA3200542A1 (en) 2019-05-28 2020-12-03 Upside Foods, Inc. Apparatuses and methods for preparing a comestible meat product
BR112022000061A2 (pt) * 2019-07-01 2022-05-24 Ology Bioservices Inc Método para o cultivo de células aderentes em um bioreator multiparalelo
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WO2021084077A1 (en) 2019-10-30 2021-05-06 Minaris Regenerative Medicine Gmbh Bioreactor for adherent cells
IL292318B2 (en) 2019-11-20 2023-04-01 Upside Foods Inc Devices and methods for preparing a meat product
KR102417445B1 (ko) * 2019-11-29 2022-07-06 주식회사 아모그린텍 세포배양장치
KR20220130743A (ko) 2020-01-20 2022-09-27 아드바 바이오테크놀로지 리미티드 생물반응기를 제어하는 장치 및 방법
CN113861296A (zh) * 2020-06-30 2021-12-31 广州凌腾生物医药有限公司 一种使用环轨摇晃式生物反应器制备双特异性抗体的方法
WO2022162722A1 (ja) * 2021-01-26 2022-08-04 株式会社日立ハイテク 無菌サンプリング装置および無菌サンプリング方法
CN114276927B (zh) * 2021-12-29 2024-05-10 上海日泰医药设备工程有限公司 一种用于生物反应器的折叠式载体柱
US11981884B2 (en) 2022-10-17 2024-05-14 Upside Foods, Inc. Pipe-based bioreactors for producing comestible meat products and methods of using the same
CN115369036B (zh) * 2022-10-21 2023-07-04 天信和(苏州)生物科技有限公司 细胞培养载体组件及生物反应器
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Also Published As

Publication number Publication date
CN102947438A (zh) 2013-02-27
EP2516618A2 (en) 2012-10-31
AU2011252063A1 (en) 2012-11-29
WO2011141512A2 (en) 2011-11-17
SG10201503666UA (en) 2015-06-29
JP2016144464A (ja) 2016-08-12
BR112012028786A2 (pt) 2015-11-24
WO2011141512A3 (en) 2012-03-15
US20220380711A1 (en) 2022-12-01
KR20130109000A (ko) 2013-10-07
JP5988962B2 (ja) 2016-09-07
US20130059339A1 (en) 2013-03-07
US20170015967A1 (en) 2017-01-19
US9399755B2 (en) 2016-07-26
JP2013526269A (ja) 2013-06-24
EP2516618B1 (en) 2020-07-08
SG185434A1 (en) 2012-12-28

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Address after: Brussels, Belgium

Patentee after: POURATRIS PRIVATE LIMITED

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Patentee before: Artelis S. A.