CN102935049A - Temperature-sensitive eye-protective gel - Google Patents
Temperature-sensitive eye-protective gel Download PDFInfo
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- CN102935049A CN102935049A CN2012105030216A CN201210503021A CN102935049A CN 102935049 A CN102935049 A CN 102935049A CN 2012105030216 A CN2012105030216 A CN 2012105030216A CN 201210503021 A CN201210503021 A CN 201210503021A CN 102935049 A CN102935049 A CN 102935049A
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Abstract
The invention relates to temperature-sensitive eye-protective gel. The temperature-sensitive eye-protective gel comprises the following raw materials in parts by weight: 3 to 10g of angelica sinensis, 4 to 15g of astragalus mongholicus, 4 to 15g of aloe, 0.008 to 0.013g of menthol, 1.67 to 1.72g of poloxamer 407, 0.08 to 0.12g of poloxamer 188, and ethanol which is weighed based on a mode that 0.01g of menthol is added to every 0.1 milliliters of ethanol. According to the temperature-sensitive eye protecting gel, the extracted substrates of the traditional Chinese medicines for protecting eyes are combined with novel temperature-sensitive gel, so that the medical components of the substrates are contained in the temperature-sensitive gel; and the temperature-sensitive gel containing the medical components of the substrates behaves like a liquid at normal temperature and behaves like a gel at the eyes temperature and can be quickly absorbed by the skin around the eyes, and no components are residual on the skin around the eyes.
Description
Technical field
The present invention relates to a kind of temperature sensitive type eye contour gel, eye protection Chinese medicine extraction substrate and Novel temperature-sensitive gel combine, make the medicinal ingredient that contains substrate in temperature sensitive glue, the thermosensitive hydrogel that adds the medicinal ingredient of substrate is liquid at normal temperatures, be that gel also can be absorbed fast by eye part skin at people's eye temperature, and finally at eye part skin, do not stay residual component.
Background technology
The technical problem solved: the eye sticker series products in the eye protection series products is that medicinal substrate adds that non-woven fabrics applies at eye at present, this series products good absorbing but because of substrate be liquid, how the substrate amount easily applies medicinal substrate after eye flows out and the face of making dirty from non-woven fabrics, and the substrate amount does not reach again the eye protection effect less.The substrate that the temperature sensitive type eye contour gel the overcomes the eye sticker series products facial problem of too much making dirty, and because all the components is all the bioactive ingredients that can be absorbed by the body, finally at eye noresidue composition.
Summary of the invention
The object of the invention is to customer service deficiency of the prior art and a kind of temperature sensitive type eye contour gel is provided, be that gel also can be absorbed fast by eye part skin at people's eye temperature, and finally at eye part skin, do not stay residual component.
The object of the present invention is achieved like this:
A kind of temperature sensitive type eye contour gel comprises the raw material of following parts by weight: the ethanol that adds the mode of 0.01 gram Mentholum to take in 3-10 gram Radix Angelicae Sinensis, the 4-15 gram Radix Astragali, 4-15 gram Aloe, 0.008-0.013 gram Mentholum, 1.67-1.72 gram poloxamer188,0.08-0.12 gram PLURONICS F87,0.1 milliliter of ethanol.
The raw material that comprises following parts by weight: the ethanol that adds the mode of 0.01 gram Mentholum to take in 9 gram Radix Angelicae Sinensis, the 9 gram Radixs Astragali, 9 gram Aloes, 0.01 gram Mentholum, 1.7 gram poloxamer188s, 0.1 gram PLURONICS F87,0.1 milliliter of ethanol and the purified water of 6.191 grams.
A kind of preparation technology of temperature sensitive type eye contour gel, (1), in the container that fills Radix Angelicae Sinensis, the Radix Astragali, Aloe, adds the water of 8 times of weight, decoct to seething with excitement and then keep 2 hours, filter, collect filtrate for later use, add again the water of 6 times of weight in filtering residue, decoct to boiling, then keep 1.5 hours, filter, collect filtrate, filtering residue discards, the filtrate of first twice is mixed, filtrate is concentrated into to 2/27, becomes Chinese medicine extraction liquid, cold preservation is standby; (2) be dissolved in 0.1 milliliter of ethanol according to 0.01 gram Mentholum, join to obtain Mentholum solution; (3) be scattered in 4 milliliters of purified water surfaces according to 1.7 gram poloxamer188s, 0.1 gram PLURONICS F87 and calculate, prepared, after sealing, under 4 ℃ of conditions, stored refrigerated is 24 hours, obtains poloxamer solution; (4) 20 gram Chinese medicine extraction liquid, 0.09 gram Mentholum solution are added in 58 gram poloxamer solution, add 21.91 gram purified water to 100 grams, in batches fill to 10ML aseptic plastic bottle, every bottle of 10 grams, sterilizing, obtain.
Poloxamer (poloxamer) is comparatively typical temperature-responsive polymer material, because having good biocompatibility, by multinational pharmacopeia, is recorded, and in the pharmaceutics field, is used widely.(2) Physiologic Studies shows: when ambient temperature is 23 ℃, human body skin of hand temperature is 30 ℃, and trunk is 32 ℃.(3) poloxamer188/PLURONICS F87 (17%/1%) phase transition temperature is 29--30 ℃, and transformation time is 30-60 S.The Main Function of the poloxamer in the present invention is at room temperature liquid for keeping this eye contour gel, when eye contour gel reaches human body eye part skin temperature, can change not runny gel into.
Radix Angelicae Sinensis, the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Have and enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize the effect of laxation.Contained ferulic acid has direct minimizing free-radical contents, and is combined with membrane phospholipid acyl ethanolamine, by direct elimination free radical, and the infringement of the antagonism radical pair tissues such as inhibited oxidation reaction and radical reaction.
The Radix Astragali, the dry root of leguminous plant Radix Astagali or Radix Astragali A.membranaceus (Fisch.) Bge..There is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, the effects such as expelling pus and promoting granulation.Chemical constitution study shows, Milkvetch Root is mainly containing saponins, flavone and glycoside and polysaccharide composition.Pharmacological research shows, the contained saponin component of the Radix Astragali is its antiinflammatory, the effective ingredient that improves immunologic function, flavone and glycoside thereof have good removing oxygen-derived free radicals, reducing the cytolipin peroxide generates, the cell SOD that can raise activity, maintain the cell homergy, there is in addition many-sided pharmacological actions such as the immunity of adjusting, antiviral.Research shows, the soap constituents be take astragaloside as main component, and flavones ingredient be take the calycosin glucoside as main.
Aloe, the dried leaves of liliaceous plant Aloe (Aloe vera (Linn.) N. L. Burman var. chinensis (Haw.) Berg.).Under its effect has and rushes down; Liver heat removing; Parasite killing.Main constipation with heat retention; The liver-fire headache; The conjunctival congestion infantile convulsion; Abdominal pain due to worm stagnation; Scabies; Hemorrhoid complicated by anal fistula; Solution Fructus Crotonis poison.For constipation, infantile malnutrition, infantile convulsion; The external treatment exudative dermatitis.Aloe polysaccharide in Aloe and vitamin have good nutrition, moist, whitening effect to the skin of human body.
The main component of Mentholum solution is Mentholum, ethanol.Mentholum is insoluble in water, is soluble in ethanol, thus first Mentholum is dissolved in to ethanol, then that Mentholum solution and medicinal liquid is miscible.
Mentholum, Mentholum is that institute extracts in the leaf of Herba Menthae and stem, is the main component in Herba Menthae and lavender quintessence oil, Mentholum and racementhol all can be used as odorant.As excitants, act on skin or mucosa pharmaceutically, refrigerant itching-relieving action is arranged; The carminative that can be used as for oral administration, for headache and nose; Pharynx; Laryngitis etc.It is mainly used in spice and medicine.
The choice experiment of poloxamer concentration
Get testing liquid 1.0ml and be laid on 10ml conical flask bottom, bottleneck seals with sealed membrane, puts it in water bath, inserts digital display thermometer (the thermometer lower end is immersed in testing liquid fully).Keep water-bath to continue slowly to heat up (speed: 0.2 ℃/min), manual inclination conical flask slightly, the temperature while not flowing with gel is defined as phase transition temperature.
Variable concentrations poloxamer188/PLURONICS F87 phase transition temperature
When ambient temperature is 23 ℃, human body skin of hand temperature is 30 ℃, and trunk is 32 ℃.Consider that cost selects 17% poloxamer188/1.0% PLURONICS F87 solution.
This invention is polluted face mainly for the substrate of eye sticker series products, and when substrate is too many, eye sticker is attached to people's eye and causes substrate to flow along face, covers in human eye when eye sticker is attached to eye and causes the eye dressing to damage.The eye protection thermosensitive hydrogel evenly spreads upon people's eye skin, can in 80 seconds, by liquid rotating, become gel, has reduced the mobility of substrate, and gel spreads upon on the eye part skin that does not have to make up, and can be issued in the situation of not damaging the eye dressing effect of eye protection.
According to modern medicine study, prove, people's eye disease major part is because the gathering of eye free radical causes, and this invention product is mainly started with from eliminating the eye free radical, adopts the pure natural medical composition to reduce the eye free radical, thereby reaches the effect of eye protection.
The specific embodiment
Below in conjunction with concrete embodiment, the invention will be further described.
A kind of preparation technology of temperature sensitive type eye contour gel adopts optimization formula technique as follows:
In the container that fills 9 gram Radix Angelicae Sinensis, the 9 gram Radixs Astragali, 9 gram Aloes, add the water of 8 times of weight, decoct to seething with excitement and then keep 2 hours, filter, collect filtrate for later use, add again the water of 6 times of weight in filtering residue, decoct to boiling, then keep 1.5 hours, filter, collect filtrate, filtering residue discards, and the filtrate of first twice is mixed, and filtrate weight is concentrated into to 2/27, become Chinese medicine extraction liquid, cold preservation is standby; (2) 0.01 gram Mentholums are dissolved in 0.1 milliliter of ethanol, join to obtain Mentholum solution; (3) 1.7 gram poloxamer188s, 0.1 gram PLURONICS F87 are scattered in 4 milliliters of purified water surfaces, are prepared, and after sealing, under 4 ℃ of conditions, stored refrigerated is 24 hours, obtains poloxamer solution; (4) 20 gram Chinese medicine extraction liquid, 0.09 gram Mentholum solution are added in 58 gram poloxamer solution, add 21.91 gram purified water to 100 grams, in batches fill to 10ML aseptic plastic bottle, every bottle of 10 grams, sterilizing, obtain.
The eye protection Chinese medicine extraction liquid made according to optimization formula, every gram extracting solution, containing Chinese medicine 2.7 grams, is tested.
1) experimental technique:
Mice is divided into to 2 groups at random, i.e. control group A group, administration group B group.Giving tested material first 24 hours, back spinal column diamond wool to be taken off, the depilation area is about 10% of body surface area, each about 50cm of both sides
2.
Mice is put into respectively to special little cage, normal diet, drinking-water, the eye protection Chinese medicine extraction liquid is smeared 1 time, each 2 grams every day in administration group mice depilation position; Purified water is smeared 1 time, each 2 grams every day in control group mice depilation position.Get mice depilation position skin after 30 days, homogenate ,-20 ℃ of Refrigerator stores.
SOD is the naturally occurring oxygen radical removing factor in body, and it can be converted into hydrogen peroxide to harmful oxygen-derived free radicals by reaction.The chemical property of oxygen-derived free radicals is very active, and the fatty acid on can the attack cells film produces malonaldehyde (MDA), therefore can carry out by measuring MDA content in skin the content of the oxygen-derived free radicals in indirect determination skin.
Press SOD, MDA determination mensuration mice depilation position skin SOD content, MDA content.Get supernatant 50 μ l and measure protein content by the Coomassie brilliant blue method, calculate in every milligram of albumen containing SOD content, MDA content.
A group (matched group) mice: the SOD average content is 0.043mmol/mg, and the MDA average content is 0.151mmol/mg.
| ? | SOD content mmol/mg | MDA content mmol/mg |
| A1 | 0.056 | 0.115 |
| A2 | 0.041 | 0.137 |
| A3 | 0.038 | 0.227 |
| A4 | 0.045 | 0.165 |
| A5 | 0.041 | 0.142 |
| A6 | 0.039 | 0.156 |
| A7 | 0.048 | 0.095 |
| A8 | 0.044 | 0.185 |
| A9 | 0.036 | 0.196 |
| A10 | 0.037 | 0.088 |
B group (administration group) mice: the SOD average content is 0.177mmol/mg, and the MDA average content is 0.060mmol/mg.
| ? | SOD content mmol/mg | MDA content mmol/mg |
| B1 | 0.142 | 0.076 |
| B2 | 0.243 | 0.048 |
| B3 | 0.178 | 0.052 |
| B4 | 0.263 | 0.041 |
| B5 | 0.164 | 0.076 |
| B6 | 0.189 | 0.082 |
| B7 | 0.195 | 0.056 |
| B8 | 0.099 | 0.068 |
| B9 | 0.122 | 0.052 |
| B10 | 0.178 | 0.047 |
Through overtesting, in 30 days, in administration group mouse skin, the SOD average content is than the many 0.134mmol/mg of SOD average content in the matched group mouse skin, and in 30 days, the interior MDA average content of administration group mouse skin is than the few 0.091mmol/mg of MDA average content in the matched group mouse skin.
Conclusion: above experimental result is known, and it is effective that preparation of the present invention reduces oxygen-derived free radicals, proves that preparation of the present invention has the effect of obvious reduction content of oxygen free radical.Preparation of the present invention can reduce the eye oxygen-derived free radicals effectively, reduces the infringement of oxygen-derived free radicals to eye, thereby reaches the effect of eye protection.
Embodiment 2:
In the container that fills 3 gram Radix Angelicae Sinensis, the 15 gram Radixs Astragali, 15 gram Aloes, add the water of 8 times of weight, decoct to seething with excitement and then keep 2 hours, filter, collect filtrate for later use, add again the water of 6 times of weight in filtering residue, decoct to boiling, then keep 1.5 hours, filter, collect filtrate, filtering residue discards, and the filtrate of first twice is mixed, and filtrate weight is concentrated into to 2/27, become Chinese medicine extraction liquid, cold preservation is standby; (2) be dissolved in mode proportioning in 0.1 milliliter of ethanol according to 0.01 gram Mentholum, take 0.013 gram Mentholum and be dissolved in the ethanol of 0.13 milliliter, join to obtain Mentholum solution; (3) 1.72 gram poloxamer188s, 0.12 gram PLURONICS F87 are scattered in 4.05 milliliters of purified water surfaces, are prepared, and after sealing, under 4 ℃ of conditions, stored refrigerated is 24 hours, obtains poloxamer solution; (4) 20 gram Chinese medicine extraction liquid, 0.09 gram Mentholum solution are added in 58 gram poloxamer solution, add 21.91 gram purified water to 100 grams, in batches fill to 10ML aseptic plastic bottle, every bottle of 10 grams, sterilizing, obtain.
Embodiment 3:
In the container that fills 15 gram Radix Angelicae Sinensis, the 4 gram Radixs Astragali, 4 gram Aloes, add the water of 8 times of weight, decoct to seething with excitement and then keep 2 hours, filter, collect filtrate for later use, add again the water of 6 times of weight in filtering residue, decoct to boiling, then keep 1.5 hours, filter, collect filtrate, filtering residue discards, and the filtrate of first twice is mixed, and filtrate weight is concentrated into to 2/27, become Chinese medicine extraction liquid, cold preservation is standby; (2) be dissolved in mode proportioning in 0.1 milliliter of ethanol according to 0.01 gram Mentholum, take 0.008 gram Mentholum and be dissolved in the ethanol of 0.08 milliliter, join to obtain Mentholum solution; (3) 1.67 gram poloxamer188s, 0.08 gram PLURONICS F87 are scattered in 3.93 milliliters of purified water surfaces, are prepared, and after sealing, under 4 ℃ of conditions, stored refrigerated is 24 hours, obtains poloxamer solution; (4) 20 gram Chinese medicine extraction liquid, 0.09 gram Mentholum solution are added in 58 gram poloxamer solution, add 21.91 gram purified water to 100 grams, in batches fill to 10ML aseptic plastic bottle, every bottle of 10 grams, sterilizing, obtain.
Embodiment 4:
In the container that fills 6 gram Radix Angelicae Sinensis, the 8 gram Radixs Astragali, 8 gram Aloes, add the water of 8 times of weight, decoct to seething with excitement and then keep 2 hours, filter, collect filtrate for later use, add again the water of 6 times of weight in filtering residue, decoct to boiling, then keep 1.5 hours, filter, collect filtrate, filtering residue discards, and the filtrate of first twice is mixed, and filtrate weight is concentrated into to 2/27, become Chinese medicine extraction liquid, cold preservation is standby; (2) be dissolved in mode proportioning in 0.1 milliliter of ethanol according to 0.01 gram Mentholum, take 0.01 gram Mentholum and be dissolved in the ethanol of 0.1 milliliter, join to obtain Mentholum solution; (3) 1.67 gram poloxamer188s, 0.08 gram PLURONICS F87 are scattered in 3.93 milliliters of purified water surfaces, are prepared, and after sealing, under 4 ℃ of conditions, stored refrigerated is 24 hours, obtains poloxamer solution; (4) 20 gram Chinese medicine extraction liquid, 0.09 gram Mentholum solution are added in 58 gram poloxamer solution, add 21.91 gram purified water to 100 grams, in batches fill to 10ML aseptic plastic bottle, every bottle of 10 grams, sterilizing, obtain.
Claims (3)
1. a temperature sensitive type eye contour gel is characterized in that: the raw material that comprises following parts by weight: the ethanol that adds the mode of 0.01 gram Mentholum to take in 3-10 gram Radix Angelicae Sinensis, the 4-15 gram Radix Astragali, 4-15 gram Aloe, 0.008-0.013 gram Mentholum, 1.67-1.72 gram poloxamer188,0.08-0.12 gram PLURONICS F87,0.1 milliliter of ethanol.
2. a kind of temperature sensitive type eye contour gel according to claim 1 is characterized in that: the raw material that comprises following parts by weight: the ethanol that adds the mode of 0.01 gram Mentholum to take in 9 gram Radix Angelicae Sinensis, the 9 gram Radixs Astragali, 9 gram Aloes, 0.01 gram Mentholum, 1.7 gram poloxamer188s, 0.1 gram PLURONICS F87,0.1 milliliter of ethanol and the purified water of 6.191 grams.
3. the preparation technology of a temperature sensitive type eye contour gel as claimed in claim 1, it is characterized in that: technique is as follows:
(1) in the container that fills Radix Angelicae Sinensis, the Radix Astragali, Aloe, add the water of 8 times of weight, decoct to seething with excitement and then keep 2 hours, filter, collect filtrate for later use, add again the water of 6 times of weight in filtering residue, decoct to boiling, then keep 1.5 hours, filter, collect filtrate, filtering residue discards, and the filtrate of first twice is mixed, and filtrate is concentrated into to 2/27, become Chinese medicine extraction liquid, cold preservation is standby; (2) be dissolved in 0.1 milliliter of ethanol according to 0.01 gram Mentholum, join to obtain Mentholum solution; (3) be scattered in 4 milliliters of purified water surfaces according to 1.7 gram poloxamer188s, 0.1 gram PLURONICS F87 and calculate, prepared, after sealing, under 4 ℃ of conditions, stored refrigerated is 24 hours, obtains poloxamer solution; (4) 20 gram Chinese medicine extraction liquid, 0.09 gram Mentholum solution are added in 58 gram poloxamer solution, add 21.91 gram purified water to 100 grams, in batches fill to 10ML aseptic plastic bottle, every bottle of 10 grams, sterilizing, obtain.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109620523A (en) * | 2018-11-01 | 2019-04-16 | 郭锦明 | It is a kind of with alleviating eye strain, steam eye patch of efficacy of tranquilizing mind and improving sleeping and preparation method thereof |
| CN109771545A (en) * | 2019-03-14 | 2019-05-21 | 盛荣秋实生物技术(广州)有限公司 | A kind of temperature sensitive bacteriostatic gel of intelligence |
| EP4289442A4 (en) * | 2021-06-29 | 2024-08-07 | Huatong Forturn China Co Ltd | Temperature sensitive gel damage repair formulation and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797331A (en) * | 2010-04-06 | 2010-08-11 | 西安中美天顺药业有限公司 | Traditional Chinese medicine formula of application for preventing ophthalmic diseases |
| CN201978189U (en) * | 2010-12-30 | 2011-09-21 | 江西宜信堂医疗科技有限公司 | Eye protecting paster |
| CN102440928A (en) * | 2011-12-05 | 2012-05-09 | 北京工商大学 | Traditional Chinese medicine composition and preparation with skin microcirculation promoting effect and preparation method thereof |
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2012
- 2012-11-30 CN CN201210503021.6A patent/CN102935049B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797331A (en) * | 2010-04-06 | 2010-08-11 | 西安中美天顺药业有限公司 | Traditional Chinese medicine formula of application for preventing ophthalmic diseases |
| CN201978189U (en) * | 2010-12-30 | 2011-09-21 | 江西宜信堂医疗科技有限公司 | Eye protecting paster |
| CN102440928A (en) * | 2011-12-05 | 2012-05-09 | 北京工商大学 | Traditional Chinese medicine composition and preparation with skin microcirculation promoting effect and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109620523A (en) * | 2018-11-01 | 2019-04-16 | 郭锦明 | It is a kind of with alleviating eye strain, steam eye patch of efficacy of tranquilizing mind and improving sleeping and preparation method thereof |
| CN109771545A (en) * | 2019-03-14 | 2019-05-21 | 盛荣秋实生物技术(广州)有限公司 | A kind of temperature sensitive bacteriostatic gel of intelligence |
| EP4289442A4 (en) * | 2021-06-29 | 2024-08-07 | Huatong Forturn China Co Ltd | Temperature sensitive gel damage repair formulation and application thereof |
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| CN102935049B (en) | 2014-04-02 |
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