CN102933234A - 可注射长效组合物的制备方法 - Google Patents

可注射长效组合物的制备方法 Download PDF

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Publication number
CN102933234A
CN102933234A CN2011800265312A CN201180026531A CN102933234A CN 102933234 A CN102933234 A CN 102933234A CN 2011800265312 A CN2011800265312 A CN 2011800265312A CN 201180026531 A CN201180026531 A CN 201180026531A CN 102933234 A CN102933234 A CN 102933234A
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CN
China
Prior art keywords
drug
release
risperidone
days
polymer
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Pending
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CN2011800265312A
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English (en)
Chinese (zh)
Inventor
伊本·古蒂耶罗阿杜里斯
玛丽亚·特雷莎·戈麦斯奥乔亚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Farmaceuticos Rovi SA
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Laboratorios Farmaceuticos Rovi SA
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Filing date
Publication date
Application filed by Laboratorios Farmaceuticos Rovi SA filed Critical Laboratorios Farmaceuticos Rovi SA
Publication of CN102933234A publication Critical patent/CN102933234A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
CN2011800265312A 2010-05-31 2011-05-31 可注射长效组合物的制备方法 Pending CN102933234A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10382153.4 2010-05-31
EP10382153.4A EP2394663B1 (en) 2010-05-31 2010-05-31 Compositions for injectable in-situ biodegradable implants
PCT/EP2011/059001 WO2011151356A2 (en) 2010-05-31 2011-05-31 Methods for the preparation of injectable depot compositions

Publications (1)

Publication Number Publication Date
CN102933234A true CN102933234A (zh) 2013-02-13

Family

ID=43301929

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800265312A Pending CN102933234A (zh) 2010-05-31 2011-05-31 可注射长效组合物的制备方法

Country Status (22)

Country Link
US (2) US10058504B2 (https=)
EP (2) EP2394663B1 (https=)
JP (1) JP5923493B2 (https=)
CN (1) CN102933234A (https=)
BR (1) BR112012030707A2 (https=)
CA (1) CA2800641C (https=)
CY (1) CY1124783T1 (https=)
DK (1) DK2582395T3 (https=)
EA (1) EA024211B1 (https=)
ES (2) ES2897976T3 (https=)
FI (1) FI2582395T3 (https=)
HR (2) HRP20211853T1 (https=)
HU (3) HUE057236T2 (https=)
LT (2) LT2394663T (https=)
MX (1) MX346167B (https=)
PL (2) PL2394663T3 (https=)
PT (2) PT2394663T (https=)
RS (2) RS64451B1 (https=)
SI (2) SI2394663T1 (https=)
SM (2) SMT202100679T1 (https=)
WO (1) WO2011151356A2 (https=)
ZA (1) ZA201209394B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104519870A (zh) * 2012-08-03 2015-04-15 罗维实验室制药股份公司 可注射组合物

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US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
EP2152315B1 (en) 2007-05-25 2016-01-06 Indivior UK Limited Sustained delivery formulations of risperidone compounds
US10285936B2 (en) 2010-05-31 2019-05-14 Laboratorios Farmacéuticos Rovi, S.A. Injectable composition with aromatase inhibitor
US10335366B2 (en) 2010-05-31 2019-07-02 Laboratorios Farmacéuticos Rovi, S.A. Risperidone or paliperidone implant formulation
EP2529757B1 (en) * 2011-05-31 2014-01-08 Laboratorios Farmaceuticos Rovi, S.A. Paliperidone implant formulation
US10350159B2 (en) 2010-05-31 2019-07-16 Laboratories Farmacéuticos Rovi, S.A. Paliperidone implant formulation
US10881605B2 (en) 2010-05-31 2021-01-05 Laboratorios Farmaceuticos Rovi, S.A. Methods for the preparation of injectable depot compositions
PT2394663T (pt) 2010-05-31 2021-11-26 Farm Rovi Lab Sa Composições para implantes biodegradáveis injectáveis
US10463607B2 (en) 2010-05-31 2019-11-05 Laboratorios Farmaceutics Rofi S.A. Antipsychotic Injectable Depot Composition
LT2394664T (lt) 2010-05-31 2016-09-26 Laboratorios Farmaceuticos Rovi, S.A. Antipsichozinė injekcinė depozitinė kompozicija
GB2481017B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
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LT2529756T (lt) * 2011-05-31 2021-07-26 Laboratorios Farmaceuticos Rovi, S.A. Risperidono ir (arba) paliperidono implantų kompozicija
US8935726B2 (en) 2012-05-11 2015-01-13 Comcast Cable Communications, Llc Generation of dynamic content interfaces
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GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
CA2998504C (en) 2015-09-21 2023-06-20 Teva Pharmaceuticals International Gmbh Sustained release olanzapine formulations
CN107811967B (zh) * 2016-09-09 2021-08-24 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心) 抗寄生虫药物原位固化缓释注射剂及其制备方法
CN109890365A (zh) * 2016-09-23 2019-06-14 戴尔普尔有限公司 小分子治疗剂化合物的组合物
WO2018070940A1 (en) * 2016-10-14 2018-04-19 Nanyang Technological University An injectable composition for localized controlled and sustained delivery system
JP7101694B2 (ja) 2016-11-16 2022-07-15 ペルシカ ファーマシューティカルズ リミテッド 腰痛のための抗生物質製剤
WO2018172850A1 (en) 2017-03-20 2018-09-27 Teva Pharmaceuticals International Gmbh Sustained release olanzapine formulaitons
EP3709970B1 (en) * 2017-11-16 2025-05-14 Persica Pharmaceuticals Ltd. Linezolid formulations
PE20210047A1 (es) 2018-06-12 2021-01-08 Farm Rovi Lab Sa Composicion inyectable
US20240100012A1 (en) 2021-01-18 2024-03-28 Mark Hasleton Pharmaceutical dosage form
CA3227324A1 (en) 2021-07-06 2023-01-12 Mark Hasleton Treatment of serotonin reuptake inhibitor withdrawal syndrome
US12594236B2 (en) 2021-07-16 2026-04-07 Laboratorios Farmaceuticos Rovi, S.A. Method of treating acute exacerbation of schizophrenia with long-acting injectable depot composition
US12318387B2 (en) 2021-07-16 2025-06-03 Laboratorios Farmaceuticos Rovi, S.A. Method of treating acute exacerbation of schizophrenia with long-acting injectable depot composition
TW202313047A (zh) 2021-09-21 2023-04-01 西班牙商禾霏藥品實驗室有限公司 抗精神病可注射儲積型組合物
AU2023281232A1 (en) 2022-05-18 2024-10-24 Laboratorios Farmacéuticos Rovi, S.A. Prolonged-release injectable compositions for use in treatment with risperidone together with cyp2d6 enzyme inhibitors

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US20040247870A1 (en) * 2003-01-22 2004-12-09 Josiah Brown Method of preparing sustained release microparticles
WO2008153611A2 (en) * 2007-05-25 2008-12-18 Qlt Usa, Inc. Sustained delivery formulations of risperidone compounds
WO2009060473A2 (en) * 2007-11-06 2009-05-14 Panacea Biotec Limited Injectable compositions, processes and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104519870A (zh) * 2012-08-03 2015-04-15 罗维实验室制药股份公司 可注射组合物

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Publication number Publication date
HRP20211853T1 (hr) 2022-03-04
PT2394663T (pt) 2021-11-26
HUE054922T2 (hu) 2021-10-28
SI2582395T1 (sl) 2023-10-30
EA201201570A1 (ru) 2013-09-30
US10058504B2 (en) 2018-08-28
US10195138B2 (en) 2019-02-05
CA2800641A1 (en) 2011-12-08
JP2013527213A (ja) 2013-06-27
EP2394663A1 (en) 2011-12-14
EP2582395B1 (en) 2023-05-10
CA2800641C (en) 2018-05-22
ES2897976T3 (es) 2022-03-03
EP2582395A2 (en) 2013-04-24
LT2394663T (lt) 2022-02-10
ES2950857T3 (es) 2023-10-16
ZA201209394B (en) 2013-08-28
PL2394663T3 (pl) 2022-02-21
PL2582395T3 (pl) 2023-08-21
WO2011151356A2 (en) 2011-12-08
PT2582395T (pt) 2023-08-18
EP2394663B1 (en) 2021-10-13
SI2394663T1 (sl) 2022-02-28
LT2582395T (lt) 2023-08-10
WO2011151356A3 (en) 2012-03-22
US20130177603A1 (en) 2013-07-11
JP5923493B2 (ja) 2016-05-24
HRP20230890T1 (hr) 2023-11-10
FI2582395T3 (fi) 2023-08-08
SMT202100679T1 (it) 2022-01-10
US20180318208A1 (en) 2018-11-08
DK2582395T3 (da) 2023-08-07
EA024211B1 (ru) 2016-08-31
BR112012030707A2 (pt) 2016-11-01
CY1124783T1 (el) 2022-11-25
MX2012013867A (es) 2013-01-24
MX346167B (es) 2017-03-08
RS64451B1 (sr) 2023-09-29
SMT202300241T1 (it) 2023-09-06
HUE057236T2 (hu) 2022-04-28
HUE063623T2 (hu) 2024-01-28
RS53205B (sr) 2014-06-30

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Application publication date: 20130213