CN102917693B - 释放特征不同的植入装置及制造和使用该装置的方法 - Google Patents

释放特征不同的植入装置及制造和使用该装置的方法 Download PDF

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Publication number
CN102917693B
CN102917693B CN201080050895.XA CN201080050895A CN102917693B CN 102917693 B CN102917693 B CN 102917693B CN 201080050895 A CN201080050895 A CN 201080050895A CN 102917693 B CN102917693 B CN 102917693B
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CN
China
Prior art keywords
implant
bioactive agent
release
polymer
different
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Application number
CN201080050895.XA
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English (en)
Chinese (zh)
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CN102917693A (zh
Inventor
布鲁斯·W·哈德森
彼得·马克兰
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Evonik Operations GmbH
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Evonik Corp
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201080050895.XA 2009-09-17 2010-09-16 释放特征不同的植入装置及制造和使用该装置的方法 Active CN102917693B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24330309P 2009-09-17 2009-09-17
US61/243,303 2009-09-17
PCT/US2010/049104 WO2011035013A2 (en) 2009-09-17 2010-09-16 Implant devices that differ by release profile and methods of making and using same

Publications (2)

Publication Number Publication Date
CN102917693A CN102917693A (zh) 2013-02-06
CN102917693B true CN102917693B (zh) 2015-05-20

Family

ID=43218276

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080050895.XA Active CN102917693B (zh) 2009-09-17 2010-09-16 释放特征不同的植入装置及制造和使用该装置的方法

Country Status (10)

Country Link
US (1) US9399018B2 (https=)
EP (1) EP2477612A2 (https=)
JP (1) JP2013505251A (https=)
KR (1) KR20120102598A (https=)
CN (1) CN102917693B (https=)
BR (1) BR112012006103B8 (https=)
CA (1) CA2774495C (https=)
IN (1) IN2012DN02656A (https=)
RU (1) RU2012115120A (https=)
WO (1) WO2011035013A2 (https=)

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* Cited by examiner, † Cited by third party
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PT1781264E (pt) 2004-08-04 2013-10-16 Evonik Corp Métodos para o fabrico de dispositivis de administração e dispositivos para a mesma
US20110091518A1 (en) * 2009-09-22 2011-04-21 Danielle Biggs Implant devices having varying bioactive agent loading configurations
WO2018064556A1 (en) 2016-09-29 2018-04-05 Gesea Biosciences Inc. Bioerodible implant for long-term drug delivery and associated methods of manufacture and use
KR102183669B1 (ko) * 2019-03-26 2020-11-26 가톨릭대학교 산학협력단 이중 약물 방출을 위한 약물 전달체
JP6905035B2 (ja) 2019-11-29 2021-07-21 Ｎｉｓｓｈａ株式会社 可食性フィルムの製造方法、フィルム製剤及び可食性フィルム

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US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US4720384A (en) 1985-05-03 1988-01-19 E. I. Du Pont De Nemours And Company Manufacture of hollow fine tubular drug delivery systems
US4976949A (en) 1985-10-25 1990-12-11 The University Of Michigan Controlled release dosage form
US4794001A (en) 1986-03-04 1988-12-27 American Home Products Corporation Formulations providing three distinct releases
DE3710175A1 (de) 1987-02-12 1988-08-25 Hoechst Ag Mehrteilige implantierbare arzneizubereitung mit langzeitwirkung
JPS63203610A (ja) * 1987-02-12 1988-08-23 ヘキスト・アクチエンゲゼルシヤフト 複数成分からなるインプラント用の持効性医薬製剤
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US5035891A (en) 1987-10-05 1991-07-30 Syntex (U.S.A.) Inc. Controlled release subcutaneous implant
JP2702729B2 (ja) * 1988-02-24 1998-01-26 エーザイ株式会社 徐放性埋込剤
US5702716A (en) 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US5178874A (en) 1989-06-30 1993-01-12 Smithkline Beechman Corporation Intermittent release dosage form
US5153002A (en) 1991-03-04 1992-10-06 University Of Montreal Biocompatible gradient controlled release implant
JP3118009B2 (ja) 1991-04-16 2000-12-18 住友製薬株式会社 多層構造を有するコラーゲンおよび／またはゼラチン製剤の製造方法
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
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US5429822A (en) 1992-03-13 1995-07-04 Cambridge Scientific, Inc. Biodegradable bursting release system
GB9223144D0 (en) 1992-11-05 1992-12-16 Scherer Corp R P Controlled release device
US5456917A (en) 1993-04-12 1995-10-10 Cambridge Scientific, Inc. Method for making a bioerodible material for the sustained release of a medicament and the material made from the method
US6447796B1 (en) 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US6855331B2 (en) 1994-05-16 2005-02-15 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US5958458A (en) 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
US6902743B1 (en) 1995-05-22 2005-06-07 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
US5705191A (en) 1995-08-18 1998-01-06 The United States Of America As Represented By The Secretary Of The Navy Sustained delivery of active compounds from tubules, with rational control
CA2291659A1 (fr) * 1997-06-04 1998-12-10 Debio Recherche Pharmaceutique S.A. Implants pour la liberation controlee de principes pharmaceutiquement actifs et procede pour leur fabrication
CA2301883A1 (en) 1997-09-11 1999-03-18 Nycomed Danmark A/S Modified release multiple-units compositions of non-steroid anti-inflammatory drug substances (nsaids)
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Also Published As

Publication number Publication date
EP2477612A2 (en) 2012-07-25
KR20120102598A (ko) 2012-09-18
BR112012006103A2 (pt) 2016-06-07
BR112012006103B8 (pt) 2021-05-25
CA2774495C (en) 2017-09-26
US20110142906A1 (en) 2011-06-16
US9399018B2 (en) 2016-07-26
WO2011035013A2 (en) 2011-03-24
JP2013505251A (ja) 2013-02-14
CN102917693A (zh) 2013-02-06
RU2012115120A (ru) 2013-10-27
WO2011035013A3 (en) 2011-12-29
BR112012006103A8 (pt) 2017-10-03
CA2774495A1 (en) 2011-03-24
IN2012DN02656A (https=) 2015-09-11
BR112012006103B1 (pt) 2020-10-27

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C53 Correction of patent of invention or patent application
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Address after: New jersey, USA

Applicant after: Evonik Corp.

Address before: New jersey, USA

Applicant before: EVONIK DEGUSSA Corp.

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Address after: Germany

Patentee after: Evonik Operations Ltd.

Country or region after: Germany

Address before: new jersey

Patentee before: Evonik Corp.

Country or region before: U.S.A.

TR01 Transfer of patent right