CN102884059B - N-酰基环胺衍生物或其可药用盐 - Google Patents
N-酰基环胺衍生物或其可药用盐 Download PDFInfo
- Publication number
- CN102884059B CN102884059B CN201180023571.1A CN201180023571A CN102884059B CN 102884059 B CN102884059 B CN 102884059B CN 201180023571 A CN201180023571 A CN 201180023571A CN 102884059 B CN102884059 B CN 102884059B
- Authority
- CN
- China
- Prior art keywords
- optionally substituted
- group
- alkyl
- halogen
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 Cc(nc1)c2[n]1ccc(**#C)c2 Chemical compound Cc(nc1)c2[n]1ccc(**#C)c2 0.000 description 7
- JLYGKPXZXHOFCR-FTNKSUMCSA-N CC(C)(C)OC(N1C[C@H](CC(O)=O)CCC1)O Chemical compound CC(C)(C)OC(N1C[C@H](CC(O)=O)CCC1)O JLYGKPXZXHOFCR-FTNKSUMCSA-N 0.000 description 1
- KXJKHSUAJCXCJX-UHFFFAOYSA-N CC(c1ccccc11)[NH+]1[O-] Chemical compound CC(c1ccccc11)[NH+]1[O-] KXJKHSUAJCXCJX-UHFFFAOYSA-N 0.000 description 1
- SXLVLFHIHXWLSJ-UHFFFAOYSA-O CC(c1ccccc1S)[NH3+] Chemical compound CC(c1ccccc1S)[NH3+] SXLVLFHIHXWLSJ-UHFFFAOYSA-O 0.000 description 1
- MPUJBXWINAUKNJ-UHFFFAOYSA-N CN(C(C1)O)c2c1cccc2 Chemical compound CN(C(C1)O)c2c1cccc2 MPUJBXWINAUKNJ-UHFFFAOYSA-N 0.000 description 1
- APDHFDKIOLTHGP-XQRVVYSFSA-N CNC1C=CC=CC1/C=C\C=O Chemical compound CNC1C=CC=CC1/C=C\C=O APDHFDKIOLTHGP-XQRVVYSFSA-N 0.000 description 1
- VISUQYLZVVQECH-UHFFFAOYSA-N CNC1C=CC=CC1CCC=O Chemical compound CNC1C=CC=CC1CCC=O VISUQYLZVVQECH-UHFFFAOYSA-N 0.000 description 1
- GMCRWAWXLHTALK-UHFFFAOYSA-N COc1c(cc(C(O)=O)[nH]2)c2ccc1F Chemical compound COc1c(cc(C(O)=O)[nH]2)c2ccc1F GMCRWAWXLHTALK-UHFFFAOYSA-N 0.000 description 1
- FWOPJXVQGMZKEP-UHFFFAOYSA-N Cc1n[nH]c2c1cccc2 Chemical compound Cc1n[nH]c2c1cccc2 FWOPJXVQGMZKEP-UHFFFAOYSA-N 0.000 description 1
- QJKUYNUQMNOFKX-MIXUXINWSA-N O=C(C1CCN(C/C=N\C2N(C3OC3c3cc(ccc(C(F)(F)F)c4)c4[n]3C3)C3=CC2)CC1)c(cc1)ccc1F Chemical compound O=C(C1CCN(C/C=N\C2N(C3OC3c3cc(ccc(C(F)(F)F)c4)c4[n]3C3)C3=CC2)CC1)c(cc1)ccc1F QJKUYNUQMNOFKX-MIXUXINWSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010-054177 | 2010-03-11 | ||
| JP2010054177 | 2010-03-11 | ||
| JP2010-285844 | 2010-12-22 | ||
| JP2010285844 | 2010-12-22 | ||
| PCT/JP2011/056497 WO2011111875A1 (en) | 2010-03-11 | 2011-03-11 | N-acyl cyclic amine derivative or pharmaceutically acceptable salt thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102884059A CN102884059A (zh) | 2013-01-16 |
| CN102884059B true CN102884059B (zh) | 2015-08-26 |
Family
ID=44563664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180023571.1A Expired - Fee Related CN102884059B (zh) | 2010-03-11 | 2011-03-11 | N-酰基环胺衍生物或其可药用盐 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8541585B2 (enExample) |
| EP (1) | EP2545046A4 (enExample) |
| JP (1) | JP5661791B2 (enExample) |
| KR (1) | KR101756495B1 (enExample) |
| CN (1) | CN102884059B (enExample) |
| AU (1) | AU2011225095C1 (enExample) |
| CA (1) | CA2792539C (enExample) |
| TW (1) | TWI475015B (enExample) |
| WO (1) | WO2011111875A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102180872B (zh) * | 2011-04-01 | 2014-04-02 | 华中科技大学 | [1,3,4]噁二唑类衍生物及其应用 |
| CN104892589A (zh) * | 2014-03-07 | 2015-09-09 | 中国科学院上海药物研究所 | 一类杂环化合物、其制备方法和用途 |
| PL245933B1 (pl) | 2014-07-04 | 2024-11-04 | Inst Farmakologii Polskiej Akademii Nauk | (Chinolino lub izochinolino) sulfonamidy amin cyklicznych, kompozycja je zawierająca, sposób ich wytwarzania oraz ich zastosowanie medyczne |
| CN105315267B (zh) * | 2014-07-30 | 2019-06-04 | 江苏恩华药业股份有限公司 | 一种酰胺类衍生物及其应用 |
| JP2019059672A (ja) * | 2015-12-28 | 2019-04-18 | 大日本住友製薬株式会社 | 治療抵抗性うつ病等の治療薬 |
| UY39569A (es) | 2020-12-17 | 2022-07-29 | Astrazeneca Ab | N-(2-(4-cianotiazolidin-3-il)-2-oxoetil)- quinolin-4-carboxamidas |
| JP7655885B2 (ja) * | 2021-06-30 | 2025-04-02 | 住友ファーマ株式会社 | 脂肪族酸アミド誘導体を含有する医薬組成物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1620452A (zh) * | 2001-12-19 | 2005-05-25 | H.隆德贝克有限公司 | 3,4－二氢－1h－异喹啉－2－基－衍生物 |
| WO2005066165A1 (en) * | 2003-12-31 | 2005-07-21 | Warner-Lambert Company Llc | N-substituted piperidine and piperazine derivatives |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133061A (en) | 1962-11-13 | 1964-05-12 | Sterling Drug Inc | Piperidine carboxamides and derivatives thereof |
| FR2285883A1 (fr) | 1974-09-30 | 1976-04-23 | Cerm Cent Europ Rech Mauvernay | Nouveaux composes chimiques a activite bronchospasmolytique et antitussive, et procede pour leur obtention |
| JPH08502474A (ja) * | 1992-10-07 | 1996-03-19 | メルク エンド カンパニー インコーポレーテッド | トコリティックオキシトシンレセプターアンタゴニスト |
| JP3162572B2 (ja) | 1993-04-28 | 2001-05-08 | 住友製薬株式会社 | インドロイルグアニジン誘導体 |
| JPH08208602A (ja) | 1994-10-18 | 1996-08-13 | Sumitomo Pharmaceut Co Ltd | インドロイルグアニジン誘導体 |
| FR2729954B1 (fr) | 1995-01-30 | 1997-08-01 | Sanofi Sa | Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
| US5861417A (en) * | 1996-12-19 | 1999-01-19 | Hoechst Marion Roussel, Inc. | Heterocyclic substituted pyrrolidine amide derivatives |
| US6166037A (en) * | 1997-08-28 | 2000-12-26 | Merck & Co., Inc. | Pyrrolidine and piperidine modulators of chemokine receptor activity |
| UA58476C2 (uk) | 1997-10-09 | 2003-08-15 | Санофі-Сентелябо | Похідні 8-азабіцикло[3.2.1]октан-3-метанаміну, фармацевтична композиція та лікарський засіб |
| US7164024B2 (en) | 2001-04-20 | 2007-01-16 | Banyu Pharmaceutical Co., Ltd. | Benzimidazolone derivatives |
| FR2824828B1 (fr) * | 2001-05-21 | 2005-05-20 | Sanofi Synthelabo | Nouveaux derives de piperidinecarboxamide, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
| WO2006033943A2 (en) | 2004-09-17 | 2006-03-30 | Exelixis, Inc | Pyrazole kinase modulators and methods of use |
| WO2007061741A2 (en) | 2005-11-17 | 2007-05-31 | Arena Pharmaceuticals, Inc. | Modulators of the h3 receptor useful for the treatment of disorders related thereto |
| JP5176281B2 (ja) | 2006-03-23 | 2013-04-03 | 大日本印刷株式会社 | リチウムイオン電池 |
-
2011
- 2011-03-11 CN CN201180023571.1A patent/CN102884059B/zh not_active Expired - Fee Related
- 2011-03-11 TW TW100108373A patent/TWI475015B/zh not_active IP Right Cessation
- 2011-03-11 CA CA2792539A patent/CA2792539C/en not_active Expired - Fee Related
- 2011-03-11 JP JP2012541257A patent/JP5661791B2/ja not_active Expired - Fee Related
- 2011-03-11 AU AU2011225095A patent/AU2011225095C1/en not_active Ceased
- 2011-03-11 WO PCT/JP2011/056497 patent/WO2011111875A1/en not_active Ceased
- 2011-03-11 EP EP11753530.2A patent/EP2545046A4/en not_active Withdrawn
- 2011-03-11 KR KR1020127024562A patent/KR101756495B1/ko not_active Expired - Fee Related
- 2011-03-11 US US13/505,161 patent/US8541585B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1620452A (zh) * | 2001-12-19 | 2005-05-25 | H.隆德贝克有限公司 | 3,4－二氢－1h－异喹啉－2－基－衍生物 |
| WO2005066165A1 (en) * | 2003-12-31 | 2005-07-21 | Warner-Lambert Company Llc | N-substituted piperidine and piperazine derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130016234A (ko) | 2013-02-14 |
| US20120214790A1 (en) | 2012-08-23 |
| CA2792539C (en) | 2017-04-18 |
| JP2013522165A (ja) | 2013-06-13 |
| AU2011225095B2 (en) | 2016-05-19 |
| EP2545046A4 (en) | 2015-03-25 |
| TWI475015B (zh) | 2015-03-01 |
| WO2011111875A1 (en) | 2011-09-15 |
| EP2545046A1 (en) | 2013-01-16 |
| AU2011225095A1 (en) | 2012-09-27 |
| AU2011225095C1 (en) | 2017-01-19 |
| US8541585B2 (en) | 2013-09-24 |
| TW201139413A (en) | 2011-11-16 |
| KR101756495B1 (ko) | 2017-07-10 |
| JP5661791B2 (ja) | 2015-01-28 |
| CA2792539A1 (en) | 2011-09-15 |
| CN102884059A (zh) | 2013-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150826 Termination date: 20180311 |