CN102875537A - 一种新的抗血栓药物的制备方法 - Google Patents

一种新的抗血栓药物的制备方法 Download PDF

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Publication number
CN102875537A
CN102875537A CN2012103312665A CN201210331266A CN102875537A CN 102875537 A CN102875537 A CN 102875537A CN 2012103312665 A CN2012103312665 A CN 2012103312665A CN 201210331266 A CN201210331266 A CN 201210331266A CN 102875537 A CN102875537 A CN 102875537A
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CN
China
Prior art keywords
formula
compound
described method
reaction
adz6140
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CN2012103312665A
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English (en)
Chinese (zh)
Inventor
王兵
孙光祥
顾斌
王敏峰
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CHANGZHOU PHARMACEUTICAL FACTORY Co Ltd
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CHANGZHOU PHARMACEUTICAL FACTORY Co Ltd
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Application filed by CHANGZHOU PHARMACEUTICAL FACTORY Co Ltd filed Critical CHANGZHOU PHARMACEUTICAL FACTORY Co Ltd
Priority to CN2012103312665A priority Critical patent/CN102875537A/zh
Publication of CN102875537A publication Critical patent/CN102875537A/zh
Priority to PCT/CN2013/073061 priority patent/WO2014036823A1/fr
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2012103312665A 2012-09-10 2012-09-10 一种新的抗血栓药物的制备方法 Pending CN102875537A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN2012103312665A CN102875537A (zh) 2012-09-10 2012-09-10 一种新的抗血栓药物的制备方法
PCT/CN2013/073061 WO2014036823A1 (fr) 2012-09-10 2013-03-22 Nouveau procédé de préparation d'un médicament antithrombotique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2012103312665A CN102875537A (zh) 2012-09-10 2012-09-10 一种新的抗血栓药物的制备方法

Publications (1)

Publication Number Publication Date
CN102875537A true CN102875537A (zh) 2013-01-16

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CN2012103312665A Pending CN102875537A (zh) 2012-09-10 2012-09-10 一种新的抗血栓药物的制备方法

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CN (1) CN102875537A (fr)
WO (1) WO2014036823A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103360396A (zh) * 2013-06-27 2013-10-23 苏州明锐医药科技有限公司 一种替格瑞洛的制备方法
CN103524429A (zh) * 2013-09-28 2014-01-22 银杏树药业(苏州)有限公司 一种替格瑞洛及其新的中间体的制备方法
WO2014036823A1 (fr) * 2012-09-10 2014-03-13 常州制药厂有限公司 Nouveau procédé de préparation d'un médicament antithrombotique
CN103992323A (zh) * 2014-04-18 2014-08-20 南通常佑药业科技有限公司 一种替格瑞洛的制备方法
WO2014155389A2 (fr) * 2013-03-25 2014-10-02 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Procédé de préparation de ticagrelor
CN104098553A (zh) * 2013-04-10 2014-10-15 江苏恒瑞医药股份有限公司 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法
WO2014166337A1 (fr) * 2013-04-07 2014-10-16 杭州领业医药科技有限公司 Forme cristalline de ticagrélor et son procédé de fabrication et son utilisation
CN104193748A (zh) * 2014-08-14 2014-12-10 严白双 一种替卡格雷的合成方法
CN105732632A (zh) * 2014-12-09 2016-07-06 翰宇药业（武汉）有限公司 一种制备替格瑞洛的方法
US10011605B2 (en) 2014-06-18 2018-07-03 Flamma Spa Process for the preparation of triazolo[4,5-D] pyrimidine cyclopentane compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1334816A (zh) * 1998-12-04 2002-02-06 阿斯特拉曾尼卡有限公司 新的三唑并(4,5－d)嘧啶化合物
US20030148888A1 (en) * 2000-06-02 2003-08-07 Ulf Larsson Novel triazolo pyrimidine compounds
CN101235024A (zh) * 2008-02-01 2008-08-06 中国科学院上海有机化学研究所 一类苯并二氢吡喃类化合物、合成方法和用途
WO2011017108A2 (fr) * 2009-07-27 2011-02-10 Auspex Pharmaceuticals, Inc. Modulateurs cyclopropylés du récepteur p2y12
WO2012138981A2 (fr) * 2011-04-06 2012-10-11 Teva Pharmaceutical Industries Ltd. Nouveaux intermédiaires et procédés pour la préparation du ticagrelor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102875537A (zh) * 2012-09-10 2013-01-16 常州制药厂有限公司 一种新的抗血栓药物的制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1334816A (zh) * 1998-12-04 2002-02-06 阿斯特拉曾尼卡有限公司 新的三唑并(4,5－d)嘧啶化合物
US20030148888A1 (en) * 2000-06-02 2003-08-07 Ulf Larsson Novel triazolo pyrimidine compounds
CN101235024A (zh) * 2008-02-01 2008-08-06 中国科学院上海有机化学研究所 一类苯并二氢吡喃类化合物、合成方法和用途
WO2011017108A2 (fr) * 2009-07-27 2011-02-10 Auspex Pharmaceuticals, Inc. Modulateurs cyclopropylés du récepteur p2y12
WO2012138981A2 (fr) * 2011-04-06 2012-10-11 Teva Pharmaceutical Industries Ltd. Nouveaux intermédiaires et procédés pour la préparation du ticagrelor

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014036823A1 (fr) * 2012-09-10 2014-03-13 常州制药厂有限公司 Nouveau procédé de préparation d'un médicament antithrombotique
WO2014155389A2 (fr) * 2013-03-25 2014-10-02 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Procédé de préparation de ticagrelor
WO2014155389A3 (fr) * 2013-03-25 2015-01-15 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Procédé de préparation de ticagrelor
CN104284897B (zh) * 2013-04-07 2016-06-01 杭州领业医药科技有限公司 替卡格雷晶型及其制备方法和用途
WO2014166337A1 (fr) * 2013-04-07 2014-10-16 杭州领业医药科技有限公司 Forme cristalline de ticagrélor et son procédé de fabrication et son utilisation
CN104284897A (zh) * 2013-04-07 2015-01-14 杭州领业医药科技有限公司 替卡格雷晶型及其制备方法和用途
US9359366B2 (en) 2013-04-10 2016-06-07 Jiangsu Hengrui Medicine Co., Ltd. Intermediate of Ticagrelor and preparation method therefor, and preparation method for Ticagrelor
WO2014166324A1 (fr) 2013-04-10 2014-10-16 江苏恒瑞医药股份有限公司 Intermédiaire de ticagrélor et procédé de préparation de celui-ci, et procédé de préparation de ticagrélor
CN104098553A (zh) * 2013-04-10 2014-10-15 江苏恒瑞医药股份有限公司 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法
CN104098553B (zh) * 2013-04-10 2017-11-28 江苏恒瑞医药股份有限公司 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法
TWI634116B (zh) * 2013-04-10 2018-09-01 江蘇恆瑞醫藥股份有限公司 替格瑞洛的中間體及其製備方法和替格瑞洛的製備方法
CN103360396A (zh) * 2013-06-27 2013-10-23 苏州明锐医药科技有限公司 一种替格瑞洛的制备方法
CN103524429A (zh) * 2013-09-28 2014-01-22 银杏树药业(苏州)有限公司 一种替格瑞洛及其新的中间体的制备方法
CN103524429B (zh) * 2013-09-28 2015-08-19 银杏树药业(苏州)有限公司 一种替格瑞洛及其新的中间体的制备方法
CN103992323A (zh) * 2014-04-18 2014-08-20 南通常佑药业科技有限公司 一种替格瑞洛的制备方法
US10011605B2 (en) 2014-06-18 2018-07-03 Flamma Spa Process for the preparation of triazolo[4,5-D] pyrimidine cyclopentane compounds
CN104193748A (zh) * 2014-08-14 2014-12-10 严白双 一种替卡格雷的合成方法
CN105732632A (zh) * 2014-12-09 2016-07-06 翰宇药业（武汉）有限公司 一种制备替格瑞洛的方法
CN105732632B (zh) * 2014-12-09 2020-05-15 翰宇药业（武汉）有限公司 一种制备替格瑞洛的方法

Also Published As

Publication number Publication date
WO2014036823A1 (fr) 2014-03-13

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Application publication date: 20130116