CN102869250A - 作为钾通道调节剂的4-(n-氮杂环烷基)酰苯胺衍生物 - Google Patents

作为钾通道调节剂的4-(n-氮杂环烷基)酰苯胺衍生物 Download PDF

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Publication number
CN102869250A
CN102869250A CN2011800161510A CN201180016151A CN102869250A CN 102869250 A CN102869250 A CN 102869250A CN 2011800161510 A CN2011800161510 A CN 2011800161510A CN 201180016151 A CN201180016151 A CN 201180016151A CN 102869250 A CN102869250 A CN 102869250A
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compound
formula
contemplates
provides
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Chinese (zh)
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J-M·韦尼耶
玛莎·德拉罗萨
H·陈
J·Z·吴
加里·李·拉尔森
兰·韦恩·切尼
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VALEANT PHARMACEUTICALS INTERNATIONAL
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VALEANT PHARMACEUTICALS INTERNATIONAL
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CN2011800161510A 2010-02-01 2011-01-25 作为钾通道调节剂的4-(n-氮杂环烷基)酰苯胺衍生物 Pending CN102869250A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/698,070 US8993593B2 (en) 2006-08-23 2010-02-01 N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
US12/698,070 2010-02-01
PCT/US2011/022345 WO2011094186A1 (en) 2010-02-01 2011-01-25 Derivatives of 4-(n-azacycloalkyl) aniilides as potassium channel modulators

Publications (1)

Publication Number Publication Date
CN102869250A true CN102869250A (zh) 2013-01-09

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CN2011800161510A Pending CN102869250A (zh) 2010-02-01 2011-01-25 作为钾通道调节剂的4-(n-氮杂环烷基)酰苯胺衍生物

Country Status (12)

Country Link
US (1) US8993593B2 (https=)
EP (1) EP2531024A4 (https=)
JP (1) JP5844285B2 (https=)
KR (1) KR101841989B1 (https=)
CN (1) CN102869250A (https=)
AU (1) AU2011209731A1 (https=)
BR (1) BR112012019199A2 (https=)
CA (1) CA2788712C (https=)
EA (1) EA201290748A1 (https=)
MX (1) MX2012008969A (https=)
SG (1) SG182799A1 (https=)
WO (1) WO2011094186A1 (https=)

Cited By (10)

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CN112384216A (zh) * 2018-05-11 2021-02-19 泽农医药公司 用于增强生物利用度和电压门控钾离子通道开放暴露的方法
CN114786658A (zh) * 2019-12-06 2022-07-22 泽农医药公司 Kv7钾离子通道开放剂治疗疼痛的用途
WO2022174667A1 (zh) * 2021-10-27 2022-08-25 上海挚盟医药科技有限公司 作为钾通道调节剂的化合物及其制备和应用
CN115190874A (zh) * 2019-10-10 2022-10-14 泽农医药公司 一种选择性钾通道调节剂的固态结晶形式
WO2023125935A1 (zh) * 2021-12-31 2023-07-06 上海翰森生物医药科技有限公司 苯并哌啶衍生物调节剂、其制备方法和应用
WO2023143388A1 (zh) * 2022-01-25 2023-08-03 上海挚盟医药科技有限公司 作为钾通道调节剂的酰胺类化合物及其制备和应用
US12319656B2 (en) 2021-10-27 2025-06-03 Shanghai Zhimeng Biopharma, Inc. Compound as potassium channel regulator and preparation and use thereof
WO2025167886A1 (zh) * 2024-02-08 2025-08-14 上海挚盟医药科技有限公司 四氢异喹啉基化合物的晶型及其应用
WO2026026968A1 (zh) * 2024-08-02 2026-02-05 江西科睿药业有限公司 一种含芳香稠环的化合物、其药物组合物和应用
TWI921036B (zh) 2024-02-08 2026-04-01 大陸商上海摯盟醫藥科技有限公司 四氫異喹啉基化合物的晶型及其應用

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CN110511220B (zh) 2018-05-22 2022-04-01 上海挚盟医药科技有限公司 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用
WO2021092439A1 (en) 2019-11-08 2021-05-14 Xenon Pharmaceuticals Inc. Methods of treating depressive disorders
US20210213009A1 (en) * 2019-12-13 2021-07-15 Xenon Pharmaceuticals Inc. Methods of treating pain
IL304920A (en) 2021-02-09 2023-10-01 Xenon Pharmaceuticals Inc A voltage-gated potassium channel opener for use in the treatment of anhedonia
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TW202404583A (zh) 2022-06-08 2024-02-01 加拿大商再諾製藥公司 吡啶胺衍生物及其作為鉀通道調節劑之用途
WO2025179128A1 (en) 2024-02-22 2025-08-28 Xenon Pharmaceuticals Inc. Azetukalner for use in the treatment of depression, anhedonia or a seizure disorder such as epilepsy in pediatric subjects
WO2026006669A1 (en) * 2024-06-28 2026-01-02 Xenon Pharmaceuticals Inc. Prodrugs of n-[4-(6-fluoro-3,4-dihydro-2(1 h)-isoquinolinyl)-2,6-dimethylphe nyl]-3,3-dimethyl- butanamide

Citations (1)

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CN101563085A (zh) * 2006-08-23 2009-10-21 威朗国际制药公司 作为钾通道调节剂的4-(n-氮杂环烷基)酰苯胺的衍生物

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