BR112012019199A2 - derivados de 4-(n-azacicloalquil) anilidas como moduladores de canais de potássio. - Google Patents
derivados de 4-(n-azacicloalquil) anilidas como moduladores de canais de potássio.Info
- Publication number
- BR112012019199A2 BR112012019199A2 BR112012019199A BR112012019199A BR112012019199A2 BR 112012019199 A2 BR112012019199 A2 BR 112012019199A2 BR 112012019199 A BR112012019199 A BR 112012019199A BR 112012019199 A BR112012019199 A BR 112012019199A BR 112012019199 A2 BR112012019199 A2 BR 112012019199A2
- Authority
- BR
- Brazil
- Prior art keywords
- azacycloalkyl
- channel modulators
- potassium channel
- anilide derivatives
- potassium
- Prior art date
Links
- 102000004257 Potassium Channel Human genes 0.000 title abstract 4
- 108020001213 potassium channel Proteins 0.000 title abstract 4
- 150000003931 anilides Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000004913 activation Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/698,070 US8993593B2 (en) | 2006-08-23 | 2010-02-01 | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| PCT/US2011/022345 WO2011094186A1 (en) | 2010-02-01 | 2011-01-25 | Derivatives of 4-(n-azacycloalkyl) aniilides as potassium channel modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012019199A2 true BR112012019199A2 (pt) | 2017-01-17 |
Family
ID=44319712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012019199A BR112012019199A2 (pt) | 2010-02-01 | 2011-01-25 | derivados de 4-(n-azacicloalquil) anilidas como moduladores de canais de potássio. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8993593B2 (https=) |
| EP (1) | EP2531024A4 (https=) |
| JP (1) | JP5844285B2 (https=) |
| KR (1) | KR101841989B1 (https=) |
| CN (1) | CN102869250A (https=) |
| AU (1) | AU2011209731A1 (https=) |
| BR (1) | BR112012019199A2 (https=) |
| CA (1) | CA2788712C (https=) |
| EA (1) | EA201290748A1 (https=) |
| MX (1) | MX2012008969A (https=) |
| SG (1) | SG182799A1 (https=) |
| WO (1) | WO2011094186A1 (https=) |
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| UA91341C2 (ru) | 2004-07-15 | 2010-07-26 | Амр Текнолоджи, Інк. | Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| AR071997A1 (es) * | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina |
| EP2429295B1 (en) | 2009-05-12 | 2013-12-25 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
| US20160058895A1 (en) | 2013-04-19 | 2016-03-03 | Oslo Universitetssykehus Hf | Radiolabeled gnrh antagonists as pet imaging agents |
| KR20190008411A (ko) | 2016-06-10 | 2019-01-23 | 사이플루어 라이프 사이언시즈, 인크 | 플로오르화 2-아미노-4-(치환된 아미노)페닐 카르밤산염 유도체 |
| FI3790548T3 (fi) | 2018-05-11 | 2023-11-17 | Xenon Pharmaceuticals Inc | Menetelmiä jänniteriippuvaisen kaliumkanavan avaajan biosaatavuuden ja eksposition tehostamiseksi |
| CN110511220B (zh) | 2018-05-22 | 2022-04-01 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用 |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| WO2021092439A1 (en) | 2019-11-08 | 2021-05-14 | Xenon Pharmaceuticals Inc. | Methods of treating depressive disorders |
| CA3159436A1 (en) * | 2019-12-06 | 2021-06-10 | James Philip JOHNSON JR | Use of a kv7 potassium channel opener for treating pain |
| US20210213009A1 (en) * | 2019-12-13 | 2021-07-15 | Xenon Pharmaceuticals Inc. | Methods of treating pain |
| IL304920A (en) | 2021-02-09 | 2023-10-01 | Xenon Pharmaceuticals Inc | A voltage-gated potassium channel opener for use in the treatment of anhedonia |
| CA3207002A1 (en) | 2021-02-09 | 2022-08-18 | Jr James Philip Johnson | Conjoint therapy for treating seizure disorders |
| EP4074696B1 (en) * | 2021-10-27 | 2026-02-04 | Shanghai Zhimeng Biopharma, Inc. | N-[4-(6-fluoro-3,4-dihydro-2(1h)-isoquinolinyl)-2,6-dimethylphenyl]-1-methyl-cyclopropane-acetamide, a potassium channel regulator for the treatment of epilepsy |
| CN113698345B (zh) * | 2021-10-27 | 2022-02-01 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的化合物及其制备和应用 |
| CN118451079A (zh) * | 2021-12-31 | 2024-08-06 | 上海翰森生物医药科技有限公司 | 苯并哌啶衍生物调节剂、其制备方法和应用 |
| CN116535353A (zh) * | 2022-01-25 | 2023-08-04 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的酰胺类化合物及其制备和应用 |
| TW202404583A (zh) | 2022-06-08 | 2024-02-01 | 加拿大商再諾製藥公司 | 吡啶胺衍生物及其作為鉀通道調節劑之用途 |
| WO2025167886A1 (zh) * | 2024-02-08 | 2025-08-14 | 上海挚盟医药科技有限公司 | 四氢异喹啉基化合物的晶型及其应用 |
| WO2025179128A1 (en) | 2024-02-22 | 2025-08-28 | Xenon Pharmaceuticals Inc. | Azetukalner for use in the treatment of depression, anhedonia or a seizure disorder such as epilepsy in pediatric subjects |
| WO2026006669A1 (en) * | 2024-06-28 | 2026-01-02 | Xenon Pharmaceuticals Inc. | Prodrugs of n-[4-(6-fluoro-3,4-dihydro-2(1 h)-isoquinolinyl)-2,6-dimethylphe nyl]-3,3-dimethyl- butanamide |
| WO2026026968A1 (zh) * | 2024-08-02 | 2026-02-05 | 江西科睿药业有限公司 | 一种含芳香稠环的化合物、其药物组合物和应用 |
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| CA2589001A1 (en) | 2004-11-19 | 2006-05-26 | Kissei Pharmaceutical Co., Ltd. | Preventive or therapeutic agent for neuropathic pain |
| EP1688141A1 (en) | 2005-01-31 | 2006-08-09 | elbion AG | The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome |
| EP1861394A1 (en) | 2005-03-03 | 2007-12-05 | H.Lundbeck A/S | Substituted pyridine derivatives |
| US7683058B2 (en) | 2005-09-09 | 2010-03-23 | H. Lundbeck A/S | Substituted pyrimidine derivatives |
| BRPI0716715B1 (pt) * | 2006-08-23 | 2021-07-06 | Xenon Pharmaceuticals, Inc | Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potássio, seus usos, produto, composição, comprimido e cápsula |
| CA2670966A1 (en) | 2006-11-28 | 2008-06-05 | Valeant Pharmaceuticals International | 1,4 diamino bicyclic retigabine analogues as potassium channel modulators |
-
2010
- 2010-02-01 US US12/698,070 patent/US8993593B2/en active Active
-
2011
- 2011-01-25 SG SG2012056438A patent/SG182799A1/en unknown
- 2011-01-25 CA CA2788712A patent/CA2788712C/en active Active
- 2011-01-25 CN CN2011800161510A patent/CN102869250A/zh active Pending
- 2011-01-25 BR BR112012019199A patent/BR112012019199A2/pt not_active Application Discontinuation
- 2011-01-25 AU AU2011209731A patent/AU2011209731A1/en not_active Abandoned
- 2011-01-25 EP EP11737504.8A patent/EP2531024A4/en not_active Withdrawn
- 2011-01-25 JP JP2012551221A patent/JP5844285B2/ja active Active
- 2011-01-25 KR KR1020127022876A patent/KR101841989B1/ko active Active
- 2011-01-25 WO PCT/US2011/022345 patent/WO2011094186A1/en not_active Ceased
- 2011-01-25 MX MX2012008969A patent/MX2012008969A/es unknown
- 2011-01-25 EA EA201290748A patent/EA201290748A1/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20110003850A1 (en) | 2011-01-06 |
| CA2788712C (en) | 2018-09-11 |
| US8993593B2 (en) | 2015-03-31 |
| CN102869250A (zh) | 2013-01-09 |
| AU2011209731A1 (en) | 2012-08-23 |
| KR101841989B1 (ko) | 2018-03-26 |
| EP2531024A4 (en) | 2013-06-19 |
| KR20120123695A (ko) | 2012-11-09 |
| EA201290748A1 (ru) | 2013-04-30 |
| EP2531024A1 (en) | 2012-12-12 |
| MX2012008969A (es) | 2012-09-07 |
| JP2013518815A (ja) | 2013-05-23 |
| JP5844285B2 (ja) | 2016-01-13 |
| SG182799A1 (en) | 2012-09-27 |
| WO2011094186A1 (en) | 2011-08-04 |
| CA2788712A1 (en) | 2011-08-04 |
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| B25G | Requested change of headquarter approved |
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| B25A | Requested transfer of rights approved |
Owner name: 1ST ORDER PHARMACEUTICALS, INC. (US) |
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| B25A | Requested transfer of rights approved |
Owner name: XENON PHARMACEUTICALS, INC. (CA) |
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