CN102858739A - 酰胺化吡咯甲酸酯化合物的方法 - Google Patents

酰胺化吡咯甲酸酯化合物的方法 Download PDF

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Publication number
CN102858739A
CN102858739A CN2010800662651A CN201080066265A CN102858739A CN 102858739 A CN102858739 A CN 102858739A CN 2010800662651 A CN2010800662651 A CN 2010800662651A CN 201080066265 A CN201080066265 A CN 201080066265A CN 102858739 A CN102858739 A CN 102858739A
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China
Prior art keywords
formula
group
compound
hydrogen
amine
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CN2010800662651A
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English (en)
Chinese (zh)
Inventor
朱杰
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Synthon BV
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Synthon BV
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Publication of CN102858739A publication Critical patent/CN102858739A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2010800662651A 2010-03-10 2010-03-10 酰胺化吡咯甲酸酯化合物的方法 Pending CN102858739A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2010/001609 WO2011110199A1 (fr) 2010-03-10 2010-03-10 Procédé d'amidation de composés de carboxylate de pyrrole

Publications (1)

Publication Number Publication Date
CN102858739A true CN102858739A (zh) 2013-01-02

Family

ID=42651146

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800662651A Pending CN102858739A (zh) 2010-03-10 2010-03-10 酰胺化吡咯甲酸酯化合物的方法

Country Status (3)

Country Link
EP (1) EP2545034A1 (fr)
CN (1) CN102858739A (fr)
WO (1) WO2011110199A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109485639A (zh) * 2018-12-20 2019-03-19 石药集团中奇制药技术（石家庄）有限公司 一种舒尼替尼制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9206163B2 (en) * 2012-03-23 2015-12-08 Laurus Labs Private Ltd. Process for the preparation of sunitinib and its acid addition salts thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1439005A (zh) * 2000-02-15 2003-08-27 苏根公司 吡咯取代的2－二氢吲哚酮蛋白激酶抑制剂
CN1823079A (zh) * 2003-07-21 2006-08-23 科莱恩产品（德国）有限公司 环状膦酸酐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005528344A (ja) 2002-02-15 2005-09-22 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー インドリノン誘導体の製造法
US7452913B2 (en) 2003-02-24 2008-11-18 Pharmacia & Upjohn Company Polymorphs of pyrrole substituted 2-indolinone protein kinase inhibitors
WO2005023765A1 (fr) 2003-09-11 2005-03-17 Pharmacia & Upjohn Company Llc Methode de catalyse de reactions d'amidation au moyen de co2
US20060009510A1 (en) 2004-07-09 2006-01-12 Pharmacia & Upjohn Company Llc Method of synthesizing indolinone compounds
BRPI0611419A2 (pt) 2005-05-26 2010-09-08 Scripps Research Inst composto, sal, tautÈmero ou pró-fármaco, método para a modulação da atividade catalìtica de uma proteìna cinase e processo para a sìntese de uma pirrolil-indolinona
EP2112148A1 (fr) 2005-09-19 2009-10-28 Pfizer Products Inc. Sels solides de 2-indolinone à substitution pyrrole
BRPI0620939A2 (pt) 2005-12-29 2011-11-29 Scripps Research Inst derivados de aminoácido de indolinona com base em inibidores de proteìna quinase
PL2079727T3 (pl) 2006-09-15 2016-08-31 Xcovery Inc Inhibitory kinazy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1439005A (zh) * 2000-02-15 2003-08-27 苏根公司 吡咯取代的2－二氢吲哚酮蛋白激酶抑制剂
CN1823079A (zh) * 2003-07-21 2006-08-23 科莱恩产品（德国）有限公司 环状膦酸酐的制备方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ARCHIMICA: "Coupling Agent T3P-The Water Scavenger", 《ARCHIMICA》 *
LI SUN ET AL.: "Discovery of 5-[5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid (2-Diethylaminoethyl)amide, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial and Platelet-Derived Growth Factor Receptor Tyrosine", 《J. MED. CHEM.》 *
吴长增等: "一种新型缩合试剂——正丙基膦酸酐", 《化学试剂》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109485639A (zh) * 2018-12-20 2019-03-19 石药集团中奇制药技术（石家庄）有限公司 一种舒尼替尼制备方法

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Publication number Publication date
WO2011110199A1 (fr) 2011-09-15
EP2545034A1 (fr) 2013-01-16

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Application publication date: 20130102