CN102850328A - 吡啶类化合物、其制备方法、包含该化合物的药物组合物及其用途 - Google Patents
吡啶类化合物、其制备方法、包含该化合物的药物组合物及其用途 Download PDFInfo
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- CN102850328A CN102850328A CN2011101832745A CN201110183274A CN102850328A CN 102850328 A CN102850328 A CN 102850328A CN 2011101832745 A CN2011101832745 A CN 2011101832745A CN 201110183274 A CN201110183274 A CN 201110183274A CN 102850328 A CN102850328 A CN 102850328A
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- piperazine
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Abstract
Description
化合物 | 抑制率 | IC50(μM) | 化合物 | 抑制率 | IC50(μM) |
IA-1 | 94.8%10μM | <0.1 | ID-1 | 96.4%10μM | <0.1 |
IA-2 | 95.2%10μM | <0.1 | ID-2 | 92.0%10μM | <0.1 |
IA-3 | 94.0%10μM | <0.1 | ID-3 | 98.4%10μM | <0.01 |
IA-4 | 94.2%10μM | <1 | ID-4 | 67.2%10μM | <1 |
IB-1 | 58.5%10μM | <1 | ID-5 | 96.7%10μM | <0.1 |
IB-2 | 98.4%10μM | <0.01 | ID-6 | 95.5%10μM | <1 |
IB-3 | 72.7%10μM | <1 | IE-1 | 83.9%10μM | <0.1 |
IB-4 | 74.9%10μM | <1 | IE-2 | 83.7%10μM | <1 |
IC-1 | 99.0%10μM | <0.01 | IF-1 | 91.0%10μM | <1 |
IC-2 | 64.8%10μM | <10 | IF-2 | 91.0%10μM | <1 |
化合物 | 抑制率 | IC50(μM) | 化合物 | 抑制率 | IC50(μM) |
IA-1 | 74.8%10μM | <1 | ID-1 | 73.2%10μM | <1 |
IA-2 | 85.2%10μM | <0.1 | ID-2 | 82.0%10μM | <0.1 |
IA-3 | 64.0%10μM | <1 | ID-3 | 68.4%10μM | <1 |
IA-4 | 74.2%10μM | <1 | ID-4 | 73.2%10μM | <1 |
IB-1 | 70.2%10μM | <1 | ID-5 | 66.7%10μM | <1 |
IB-2 | 73.3%10μM | <1 | ID-6 | 85.5%10μM | <0.1 |
IB-3 | 72.7%10μM | <1 | IE-1 | 63.9%10μM | <1 |
IB-4 | 74.9%10μM | <1 | IE-2 | 73.7%10μM | <1 |
IC-1 | 69.0%10μM | <1 | IF-1 | 71.0%10μM | <1 |
IC-2 | 74.8%10μM | <10 | IF-2 | 81.0%10μM | <0.1 |
Claims (10)
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