CN102844293B - 酮酯的氢化方法 - Google Patents

酮酯的氢化方法 Download PDF

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Publication number
CN102844293B
CN102844293B CN201180019495.7A CN201180019495A CN102844293B CN 102844293 B CN102844293 B CN 102844293B CN 201180019495 A CN201180019495 A CN 201180019495A CN 102844293 B CN102844293 B CN 102844293B
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solvent
residue
methods according
formula
binap
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CN201180019495.7A
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Chinese (zh)
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CN102844293A (zh
Inventor
M·比克尔
M·A·卡洛坎达维拉
G·黑克曼
L·泽法普亚
H·G·内登
C·马兰
J·皮埃龙
D·维吉尼
T·瓦尔德
A·扎诺蒂-杰罗萨
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Lonza AG
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Lonza AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201180019495.7A 2010-05-11 2011-05-10 酮酯的氢化方法 Active CN102844293B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US33346210P 2010-05-11 2010-05-11
EP10004966A EP2386536A1 (en) 2010-05-11 2010-05-11 A process for the hydrogenation of ketoesters
US61/333,462 2010-05-11
EP10004966.7 2010-05-11
PCT/EP2011/002323 WO2011141160A1 (en) 2010-05-11 2011-05-10 A process for the hydrogenation of ketoesters

Publications (2)

Publication Number Publication Date
CN102844293A CN102844293A (zh) 2012-12-26
CN102844293B true CN102844293B (zh) 2016-01-27

Family

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CN201180019495.7A Active CN102844293B (zh) 2010-05-11 2011-05-10 酮酯的氢化方法

Country Status (8)

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US (1) US8431741B2 (enExample)
EP (2) EP2386536A1 (enExample)
JP (1) JP6018046B2 (enExample)
KR (1) KR101848763B1 (enExample)
CN (1) CN102844293B (enExample)
ES (1) ES2567408T3 (enExample)
TW (1) TWI519505B (enExample)
WO (1) WO2011141160A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102633664B (zh) * 2012-03-30 2014-05-28 广西新晶科技有限公司 一种左旋肉碱的制备方法
CN102633705A (zh) * 2012-03-31 2012-08-15 石家庄利康医药科技有限公司 一种制备奥拉西坦的方法
CN103709058B (zh) * 2013-12-10 2015-09-02 苏州汉酶生物技术有限公司 一种左旋肉碱的合成方法
CN105218371A (zh) * 2015-09-24 2016-01-06 上海交通大学 光学纯的3-羟基-4-(2,4,5-三氟苯基)丁酸乙酯的制备方法
CN109851506B (zh) * 2019-01-30 2020-09-15 凯特立斯（深圳）科技有限公司 钌-双膦催化剂催化的简单酮的不对称还原胺化制备手性伯胺

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003097569A1 (en) * 2002-05-22 2003-11-27 Phoenix Chemicals Limited Continuous process for the enantioselective catalytic hydrogenation of beta-ketoesters

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0699367B2 (ja) 1987-06-11 1994-12-07 高砂香料工業株式会社 光学活性アルコ−ルの製法
JPH0678277B2 (ja) 1988-02-19 1994-10-05 高砂香料工業株式会社 光学活性アルコールおよびその誘導体の製造方法
JPH0757758B2 (ja) 1988-10-24 1995-06-21 高砂香料工業株式会社 ルテニウム―ホスフィン錯体
GB8911732D0 (en) 1989-05-22 1989-07-05 Ethyl Petroleum Additives Ltd Lubricant compositions
IT1303757B1 (it) 1998-11-16 2001-02-23 Sigma Tau Ind Farmaceuti Processo industriale per la produzione di l-carnitina.
NL1014280C2 (nl) * 2000-02-03 2001-08-06 Dsm Nv Werkwijze voor de bereiding van melamine uit ureum.
JP4601779B2 (ja) * 2000-07-25 2010-12-22 高砂香料工業株式会社 光学活性アルコールの製造方法
GB2401864B (en) * 2003-05-21 2007-11-14 Phoenix Chemicals Ltd Process and catalytic composition
EP1528053A1 (en) 2003-10-31 2005-05-04 Lonza Ag Process for the preparation of (S)- or (R)-4-halo-3-hydroxybutyrates
US6939981B1 (en) * 2004-06-25 2005-09-06 Eastman Chemical Company Ruthenium complexes of phosphine-aminophosphine ligands
JP2006206570A (ja) * 2004-12-27 2006-08-10 Nippon Synthetic Chem Ind Co Ltd:The 光学活性β−ヒドロキシアミノ酸誘導体の製造方法
CN101117304B (zh) * 2006-08-03 2011-12-21 中国科学院化学研究所 一种进行不对称催化氢化反应的方法
GB0822064D0 (en) * 2008-12-03 2009-01-07 Johnson Matthey Plc Process for preparing cationic ruthenium complexes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003097569A1 (en) * 2002-05-22 2003-11-27 Phoenix Chemicals Limited Continuous process for the enantioselective catalytic hydrogenation of beta-ketoesters

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A class of readily available optically pure 7,7"-disubstituted BINAPs for asymmetric catalysis;Wei-Cheng Yuan et al;《Tetrahedron》;20090523;第65卷(第21期);第4135页表8 *
Enantioselective hydrogenation of β-keto esters catalyzed bu chiral binaphthylbisphosphine ruthenium complexes;V.A.Pavlov et al;《Russian Chemical Bulletin》;20000430;第49卷(第4期);第728-731页 *

Also Published As

Publication number Publication date
KR101848763B1 (ko) 2018-05-28
ES2567408T3 (es) 2016-04-22
TWI519505B (zh) 2016-02-01
KR20130079394A (ko) 2013-07-10
EP2569275A1 (en) 2013-03-20
JP6018046B2 (ja) 2016-11-02
CN102844293A (zh) 2012-12-26
WO2011141160A1 (en) 2011-11-17
US8431741B2 (en) 2013-04-30
JP2013526493A (ja) 2013-06-24
EP2386536A1 (en) 2011-11-16
US20120016153A1 (en) 2012-01-19
TW201213280A (en) 2012-04-01
HK1179943A1 (zh) 2013-10-11
EP2569275B1 (en) 2016-01-27

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