IT1303757B1 - Processo industriale per la produzione di l-carnitina. - Google Patents

Processo industriale per la produzione di l-carnitina.

Info

Publication number
IT1303757B1
IT1303757B1 IT1998MI002477A ITMI982477A IT1303757B1 IT 1303757 B1 IT1303757 B1 IT 1303757B1 IT 1998MI002477 A IT1998MI002477 A IT 1998MI002477A IT MI982477 A ITMI982477 A IT MI982477A IT 1303757 B1 IT1303757 B1 IT 1303757B1
Authority
IT
Italy
Prior art keywords
chloro
carnitine
reduction
production
carnitina
Prior art date
Application number
IT1998MI002477A
Other languages
English (en)
Inventor
Maria Ornella Tinti
Sergio Penco
Oreste Piccolo
Fausto Bonifacio
Cristina Crescenzi
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT1998MI002477A priority Critical patent/IT1303757B1/it
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Priority to DK99956324T priority patent/DK1131279T3/da
Priority to ES99956324T priority patent/ES2220128T3/es
Priority to AU12953/00A priority patent/AU1295300A/en
Priority to DE69917318T priority patent/DE69917318T2/de
Priority to JP2000582358A priority patent/JP2002529528A/ja
Priority to CNB998133655A priority patent/CN1255375C/zh
Priority to KR1020017005577A priority patent/KR100575605B1/ko
Priority to CA002349536A priority patent/CA2349536A1/en
Priority to EP99956324A priority patent/EP1131279B1/en
Priority to AT99956324T priority patent/ATE266622T1/de
Priority to PT99956324T priority patent/PT1131279E/pt
Priority to PCT/IT1999/000365 priority patent/WO2000029370A1/en
Publication of ITMI982477A1 publication Critical patent/ITMI982477A1/it
Priority to US09/777,013 priority patent/US6451972B1/en
Application granted granted Critical
Publication of IT1303757B1 publication Critical patent/IT1303757B1/it
Priority to US09/849,363 priority patent/US6566552B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
IT1998MI002477A 1998-11-16 1998-11-16 Processo industriale per la produzione di l-carnitina. IT1303757B1 (it)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IT1998MI002477A IT1303757B1 (it) 1998-11-16 1998-11-16 Processo industriale per la produzione di l-carnitina.
AT99956324T ATE266622T1 (de) 1998-11-16 1999-11-12 Industrielles verfahren zur herstellung von l- carnitin
AU12953/00A AU1295300A (en) 1998-11-16 1999-11-12 Industrial process for the production of l-carnitine
DE69917318T DE69917318T2 (de) 1998-11-16 1999-11-12 Industrielles verfahren zur herstellung von l-carnitin
JP2000582358A JP2002529528A (ja) 1998-11-16 1999-11-12 Ｌ−カルニチンの製造のための工業的方法
CNB998133655A CN1255375C (zh) 1998-11-16 1999-11-12 生产l－肉碱的工业方法
DK99956324T DK1131279T3 (da) 1998-11-16 1999-11-12 Industriel fremgangsmåde til fremstilling af L-carnitin
CA002349536A CA2349536A1 (en) 1998-11-16 1999-11-12 Industrial process for the preparation of l-carnitine
EP99956324A EP1131279B1 (en) 1998-11-16 1999-11-12 Industrial process for the production of l-carnitine
ES99956324T ES2220128T3 (es) 1998-11-16 1999-11-12 Procedimiento industrial para la produccion de l-carnitina.
PT99956324T PT1131279E (pt) 1998-11-16 1999-11-12 Processo industrial para a producao de l-carnitina
PCT/IT1999/000365 WO2000029370A1 (en) 1998-11-16 1999-11-12 Industrial process for the production of l-carnitine
KR1020017005577A KR100575605B1 (ko) 1998-11-16 1999-11-12 Ｌ-카르니틴의 산업적인 제조 방법
US09/777,013 US6451972B1 (en) 1998-11-16 2001-02-06 Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors
US09/849,363 US6566552B2 (en) 1998-11-16 2001-05-07 Industrial process for the production of L-carnitine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998MI002477A IT1303757B1 (it) 1998-11-16 1998-11-16 Processo industriale per la produzione di l-carnitina.

Publications (2)

Publication Number Publication Date
ITMI982477A1 ITMI982477A1 (it) 2000-05-16
IT1303757B1 true IT1303757B1 (it) 2001-02-23

Family

ID=11381066

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1998MI002477A IT1303757B1 (it) 1998-11-16 1998-11-16 Processo industriale per la produzione di l-carnitina.

Country Status (14)

Country Link
US (1) US6566552B2 (it)
EP (1) EP1131279B1 (it)
JP (1) JP2002529528A (it)
KR (1) KR100575605B1 (it)
CN (1) CN1255375C (it)
AT (1) ATE266622T1 (it)
AU (1) AU1295300A (it)
CA (1) CA2349536A1 (it)
DE (1) DE69917318T2 (it)
DK (1) DK1131279T3 (it)
ES (1) ES2220128T3 (it)
IT (1) IT1303757B1 (it)
PT (1) PT1131279E (it)
WO (1) WO2000029370A1 (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100449750B1 (ko) * 2001-12-13 2004-09-22 화일약품주식회사 라세믹 알킬 4-클로로-3-히드록시부티레이트의 제조방법
GB0211716D0 (en) * 2002-05-22 2002-07-03 Phoenix Chemicals Ltd Process
CA2672687A1 (en) * 2004-07-08 2006-02-16 Merck & Co., Inc. Formation of tetra-substituted enamides and stereoselective reduction thereof
US7422653B2 (en) * 2004-07-13 2008-09-09 Applied Materials, Inc. Single-sided inflatable vertical slit valve
CN100348573C (zh) * 2004-07-28 2007-11-14 香港理工大学 一种制备l－肉碱的方法
US7927346B2 (en) * 2004-09-10 2011-04-19 Stryker Corporation Diversion device to increase cerebral blood flow
CN1312118C (zh) * 2004-11-10 2007-04-25 浙江大学 肉碱的合成工艺
EP2096103A4 (en) 2006-11-09 2012-11-21 Mitsubishi Rayon Co PROCESS FOR THE PRODUCTION OF BETAINE
TWI400223B (zh) * 2007-11-16 2013-07-01 Lonza Ag 製備甜菜鹼的方法
JP2010119357A (ja) * 2008-11-21 2010-06-03 Mitsubishi Rayon Co Ltd 光学活性４−ハロ−３−ヒドロキシブチルアミド及び光学活性カルニチンアミドの製造方法
EP2386536A1 (en) 2010-05-11 2011-11-16 Lonza Ltd. A process for the hydrogenation of ketoesters
CN101875616B (zh) * 2010-06-12 2012-11-21 胡建荣 一种左卡尼汀化合物及其制法
KR20160037031A (ko) 2014-09-26 2016-04-05 엔자이텍 주식회사 라세믹 또는 광학적으로 활성이 있는 D 또는 L-α-글리세로포스포릴콜린 고체의 제조방법
CN108912022A (zh) * 2018-07-26 2018-11-30 湖北吉和昌化工科技有限公司 一种聚二硫二丙烷磺酸钠的提纯方法
CN111592466B (zh) 2020-06-05 2022-08-19 复旦大学 一种左卡尼汀的微反应连续流合成方法
CN116655481B (zh) * 2023-06-14 2023-11-28 海南卓科制药有限公司 一种工业化合成左卡尼汀的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0699367B2 (ja) * 1987-06-11 1994-12-07 高砂香料工業株式会社 光学活性アルコ−ルの製法
JPH0678277B2 (ja) * 1988-02-19 1994-10-05 高砂香料工業株式会社 光学活性アルコールおよびその誘導体の製造方法
JPH0641445B2 (ja) * 1988-12-22 1994-06-01 高砂香料工業株式会社 光学活性カルニチンエステルの製法
FR2693190B1 (fr) * 1992-07-02 1994-09-23 Elf Aquitaine Procédé d'hydrogénation énantiosélectif de la double liaison C=O OXO.
DE4330730A1 (de) * 1993-09-10 1995-03-16 Bayer Ag Neue Bisphosphine für asymmetrische Hydrierkatalysatoren
IT1270082B (it) * 1994-07-12 1997-04-28 Univ Degli Studi Milano Difosfine eteroaromatiche come leganti chirali, complessi tra dette difosfine e metalli di transizione ed impiego di detti complessi come catalizzatori chirali
JP3652394B2 (ja) * 1995-01-27 2005-05-25 高砂香料工業株式会社 Ｎ−置換−７−アミノ−５−ヒドロキシ−３−オキソヘプタン酸誘導体およびその製造法
US5614031A (en) 1995-05-11 1997-03-25 Cushing; Ernest W. Method and apparatus for washing a fibrous mat
IT1299068B1 (it) * 1998-04-10 2000-02-07 Chemi Spa Legandi fosforati chirali e loro complessi organometallici, utili come catalizzatori in sintesi stereoselettive

Also Published As

Publication number Publication date
CA2349536A1 (en) 2000-05-25
KR100575605B1 (ko) 2006-05-02
AU1295300A (en) 2000-06-05
US6566552B2 (en) 2003-05-20
CN1326435A (zh) 2001-12-12
DE69917318T2 (de) 2005-06-02
CN1255375C (zh) 2006-05-10
WO2000029370A1 (en) 2000-05-25
EP1131279B1 (en) 2004-05-12
KR20010080380A (ko) 2001-08-22
ES2220128T3 (es) 2004-12-01
ATE266622T1 (de) 2004-05-15
JP2002529528A (ja) 2002-09-10
DE69917318D1 (de) 2004-06-17
PT1131279E (pt) 2004-09-30
ITMI982477A1 (it) 2000-05-16
US20020165408A1 (en) 2002-11-07
DK1131279T3 (da) 2004-09-20
EP1131279A1 (en) 2001-09-12

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