DK1131279T3 - Industriel fremgangsmåde til fremstilling af L-carnitin - Google Patents
Industriel fremgangsmåde til fremstilling af L-carnitinInfo
- Publication number
- DK1131279T3 DK1131279T3 DK99956324T DK99956324T DK1131279T3 DK 1131279 T3 DK1131279 T3 DK 1131279T3 DK 99956324 T DK99956324 T DK 99956324T DK 99956324 T DK99956324 T DK 99956324T DK 1131279 T3 DK1131279 T3 DK 1131279T3
- Authority
- DK
- Denmark
- Prior art keywords
- carnitine
- chloro
- reduction
- preparation
- substrate
- Prior art date
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000006722 reduction reaction Methods 0.000 abstract 3
- 239000003054 catalyst Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 abstract 2
- VCPNLOMAQUZMBY-UHFFFAOYSA-N 4-chloro-3-oxobutanamide Chemical compound NC(=O)CC(=O)CCl VCPNLOMAQUZMBY-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 abstract 1
- -1 alkyl 4-chloro-3-oxobutyrate Chemical compound 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 229910052707 ruthenium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Automobile Manufacture Line, Endless Track Vehicle, Trailer (AREA)
- General Factory Administration (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998MI002477A IT1303757B1 (it) | 1998-11-16 | 1998-11-16 | Processo industriale per la produzione di l-carnitina. |
| PCT/IT1999/000365 WO2000029370A1 (en) | 1998-11-16 | 1999-11-12 | Industrial process for the production of l-carnitine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1131279T3 true DK1131279T3 (da) | 2004-09-20 |
Family
ID=11381066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99956324T DK1131279T3 (da) | 1998-11-16 | 1999-11-12 | Industriel fremgangsmåde til fremstilling af L-carnitin |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6566552B2 (da) |
| EP (1) | EP1131279B1 (da) |
| JP (1) | JP2002529528A (da) |
| KR (1) | KR100575605B1 (da) |
| CN (1) | CN1255375C (da) |
| AT (1) | ATE266622T1 (da) |
| AU (1) | AU1295300A (da) |
| CA (1) | CA2349536A1 (da) |
| DE (1) | DE69917318T2 (da) |
| DK (1) | DK1131279T3 (da) |
| ES (1) | ES2220128T3 (da) |
| IT (1) | IT1303757B1 (da) |
| PT (1) | PT1131279E (da) |
| WO (1) | WO2000029370A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100449750B1 (ko) * | 2001-12-13 | 2004-09-22 | 화일약품주식회사 | 라세믹 알킬 4-클로로-3-히드록시부티레이트의 제조방법 |
| GB0211716D0 (en) * | 2002-05-22 | 2002-07-03 | Phoenix Chemicals Ltd | Process |
| JP2008505903A (ja) | 2004-07-08 | 2008-02-28 | メルク エンド カムパニー インコーポレーテッド | 四置換エナミドの形成およびこの立体選択的還元 |
| US7422653B2 (en) * | 2004-07-13 | 2008-09-09 | Applied Materials, Inc. | Single-sided inflatable vertical slit valve |
| CN100348573C (zh) * | 2004-07-28 | 2007-11-14 | 香港理工大学 | 一种制备l－肉碱的方法 |
| US7927346B2 (en) * | 2004-09-10 | 2011-04-19 | Stryker Corporation | Diversion device to increase cerebral blood flow |
| CN1312118C (zh) * | 2004-11-10 | 2007-04-25 | 浙江大学 | 肉碱的合成工艺 |
| US8334132B2 (en) | 2006-11-09 | 2012-12-18 | Mitsubishi Rayon Co., Ltd. | Process for production of a betaine such as carnitine |
| TWI400223B (zh) * | 2007-11-16 | 2013-07-01 | Lonza Ag | 製備甜菜鹼的方法 |
| JP2010119357A (ja) * | 2008-11-21 | 2010-06-03 | Mitsubishi Rayon Co Ltd | 光学活性４−ハロ−３−ヒドロキシブチルアミド及び光学活性カルニチンアミドの製造方法 |
| EP2386536A1 (en) | 2010-05-11 | 2011-11-16 | Lonza Ltd. | A process for the hydrogenation of ketoesters |
| CN101875616B (zh) * | 2010-06-12 | 2012-11-21 | 胡建荣 | 一种左卡尼汀化合物及其制法 |
| KR20160037031A (ko) | 2014-09-26 | 2016-04-05 | 엔자이텍 주식회사 | 라세믹 또는 광학적으로 활성이 있는 D 또는 L-α-글리세로포스포릴콜린 고체의 제조방법 |
| CN108912022A (zh) * | 2018-07-26 | 2018-11-30 | 湖北吉和昌化工科技有限公司 | 一种聚二硫二丙烷磺酸钠的提纯方法 |
| CN111592466B (zh) | 2020-06-05 | 2022-08-19 | 复旦大学 | 一种左卡尼汀的微反应连续流合成方法 |
| CN116655481B (zh) * | 2023-06-14 | 2023-11-28 | 海南卓科制药有限公司 | 一种工业化合成左卡尼汀的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0699367B2 (ja) * | 1987-06-11 | 1994-12-07 | 高砂香料工業株式会社 | 光学活性アルコ−ルの製法 |
| JPH0678277B2 (ja) * | 1988-02-19 | 1994-10-05 | 高砂香料工業株式会社 | 光学活性アルコールおよびその誘導体の製造方法 |
| JPH0641445B2 (ja) * | 1988-12-22 | 1994-06-01 | 高砂香料工業株式会社 | 光学活性カルニチンエステルの製法 |
| FR2693190B1 (fr) * | 1992-07-02 | 1994-09-23 | Elf Aquitaine | Procédé d'hydrogénation énantiosélectif de la double liaison C=O OXO. |
| DE4330730A1 (de) * | 1993-09-10 | 1995-03-16 | Bayer Ag | Neue Bisphosphine für asymmetrische Hydrierkatalysatoren |
| IT1270082B (it) * | 1994-07-12 | 1997-04-28 | Univ Degli Studi Milano | Difosfine eteroaromatiche come leganti chirali, complessi tra dette difosfine e metalli di transizione ed impiego di detti complessi come catalizzatori chirali |
| JP3652394B2 (ja) * | 1995-01-27 | 2005-05-25 | 高砂香料工業株式会社 | Ｎ−置換−７−アミノ−５−ヒドロキシ−３−オキソヘプタン酸誘導体およびその製造法 |
| US5614031A (en) | 1995-05-11 | 1997-03-25 | Cushing; Ernest W. | Method and apparatus for washing a fibrous mat |
| IT1299068B1 (it) * | 1998-04-10 | 2000-02-07 | Chemi Spa | Legandi fosforati chirali e loro complessi organometallici, utili come catalizzatori in sintesi stereoselettive |
-
1998
- 1998-11-16 IT IT1998MI002477A patent/IT1303757B1/it active
-
1999
- 1999-11-12 CN CNB998133655A patent/CN1255375C/zh not_active Expired - Fee Related
- 1999-11-12 WO PCT/IT1999/000365 patent/WO2000029370A1/en active IP Right Grant
- 1999-11-12 PT PT99956324T patent/PT1131279E/pt unknown
- 1999-11-12 DE DE69917318T patent/DE69917318T2/de not_active Expired - Fee Related
- 1999-11-12 JP JP2000582358A patent/JP2002529528A/ja active Pending
- 1999-11-12 KR KR1020017005577A patent/KR100575605B1/ko not_active IP Right Cessation
- 1999-11-12 AT AT99956324T patent/ATE266622T1/de not_active IP Right Cessation
- 1999-11-12 ES ES99956324T patent/ES2220128T3/es not_active Expired - Lifetime
- 1999-11-12 AU AU12953/00A patent/AU1295300A/en not_active Abandoned
- 1999-11-12 DK DK99956324T patent/DK1131279T3/da active
- 1999-11-12 CA CA002349536A patent/CA2349536A1/en not_active Abandoned
- 1999-11-12 EP EP99956324A patent/EP1131279B1/en not_active Expired - Lifetime
-
2001
- 2001-05-07 US US09/849,363 patent/US6566552B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT1131279E (pt) | 2004-09-30 |
| KR100575605B1 (ko) | 2006-05-02 |
| WO2000029370A1 (en) | 2000-05-25 |
| EP1131279A1 (en) | 2001-09-12 |
| EP1131279B1 (en) | 2004-05-12 |
| CN1255375C (zh) | 2006-05-10 |
| KR20010080380A (ko) | 2001-08-22 |
| CN1326435A (zh) | 2001-12-12 |
| CA2349536A1 (en) | 2000-05-25 |
| ES2220128T3 (es) | 2004-12-01 |
| AU1295300A (en) | 2000-06-05 |
| ITMI982477A1 (it) | 2000-05-16 |
| US6566552B2 (en) | 2003-05-20 |
| JP2002529528A (ja) | 2002-09-10 |
| IT1303757B1 (it) | 2001-02-23 |
| US20020165408A1 (en) | 2002-11-07 |
| DE69917318D1 (de) | 2004-06-17 |
| DE69917318T2 (de) | 2005-06-02 |
| ATE266622T1 (de) | 2004-05-15 |
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