CN102824493A - Bupleurum tenue oral liquid for veterinary use and preparation method thereof - Google Patents
Bupleurum tenue oral liquid for veterinary use and preparation method thereof Download PDFInfo
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- Fodder In General (AREA)
- Medicines Containing Plant Substances (AREA)
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Abstract
The invention relates to a bupleurum tenue oral liquid for veterinary use and a preparation method thereof. The effective components of the oral liquid are simple. The preparation method comprises the following steps: preparing materials; extracting bupleurum tenue volatile oil by utilizing a steam distillation method; decocting an extracting liquid medicine; mixing the liquid; preparing a finished product, and the like. According to the preparation method, firstly distilling the bupleurum tenue to extract the bupleurum tenue volatile oil; and then decocting a solid bupleurum tenue medicinal material and other components after the secondary distilling. Compared with the existing bupleurum tenue decoction oral liquid for human use, the bupleurum tenue oral liquid provided by the invention has the advantages of reduction in category of raw materials and production cost. The clinical tests prove that after sicken livestock drinking the bupleurum tenue oral liquid for veterinary use mixed with drinking water, the symptom of pathogenic fever is effectively treated. Therefore, the bupleurum tenue oral liquid provided by the invention can remarkably relieve the symptoms of the pathogenic fever of the livestock, enables to to livestock to increase food consumption and keep nutrient balance. As a result, the percent conversion of feed is improved, and the weight and the laying rate of chicken are restored more quickly. The bupleurum tenue oral liquid is suitable for treatment of the livestock suffering from the pathogenic fever.
Description
Technical field
The invention belongs to the veterinary drug technical field, be specifically related to a kind of little Radix Bupleuri oral liquid for animals and preparation method thereof.
Background technology
The poultry fever caused by exogenous pathogenic factors constantly takes place, and is fast when the symptom of ill poultry shows as spiritual fashion, loss of appetite, and dry mouth and lack of saliva causes serious economy loss for China's aquaculture.Above-mentioned treatment of conditions is generally adopted the heat-clearing and toxic substances removing medicine, though the herbal species of heat-clearing and toxic substances removing is a lot, on using, do not have yet than quantum jump so far, main cause is that product forms is simple, and preparation technology falls behind, clinical use inconvenience etc.
At present, normal use is the medicine that is used to treat the poultry fever caused by exogenous pathogenic factors---bupleurum root powder in the veterinary drug, also discloses the prescription of bupleurum root powder agent in " Chinese veterinary drug allusion quotation ", related contents such as method for making.Bupleurum root powder is the side of simplifying of Herba Sidae Rhombifoliae soup, has treating SHAO YANG disease by mediation, strengthening vital QI to eliminate pathogenic factors; The antipyretic effect, but because powder can not be used for poultry and drink, can only be used for spice; Stir uneven phenomenon and in the spice process, exist, also be not suitable for the breed factory of particulate material, and because powder can not be water-soluble; Must mix in feedstuff, poultry get and can cause all generally that after being ill feed intake descends, so powder can not guarantee every poultry enough medicines of can both searching for food; Therapeutic effect is not very desirable, has limited the use of Chinese powder medicine.
A kind of " Preparation method and its quality control technique of Herba Sidae Rhombifoliae soup oral liquid " disclosed among the Chinese invention patent CN1706417; This oral liquid is taken as people's medicine; Its prescription comprises Radix Bupleuri, Radix Scutellariae, Radix Ginseng, the Rhizoma Pinelliae, Radix Glycyrrhizae, Rhizoma Zingiberis Recens and seven kinds of prescriptions of Fructus Jujubae, and its preparation method is that all prescriptions are flooded, distillation, decoction, precipitate with ethanol, concentrate and get final product.This all components is flooded together, distills and decocts,, do not have specific aim during effective component extracting, and the component that obtained Herba Sidae Rhombifoliae soup relates to is more the method that the effective ingredient of all components comprehensively extracts; In addition, relate to valuable medical materials such as Radix Ginseng in its prescription, improved production cost comparatively speaking, also be not suitable for applying in animal husbandry.Also have, " people's medicine is for animals " belongs to infringement at present, plays " veterinary drug management rules " the 62nd regulation of execution on November 1st, 2004: forbid human drugs are used for animal, violate the rules, answer strictness to forbid.Therefore, can not be simply the Herba Sidae Rhombifoliae soup oral liquid of people's medicine be used to poultry.It is thus clear that the medicament of developing the fever caused by exogenous pathogenic factors of a kind of treatment poultry for animals is significant.
Summary of the invention
The technical problem that the present invention will solve; Provide a kind of little Radix Bupleuri oral liquid for animals and preparation method thereof, its effective ingredient is simple, and this method for preparing is at first distilled Radix Bupleuri; Extract Radix Bupleuri volatile oil; The solid Radix Bupleuri medical material behind the second distillation and other component are decocted, more existing human Herba Sidae Rhombifoliae soup oral liquid raw material type reduces again, and production cost reduces.
For solving the problems of the technologies described above, the technical scheme that the present invention taked is:
A kind of little Radix Bupleuri oral liquid for animals, process its raw materials of effective components and comprise in parts by weight::
20～100 parts of Radix Bupleuri, 20～100 parts of Radix Scutellariaes, 15～80 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s,
20～100 parts of Radix Codonopsis, 5～50 parts in Radix Glycyrrhizae, 0.02～1.0 part of antiseptic.
As a kind of qualification of the present invention, described antiseptic is a kind of in sodium benzoate, sorbic acid, propyl p-hydroxybenzoate or the ethylparaben.
Further qualification as above-mentioned qualification:
The weight of described sodium benzoate is 0.3～1.0 part;
The weight of described sorbic acid is 0.02～0.05 part;
The weight of described propyl p-hydroxybenzoate is 0.05～0.1 part;
The weight of described ethylparaben is 0.05～0.1 part.
The present invention also provides the method for preparing above-mentioned little Radix Bupleuri oral liquid for animals, and it carries out according to the following steps order:
(1) gets the raw materials ready
With detecting qualified Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Codonopsis, Radix Glycyrrhizae Chinese medicine of the five flavours material, take by weighing respective amount, subsequent use;
(2) steam distillation extracts Radix Bupleuri volatile oil
Radix Bupleuri is ground into coarse powder, adds the water of 3～5 times of amount volumes, be heated to 80 ℃, soak 30min post-heating backflow 1h, use steam distillation, collect Radix Bupleuri distillate A just;
With the Radix Bupleuri of collecting just distillate A carry out redistillation and extract, promptly get the solid Radix Bupleuri medical material Z behind Radix Bupleuri volatile oil C and the second distillation;
(3) decoct the extraction medicinal liquid
Solid Radix Bupleuri medical material Z, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Codonopsis, Radix Glycyrrhizae are put into extraction pot together, add the water of 8～10 times of volumes, behind the soak at room temperature 30min, add Radix Scutellariae behind the decoction 30min, decoct 30min again, get decoction liquor; The water that medicinal residues add 8～10 times of volumes carries out the secondary decoction, decocts 1h, gets decoction liquor; Merge decoction liquor twice, put coldly, filter, filtrate decompression concentrates, and puts coldly, adds 30%～70% ethanol, stirs, and leaves standstill, filter, the united extraction medicinal liquid, after concentrating concentrated solution D;
(4) dosing
With adding the Tween-80 mixing among the Radix Bupleuri volatile oil C of gained, slowly join among the concentrated solution D again, stir, add antiseptic, promptly get dosing E;
(5) preparation of finished product
The pH value of regulating dosing E is 4.0～7.0, fill, and sterilization promptly gets little Radix Bupleuri oral liquid for animals.
Owing to adopted above-mentioned technical scheme, the present invention compared with prior art, the technological progress that is obtained is:
The effective ingredient of little Radix Bupleuri oral liquid for animals is simple, and its preparation method at first distills Radix Bupleuri, extracts Radix Bupleuri volatile oil, other component is decocted again, and more existing Herba Sidae Rhombifoliae soup oral liquid raw material type reduces, and production cost reduces.Through after the clinical trial, little Radix Bupleuri oral liquid mixes the back and mixes drink for ill domestic animal fowl with the water of drinking, condition of illness is obtained the effective treatment.After using the prepared little Radix Bupleuri oral liquid of the present invention, significantly relief of symptoms increases feed intake, keeps the body nutritive equilibrium, thereby improves food conversion ratio; When being used to treat the chicken that suffers from fever caused by exogenous pathogenic factors, can comparatively fast recover body weight and the laying rate of chicken, and the optimum prescription among the present invention all is superior to the prescription proportioning in " Chinese veterinary drug allusion quotation " for laying rate and therapeutic effect aspect.
The present invention is applicable to the treatment of the fever caused by exogenous pathogenic factors of poultry.
The present invention below will combine specific embodiment to do further explain.
The specific embodiment
Embodiment 1
A kind of little Radix Bupleuri oral liquid for animals, process its raw materials of effective components and comprise by weight:
Radix Bupleuri 50 g, Radix Scutellariae 50 g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 40 g,
Radix Codonopsis 40 g, Radix Glycyrrhizae 20 g, antiseptic 0.5 g.
Wherein, described antiseptic is a sodium benzoate.
The method of above-mentioned little Radix Bupleuri oral liquid for animals, it carries out according to the following steps order:
(1) gets the raw materials ready
With Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Codonopsis, Radix Glycyrrhizae Chinese medicine of the five flavours material, detect qualified after, take by weighing corresponding weight, subsequent use;
(2) steam distillation extracts Radix Bupleuri volatile oil
Radix Bupleuri is ground into coarse powder, adds the water of 5 times of amounts, be heated to 80 ℃, soak 30min post-heating backflow 1h, use steam distillation, collect Radix Bupleuri distillate A just;
With the Radix Bupleuri of collecting just distillate A carry out redistillation and extract, promptly get the solid Radix Bupleuri medical material Z behind Radix Bupleuri volatile oil C and the second distillation;
(3) decoct the extraction medicinal liquid
Solid Radix Bupleuri medical material Z, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Codonopsis, Radix Glycyrrhizae are put into extraction pot together, add the water of 10 times of volumes, behind the soak at room temperature 30min, add Radix Scutellariae behind the decoction 30min, decoct 30min again, get decoction liquor; The water that medicinal residues add 10 times of volumes carries out the secondary decoction, decocts 1h, gets decoction liquor; Merge decoction liquor twice, put cold (promptly being cooled to room temperature), filter, filtrate decompression concentrates, and puts cold (promptly being cooled to room temperature), adds 70% ethanol, stirs, and leaves standstill, and filters, and the united extraction medicinal liquid gets concentrated solution D after concentrating;
(4) dosing
With adding the Tween-80 mixing among the Radix Bupleuri volatile oil C of gained, slowly join among the concentrated solution D again, stir, add antiseptic, promptly get dosing E;
(5) preparation of finished product
The pH value of regulating dosing E is 7.0, fill, and sterilization promptly gets little Radix Bupleuri oral liquid for animals.The crude drug total amount that contains among the prepared little Radix Bupleuri oral liquid 1mL is about 1g.
Application case 1:The Shijiazhuang City, Hebei Province raiser has supported 5000 blue ashes in sea, and the spirit Mi that withers appears in 180 ages in days; Feed intake descends, respiratory symptom, and indivedual chickens occur slow-witted upright, draw the yellow-white loose stool; Laying rate descends, and after being undertaken treating in four days by escherichia coli, symptom disappears basically; But feed intake does not increase always, and body is become thin, and laying rate is lower.
[cuing open the inspection result] chosen five chickens that become thin, and dissects; The dissection symptom is following: edema, hyperemia and congestion pathological changes appear in gastric mucosa; Liver swelling, jaundice, frangible.
Formulate therapeutic scheme to above-mentioned situation, therapeutic scheme 1 adopts the prepared for animals little Radix Bupleuri oral liquid of the present invention to treat; Therapeutic scheme 2 adopts the bupleurum root powder agent that is provided in " Chinese veterinary drug allusion quotation " to treat, and concrete therapeutic scheme and therapeutic outcome are following:
[therapeutic scheme 1] at first strengthened feeding and management, and waterline is thoroughly cleaned up, and reuse cod-liver oil drinking-water mixes drink with the prepared little Radix Bupleuri oral liquid of the present invention, and dosage is 0.25mL//day, logotype three days.
Paid a return visit in the 4th day, feed intake increases, and does not rebound, and laying rate was from bottom out in the 3rd day.
[therapeutic scheme 2] at first strengthened feeding and management, and waterline is thoroughly cleaned up, and again bupleurum root powder and feedstuff carried out the stirring and evenly mixing raising, and it is edible to supply fowl to concentrate, continuous three days.
Paid a return visit in the 4th day, feed intake slightly increases, and laying rate is still lower.
Analysis result:Because the bupleurum root powder agent can not be water-soluble, must mix in feedstuff, chicken gets and can cause all generally that after being ill feed intake descends, so the bupleurum root powder agent can not guarantee every chicken enough medicines of can both searching for food, therapeutic effect is not very desirable.Little Radix Bupleuri oral liquid mixes the back and drinks for ill domestic animal fowl with the water of drinking, condition of illness is obtained the effective treatment.
Application case 2:Shandong one raiser supports 11000 of the blue brown laying hens in sea, and 285 age in days chickens are mass-sended after being ill, and local veterinary is diagnosed as infectious laryngotracheitis, treat after 7 days, and be about 10% through the statistics mortality rate, about 10000 of residue chicken number.The recurrent cough still appears in the chicken crowd, the white expectorant of the clear rare foam of expectoration, and feed intake is on the low side, and laying rate is about 65%.
[cuing open the inspection result] chosen five chickens that become thin, and dissects; The dissection symptom is following: the inflammation of larynx mucosa, swelling.
The chicken crowd is divided into four groups, compares test, result of the test is following:
The computational methods of above-mentioned therapeutic outcome are following:
[cure rate] according to there not being cough, and feed intake, amount of drinking water are normal, do not have the judgement clinical cure of sequela, calculates cure rate.
After [inefficiency] all medications, cough, feed intake, amount of drinking water are normal etc., and nothings is clearly better, and sb.'s illness took a turn for the worse, even depleted dead, and cuing open inspection has being calculated as of tangible pathological change invalid, accounts for every group of sum ratio calculating inefficiency according to invalid number of elements.
After [obvious effective rate] all medications, main pathological symptom is alleviated to some extent, but do not cure fully be calculated as produce effects, the ratio that accounts for every group of sum according to the produce effects number of elements is calculated obvious effective rate.
After [effective percentage] all medications, main pathology transference cure, it is normal that each item physical signs is recovered; No sequel (promptly cure), or cardinal symptom alleviates to some extent, but cure (being produce effects) fully; Be effectively, the ratio that accounts for every group of sum according to effective number of elements is calculated effective percentage.
Analysis result: the chicken crowd gets after being ill, owing to dyspnea, asthma, cough, causes and suffers from the decline of chicken feed intake; Growth promoter is slow, and feed conversion rate is low, use the prepared little Radix Bupleuri oral liquid of the present invention after; Significantly relief of symptoms increases feed intake, keeps the body nutritive equilibrium; Thereby improve food conversion ratio, comparatively fast recover body weight and the laying rate of chicken.Optimum prescription among the present invention all is superior to the prescription proportioning in " Chinese veterinary drug allusion quotation " for laying rate and therapeutic effect aspect.
Embodiment 2-13
Embodiment 2-13 is similar with embodiment 1 described method for preparing, and difference only is that the constituent content of parameter related in the preparation process and little Radix Bupleuri oral liquid is different, specifically shown in table 1～table 3:
What wherein, the adjusting of pH value was used is the hydrochloric acid of 0.1mol/L or the sodium hydroxide solution of 0.1mol/L.
Embodiment 14
Prepared for animals little Radix Bupleuri oral liquid among above-mentioned all embodiment of the present invention is respectively applied for chicken, duck, cattle, horse, sheep and pig that fever caused by exogenous pathogenic factors is suffered from treatment, proves that product of the present invention can significantly alleviate the disease of poultry, increases feed intake.In the actual therapeutic process, dosage is controlled as follows:
1.5 the chicken of～2.0kg and duck, dosage are 0.25～1.0mL/; The sheep and the pig that are about 60kg, dosage are 10～30mL//day; The cattle and the horse dosage that are about 400kg are 50～200mL//day.
Claims (7)
1. little Radix Bupleuri oral liquid for animals,
It is characterized in thatProcessing its raw materials of effective components comprises in parts by weight:
20～100 parts of Radix Bupleuri, 20～100 parts of Radix Scutellariaes, 15～80 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s,
20～100 parts of Radix Codonopsis, 5～50 parts in Radix Glycyrrhizae, 0.02～1.0 part of antiseptic.
2. little Radix Bupleuri oral liquid for animals according to claim 1,
It is characterized in that:Described antiseptic is a kind of in sodium benzoate, sorbic acid, propyl p-hydroxybenzoate or the ethylparaben.
3. little Radix Bupleuri oral liquid for animals according to claim 2,
It is characterized in that:The weight of described sodium benzoate is 0.3～1.0 part.
4. the method for preparing of little Radix Bupleuri oral liquid for animals according to claim 2,
It is characterized in that:The weight of described sorbic acid is 0.02～0.05 part.
5. the method for preparing of little Radix Bupleuri oral liquid for animals according to claim 2,
It is characterized in that:The weight of described propyl p-hydroxybenzoate is 0.05～0.1 part.
6. the method for preparing of little Radix Bupleuri oral liquid for animals according to claim 2,
It is characterized in that:The weight of described ethylparaben is 0.05～0.1 part.
7. method for preparing like each described little Radix Bupleuri oral liquid for animals among the claim 1-6,
It is characterized in thatIt carries out according to the following steps order:
(1) gets the raw materials ready
With detecting qualified Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Codonopsis, Radix Glycyrrhizae Chinese medicine of the five flavours material altogether, respectively take by weighing respective amount, subsequent use;
(2) steam distillation extracts Radix Bupleuri volatile oil
Radix Bupleuri is ground into coarse powder, adds the water of 3～5 times of amounts, be heated to 80 ℃, soak 30min post-heating backflow 1h, extract, collect and obtain Radix Bupleuri distillate A just with steam distillation;
With Radix Bupleuri just distillate A carry out redistillation, promptly get the solid Radix Bupleuri medical material Z behind Radix Bupleuri volatile oil C and the second distillation;
(3) decoct the extraction medicinal liquid
Solid Radix Bupleuri medical material Z, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Codonopsis, Radix Glycyrrhizae are put into extraction pot together, add the water of 8～10 times of volumes, behind the soak at room temperature 30min, add Radix Scutellariae behind the decoction 30min, decoct 30min again, get decoction liquor; The water that medicinal residues add 8～10 times of volumes carries out the secondary decoction, decocts 1h, gets decoction liquor; Merge decoction liquor twice, put coldly, filter, filtrate decompression concentrates, and puts coldly, adds 30%～70% ethanol, stirs, and leaves standstill, filter, the united extraction medicinal liquid, after concentrating concentrated solution D;
(4) dosing
Add Tween-80 among the Radix Bupleuri volatile oil C with gained, mixing slowly joins among the concentrated solution D again, stirs, and adds antiseptic, promptly gets dosing E;
(5) preparation of finished product
The pH value of regulating dosing E is 4.0～7.0, fill, and sterilization promptly gets little Radix Bupleuri oral liquid for animals.
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| CN105726689A (en) * | 2016-03-30 | 2016-07-06 | 南宁市百济生物工程有限公司 | Antiviral oral liquid for livestock and preparation method thereof |
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| CN1188005A (en) * | 1997-01-13 | 1998-07-22 | 山东省中医药研究所 | Chinese herbal medicine oral liquor for curing wind-heat common cold and its preparing method |
| CN1706417A (en) * | 2004-06-05 | 2005-12-14 | 余世春 | Prepn process and quality control technology of decoction of bupleurum root for regulating Shaoyang |
| CN1939486A (en) * | 2006-09-28 | 2007-04-04 | 天津生机集团有限公司 | Chinese-medicinal composition for treating fowl cough and fever |
| CN102100885A (en) * | 2009-12-17 | 2011-06-22 | 苏州知微堂生物科技有限公司 | Preparation technology and production method of integrated minor bupleurum decoction novel dosage form |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1188005A (en) * | 1997-01-13 | 1998-07-22 | 山东省中医药研究所 | Chinese herbal medicine oral liquor for curing wind-heat common cold and its preparing method |
| CN1706417A (en) * | 2004-06-05 | 2005-12-14 | 余世春 | Prepn process and quality control technology of decoction of bupleurum root for regulating Shaoyang |
| CN1939486A (en) * | 2006-09-28 | 2007-04-04 | 天津生机集团有限公司 | Chinese-medicinal composition for treating fowl cough and fever |
| CN102100885A (en) * | 2009-12-17 | 2011-06-22 | 苏州知微堂生物科技有限公司 | Preparation technology and production method of integrated minor bupleurum decoction novel dosage form |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105726689A (en) * | 2016-03-30 | 2016-07-06 | 南宁市百济生物工程有限公司 | Antiviral oral liquid for livestock and preparation method thereof |
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