CN105535198B - Traditional Chinese medicine composition for treating poultry hydropericardium - Google Patents
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Abstract
The invention discloses a traditional Chinese medicine composition for treating poultry hydropericardium, which comprises the following raw materials in percentage by weight: 10 to 40 percent of prepared common monkshood daughter root, 10 to 30 percent of cinnamon, 5 to 20 percent of angelica, 5 to 20 percent of Szechuan lovage rhizome, 5 to 20 percent of tangerine peel, 5 to 15 percent of white paeony root, 5 to 15 percent of largehead atractylodes rhizome, 5 to 15 percent of Indian buead, 2 to 10 percent of ginseng leaf, 2 to 15 percent of honey-fried licorice root and 2 to 15 percent of Chinese date. The traditional Chinese medicine composition prepared by the invention not only accords with the basic theory of traditional Chinese (veterinary) medicine, but also has the test in veterinary clinical application. Through the traditional Chinese medicine composition and the use method and the dosage thereof, the traditional Chinese medicine composition has definite treatment effect on poultry pericardial effusion, has a protection function on liver diseases, and has good protection and rehabilitation functions on kidney, ovary, thymus, bursa of fabricius and other immune organs; the medicine can improve the flavor of the mobility product (meat protein) after being digested and absorbed, and also avoids the defect of chemical medicine residue, thereby having wide market demand prospect.
Description
Technical Field
The invention belongs to the technical field of veterinary drug preparations, and particularly relates to a traditional Chinese medicine composition for treating poultry hydropericardium.
Background
In recent years, a disease with pericardial effusion as an important characteristic is increasingly appeared in the poultry breeding industry, and compared with poultry such as ducks, geese and the like, the disease is especially serious in broiler farms, the morbidity is different from 30-90%, the mortality is different from 10-50%, but the mortality is mostly about 30%. In a sick chicken farm, besides the pericardial effusion which is a relatively stable important characteristic, one or more of pulmonary edema, liver necrosis, thymus gland, bursa of fabricius and other immune organs are also commonly accompanied, which causes huge economic loss to the chicken industry and is a hot problem in current veterinary clinical research.
From public reported data and our practice, the age of the disease day is mostly concentrated on 2-7 weeks, the latent period is generally not more than 4 days, and the disease is rapid in a well-grown chicken flock and is usually suddenly dead. Sometimes there is no other obvious change except a slight retardation of growth, and only death is shown. The mortality rate is in an increasing trend in the first 3-5 days, the death peak is after 5-7 days, the death peak can last for 5-8 days, and then the disease course begins to decrease for 10-14 days. The sick chickens mostly show lassitude, disharmony and lusterless feathers, individual anorexia, no increase or decrease of food consumption, and individual white loose stools.
The most important pathological feature is that much yellowish jelly-like liquid is in the pericardium when dissected. Other characteristics include one or more of necrosis or mottled color of the liver, slight edema of the lung, swelling of the kidney or urate deposition to some extent, atrophy of immune organs such as the thymus and the bursa of fabricius, and ovarian growth arrest. Some samples can be observed in the liver cell nucleus under the microscope, and parvovirus or adenovirus can be separated from the pathological material.
Different conclusions have been drawn based on different studies, but the effect of using it in practice is often limited. Measures such as administration of different antibacterial agents, supplementation of different trace elements, improvement of feed management conditions, improvement of feed material quality, even production of a specialized yolk antibody, and the like are still of little effect, and some of the once effective measures often occur with a phenomenon that cannot be reproduced repeatedly. In conclusion, for the diseases which are caused by the pericardial effusion which is an important characteristic of the poultry, the method has been proposed as 32429and the first mode. Poultry pericardial effusion has become an untreatable disease in veterinary clinics, a problem that plagues the veterinary industry, and this disease is causing increasing economic losses.
Therefore, there is a great need in veterinary clinical practice to find a safe, inexpensive medicament or measure that is effective against poultry pericardial effusion.
Disclosure of Invention
Aiming at the problems in the prior art, the invention aims to provide a traditional Chinese medicine composition for treating poultry hydropericardium, in order to more safely and more effectively reduce the loss of diseases which take the hydropericardium as an important characteristic to the breeding industry.
The technical scheme adopted by the invention is as follows:
a traditional Chinese medicine composition for treating poultry hydropericardium comprises the following raw materials in percentage by weight:
10 to 40 percent of prepared common monkshood daughter root, 10 to 30 percent of cinnamon, 5 to 20 percent of angelica, 5 to 20 percent of Szechuan lovage rhizome, 5 to 20 percent of tangerine peel, 5 to 15 percent of white paeony root, 5 to 15 percent of largehead atractylodes rhizome, 5 to 15 percent of Indian buead, 2 to 10 percent of ginseng leaf, 2 to 15 percent of honey-fried licorice root and 2 to 15 percent of Chinese date.
Further, the Chinese medicinal composition is processed into powder, liquid, paste, granules, capsules or other pharmaceutically acceptable physical forms.
Further, the use method and the dosage of the traditional Chinese medicine composition are as follows: the composition is processed and extracted to prepare liquid medicine, and 1 liter of liquid medicine is mixed with 10 kg-1500 kg of water to be freely drunk by poultry.
Furthermore, the traditional Chinese medicine composition is applied to preparing medicines for treating stem cell injury and improving meat quality and flavor of poultry.
The theoretical basis to which the present invention relates is in traditional (veterinary) medicine. According to the guidance of the basic theory of Yin-Yang five-row and zang-fu organs in traditional (veterinary) medicine, the pathogenesis of pericardial effusion is considered to be the reason that heart-yang fails to warm kidney water and can not support spleen-earth, so that spleen-earth yang deficiency can not restrict kidney water and can also cause abnormal liver-wood catharsis. The detailed description is as follows:
physiologically, five zang organs should mutually strengthen, restrain and coordinate, their centers are closely related to kidneys, heart yang should continuously descend to support kidney yang, and heart yang and kidney yang warm kidney yin together to make kidney water cold, so pathologically, they will mutually affect each other, and once heart yang fails to vibrate, three adverse effects will be produced.
The first reason why heart yang fails to perform the warming function of kidney water is that kidney water tends to congeal and generate water vapor to blow the heart, which is the main reason for jelly-like accumulation in the pericardium.
In addition, the heart-yang deficiency also produces two related effects, one is that the heart-yang supports insufficient spleen-earth, and causes spleen-earth yang deficiency, which leads to the normal functions of 'spleen governing transportation and transformation, exterior and interior with stomach' to be limited, and the normal functions of spleen transporting and transforming water-dampness are reduced, and excessive water-dampness stays in the body, especially causes abnormal accumulation of liquid in the pericardium; the other is the 'son-mother-qi stealing' which causes the disorder of liver qi in smoothing flow of qi due to heart-yang deficiency, the disorder of liver qi in smoothing flow of qi not only affects the appetite and digestion function together with spleen-earth yang deficiency, and shows as liver necrosis or mottle color, decreased food intake and loose stool, but also can not sufficiently smooth the triple energizer to regulate the rising and falling of water, shows as water metabolism disorder and excessive water retention in the body.
The above factors cause diseases with jelly-like pericardial effusion as an important characteristic. Therefore, in terms of treatment, the treatment should focus on the improvement of vibration, warming and tonifying heart yang, strengthening spleen to promote diuresis, soothing liver to regulate qi.
The beneficial results of the invention are:
the traditional Chinese medicine composition disclosed by the invention selects radix aconiti lateralis preparata as a monarch drug, enters heart, kidney and spleen channels, tonifies heart yang, and supports kidney yang to warm kidney yin and kidney water, so that cold qi is dispelled, and the viscosity of jelly-like pericardial effusion is reduced; cinnamon, angelica, ligusticum wallichii and dried orange peel are selected as ministerial drugs, enter pericardium, kidney, spleen and liver channels, assist the monkshood to strengthen yang and dispel cold, and achieve the effects of activating blood circulation, dissipating blood stasis, soothing liver and regulating qi; white paeony root, largehead atractylodes rhizome, Indian buead and ginseng leaf are selected as adjuvant drugs, enter heart, liver, spleen, lung and kidney channels, nourish blood and soften liver, strengthen spleen and stomach, accelerate the metabolic process of redundant water liquid and reduce the retention of pericardial effusion; mix prepared licorice and Chinese date as "guiding drugs", enter heart, spleen and stomach channels, tonify heart yang, strengthen the function of monkshood, coordinate the drugs, and play the roles of warming heart yang, strengthening spleen, promoting diuresis, soothing liver and regulating qi.
The traditional Chinese medicine composition has a protective effect on the liver function of a sick animal by matching with the components of white paeony root, tuckahoe and the like with the functions of nourishing blood and softening liver, can strengthen the detoxification function of the liver, promote the secretion of bile and the improvement of feed intake, strengthen the elasticity and the absorption function of renal tubular endothelial cells and relieve the swelling and swelling degree of the kidney.
The traditional Chinese medicine composition can improve the cellular immunity and humoral immunity of animal organisms to enhance the basic resistance by regulating the physiological functions of immune organs such as thymus, bursa of fabricius and the like by matching components such as bighead atractylodes rhizome, ginseng leaves and the like, greatly reduces the morbidity in the feeding process and prolongs the healthy growth time.
The traditional Chinese medicine composition disclosed by the invention is reasonably matched with the components such as the Chinese angelica, the ligusticum wallichii, the dried orange peel and the cinnamon, is rich in beneficial volatile fat-soluble substances, and can promote the recovery of ovarian function and improve the flavor of animal products (meat, eggs and milk) after being digested and absorbed, so that the consumption quality of animal food can be improved, and the market demand prospect is wide.
The traditional Chinese medicine composition contains a plurality of traditional Chinese medicines, is safe and nontoxic, has very complicated separable chemical substances, and has very many corresponding effects. Therefore, the diversity of the components of the traditional Chinese medicine composition provides a material basis for the diversity of the functions of the traditional Chinese medicine composition, and the traditional Chinese medicine composition has a very good help for improving the health level of animals and the economic benefit of the breeding industry.
The traditional Chinese medicine composition prepared by the invention not only accords with the basic theory of traditional Chinese (veterinary) medicine, but also has the test in veterinary clinical application. The traditional Chinese medicine composition and the use method and the dosage thereof have definite treatment effect on poultry pericardial effusion, avoid the defect of chemical drug residue, and have positive significance for promoting the healthy growth of animals, improving the economic benefit of breeding industry and ensuring the safety of animal food.
Detailed Description
The present invention will be further described with reference to the following examples.
A traditional Chinese medicine composition for treating poultry hydropericardium comprises the following raw materials in percentage by weight: 10 to 40 percent of prepared common monkshood daughter root, 10 to 30 percent of cinnamon, 5 to 20 percent of angelica, 5 to 20 percent of Szechuan lovage rhizome, 5 to 20 percent of tangerine peel, 5 to 15 percent of white paeony root, 5 to 15 percent of largehead atractylodes rhizome, 5 to 15 percent of Indian buead, 2 to 10 percent of ginseng leaf, 2 to 15 percent of honey-fried licorice root and 2 to 15 percent of Chinese date.
Further, the Chinese medicinal composition is processed into powder, liquid, paste, granules, capsules or pharmaceutically acceptable physical forms.
Further, the use method and the dosage of the traditional Chinese medicine composition are as follows: the composition is processed and extracted to prepare liquid medicine, and the liquid medicine is added with 10 kg-1500 kg of water according to 1 liter of liquid medicine for poultry to drink freely.
The composition is tested, and the contents of toxic and harmful substances of lead (pb) and arsenic (As) do not exceed the standard specified in pharmacopoeia of the people's republic of China and animal, department II.
Example 1
A small chicken farm, namely 21-day-old large-sized broiler, comprises four sheds, each shed is 7900 more, and the overall situation of a large group is basically normal. Wherein, the number of dead people is only changed between the shed No. 3 and the shed No. 4 for two consecutive days, and the number of dead people is 68 or 73. Through careful observation and inquiry of farmers, the feed intake is one bag less than the standard feed intake, the excrement, drinking water, the mental state of chicken flocks, ventilation and temperature are basically normal, and no obvious abnormality is seen on the whole. Dead chickens are judged to die from 'excessive hydropericardium' only through anatomical diagnosis, and have the main pathological changes as follows: 7/13 account for more yellowish jelly-like liquid in the pericardium, 5/13 account for a small amount of yellowish jelly-like liquid in the pericardium, and 1/13 account for no abnormality in the pericardium; meanwhile, 6/13 with liver color nonuniformity and necrotic spots, 6/13 with liver color nonuniformity and no dead spots and 1/13 with normal liver appearance; one or more of the other organs and sites such as the lung and kidney had slightly swollen area 5/13, while no swollen area 8/13 was observed.
The chicken flocks were divided into A, B groups, with group A as the control group and group B as the test group, using the central passage in the chicken house as the boundary.
The control group adopts a conservative scheme of drinking water of florfenicol powder and mixing materials of traditional Chinese medicine of Wuling san according to general measures. Commercially available 10% florfenicol powder was administered to drinking water at a dose of 20mg per 1kg body weight; the powder is mixed with 500kg complete feed at a ratio of 1kg for administration, and is continuously treated for 4 days.
The test group used the Chinese medicinal composition of the invention as a therapeutic drug. According to the proportion of 25kg of prepared monkshood, 10kg of cinnamon, 5kg of angelica, 10kg of ligusticum wallichii, 10kg of dried orange peel, 5kg of white paeony root, 10kg of bighead atractylodes rhizome, 10kg of tuckahoe, 5kg of ginseng leaf, 5kg of honey-fried licorice root and 5kg of Chinese date, 8 times of water is added for decoction twice, the liquid medicines in the two times are combined, concentrated and stood, filtered, and the supernatant is taken for split charging for standby. 1 liter of the liquid medicine is mixed with 800kg of water to be freely drunk by sick chicken groups suffering from the pericardial effusion for 5 days.
Example 2
A traditional Chinese medicine composition for treating poultry hydropericardium comprises the following raw materials in percentage by weight:
10kg of prepared monkshood, 30kg of cinnamon, 5kg of angelica, 20kg of ligusticum wallichii, 5kg of dried orange peel, 15kg of white paeony root, 6kg of bighead atractylodes rhizome, 5kg of tuckahoe, 2kg of ginseng leaf, 2kg of honey-fried licorice root and 2kg of Chinese date. Adding 8 times of water, decocting twice, mixing the two liquid medicines, concentrating, standing, filtering, taking supernatant, and packaging for later use. 1 liter of the liquid medicine is mixed with 1200kg of water to be freely drunk by sick chicken groups suffering from the pericardial effusion for 5 days.
Example 3
A traditional Chinese medicine composition for treating poultry hydropericardium comprises the following raw materials in percentage by weight:
40kg of prepared monkshood, 9kg of cinnamon, 20kg of angelica, 5kg of ligusticum wallichii, 5kg of dried orange peel, 5kg of white paeony root, 5kg of bighead atractylodes rhizome, 5kg of poria cocos, 2kg of ginseng leaf, 2kg of honey-fried licorice root and 2kg of Chinese date. Adding 8 times of water, decocting twice, mixing the two liquid medicines, concentrating, standing, filtering, taking supernatant, and packaging for later use. 1 liter of the liquid medicine is mixed with 1000kg of water to be freely drunk by sick chicken groups suffering from the pericardial effusion for 5 days.
Example 4
A traditional Chinese medicine composition for treating poultry hydropericardium comprises the following raw materials in percentage by weight:
10kg of prepared monkshood, 10kg of cinnamon, 5kg of angelica, 5kg of ligusticum wallichii, 5kg of dried orange peel, 5kg of white paeony root, 15kg of bighead atractylodes rhizome, 15kg of tuckahoe, 10kg of ginseng leaf, 10kg of honey-fried licorice root and 10kg of Chinese date. Adding 8 times of water, decocting twice, mixing the two liquid medicines, concentrating, standing, filtering, taking supernatant, and packaging for later use. 1 liter of the liquid medicine is mixed with 900kg of water to be freely drunk by sick chicken groups suffering from the pericardial effusion for 5 days.
Example 5
A traditional Chinese medicine composition for treating poultry hydropericardium comprises the following raw materials in percentage by weight:
20kg of prepared monkshood, 20kg of cinnamon, 10kg of angelica, 10kg of ligusticum wallichii, 8kg of dried orange peel, 8kg of white paeony root, 7kg of bighead atractylodes rhizome, 7kg of poria cocos, 3kg of ginseng leaf, 3kg of honey-fried licorice root and 4kg of Chinese date. Adding 8 times of water, decocting twice, mixing the two liquid medicines, concentrating, standing, filtering, taking supernatant, and packaging for later use. 1 liter of the liquid medicine is mixed with 900kg of water to be freely drunk by sick chicken groups suffering from the pericardial effusion for 5 days.
The mental status, feed intake, death number and hydropericardium of the large group of the control group and the test group are counted respectively on the fifth day. Statistical results are presented as averages, as shown in the following table.
Conclusion analysis:
1. in the aspect of mental status of a large group, a test group is obviously better than a control group, which shows that compared with a common medicine compatibility scheme, the traditional Chinese medicine composition has an obvious effect on recovering the overall health of chicken groups.
2. In the aspect of average food intake, the average food intake of the test group is 16.5% higher than that of the control group and is basically close to the normal food intake, which shows that the traditional Chinese medicine composition has the function of recovering the food intake more quickly compared with the common medicine compatibility scheme.
3. In the aspect of death number, the average of the test group is 75.6% lower than that of the control group, which indicates that the treatment of the treatment scheme of the control group fails, and also indicates that the traditional Chinese medicine composition can quickly treat death caused by hydropericardium.
4. In the aspect of observing the pericardial effusion of the live chicken by a caesarean section, the 5/5 pericardium of the control group has more yellowish jelly-like effusion, while the test groups of the examples 2 and 3 only have 1/5 visible trace pericardial effusion but almost approximate to the normal amount, which shows that the traditional Chinese medicine composition has faster and better curative effect on treating the pericardial effusion of the chicken.
In conclusion, the oral liquid prepared by the extraction process has a definite therapeutic effect on poultry pericardial effusion, and the defect of chemical drug residue is avoided.
The above description is only for the specific embodiments of the present invention, and not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the protection scope of the present invention.
Claims (3)
1. The traditional Chinese medicine composition for treating poultry pericardial effusion is characterized by comprising the following raw materials in percentage by weight: 10kg to 40kg of prepared aconite, 10kg to 30kg of cinnamon, 5kg to 20kg of angelica, 5kg to 20kg of rhizoma ligustici wallichii, 5kg to 20kg of dried orange peel, 5kg to 15kg of white paeony root, 5kg to 15kg of bighead atractylodes rhizome, 5kg to 15kg of tuckahoe, 2kg to 10kg of ginseng leaf, 2kg to 15kg of honey-fried licorice root and 2kg to 15kg of Chinese date; the pericardial effusion is jelly-like pericardial effusion.
2. The traditional Chinese medicine composition for treating poultry pericardial effusion according to claim 1, characterized in that the traditional Chinese medicine composition is processed into powder, liquid, paste, granules, capsules or other pharmaceutically acceptable physical forms.
3. The traditional Chinese medicine composition for treating poultry pericardial effusion according to claim 1 or 2, characterized in that the preparation method of the traditional Chinese medicine composition is as follows: adding 8 times of water, decocting twice, mixing the two liquid medicines, concentrating, standing, filtering, taking supernatant, and packaging for later use; the dosage of the traditional Chinese medicine composition is as follows: 1 liter of the liquid medicine is mixed with 800 kg-1000 kg of water to be freely drunk by sick chicken flocks with pericardial effusion for 5 days.
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| CN105878716B (en) * | 2016-05-30 | 2019-09-13 | 山东省农业科学院家禽研究所 | A kind of Chinese herbal compound preparation for preventing and treating chicken hydropericardium syndrome |
| CN106729707B (en) * | 2017-01-19 | 2021-08-24 | 天津市中升挑战生物科技有限公司 | Composite yolk antibody for preventing and treating chicken pericardial effusion-hepatitis syndrome and preparation method thereof |
| CN108478639B (en) * | 2018-05-28 | 2020-11-10 | 安徽科技学院 | Traditional Chinese medicine composition for treating/preventing poultry Ankara disease and preparation method and application thereof |
| CN111480746A (en) * | 2020-04-26 | 2020-08-04 | 黑龙江省农业科学院畜牧兽医分院 | Preparation method and application of feed additive for resisting hydropericardium syndrome of chickens |
| CN113117011A (en) * | 2021-06-04 | 2021-07-16 | 济南广盛源生物科技有限公司 | Traditional Chinese medicine composition for preventing and treating poultry hydropericardium syndrome |
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