CN102821754B - 多层熔融挤出膜 - Google Patents

多层熔融挤出膜 Download PDF

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Publication number
CN102821754B
CN102821754B CN201180016068.3A CN201180016068A CN102821754B CN 102821754 B CN102821754 B CN 102821754B CN 201180016068 A CN201180016068 A CN 201180016068A CN 102821754 B CN102821754 B CN 102821754B
Authority
CN
China
Prior art keywords
layer
film
active component
active ingredient
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201180016068.3A
Other languages
English (en)
Chinese (zh)
Other versions
CN102821754A (zh
Inventor
M.霍尔
K.科彭斯
M.里德
U.施雷萨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Global Technologies LLC
Original Assignee
Dow Global Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Global Technologies LLC filed Critical Dow Global Technologies LLC
Publication of CN102821754A publication Critical patent/CN102821754A/zh
Application granted granted Critical
Publication of CN102821754B publication Critical patent/CN102821754B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
CN201180016068.3A 2010-03-26 2011-02-25 多层熔融挤出膜 Expired - Fee Related CN102821754B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31789310P 2010-03-26 2010-03-26
US61/317,893 2010-03-26
PCT/US2011/026230 WO2011119288A2 (en) 2010-03-26 2011-02-25 Multilayer melt-extruded film

Publications (2)

Publication Number Publication Date
CN102821754A CN102821754A (zh) 2012-12-12
CN102821754B true CN102821754B (zh) 2014-06-18

Family

ID=43901622

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180016068.3A Expired - Fee Related CN102821754B (zh) 2010-03-26 2011-02-25 多层熔融挤出膜

Country Status (6)

Country Link
US (1) US20110236443A1 (enExample)
EP (1) EP2552402B1 (enExample)
JP (1) JP5749790B2 (enExample)
KR (1) KR20130010482A (enExample)
CN (1) CN102821754B (enExample)
WO (1) WO2011119288A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
CN105816434B (zh) * 2016-04-19 2019-09-17 山东新华制药股份有限公司 布洛芬颗粒及其制备方法
KR101790666B1 (ko) * 2017-06-27 2017-10-26 (주)조안엠앤에스 애완동물용 구강용해필름
CN112218529A (zh) * 2018-04-27 2021-01-12 福莱西因赛特股份有限公司 包含1-甲基环丙烯与α-环糊精的络合物的组合物和制品

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19852826A1 (de) * 1998-11-17 2000-05-18 Aventis Res & Tech Gmbh & Co Poly(alpha-1,4-D-Glucan)
US6375963B1 (en) * 1999-06-16 2002-04-23 Michael A. Repka Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof
WO2007112285A2 (en) * 2006-03-24 2007-10-04 Auxilium Pharmaceuticals, Inc. Process for the preparation of a hot-melt extruded laminate

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA849081A (en) * 1967-03-02 1970-08-11 Du Pont Of Canada Limited PRODUCTION OF ETHYLENE/.alpha.-OLEFIN COPOLYMERS OF IMPROVED PHYSICAL PROPERTIES
US4645812A (en) 1983-02-28 1987-02-24 Henkel Corporation Method of suspension polymerization of vinyl chloride
US4729190A (en) * 1983-10-27 1988-03-08 Ciba-Geigy Corporation Membrane-forming polymeric systems
US5272236A (en) * 1991-10-15 1993-12-21 The Dow Chemical Company Elastic substantially linear olefin polymers
TW207987B (enExample) 1991-03-20 1993-06-21 Hoechst Ag
EP0580860B2 (en) * 1991-04-16 2004-12-15 Nippon Shinyaku Company, Limited Method of manufacturing solid dispersion
US5278272A (en) * 1991-10-15 1994-01-11 The Dow Chemical Company Elastic substantialy linear olefin polymers
ID16442A (id) 1996-01-22 1997-10-02 Dow Chemical Co Polimer etilena berat molekul ultra rendah
US7666337B2 (en) * 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US20040180077A1 (en) * 2003-03-05 2004-09-16 Riker Donald K. Rapidly dissolving edible strips for treating obesity
US20050186257A1 (en) * 2004-02-20 2005-08-25 Todd Manegold Dissolvable film and method of manufacture
JP2010515761A (ja) * 2007-01-12 2010-05-13 モノソル アールエックス リミテッド ライアビリティ カンパニー 高用量フィルム組成物およびその製法
JP5165428B2 (ja) * 2008-03-18 2013-03-21 日生化学株式会社 積層体

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19852826A1 (de) * 1998-11-17 2000-05-18 Aventis Res & Tech Gmbh & Co Poly(alpha-1,4-D-Glucan)
US6375963B1 (en) * 1999-06-16 2002-04-23 Michael A. Repka Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof
WO2007112285A2 (en) * 2006-03-24 2007-10-04 Auxilium Pharmaceuticals, Inc. Process for the preparation of a hot-melt extruded laminate

Also Published As

Publication number Publication date
WO2011119288A2 (en) 2011-09-29
JP2013523635A (ja) 2013-06-17
JP5749790B2 (ja) 2015-07-15
CN102821754A (zh) 2012-12-12
EP2552402A2 (en) 2013-02-06
EP2552402B1 (en) 2016-11-23
WO2011119288A3 (en) 2012-05-24
US20110236443A1 (en) 2011-09-29
KR20130010482A (ko) 2013-01-28

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SE01 Entry into force of request for substantive examination
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GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20140618

Termination date: 20200225

CF01 Termination of patent right due to non-payment of annual fee