CN102812003B - 吡咯烷羧酸衍生物、药物组合物以及在代谢紊乱中作为g-蛋白偶联受体43(gpr43)激动剂使用的方法 - Google Patents

吡咯烷羧酸衍生物、药物组合物以及在代谢紊乱中作为g-蛋白偶联受体43(gpr43)激动剂使用的方法 Download PDF

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CN102812003B
CN102812003B CN201080064345.3A CN201080064345A CN102812003B CN 102812003 B CN102812003 B CN 102812003B CN 201080064345 A CN201080064345 A CN 201080064345A CN 102812003 B CN102812003 B CN 102812003B
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pyrrolidine
carboxylic acid
chlorophenyl
biphenyl
carbonyl
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CN102812003A (zh
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哈米德·霍维达
迪迪埃·席尔斯
卢迪维·祖特
朱利安·帕克
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Epick Therapeutic Co
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Euroscreen SA
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CN201080064345.3A 2009-12-18 2010-12-17 吡咯烷羧酸衍生物、药物组合物以及在代谢紊乱中作为g-蛋白偶联受体43(gpr43)激动剂使用的方法 Active CN102812003B (zh)

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EP09306270.1 2009-12-18
EP09306270 2009-12-18
US37337010P 2010-08-13 2010-08-13
US61/373,370 2010-08-13
US37601310P 2010-08-23 2010-08-23
US61/376,013 2010-08-23
PCT/EP2010/070040 WO2011073376A1 (en) 2009-12-18 2010-12-17 Pyrrolidine or thiazolidine carboxylic acid derivatives, pharmaceutical composition and methods for use in treating metabolic disordersas as agonists of g- protein coupled receptor 43 (gpr43)

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CN102812003B true CN102812003B (zh) 2015-01-21

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KR101656662B1 (ko) 2014-11-18 2016-09-12 한국생명공학연구원 2-옥소-1,2,3,4-테트라하이드로피리미딘-5-카르복사미드 유도체를 유효성분으로 함유하는 대사성 질환 예방 또는 치료용 약학적 조성물
CN107033015B (zh) * 2017-06-02 2019-04-30 南京欧信医药技术有限公司 一种药物中间体的合成方法
TWI796596B (zh) 2018-02-13 2023-03-21 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
KR102591947B1 (ko) 2018-04-19 2023-10-25 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
MX2021000100A (es) 2018-07-13 2021-03-25 Gilead Sciences Inc Inhibidores de muerte programada-1 (pd-1)/ ligando de muerte programada 1 (pd-l1).
JP7158577B2 (ja) 2018-10-24 2022-10-21 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤
KR20210145787A (ko) 2019-04-02 2021-12-02 알리고스 테라퓨틱스 인코포레이티드 Prmt5를 표적으로 하는 화합물
WO2021018786A1 (en) 2019-07-26 2021-02-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of ffar2 agonists for the treatment of bacterial superinfections post-viral infection
CN110981779B (zh) * 2019-11-23 2021-02-26 武汉理工大学 R-2-(2,5-二氟苯基)吡咯烷的合成方法
US12528769B2 (en) 2020-06-10 2026-01-20 Epics Therapeutics Synthesis of (2S,5R)-5-(2-chlorophenyl)-1-(2′-methoxy-[1,1′-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid
JP2023540344A (ja) 2020-09-03 2023-09-22 センテッサ ファーマシューティカルズ （オレキシア） リミテッド 二環式複素環誘導体およびオレキシン－２受容体アゴニストとしてのそれらの使用
CN120077024A (zh) 2022-10-11 2025-05-30 艾匹克治疗公司 (2s,5r)-5-(2-氯苯基)-1-(2'-甲氧基-[1,1'-联苯]-4-羰基)吡咯烷-2-羧酸的多晶型物及其制备方法

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