BR112012018374B1 - Derivados de ácido carboxílico de pirrolidina ou tiazolidina para distúrbios metabólicos como agonistas de receptor 43 acoplado à proteína g (gpr43), seu processo de preparação e composição farmacêutica - Google Patents

Derivados de ácido carboxílico de pirrolidina ou tiazolidina para distúrbios metabólicos como agonistas de receptor 43 acoplado à proteína g (gpr43), seu processo de preparação e composição farmacêutica Download PDF

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BR112012018374B1
BR112012018374B1 BR112012018374-5A BR112012018374A BR112012018374B1 BR 112012018374 B1 BR112012018374 B1 BR 112012018374B1 BR 112012018374 A BR112012018374 A BR 112012018374A BR 112012018374 B1 BR112012018374 B1 BR 112012018374B1
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pyrrolidine
carboxylic acid
chlorophenyl
biphenyl
carbonyl
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BR112012018374-5A
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Portuguese (pt)
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BR112012018374A2 (pt
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Hamid Hoveyda
Didier Schils
Ludivine Zoute
Julien Parcq
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Epics Therapeutics
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BR112012018374-5A 2009-12-18 2010-12-17 Derivados de ácido carboxílico de pirrolidina ou tiazolidina para distúrbios metabólicos como agonistas de receptor 43 acoplado à proteína g (gpr43), seu processo de preparação e composição farmacêutica BR112012018374B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP09306270 2009-12-18
EP09306270.1 2009-12-18
US37337010P 2010-08-13 2010-08-13
US61/373.370 2010-08-13
US37601310P 2010-08-23 2010-08-23
US61/376.013 2010-08-23
PCT/EP2010/070040 WO2011073376A1 (en) 2009-12-18 2010-12-17 Pyrrolidine or thiazolidine carboxylic acid derivatives, pharmaceutical composition and methods for use in treating metabolic disordersas as agonists of g- protein coupled receptor 43 (gpr43)

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BR112012018374A2 BR112012018374A2 (pt) 2017-03-28
BR112012018374B1 true BR112012018374B1 (pt) 2021-09-21

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WO2022207935A1 (en) 2021-04-02 2022-10-06 Orexia Therapeutics Limited 2-(3-ethynylbenzyl)-substituted heterocycle derivatives as orexin-2 agonists
KR20250084188A (ko) 2022-10-11 2025-06-10 에픽스 테라퓨틱스 (2s,5r)-5-(2-클로로페닐)-1-(2'-메톡시-[1,1'-비페닐]-4-카르보닐)피롤리딘-2-카르복실산의다형체 및 이의 제조 방법

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