CN102781454B - 用于治疗性治疗肿瘤疾病的来源于成体干细胞的微泡（mv） - Google Patents

用于治疗性治疗肿瘤疾病的来源于成体干细胞的微泡（mv） Download PDF

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Publication number
CN102781454B
CN102781454B CN201180011925.0A CN201180011925A CN102781454B CN 102781454 B CN102781454 B CN 102781454B CN 201180011925 A CN201180011925 A CN 201180011925A CN 102781454 B CN102781454 B CN 102781454B
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cells
mvs
microvesicles
tumors
stem cells
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CN102781454A (zh
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斯特凡尼亚·布鲁诺
玛利亚·比阿特丽斯·赫雷拉桑切斯
瓦伦丁娜·丰萨托
乔瓦尼·卡穆西
奇罗·泰塔
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Fresenius Medical Care Deutschland GmbH
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Fresenius Medical Care Deutschland GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201180011925.0A 2010-03-02 2011-02-28 用于治疗性治疗肿瘤疾病的来源于成体干细胞的微泡（mv） Active CN102781454B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10425052.7 2010-03-02
EP10425052A EP2363136A1 (en) 2010-03-02 2010-03-02 Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease
PCT/EP2011/052945 WO2011107437A1 (en) 2010-03-02 2011-02-28 Microvesicles (mvs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease

Publications (2)

Publication Number Publication Date
CN102781454A CN102781454A (zh) 2012-11-14
CN102781454B true CN102781454B (zh) 2015-12-16

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CN201180011925.0A Active CN102781454B (zh) 2010-03-02 2011-02-28 用于治疗性治疗肿瘤疾病的来源于成体干细胞的微泡（mv）

Country Status (10)

Country Link
US (4) US9717760B2 (https=)
EP (2) EP2363136A1 (https=)
JP (1) JP5841952B2 (https=)
CN (1) CN102781454B (https=)
DK (1) DK2542250T3 (https=)
ES (1) ES2554492T3 (https=)
HU (1) HUE026292T2 (https=)
PL (1) PL2542250T3 (https=)
PT (1) PT2542250E (https=)
WO (1) WO2011107437A1 (https=)

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TWI762890B (zh) 2010-05-12 2022-05-01 開曼群島商英瑞金公司 生物活性腎細胞
ITRM20110403A1 (it) * 2011-07-28 2013-01-29 Ospedale Pediatrico Bambino Gesu Microvescicole isolate da cellule mesenchimali come agenti immunosoppressori.
CN102357071B (zh) * 2011-10-26 2013-10-23 重庆医科大学附属儿童医院 载紫杉醇纳米微泡及其制备方法
KR102246369B1 (ko) * 2011-11-30 2021-04-29 아스텔라스 인스티튜트 포 리제너러티브 메디슨 중간엽 간질 세포 및 이에 관련된 용도
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
US11286463B2 (en) 2012-03-08 2022-03-29 Advanced ReGen Medical Technologies, LLC Reprogramming of aged adult stem cells
US9745551B2 (en) 2012-07-12 2017-08-29 Imstem Biotechnology, Inc. Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
CR20160307A (es) 2013-12-20 2016-11-08 Advanced Regen Medical Tech Llc Composiciones para la restauración de células y métodos para la preparación y utilización de las mismas
US10772911B2 (en) 2013-12-20 2020-09-15 Advanced ReGen Medical Technologies, LLC Cell free compositions for cellular restoration and methods of making and using same
EP4445915A3 (en) * 2014-03-24 2025-01-22 Advanced Regen Medical Technologies, LLC Cell free compositions for cellular restoration and methods of making and using same
WO2015179301A1 (en) * 2014-05-19 2015-11-26 Eleftherios Papoutsakis Megakaryocytic particles and microparticles for cell therapy & fate modification of stem and progenitor cells
EP3436081A4 (en) 2016-04-29 2019-07-24 Advanced Regen Medical Technologies, LLC Microrna compositions and methods of making and using same
US11395832B2 (en) 2017-12-14 2022-07-26 Unicyte Ev Ag Pharmaceutical carriers containing miRNAs for use in the treatment of renal cancer
US10717981B2 (en) 2018-01-18 2020-07-21 Advanced ReGen Medical Technologies, LLC Therapeutic compositions and methods of making and using the same
WO2019197442A1 (en) * 2018-04-12 2019-10-17 Unicyte Ev Ag A combination of active ingredients for the treatment of tumor
CN111494417B (zh) * 2020-02-10 2024-04-09 寇晓星 诱导性细胞外囊泡在制备治疗肿瘤药物中的应用
CA3178268A1 (en) 2020-05-11 2021-11-18 Jonathan Thon Compositions and methods related to megakaryocyte-derived extracellular vesicles
KR102601831B1 (ko) * 2020-09-23 2023-11-14 대한민국 고형암 증식 억제 효과를 갖는 개과동물의 엑소좀
JP2024518770A (ja) 2021-04-26 2024-05-02 ストーム バイオ インコーポレイテッド ファンコニ貧血のための巨核球由来細胞外小胞に関する組成物及び方法
EP4534649A1 (en) * 2023-10-03 2025-04-09 Unicyte AG A method of qualifying as pharmaceutically active a batch of undifferentiated adult stem cells having the potential to differentiate along the hepatic lineage

Citations (2)

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WO2009087361A1 (en) * 2008-01-04 2009-07-16 Lydac Neuroscience Limited Microvesicles
WO2009105044A1 (en) * 2008-02-22 2009-08-27 Agency For Science, Technology And Research (A*Star) Mesenchymal stem cell particles

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US8148335B2 (en) * 2004-06-23 2012-04-03 Children's Hospital & Research Center Oakland De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy
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ES2575868T3 (es) * 2007-09-14 2016-07-01 The Ohio State University Research Foundation Expresión de miARN en microvesículas de sangre periférica humana y sus usos
EP2209481B1 (en) 2007-10-15 2013-03-13 Fresenius Medical Care Deutschland GmbH Use of microvesicles (mvs) for preparing a medicament having adjuvant activity on endothelial cell transplantation, particularly in the treatment of diabetes by pancreatic islet transplantation, and related method
ES2523098T3 (es) * 2007-10-29 2014-11-20 Fresenius Medical Care Deutschland Gmbh Microvesícula (MV) derivada de células madre para su uso en la inhibición de la apoptosis inducida por un agente citostático
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EP2363136A1 (en) * 2010-03-02 2011-09-07 Fresenius Medical Care Deutschland GmbH Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease

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Also Published As

Publication number Publication date
JP5841952B2 (ja) 2016-01-13
PL2542250T3 (pl) 2016-04-29
CN102781454A (zh) 2012-11-14
EP2542250A1 (en) 2013-01-09
JP2013520971A (ja) 2013-06-10
PT2542250E (pt) 2015-12-09
US20120321723A1 (en) 2012-12-20
US20230248774A1 (en) 2023-08-10
HUE026292T2 (en) 2016-05-30
US20170348356A1 (en) 2017-12-07
EP2542250B1 (en) 2015-08-26
DK2542250T3 (en) 2015-12-07
ES2554492T3 (es) 2015-12-21
WO2011107437A1 (en) 2011-09-09
EP2363136A1 (en) 2011-09-07
US9717760B2 (en) 2017-08-01
US10105395B2 (en) 2018-10-23
US20190060369A1 (en) 2019-02-28

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