CN102781454B - 用于治疗性治疗肿瘤疾病的来源于成体干细胞的微泡（mv） - Google Patents

用于治疗性治疗肿瘤疾病的来源于成体干细胞的微泡（mv） Download PDF

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Publication number
CN102781454B
CN102781454B CN201180011925.0A CN201180011925A CN102781454B CN 102781454 B CN102781454 B CN 102781454B CN 201180011925 A CN201180011925 A CN 201180011925A CN 102781454 B CN102781454 B CN 102781454B
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cells
mvs
microvesicles
tumors
stem cells
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CN102781454A (zh
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斯特凡尼亚·布鲁诺
玛利亚·比阿特丽斯·赫雷拉桑切斯
瓦伦丁娜·丰萨托
乔瓦尼·卡穆西
奇罗·泰塔
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Fresenius Medical Care Deutschland GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
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  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201180011925.0A 2010-03-02 2011-02-28 用于治疗性治疗肿瘤疾病的来源于成体干细胞的微泡（mv） Active CN102781454B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10425052.7 2010-03-02
EP10425052A EP2363136A1 (en) 2010-03-02 2010-03-02 Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease
PCT/EP2011/052945 WO2011107437A1 (en) 2010-03-02 2011-02-28 Microvesicles (mvs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease

Publications (2)

Publication Number Publication Date
CN102781454A CN102781454A (zh) 2012-11-14
CN102781454B true CN102781454B (zh) 2015-12-16

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Country Status (10)

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US (4) US9717760B2 (https=)
EP (2) EP2363136A1 (https=)
JP (1) JP5841952B2 (https=)
CN (1) CN102781454B (https=)
DK (1) DK2542250T3 (https=)
ES (1) ES2554492T3 (https=)
HU (1) HUE026292T2 (https=)
PL (1) PL2542250T3 (https=)
PT (1) PT2542250E (https=)
WO (1) WO2011107437A1 (https=)

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CN103154236B (zh) 2010-05-12 2016-08-31 再生医学Tx有限责任公司 生物活性肾细胞
ITRM20110403A1 (it) * 2011-07-28 2013-01-29 Ospedale Pediatrico Bambino Gesu Microvescicole isolate da cellule mesenchimali come agenti immunosoppressori.
CN102357071B (zh) * 2011-10-26 2013-10-23 重庆医科大学附属儿童医院 载紫杉醇纳米微泡及其制备方法
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
SI2785359T1 (sl) 2011-11-30 2018-11-30 Astellas Institute For Regenerative Medicine Mezenhimske stromalne celice in uporabe povezane z njimi
US11286463B2 (en) 2012-03-08 2022-03-29 Advanced ReGen Medical Technologies, LLC Reprogramming of aged adult stem cells
HK1208054A1 (en) 2012-07-12 2016-02-19 爱姆斯坦生物技术公司 Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
US10772911B2 (en) 2013-12-20 2020-09-15 Advanced ReGen Medical Technologies, LLC Cell free compositions for cellular restoration and methods of making and using same
US20150174166A1 (en) 2013-12-20 2015-06-25 Advanced ReGen Medical Technologies, LLC Compositions for Cellular Restoration and Methods of Making and Using Same
EP4445915A3 (en) * 2014-03-24 2025-01-22 Advanced Regen Medical Technologies, LLC Cell free compositions for cellular restoration and methods of making and using same
US10538738B2 (en) * 2014-05-19 2020-01-21 Eleftherios Papoutsakis Megakaryocytic particles and microparticles for cell therapy and fate modification of stem and progenitor cells
US11203754B2 (en) 2016-04-29 2021-12-21 Advanced ReGen Medical Technologies, LLC Microrna compositions and methods of making and using same
CN111601890B (zh) * 2017-12-14 2024-04-19 联合细胞Ev股份公司 用于治疗肾癌的包含miRNA的药物载体
EP3740576A4 (en) 2018-01-18 2021-10-20 Advanced Regen Medical Technologies, LLC THERAPEUTIC COMPOSITIONS AND THEIR PREPARATION AND USE METHODS
WO2019197442A1 (en) * 2018-04-12 2019-10-17 Unicyte Ev Ag A combination of active ingredients for the treatment of tumor
CN111494417B (zh) * 2020-02-10 2024-04-09 寇晓星 诱导性细胞外囊泡在制备治疗肿瘤药物中的应用
US20230190815A1 (en) 2020-05-11 2023-06-22 Strm.Bio Incorporated Compositions and methods related to megakaryocyte-derived extracellular vesicles
KR102601831B1 (ko) * 2020-09-23 2023-11-14 대한민국 고형암 증식 억제 효과를 갖는 개과동물의 엑소좀
AU2022264498A1 (en) 2021-04-26 2023-09-28 Strm.Bio Incorporated Compositions and methods related to megakaryocyte-derived extracellular vesicles for fanconi anemia
EP4534649A1 (en) * 2023-10-03 2025-04-09 Unicyte AG A method of qualifying as pharmaceutically active a batch of undifferentiated adult stem cells having the potential to differentiate along the hepatic lineage

Citations (2)

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WO2009087361A1 (en) * 2008-01-04 2009-07-16 Lydac Neuroscience Limited Microvesicles
WO2009105044A1 (en) * 2008-02-22 2009-08-27 Agency For Science, Technology And Research (A*Star) Mesenchymal stem cell particles

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JP4772958B2 (ja) * 1998-02-09 2011-09-14 ブラッコ・リサーチ・ソシエテ・アノニム 生物学的に活性な媒質の標的に向けた送達
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EP2610342B1 (en) * 2007-09-14 2016-05-04 The Ohio State University Research Foundation MiRNA Expression in Human Peripheral Blood Microvesicles and uses Thereof
US20100233216A1 (en) * 2007-10-15 2010-09-16 Vincenzo Cantaluppi Use of microvesicles (mvs) for preparing a medicament having adjuvant activity on endothelial cell transplantation, particularly in the treatment of diabetes by pancreatic islet transplantation, and related method
CN101854941B (zh) * 2007-10-29 2013-03-27 弗雷森纽斯医疗护理德国有限责任公司 衍生自干细胞的微泡(MVs)用于制备用于受损或损伤组织或器官的内皮/上皮再生的药物的用途、以及相关体外和体内方法
EP2186883A1 (en) 2008-11-04 2010-05-19 Fresenius Medical Care An isolated multipotent mesenchymal stem cell from human adult glomeruli (hGL-MSC), a method of preparing thereof and uses thereof in the regenerative medicine of the kidney
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WO2009105044A1 (en) * 2008-02-22 2009-08-27 Agency For Science, Technology And Research (A*Star) Mesenchymal stem cell particles

Also Published As

Publication number Publication date
PT2542250E (pt) 2015-12-09
WO2011107437A1 (en) 2011-09-09
HUE026292T2 (en) 2016-05-30
EP2542250A1 (en) 2013-01-09
PL2542250T3 (pl) 2016-04-29
US20120321723A1 (en) 2012-12-20
EP2542250B1 (en) 2015-08-26
JP5841952B2 (ja) 2016-01-13
JP2013520971A (ja) 2013-06-10
ES2554492T3 (es) 2015-12-21
US20170348356A1 (en) 2017-12-07
CN102781454A (zh) 2012-11-14
US20190060369A1 (en) 2019-02-28
US9717760B2 (en) 2017-08-01
US10105395B2 (en) 2018-10-23
EP2363136A1 (en) 2011-09-07
US20230248774A1 (en) 2023-08-10
DK2542250T3 (en) 2015-12-07

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