JP5841952B2 - 腫瘍性疾患の治療的処置にて用いるための成体幹細胞由来の微細小胞(mv) - Google Patents
腫瘍性疾患の治療的処置にて用いるための成体幹細胞由来の微細小胞(mv) Download PDFInfo
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- JP5841952B2 JP5841952B2 JP2012555384A JP2012555384A JP5841952B2 JP 5841952 B2 JP5841952 B2 JP 5841952B2 JP 2012555384 A JP2012555384 A JP 2012555384A JP 2012555384 A JP2012555384 A JP 2012555384A JP 5841952 B2 JP5841952 B2 JP 5841952B2
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Description
(Pomalidomide)、エピルビシン(Epirubicin)、5FU、スニチニブ(Sunitinib)、ラ−パチニブ(La-patinib)、カネルチニブ(Canertinib)、シクロホスファミド
(cyclophosphamide)、ドキソルビシン(doxorubicin)、レナリドミデン/デキサメタゾン(Lenalidomiden/Dexamethason)、ポ−マリドミド(Po-malidomide)/デキサメタゾン、カルボプラチン(Carboplatin)、ラパマイシン(Rapamycin)、ミトキサントロン(mitoxantron)、オキサリプラチン(oxaliplatin)、ドキセタセル(docetaxel)、ビノレルビン(vinorelbin)、ビンクリスチン(vincristine)およびその組み合わせが挙げられる。ドキソルビシンおよび/またはビンクリスチンと、成体幹細胞より由来のMVとの組み合わせの投与が極めて好ましい。というのも、かかる組み合わせは相乗作用を発揮することが示されたからである(図13を参照)。
ヒトBM−MSCから由来のMVの抗腫瘍活性を、HepG2、MCF−7、SKOV−3およびKS細胞株に対してその増殖を阻害し、そのアポトーシスを誘発する能力を測定することによりインビトロにて評価した。
Claims (11)
- 腫瘍性疾患の治療的処置のための多能性または複能性成体幹細胞由来の微細小胞(MV)を含む、医薬。
- 多能性または複能性成体幹細胞が間充織幹細胞および肝臓幹細胞からなる群より選択される、請求項1記載の医薬。
- 多能性または複能性成体幹細胞が骨髄由来のヒト間充織幹細胞(BM−MSC)、脱糸球体嚢由来のヒト間充織幹細胞(Gl−MSC)およびヒト非楕円形肝臓幹細胞(HLSC)からなる群より選択される、請求項2記載の医薬。
- 腫瘍性疾患が肝臓腫瘍、上皮腫瘍、乳房腫瘍、肺腫瘍、前立腺腫瘍、胃腫瘍、結腸腫瘍および卵巣腫瘍からなる群より選択される、請求項1ないし3のいずれかに記載の医薬。
- 腫瘍性疾患の治療的処置が、その必要とする患者に、患者の体重1kg当たり0.1−200マイクログラムの用量で微細小胞を投与することを含む、請求項1ないし4のいずれかに記載の医薬。
- 腫瘍性疾患の治療的処置が、その必要とする患者に、患者の体重1kg当たり1−150マイクログラムの用量で微細小胞を投与することを含む、請求項1ないし4のいずれかに記載の医薬。
- 腫瘍性疾患の治療的処置が、その必要とする患者に、患者の体重1kg当たり3−120マイクログラムの用量で微細小胞を投与することを含む、請求項1ないし4のいずれかに記載の医薬。
- 局所的または全身的投与に適する医薬剤形の、請求項1ないし7のいずれかに記載の医薬。
- 治療的処置が1または複数の細胞傷害性および/または細胞増殖抑制性薬剤を投与することを含む、請求項1ないし8のいずれかに記載の医薬。
- 細胞傷害性および/または細胞増殖抑制性薬剤が、パクリタキセル、レナリドミド、ポマリドミド、エピルビシン、5FU、スニチニブ、ラパチニブ、カネルチニブ、シクロホスファミド、ドキソルビシン、レナリドミド/デキサメタゾン、ポマリドミド/デキサメタゾン、カルボプラチン、ラパマイシン、ミトキサントロン、オキサリプラチン、ドキセタセル、ビノレルビン、ビンクリスチンおよびその組み合わせからなる群より選択される、請求項9記載の医薬。
- 細胞傷害性および/または細胞増殖抑制性薬剤がドキソルビシンまたはビンクリスチンである、請求項10記載の医薬。
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EP10425052.7 | 2010-03-02 | ||
EP10425052A EP2363136A1 (en) | 2010-03-02 | 2010-03-02 | Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease |
PCT/EP2011/052945 WO2011107437A1 (en) | 2010-03-02 | 2011-02-28 | Microvesicles (mvs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease |
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JP2013520971A JP2013520971A (ja) | 2013-06-10 |
JP2013520971A5 JP2013520971A5 (ja) | 2014-04-03 |
JP5841952B2 true JP5841952B2 (ja) | 2016-01-13 |
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US (4) | US9717760B2 (ja) |
EP (2) | EP2363136A1 (ja) |
JP (1) | JP5841952B2 (ja) |
CN (1) | CN102781454B (ja) |
DK (1) | DK2542250T3 (ja) |
ES (1) | ES2554492T3 (ja) |
HU (1) | HUE026292T2 (ja) |
PL (1) | PL2542250T3 (ja) |
PT (1) | PT2542250E (ja) |
WO (1) | WO2011107437A1 (ja) |
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EP2363136A1 (en) * | 2010-03-02 | 2011-09-07 | Fresenius Medical Care Deutschland GmbH | Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease |
EP2569418B1 (en) | 2010-05-12 | 2016-11-02 | RegenMed (Cayman) Ltd. | Bioactive renal cells |
ITRM20110403A1 (it) * | 2011-07-28 | 2013-01-29 | Ospedale Pediatrico Bambino Gesu | Microvescicole isolate da cellule mesenchimali come agenti immunosoppressori. |
CN102357071B (zh) * | 2011-10-26 | 2013-10-23 | 重庆医科大学附属儿童医院 | 载紫杉醇纳米微泡及其制备方法 |
KR102525175B1 (ko) * | 2011-11-30 | 2023-04-21 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 중간엽 간질 세포 및 이에 관련된 용도 |
US11286463B2 (en) | 2012-03-08 | 2022-03-29 | Advanced ReGen Medical Technologies, LLC | Reprogramming of aged adult stem cells |
US10772911B2 (en) | 2013-12-20 | 2020-09-15 | Advanced ReGen Medical Technologies, LLC | Cell free compositions for cellular restoration and methods of making and using same |
WO2015148534A1 (en) * | 2014-03-24 | 2015-10-01 | Advanced ReGen Medical Technologies, LLC | Cell free compositions for cellular restoration and methods of making and using same |
CR20160307A (es) | 2013-12-20 | 2016-11-08 | Advanced Regen Medical Tech Llc | Composiciones para la restauración de células y métodos para la preparación y utilización de las mismas |
US10538738B2 (en) * | 2014-05-19 | 2020-01-21 | Eleftherios Papoutsakis | Megakaryocytic particles and microparticles for cell therapy and fate modification of stem and progenitor cells |
WO2017190000A1 (en) | 2016-04-29 | 2017-11-02 | Advanced ReGen Medical Technologies, LLC | Microrna compositions and methods of making and using same |
WO2019115748A1 (en) * | 2017-12-14 | 2019-06-20 | Unicyte Ev Ag | PHARMACEUTICAL CARRIERS CONTAINING miRNAs FOR USE IN THE TREATMENT OF RENAL CANCER |
US10717981B2 (en) | 2018-01-18 | 2020-07-21 | Advanced ReGen Medical Technologies, LLC | Therapeutic compositions and methods of making and using the same |
WO2019197442A1 (en) * | 2018-04-12 | 2019-10-17 | Unicyte Ev Ag | A combination of active ingredients for the treatment of tumor |
CN111494417B (zh) * | 2020-02-10 | 2024-04-09 | 寇晓星 | 诱导性细胞外囊泡在制备治疗肿瘤药物中的应用 |
KR102601831B1 (ko) * | 2020-09-23 | 2023-11-14 | 대한민국 | 고형암 증식 억제 효과를 갖는 개과동물의 엑소좀 |
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JP4772958B2 (ja) * | 1998-02-09 | 2011-09-14 | ブラッコ・リサーチ・ソシエテ・アノニム | 生物学的に活性な媒質の標的に向けた送達 |
US20020177551A1 (en) * | 2000-05-31 | 2002-11-28 | Terman David S. | Compositions and methods for treatment of neoplastic disease |
US7128903B2 (en) * | 2001-10-03 | 2006-10-31 | Innovative Pharmaceutical Concepts (Ipc) Inc. | Pharmaceutical preparations useful for treating tumors and lesions of the skin and the mucous membranes and methods and kits using same |
WO2005121369A2 (en) * | 2004-06-02 | 2005-12-22 | Sourcepharm, Inc. | Rna-containing microvesicles and methods therefor |
US8148335B2 (en) * | 2004-06-23 | 2012-04-03 | Children's Hospital & Research Center Oakland | De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy |
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WO2006126219A1 (en) | 2005-05-26 | 2006-11-30 | Fresenius Medical Care Deutschland G.M.B.H. | Liver progenitor cells |
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PL2211875T3 (pl) * | 2007-10-29 | 2013-11-29 | Fresenius Medical Care Deutschland Gmbh | Zastosowanie mikropęcherzyków (MV) pochodzących z komórek macierzystych do wytwarzania leku do regeneracji śródbłonkowej/nabłonkowej uszkodzonych lub poddanych urazowi tkanek lub narządów i związane z nimi sposoby in vitro i in vivo |
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AU2009215934C1 (en) * | 2008-02-22 | 2014-05-08 | Agency For Science, Technology And Research (A*Star) | Mesenchymal stem cell particles |
EP2186883A1 (en) | 2008-11-04 | 2010-05-19 | Fresenius Medical Care | An isolated multipotent mesenchymal stem cell from human adult glomeruli (hGL-MSC), a method of preparing thereof and uses thereof in the regenerative medicine of the kidney |
EP2363136A1 (en) * | 2010-03-02 | 2011-09-07 | Fresenius Medical Care Deutschland GmbH | Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease |
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US10105395B2 (en) | 2018-10-23 |
EP2542250B1 (en) | 2015-08-26 |
US20170348356A1 (en) | 2017-12-07 |
HUE026292T2 (en) | 2016-05-30 |
EP2542250A1 (en) | 2013-01-09 |
DK2542250T3 (en) | 2015-12-07 |
CN102781454B (zh) | 2015-12-16 |
US9717760B2 (en) | 2017-08-01 |
WO2011107437A1 (en) | 2011-09-09 |
CN102781454A (zh) | 2012-11-14 |
PT2542250E (pt) | 2015-12-09 |
US20230248774A1 (en) | 2023-08-10 |
PL2542250T3 (pl) | 2016-04-29 |
JP2013520971A (ja) | 2013-06-10 |
US20120321723A1 (en) | 2012-12-20 |
US20190060369A1 (en) | 2019-02-28 |
EP2363136A1 (en) | 2011-09-07 |
ES2554492T3 (es) | 2015-12-21 |
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