CN102781425B - 含有维生素d类似物以及溶剂和表面活性剂混合物的皮肤用组合物 - Google Patents

含有维生素d类似物以及溶剂和表面活性剂混合物的皮肤用组合物 Download PDF

Info

Publication number
CN102781425B
CN102781425B CN201080063418.7A CN201080063418A CN102781425B CN 102781425 B CN102781425 B CN 102781425B CN 201080063418 A CN201080063418 A CN 201080063418A CN 102781425 B CN102781425 B CN 102781425B
Authority
CN
China
Prior art keywords
compositions
composition
mixture
weight ratio
glyceride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201080063418.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN102781425A (zh
Inventor
K·彼得松
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharma AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharma AS filed Critical Leo Pharma AS
Publication of CN102781425A publication Critical patent/CN102781425A/zh
Application granted granted Critical
Publication of CN102781425B publication Critical patent/CN102781425B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
CN201080063418.7A 2009-12-22 2010-12-22 含有维生素d类似物以及溶剂和表面活性剂混合物的皮肤用组合物 Active CN102781425B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPCT/DK2009/000265 2009-12-22
DK2009000265 2009-12-22
US29310510P 2010-01-07 2010-01-07
US61/293,105 2010-01-07
PCT/DK2010/000182 WO2011076207A2 (en) 2009-12-22 2010-12-22 Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants

Publications (2)

Publication Number Publication Date
CN102781425A CN102781425A (zh) 2012-11-14
CN102781425B true CN102781425B (zh) 2014-08-13

Family

ID=43618132

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080063418.7A Active CN102781425B (zh) 2009-12-22 2010-12-22 含有维生素d类似物以及溶剂和表面活性剂混合物的皮肤用组合物

Country Status (13)

Country Link
US (2) US20120322776A1 (enExample)
EP (1) EP2515865B1 (enExample)
JP (1) JP5873439B2 (enExample)
CN (1) CN102781425B (enExample)
AU (1) AU2010335654B2 (enExample)
BR (1) BR112012015433B8 (enExample)
CA (1) CA2785251A1 (enExample)
IL (1) IL220514A (enExample)
MX (1) MX2012007229A (enExample)
NZ (1) NZ600999A (enExample)
RU (1) RU2560677C2 (enExample)
WO (1) WO2011076207A2 (enExample)
ZA (1) ZA201204620B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5570442B2 (ja) * 2011-01-24 2014-08-13 株式会社シャネル化粧品技術開発研究所 水中油型乳化組成物及びその製造方法
CN104822392B (zh) * 2012-11-30 2017-09-08 利奥制药有限公司 抑制活化的t‑细胞中il‑22表达的方法
EP3084432B1 (en) * 2013-12-19 2018-03-21 Universiteit Gent Quantification of glucocorticoids in fish scales, spines, fin rays or otoliths as biomarkers for chronic stress
CN104666312B (zh) * 2015-02-12 2017-11-07 重庆华邦制药有限公司 含有卡泊三醇和二丙酸倍他米松的制剂
CN106265511A (zh) * 2016-08-22 2017-01-04 江苏知原药业有限公司 一种性能优异的卡泊三醇倍他米松自微乳制剂
CN106265485A (zh) * 2016-08-22 2017-01-04 江苏知原药业有限公司 一种稳定性改善的卡泊三醇组合物
CN106442841B (zh) * 2016-12-16 2018-09-14 上海景峰制药有限公司 一种药物中阳离子表面活性剂的分离检测方法
EP3639854A4 (en) 2017-06-16 2021-03-03 The Doshisha MTOR INHIBITIVE MEDICINAL PRODUCT FOR THE TREATMENT OR PREVENTION OF OPHTHALMIC SYMPTOMS, DISORDERS, OR DISEASES AND USE THEREOF
KR102678365B1 (ko) * 2018-03-20 2024-06-26 재단법인 경기도경제과학진흥원 콜레칼시페롤의 가용화 조성물 및 그 제조방법
EP3741378A1 (de) 2019-05-23 2020-11-25 Dimitrios Tsakouridis Zusammensetzung zur topischen behandlung und pflege der psoriatischen haut
CA3091554A1 (en) * 2020-08-28 2022-02-28 Triple Hair Inc. Formulations for reducing hair loss and/or increasing hair regrowth
JP7633712B2 (ja) * 2023-05-12 2025-02-20 アピ株式会社 外用組成物
JP2024163642A (ja) * 2023-05-12 2024-11-22 アピ株式会社 外用組成物
CN118304279B (zh) * 2024-03-27 2025-04-25 青岛双鲸药业股份有限公司 一种骨化三醇自微乳口溶膜及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060189586A1 (en) * 2003-06-11 2006-08-24 Cleland Jeffrey L Pharmaceutical compositions comprising active vitamin D compounds
WO2006134272A1 (fr) * 2005-06-17 2006-12-21 Galderma Research & Development Composition pharmaceutique comprenant un elastomere organopolysiloxane et un principe actif solubilise
CN101541304A (zh) * 2006-11-30 2009-09-23 盖尔德玛公司 含有维生素d的衍生物的呈软膏形式的组合物

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2753377B1 (fr) * 1996-09-19 1999-09-24 Rhone Merieux Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
JP2655190B2 (ja) * 1989-06-21 1997-09-17 エスエス製薬 株式会社 コルチコステロイド含有軟膏剤
AU667316B2 (en) * 1991-07-26 1996-03-21 Smithkline Beecham Corporation W/O microemulsions
US5766628A (en) * 1992-02-24 1998-06-16 Merz + Co. Gmbh & Co. Bath and shower composition having vesicle-forming properties and method for the production and use thereof
US5763426A (en) 1993-01-15 1998-06-09 Leo Pharmaceutical Products Ltd. Crystalline form of a vitamin D analogue
WO1994023749A1 (fr) 1993-04-19 1994-10-27 Institute For Advanced Skin Research Inc. Preparation en microemulsion contenant une substance difficilement absorbable
GB9405304D0 (en) 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
GB9602111D0 (en) * 1996-02-02 1996-04-03 Unilever Plc Personal care composition
GB9611603D0 (en) * 1996-06-04 1996-08-07 Leo Pharm Prod Ltd Chemical compounds
KR20010032892A (ko) * 1997-12-09 2001-04-25 나가야마 오사무 비타민 ｄ３유도체를 함유하는 크림제
US5989531A (en) * 1998-11-13 1999-11-23 Colgate-Palmolive Company Antiperspirant formulation for porous applicator
GB9903547D0 (en) * 1999-02-16 1999-04-07 Novartis Ag Organic compounds
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6582683B2 (en) * 2000-01-04 2003-06-24 Skinvisible Pharmaceuticals, Inc. Dermal barrier composition
DK1331927T3 (da) * 2000-10-27 2008-05-05 Leo Pharma As Topisk komposition der indeholder mindst et D-vitamin eller en D-vitamin analog og mindst et kosttikosteroid
US7005557B2 (en) * 2001-07-03 2006-02-28 The Procter & Gamble Company Film-forming compositions for protecting skin from body fluids and articles made therefrom
IL164163A0 (en) * 2002-04-09 2005-12-18 Pharmacia Corp Process for preparing a finely self-emulsifiable pharmaceutical composition
BRPI0411341A (pt) * 2003-06-17 2006-07-11 Du Pont proteìnas modificadas da soja em composições para enrijecimento da pele
ZA200510137B (en) 2003-07-24 2007-04-25 Leo Pharma As Novel aminobenzophenone compounds
US8795693B2 (en) * 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US20090105336A1 (en) * 2004-04-19 2009-04-23 Strategic Science & Technologies, Llc Beneficial Effects of Increasing Local Blood Flow
CA2567683A1 (en) * 2004-06-17 2005-12-29 Galderma S.A. Composition in spray form comprising a combination of a corticoid and a vitamin d derivative in an oily phase
FR2871694B1 (fr) * 2004-06-17 2008-07-04 Galderma Sa Composition pharmaceutique comprenant un onguent oleagineux et deux principes actifs solubilises
KR101260236B1 (ko) 2004-12-13 2013-05-06 레오 파마 에이/에스 트리아졸 치환된 아미노벤조페논 화합물
EP1827297A1 (en) * 2004-12-23 2007-09-05 Unilever Plc Water-in-oil emulsions for hair treatment
CA2608021A1 (en) * 2005-05-10 2006-11-16 Dermipsor Ltd. Compositions and methods for skin care
CA2612408A1 (en) * 2005-06-15 2006-12-28 Apollo Pharmaceutical, Inc. Pharmaceutical composition comprising a mahonia aquifolium extract for the treatment of psoriasis
US20070249055A1 (en) * 2006-04-24 2007-10-25 The Procter & Gamble Company Method of measuring lotion and additive ingredient transfer
US20080260655A1 (en) * 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
AU2007336538B2 (en) 2006-12-22 2012-04-05 Leo Pharma A/S Substituted acetophenones useful as PDE4 inhibitors
KR101571654B1 (ko) 2007-02-28 2015-11-25 레오 파마 에이/에스 신규한 포스포디에스테라제 억제제
EP1970049A1 (en) * 2007-03-15 2008-09-17 Drug Delivery Solutions Limited Polyaphron topical composition with vitamin D and corticosteroid
US20100099710A1 (en) 2007-04-19 2010-04-22 Lene Jensen Src family kinase inhibitors
HRP20231142T3 (hr) * 2007-04-25 2024-01-05 Eirgen Pharma Ltd. Kontrolirano oslobađanje 25-hidroksivitamina d
US20100189674A1 (en) 2007-05-11 2010-07-29 Sonneborn Inc. Petrolatum Having Silicone-Like Properties
US20080299156A1 (en) * 2007-06-01 2008-12-04 L'oreal Skin care compositions containing a high internal phase emulsion
SG172206A1 (en) 2008-12-19 2011-07-28 Leo Pharma As Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases
JP2012531393A (ja) * 2009-06-29 2012-12-10 グラクソ グループ リミテッド 新規の医学的使用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060189586A1 (en) * 2003-06-11 2006-08-24 Cleland Jeffrey L Pharmaceutical compositions comprising active vitamin D compounds
WO2006134272A1 (fr) * 2005-06-17 2006-12-21 Galderma Research & Development Composition pharmaceutique comprenant un elastomere organopolysiloxane et un principe actif solubilise
CN101541304A (zh) * 2006-11-30 2009-09-23 盖尔德玛公司 含有维生素d的衍生物的呈软膏形式的组合物

Also Published As

Publication number Publication date
CA2785251A1 (en) 2011-06-30
RU2012130421A (ru) 2014-01-27
EP2515865A2 (en) 2012-10-31
JP5873439B2 (ja) 2016-03-01
US20120322776A1 (en) 2012-12-20
WO2011076207A3 (en) 2012-03-01
BR112012015433B1 (pt) 2019-04-24
BR112012015433A2 (pt) 2016-03-15
AU2010335654A1 (en) 2012-07-26
WO2011076207A2 (en) 2011-06-30
CN102781425A (zh) 2012-11-14
US20160324875A1 (en) 2016-11-10
HK1177899A1 (en) 2013-08-30
JP2013515018A (ja) 2013-05-02
IL220514A (en) 2017-01-31
NZ600999A (en) 2014-06-27
BR112012015433B8 (pt) 2020-03-03
AU2010335654B2 (en) 2015-04-09
MX2012007229A (es) 2012-07-30
RU2560677C2 (ru) 2015-08-20
ZA201204620B (en) 2013-09-25
EP2515865B1 (en) 2016-12-14

Similar Documents

Publication Publication Date Title
CN102781425B (zh) 含有维生素d类似物以及溶剂和表面活性剂混合物的皮肤用组合物
RU2602171C2 (ru) Композиция, содержащая липидные наночастицы и кортикостероид или производное витамина d
RU2500387C1 (ru) Фармацевтическая композиция, содержащая аналог витамина d и смесь сорастворитель - поверхностно-активное вещество
EP2515866B1 (en) Pharmaceutical composition comprising solvent mixture and a vitamin d derivative or analogue
US20140322331A1 (en) Calcipotriol monohydrate nanocrystals
US9254296B2 (en) Pharmaceutical composition comprising vitamin D analogue and cosolvent-surfactant mixture
HK1177899B (en) Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants
HK1177695B (en) Pharmaceutical composition comprising vitamin d analogue and cosolvent-surfactant mixture
HK1177696B (en) Pharmaceutical composition comprising solvent mixture and a vitamin d derivative or analogue

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1177899

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1177899

Country of ref document: HK