CN102770437B - 多肽的天然连接方法 - Google Patents

多肽的天然连接方法 Download PDF

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Publication number
CN102770437B
CN102770437B CN201080055379.6A CN201080055379A CN102770437B CN 102770437 B CN102770437 B CN 102770437B CN 201080055379 A CN201080055379 A CN 201080055379A CN 102770437 B CN102770437 B CN 102770437B
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CN
China
Prior art keywords
polypeptide
formula
amino
ligation
group
Prior art date
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Active
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CN201080055379.6A
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English (en)
Chinese (zh)
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CN102770437A (zh
Inventor
雷达·姆希迪亚
朱利恩·德尔
纳塔莉·奥利维耶
奥列格·梅尔尼克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lille First University-Science And Technology
NATIONAL CENTER FOR SCIENTIFIC RESEARCH
Universite Lille 2 Droit et Sante
Institut Pasteur
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite Lille 1 Sciences et Technologies
Universite Lille 2 Droit et Sante
Institut Pasteur de Lille
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Publication of CN102770437A publication Critical patent/CN102770437A/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201080055379.6A 2009-10-29 2010-10-28 多肽的天然连接方法 Active CN102770437B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0957639A FR2952058B1 (fr) 2009-10-29 2009-10-29 Procede de ligation native de polypeptides
FR0957639 2009-10-29
PCT/IB2010/054897 WO2011051906A1 (fr) 2009-10-29 2010-10-28 Procede de ligation native de polypeptides

Publications (2)

Publication Number Publication Date
CN102770437A CN102770437A (zh) 2012-11-07
CN102770437B true CN102770437B (zh) 2016-04-20

Family

ID=42145118

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080055379.6A Active CN102770437B (zh) 2009-10-29 2010-10-28 多肽的天然连接方法

Country Status (9)

Country Link
US (1) US9029503B2 (https=)
EP (1) EP2493909B1 (https=)
JP (1) JP5785177B2 (https=)
CN (1) CN102770437B (https=)
CA (1) CA2778875C (https=)
DK (1) DK2493909T3 (https=)
ES (1) ES2493917T3 (https=)
FR (1) FR2952058B1 (https=)
WO (1) WO2011051906A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012005691A1 (en) * 2010-07-06 2012-01-12 Nanyang Technological University Compound for use in peptide synthesis
FR2971509B1 (fr) * 2011-02-16 2013-02-22 Centre Nat Rech Scient Procede de preparation de peptides par assemblage de multiples fragments peptidiques
FR2981352B1 (fr) * 2011-10-17 2015-07-03 Centre Nat Rech Scient Procede de synthese de proteines
FR2988392B1 (fr) * 2012-03-21 2014-04-11 Centre Nat Rech Scient Procede de ligation native

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1200147A (zh) * 1995-09-01 1998-11-25 科里克萨有限公司 用于免疫治疗和诊断结核病的化合物和方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0832096T1 (en) * 1995-05-04 2001-12-31 Scripps Research Inst Synthesis of proteins by native chemical ligation
WO1998028434A1 (en) * 1996-12-24 1998-07-02 The Scripps Research Institute General chemical ligation
US6570040B2 (en) 2000-03-16 2003-05-27 The Regents Of The University Of California Chemoselective ligation
DE60110127T2 (de) 2000-05-12 2006-02-02 Wisconsin Alumni Research Foundation, Madison Ligationsverfahren und reagenzien zur bildung einer amid-bindung
BR0113579A (pt) * 2000-09-08 2003-06-17 Gryphon Therapeutics Inc Proteìnas sintéticas modificadas por polìmero
CA2477159A1 (en) * 2002-02-20 2003-08-28 Invitrogen Corporation Highly homogeneous molecular markers for electrophoresis
US7667076B2 (en) 2005-09-14 2010-02-23 Regents Of The University Of California Amide forming chemical ligation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1200147A (zh) * 1995-09-01 1998-11-25 科里克萨有限公司 用于免疫治疗和诊断结核病的化合物和方法

Also Published As

Publication number Publication date
EP2493909A1 (fr) 2012-09-05
JP5785177B2 (ja) 2015-09-24
FR2952058A1 (fr) 2011-05-06
CN102770437A (zh) 2012-11-07
JP2013509396A (ja) 2013-03-14
WO2011051906A1 (fr) 2011-05-05
ES2493917T3 (es) 2014-09-12
FR2952058B1 (fr) 2013-10-04
US20120220721A1 (en) 2012-08-30
US9029503B2 (en) 2015-05-12
CA2778875A1 (fr) 2011-05-05
CA2778875C (fr) 2017-11-07
EP2493909B1 (fr) 2014-05-21
DK2493909T3 (da) 2014-08-25

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Effective date of registration: 20160129

Address after: France

Applicant after: National Center for scientific research

Applicant after: Pasteur Institut

Applicant after: Lille the first university-science and technology

Applicant after: Univ Lille Ii Droit & Sante

Address before: France

Applicant before: National Center for scientific research

Applicant before: Pasteur Institut

C14 Grant of patent or utility model
GR01 Patent grant