CA2778875C - Procede de ligation native de polypeptides - Google Patents

Procede de ligation native de polypeptides Download PDF

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Publication number
CA2778875C
CA2778875C CA2778875A CA2778875A CA2778875C CA 2778875 C CA2778875 C CA 2778875C CA 2778875 A CA2778875 A CA 2778875A CA 2778875 A CA2778875 A CA 2778875A CA 2778875 C CA2778875 C CA 2778875C
Authority
CA
Canada
Prior art keywords
polypeptide
formula
amino acid
trt
ligation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2778875A
Other languages
English (en)
French (fr)
Other versions
CA2778875A1 (fr
Inventor
Reda Mhidia
Julien Dheur
Nathalie Ollivier
Oleg Melnyk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite Lille 1 Sciences et Technologies
Universite Lille 2 Droit et Sante
Institut Pasteur de Lille
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite Lille 1 Sciences et Technologies
Universite Lille 2 Droit et Sante
Institut Pasteur de Lille
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Universite Lille 1 Sciences et Technologies, Universite Lille 2 Droit et Sante, Institut Pasteur de Lille filed Critical Centre National de la Recherche Scientifique CNRS
Publication of CA2778875A1 publication Critical patent/CA2778875A1/fr
Application granted granted Critical
Publication of CA2778875C publication Critical patent/CA2778875C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2778875A 2009-10-29 2010-10-28 Procede de ligation native de polypeptides Active CA2778875C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0957639A FR2952058B1 (fr) 2009-10-29 2009-10-29 Procede de ligation native de polypeptides
FR0957639 2009-10-29
PCT/IB2010/054897 WO2011051906A1 (fr) 2009-10-29 2010-10-28 Procede de ligation native de polypeptides

Publications (2)

Publication Number Publication Date
CA2778875A1 CA2778875A1 (fr) 2011-05-05
CA2778875C true CA2778875C (fr) 2017-11-07

Family

ID=42145118

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2778875A Active CA2778875C (fr) 2009-10-29 2010-10-28 Procede de ligation native de polypeptides

Country Status (9)

Country Link
US (1) US9029503B2 (https=)
EP (1) EP2493909B1 (https=)
JP (1) JP5785177B2 (https=)
CN (1) CN102770437B (https=)
CA (1) CA2778875C (https=)
DK (1) DK2493909T3 (https=)
ES (1) ES2493917T3 (https=)
FR (1) FR2952058B1 (https=)
WO (1) WO2011051906A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012005691A1 (en) * 2010-07-06 2012-01-12 Nanyang Technological University Compound for use in peptide synthesis
FR2971509B1 (fr) * 2011-02-16 2013-02-22 Centre Nat Rech Scient Procede de preparation de peptides par assemblage de multiples fragments peptidiques
FR2981352B1 (fr) * 2011-10-17 2015-07-03 Centre Nat Rech Scient Procede de synthese de proteines
FR2988392B1 (fr) * 2012-03-21 2014-04-11 Centre Nat Rech Scient Procede de ligation native

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0832096T1 (en) * 1995-05-04 2001-12-31 Scripps Research Inst Synthesis of proteins by native chemical ligation
TR200901109T1 (tr) 1995-09-01 2012-02-21 Corixa Corporation Tüberkülozun teşhisi ve immünoterapi yolu ile önlenmesine mahsus yöntemler ve bileşikler
WO1998028434A1 (en) * 1996-12-24 1998-07-02 The Scripps Research Institute General chemical ligation
US6570040B2 (en) 2000-03-16 2003-05-27 The Regents Of The University Of California Chemoselective ligation
DE60110127T2 (de) 2000-05-12 2006-02-02 Wisconsin Alumni Research Foundation, Madison Ligationsverfahren und reagenzien zur bildung einer amid-bindung
BR0113579A (pt) * 2000-09-08 2003-06-17 Gryphon Therapeutics Inc Proteìnas sintéticas modificadas por polìmero
CA2477159A1 (en) * 2002-02-20 2003-08-28 Invitrogen Corporation Highly homogeneous molecular markers for electrophoresis
US7667076B2 (en) 2005-09-14 2010-02-23 Regents Of The University Of California Amide forming chemical ligation

Also Published As

Publication number Publication date
EP2493909A1 (fr) 2012-09-05
JP5785177B2 (ja) 2015-09-24
FR2952058A1 (fr) 2011-05-06
CN102770437A (zh) 2012-11-07
JP2013509396A (ja) 2013-03-14
WO2011051906A1 (fr) 2011-05-05
ES2493917T3 (es) 2014-09-12
FR2952058B1 (fr) 2013-10-04
US20120220721A1 (en) 2012-08-30
US9029503B2 (en) 2015-05-12
CN102770437B (zh) 2016-04-20
CA2778875A1 (fr) 2011-05-05
EP2493909B1 (fr) 2014-05-21
DK2493909T3 (da) 2014-08-25

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