CN102753199A - 癌干细胞标记物及其用途 - Google Patents

癌干细胞标记物及其用途 Download PDF

Info

Publication number
CN102753199A
CN102753199A CN2011800065922A CN201180006592A CN102753199A CN 102753199 A CN102753199 A CN 102753199A CN 2011800065922 A CN2011800065922 A CN 2011800065922A CN 201180006592 A CN201180006592 A CN 201180006592A CN 102753199 A CN102753199 A CN 102753199A
Authority
CN
China
Prior art keywords
cell
stem cell
cancer
cancer stem
tumor associated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800065922A
Other languages
English (en)
Chinese (zh)
Inventor
S·戈勒茨
U·卡斯滕
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glycotope GmbH
Original Assignee
Glycotope GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycotope GmbH filed Critical Glycotope GmbH
Publication of CN102753199A publication Critical patent/CN102753199A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57469Immunoassay; Biospecific binding assay; Materials therefor for cancer involving tumor associated glycolinkage, i.e. TAG
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN2011800065922A 2010-01-20 2011-01-20 癌干细胞标记物及其用途 Pending CN102753199A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US29673810P 2010-01-20 2010-01-20
EP10000527A EP2347769A1 (en) 2010-01-20 2010-01-20 Cancer stem cell markers and uses thereof
US61/296,738 2010-01-20
EP10000527.1 2010-01-20
PCT/EP2011/000217 WO2011089004A1 (en) 2010-01-20 2011-01-20 Cancer stem cell markers and uses thereof

Publications (1)

Publication Number Publication Date
CN102753199A true CN102753199A (zh) 2012-10-24

Family

ID=42173400

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800065922A Pending CN102753199A (zh) 2010-01-20 2011-01-20 癌干细胞标记物及其用途

Country Status (8)

Country Link
US (1) US20120294859A1 (cg-RX-API-DMAC7.html)
EP (2) EP2347769A1 (cg-RX-API-DMAC7.html)
JP (2) JP2013517487A (cg-RX-API-DMAC7.html)
CN (1) CN102753199A (cg-RX-API-DMAC7.html)
AU (1) AU2011208874B2 (cg-RX-API-DMAC7.html)
BR (1) BR112012018132A2 (cg-RX-API-DMAC7.html)
CA (1) CA2786212A1 (cg-RX-API-DMAC7.html)
WO (1) WO2011089004A1 (cg-RX-API-DMAC7.html)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103969437A (zh) * 2014-04-22 2014-08-06 广州恒泰生物科技有限公司 用于卵巢癌早中期快速诊断试剂盒的制备方法
CN111363008A (zh) * 2020-03-18 2020-07-03 北京鼎成肽源生物技术有限公司 一种输卵管癌靶标抗原组合、输卵管癌靶标抗原组合刺激培养的ctl细胞及其应用
CN113804531A (zh) * 2021-09-10 2021-12-17 北京大学 一种细胞高活性染色方法
CN115916349A (zh) * 2020-06-30 2023-04-04 葛莱高托普有限公司 针对Lewis Y的人源化抗体
CN116718774A (zh) * 2023-07-07 2023-09-08 杭州准星医学科技有限公司 一种用于肿瘤体外诊断的试剂盒及其使用方法

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
ES2442024T3 (es) 2008-07-15 2014-02-07 Academia Sinica Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
AU2011295722B2 (en) 2010-09-03 2016-04-21 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
US9778264B2 (en) 2010-09-03 2017-10-03 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
WO2012039430A1 (ja) * 2010-09-21 2012-03-29 株式会社Gpバイオサイエンス がん幹細胞の単離方法
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
US9914956B2 (en) 2012-08-18 2018-03-13 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
EP2972390B1 (en) 2013-03-14 2017-11-08 The United States Of America, As Represented By The Sectretary, Department Of Health And Human Services Hyposialylation disorders
WO2014210397A1 (en) 2013-06-26 2014-12-31 Academia Sinica Rm2 antigens and use thereof
US9981030B2 (en) 2013-06-27 2018-05-29 Academia Sinica Glycan conjugates and use thereof
EP3041484B1 (en) 2013-09-06 2021-03-03 Academia Sinica Human inkt cell activation using glycolipids with altered glycosyl groups
HK1222569A1 (zh) 2013-09-17 2017-07-07 Obi Pharma, Inc. 用於诱导免疫反应的糖疫苗组合物及其治疗癌症的用途
JP2017507118A (ja) 2014-01-16 2017-03-16 アカデミア シニカAcademia Sinica がんの処置および検出のための組成物および方法
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
TWI687428B (zh) 2014-03-27 2020-03-11 中央研究院 反應性標記化合物及其用途
US10023651B2 (en) 2014-04-18 2018-07-17 The Research Foundation For The State University Of New York Humanized anti-TF-antigen antibodies
EP3797793A1 (en) * 2014-04-18 2021-03-31 The Research Foundation of the State University of New York at Buffalo Humanized anti-tf-antigen antibodies
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
KR102512592B1 (ko) 2014-05-27 2023-03-21 아카데미아 시니카 항-her2 글리코항체 및 이의 용도
EP3149036A4 (en) 2014-05-27 2017-12-27 Academia Sinica Anti-cd20 glycoantibodies and uses thereof
CA2950423A1 (en) 2014-05-27 2015-12-03 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
AU2015267044A1 (en) 2014-05-28 2016-12-15 Academia Sinica Anti-TNF-alpha glycoantibodies and uses thereof
WO2016040369A2 (en) 2014-09-08 2016-03-17 Academia Sinica HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS
CA2967595A1 (en) 2014-11-12 2016-05-19 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
CN107430127B (zh) * 2015-01-24 2020-08-28 中央研究院 癌症标记及其使用方法
KR102691114B1 (ko) 2015-01-24 2024-08-01 아카데미아 시니카 신규한 글리칸 콘주게이트 및 이를 사용하는 방법
US10493087B2 (en) 2015-02-25 2019-12-03 The United States of America, as represented by National Institute of Health Sialylation-increasing therapies for diseases associated with oxidative stress
AR105910A1 (es) 2015-09-04 2017-11-22 Obi Pharma Inc Matrices de glicano y método de uso
CA3002097A1 (en) 2015-11-12 2017-05-18 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
WO2017100796A1 (en) * 2015-12-11 2017-06-15 SINACA, Academia Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
TW201808978A (zh) 2016-03-08 2018-03-16 中央研究院 N-聚醣及其陣列之模組化合成方法
BR112018070097A2 (pt) 2016-03-29 2019-02-12 Obi Pharma, Inc. anticorpo, hibridoma, composição farmacêutica, método para tratar câncer em um indivíduo, método para inibir a proliferação de células cancerígenas, método para diagnosticar o câncer em um indivíduo, método para tratar um paciente humano, método para fazer imagens de um indivíduo, conjugado de fármaco-anticorpo (adc), método para tratar câncer, anticorpo biespecífico e método para preparar uma população de anticorpos homogêneos
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
TWI697333B (zh) 2016-04-22 2020-07-01 台灣浩鼎生技股份有限公司 經由Globo系列抗原之免疫活化或免疫調節之癌症免疫療法
JP2019527690A (ja) 2016-07-27 2019-10-03 オービーアイ ファーマ,インコーポレイテッド 免疫原性/治療用グリカン組成物およびその使用
JP7121724B2 (ja) 2016-07-29 2022-08-18 オービーアイ ファーマ,インコーポレイテッド ヒト抗体、医薬組成物及び方法
US10538592B2 (en) 2016-08-22 2020-01-21 Cho Pharma, Inc. Antibodies, binding fragments, and methods of use
EP3541847A4 (en) 2016-11-17 2020-07-08 Seattle Genetics, Inc. COMPOUNDS INTERACTING WITH GLYCANE AND METHODS OF USE
EP3543337B1 (en) * 2016-11-18 2022-04-20 Astellas Pharma Inc. Novel anti-human muc1 antibody fab fragment
WO2018094414A1 (en) 2016-11-21 2018-05-24 Obi Pharma, Inc. Conjugated biological molecules, pharmaceutical compositions and methods
JP2020510671A (ja) 2017-03-03 2020-04-09 シアトル ジェネティックス, インコーポレイテッド グリカン相互作用化合物および使用の方法
WO2018178047A1 (en) * 2017-03-29 2018-10-04 Glycotope Gmbh Multispecific antibody constructs binding to muc1 and cd3
TWI795415B (zh) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類CEACAM5抗體Fab片段
CA3092470A1 (en) 2018-02-27 2019-09-06 Incyte Corporation Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors
PT110722B (pt) * 2018-05-03 2021-08-17 Instituto De Patologia E Imunologia Molecular Da Univ Do Porto Ipatimup Uso de anticorpos para o antigénio thomsen-friedenreich num método e estojo para avaliação de instabilidade de microsatelites
JP7360766B2 (ja) 2018-05-17 2023-10-13 アステラス製薬株式会社 抗ヒトMUC1抗体Fabフラグメント、ペプチドリンカー及び/又は配位子を含む複合体
US12479926B2 (en) 2018-05-18 2025-11-25 Daiichi Sankyo Co., Ltd. Anti-MUC1 antibody-drug conjugate
WO2019222677A1 (en) 2018-05-18 2019-11-21 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
WO2020006176A1 (en) 2018-06-27 2020-01-02 Obi Pharma, Inc. Glycosynthase variants for glycoprotein engineering and methods of use
AU2019297361B2 (en) 2018-07-05 2024-06-27 Incyte Corporation Fused pyrazine derivatives as A2A / A2B inhibitors
JP7374544B2 (ja) 2018-10-10 2023-11-07 アステラス製薬株式会社 標識部-抗ヒト抗体Fabフラグメント複合体を含む医薬組成物
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
CN110161241A (zh) * 2019-04-30 2019-08-23 丁晓昆 一种快速检测生物组织切片cosmc基因突变试剂盒
CA3166533A1 (en) 2020-01-03 2021-07-08 Incyte Corporation Anti-cd73 antibodies and uses thereof
JP2023509442A (ja) 2020-01-03 2023-03-08 インサイト・コーポレイション Cd73阻害剤とa2a/a2bアデノシン受容体阻害剤の併用療法
AU2021411952A1 (en) 2020-12-29 2023-08-10 Incyte Corporation Combination therapy comprising a2a/a2b inhibitors, pd-1/pd-l1 inhibitors, and anti-cd73 antibodies
CA3224907A1 (en) * 2021-07-16 2023-03-02 Claude Perreault Novel tumor-specific antigens for cancer stem cells and uses thereof
CN119955728A (zh) * 2022-08-01 2025-05-09 首都医科大学附属北京胸科医院 恶性表型大细胞肺癌细胞株及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020192223A1 (en) * 1989-06-30 2002-12-19 Ingegerg Hellstrom Novel antibody conjugates reactive with human carcinomas
US20060251668A1 (en) * 2002-11-29 2006-11-09 Steffen Goletz Tumor-specific recognition molecules
US7374755B2 (en) * 2004-07-26 2008-05-20 The Research Foundation Of State University Of New York Therapeutic use of anti-TF-Antigen antibody
US20090041836A1 (en) * 2006-01-03 2009-02-12 University Of Georgia Research Foundation, Inc. Glycolipopeptide and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1654353B1 (en) 2003-08-18 2013-05-22 Glycotope GmbH Tumour cell lines nm-f9 (dsm acc2606) and nm-d4 (dsm acc2605), uses threreof
WO2007140011A2 (en) * 2006-05-26 2007-12-06 The Government Of The United States Of America Erythroid progenitor cells and methods for producing parvovirus b19 therein

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020192223A1 (en) * 1989-06-30 2002-12-19 Ingegerg Hellstrom Novel antibody conjugates reactive with human carcinomas
US20060251668A1 (en) * 2002-11-29 2006-11-09 Steffen Goletz Tumor-specific recognition molecules
US7374755B2 (en) * 2004-07-26 2008-05-20 The Research Foundation Of State University Of New York Therapeutic use of anti-TF-Antigen antibody
US20090041836A1 (en) * 2006-01-03 2009-02-12 University Of Georgia Research Foundation, Inc. Glycolipopeptide and uses thereof

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103969437A (zh) * 2014-04-22 2014-08-06 广州恒泰生物科技有限公司 用于卵巢癌早中期快速诊断试剂盒的制备方法
CN111363008A (zh) * 2020-03-18 2020-07-03 北京鼎成肽源生物技术有限公司 一种输卵管癌靶标抗原组合、输卵管癌靶标抗原组合刺激培养的ctl细胞及其应用
CN113388023A (zh) * 2020-03-18 2021-09-14 北京鼎成肽源生物技术有限公司 一种输卵管癌靶标抗原、输卵管癌靶标抗原刺激培养的ctl细胞及其应用
CN113429473A (zh) * 2020-03-18 2021-09-24 北京鼎成肽源生物技术有限公司 一种输卵管癌靶标抗原、输卵管癌靶标抗原刺激培养的ctl细胞及其应用
CN111363008B (zh) * 2020-03-18 2021-11-16 北京鼎成肽源生物技术有限公司 一种输卵管癌靶标抗原组合、输卵管癌靶标抗原组合刺激培养的ctl细胞及其应用
CN113429473B (zh) * 2020-03-18 2022-11-04 北京鼎成肽源生物技术有限公司 一种输卵管癌靶标抗原、输卵管癌靶标抗原刺激培养的ctl细胞及其应用
CN115916349A (zh) * 2020-06-30 2023-04-04 葛莱高托普有限公司 针对Lewis Y的人源化抗体
US12415864B2 (en) 2020-06-30 2025-09-16 Pentixapharm Ag Humanized antibodies against Lewis Y
CN113804531A (zh) * 2021-09-10 2021-12-17 北京大学 一种细胞高活性染色方法
CN113804531B (zh) * 2021-09-10 2024-02-06 北京大学 一种细胞高活性染色方法
CN116718774A (zh) * 2023-07-07 2023-09-08 杭州准星医学科技有限公司 一种用于肿瘤体外诊断的试剂盒及其使用方法

Also Published As

Publication number Publication date
JP2013517487A (ja) 2013-05-16
EP2525832A1 (en) 2012-11-28
WO2011089004A1 (en) 2011-07-28
CA2786212A1 (en) 2011-07-28
US20120294859A1 (en) 2012-11-22
EP2347769A1 (en) 2011-07-27
AU2011208874B2 (en) 2015-06-25
AU2011208874A1 (en) 2012-08-02
JP2016047848A (ja) 2016-04-07
BR112012018132A2 (pt) 2017-06-20

Similar Documents

Publication Publication Date Title
CN102753199A (zh) 癌干细胞标记物及其用途
Nishiwada et al. Nectin-4 expression contributes to tumor proliferation, angiogenesis and patient prognosis in human pancreatic cancer
Oak et al. Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2‐positive cancer cells and cancer stem cells
JP5689133B2 (ja) 結腸直腸癌におけるpodxlタンパク質
JP6795813B2 (ja) がん細胞の検出方法、がん細胞内に物質を導入するための試薬、及びがん治療用組成物
Lin et al. Expression of CD176 (Thomsen‐Friedenreich antigen) on lung, breast and liver cancer‐initiating cells
JPWO2008056833A1 (ja) invivoで抗腫瘍活性を有する抗ヒトDlk−1抗体
CN108064343B (zh) 用于前列腺癌分析的组合物和方法
JPWO2009116670A1 (ja) invivoで抗腫瘍活性を有する抗ヒトDlk−1抗体
RU2641968C2 (ru) Композиции и способы анализа рака предстательной железы
JP2020125352A (ja) 抗−cd43抗体およびその癌治療用途
Okamura et al. Superficially located enlarged lymphoid follicles characterise nodular gastritis
CN101553259A (zh) 显示cd63表面表达的细胞的细胞毒性介导
Glumac et al. The identification of a novel antibody for CD133 using human antibody phage display
JP2019528437A (ja) 腫瘍関連マクロファージをターゲティングすることによるガン疾患の処置方法
KR101374758B1 (ko) 항-사이토케라틴 8/18 복합체 자가면역항체를 포함하는 암 진단 마커 및 이의 항원을 포함하는 암 진단용 조성물
Lin et al. Co-expression of CD173 (H2) and CD174 (Lewis Y) with CD44 suggests that fucosylated histo-blood group antigens are markers of breast cancer-initiating cells
US9206258B2 (en) Anti-prostate cancer antibodies and methods of detection and treatment of prostate cancer using the same
JP5711877B2 (ja) 癌の悪性度の検知方法及び癌の悪性度の診断剤
WO2025026204A1 (en) Antibodies against ror1 and uses thereof
US20130143231A1 (en) MST1/STK4 PHOSPHO-THREONINE 120 (pMST-T120) ANTIBODY
WO2020171171A1 (ja) 抗hla-dr抗体、およびそのがん治療用途
HK1255484A1 (en) Compositions and methods for prostate cancer analysis
HK1255484B (en) Compositions and methods for prostate cancer analysis
JP2011001267A (ja) 大腸癌治療薬

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20121024