CN102741259B - 硝基咪唑并噁嗪和硝基咪唑并噁唑的类似物及其用途 - Google Patents

硝基咪唑并噁嗪和硝基咪唑并噁唑的类似物及其用途 Download PDF

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Publication number
CN102741259B
CN102741259B CN201080041655.3A CN201080041655A CN102741259B CN 102741259 B CN102741259 B CN 102741259B CN 201080041655 A CN201080041655 A CN 201080041655A CN 102741259 B CN102741259 B CN 102741259B
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China
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methyl
nitro
oxazine
imidazo
dihydro
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Expired - Fee Related
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English (en)
Chinese (zh)
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CN102741259A (zh
Inventor
安德鲁·M·托姆普松
威廉·亚历山大·丹尼
亚德里恩·布拉泽
马振坤
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Global Alliance for TB Drug Development
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Global Alliance for TB Drug Development
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pulmonology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201080041655.3A 2009-07-31 2010-07-30 硝基咪唑并噁嗪和硝基咪唑并噁唑的类似物及其用途 Expired - Fee Related CN102741259B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23042209P 2009-07-31 2009-07-31
US61/230,422 2009-07-31
PCT/US2010/043908 WO2011014776A1 (en) 2009-07-31 2010-07-30 Nitroimidazooxazine and nitroimidazooxazole analogues and their uses

Publications (2)

Publication Number Publication Date
CN102741259A CN102741259A (zh) 2012-10-17
CN102741259B true CN102741259B (zh) 2016-04-13

Family

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CN201080041655.3A Expired - Fee Related CN102741259B (zh) 2009-07-31 2010-07-30 硝基咪唑并噁嗪和硝基咪唑并噁唑的类似物及其用途

Country Status (13)

Country Link
US (1) US8293734B2 (enExample)
EP (1) EP2459570B1 (enExample)
JP (1) JP5685254B2 (enExample)
KR (1) KR101738868B1 (enExample)
CN (1) CN102741259B (enExample)
AU (1) AU2010278779B2 (enExample)
BR (1) BR112012002214B1 (enExample)
CA (1) CA2769263C (enExample)
ES (1) ES2530266T3 (enExample)
NZ (1) NZ598165A (enExample)
RU (1) RU2540860C2 (enExample)
WO (1) WO2011014776A1 (enExample)
ZA (1) ZA201201259B (enExample)

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GB201012209D0 (en) * 2010-05-31 2010-09-08 Ge Healthcare Ltd In vivo imaging agent
JP5916739B2 (ja) * 2011-04-15 2016-05-11 大塚製薬株式会社 ６，７−ジヒドロイミダゾ［２，１−ｂ］［１，３］オキサジン化合物
JP2015006994A (ja) * 2011-10-28 2015-01-15 大正製薬株式会社 ジヒドロイミダゾオキサゾール誘導体
KR101918469B1 (ko) * 2012-06-04 2018-11-15 한국화학연구원 바이사이클릭 니트로이미다졸 유도체 또는 이들의 광학이성질체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약제학적 조성물
US10301294B2 (en) * 2013-03-13 2019-05-28 The Broad Institute Inc. Compounds for the treatment of tuberculosis
CN104059082B (zh) * 2013-03-21 2016-08-03 苏州迈泰生物技术有限公司 硝基咪唑杂环类化合物及其在制备治疗结核病药物中的应用
KR101564425B1 (ko) 2013-11-26 2015-10-30 한국화학연구원 신규한 바이사이클릭 니트로이미다졸 카바메이트 화합물, 이를 제조하는 방법 및 이를 유효성분으로 함유하는 결핵 질환의 예방 또는 치료용 약제학적 조성물
TWI687409B (zh) 2014-08-28 2020-03-11 日商大塚製藥股份有限公司 稠合雜環化合物
KR101682356B1 (ko) 2014-11-04 2016-12-06 한국화학연구원 이미다조 옥사진 유도체, 이의 약학적으로 허용 가능한 염 또는 이의 광학이성질체 및 이를 유효성분으로 함유하는 약제학적 조성물
WO2016119706A1 (zh) 2015-01-29 2016-08-04 南京明德新药研发股份有限公司 抗肺结核病的硝基咪唑衍生物
GB201519054D0 (en) * 2015-10-28 2015-12-09 Univ Dundee Composition
JP6905506B2 (ja) 2016-02-26 2021-07-21 大塚製薬株式会社 ピペリジン誘導体
CN108727406B (zh) 2017-03-28 2021-12-07 北京协和制药二厂 含氮杂环取代的苯并噁嗪噁唑烷酮类化合物及其制备方法和用途
WO2020223267A1 (en) * 2019-05-01 2020-11-05 Boehringer Ingelheim International Gmbh (r)-(2-methyloxiran-2-yl)methyl 4-bromobenzenesulfonate
KR20240122521A (ko) 2021-12-14 2024-08-12 베링거 인겔하임 인터내셔날 게엠베하 만성 신장 질환 치료용 알도스테론 신타아제 억제제
CN114249747A (zh) * 2021-12-27 2022-03-29 苏州虞美景盛新药开发有限公司 一种用于治疗广泛耐药性结核病的硝基咪唑吡喃类药物的新合成工艺

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WO1997001562A1 (en) * 1995-06-26 1997-01-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
EP1555267A1 (en) * 2002-10-11 2005-07-20 Otsuka Pharmaceutical Co., Ltd. 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES
CN101268084A (zh) * 2005-07-28 2008-09-17 沃泰克斯药物股份有限公司 天冬氨酸特异性半胱氨酸蛋白酶抑制剂前体药物
EP1678185B1 (en) * 2003-10-31 2008-10-08 Otsuka Pharmaceutical Co., Ltd. 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compounds for the treatment of tuberculosis

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IL41744A0 (en) 1972-03-16 1973-05-31 Ciba Geigy Ag New aryl ether derivatives,their production and their use as pesticides
CH568715A5 (enExample) 1972-03-16 1975-11-14 Ciba Geigy Ag
FR2575158B1 (fr) 1984-12-20 1987-10-02 Pf Medicament Arylalcoyloxymethyl-2 morpholines, leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central
SU1271861A1 (ru) * 1985-05-07 1986-11-23 Иркутский институт органической химии СО АН СССР Способ получени 2,2-диметил-3-цианометилиденбензимидазо @ 2,1- @ -1,3-оксазолидина
US6087358A (en) 1995-06-26 2000-07-11 Pathogenesis Corporation Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof
JP4787529B2 (ja) 2004-04-09 2011-10-05 大塚製薬株式会社 医薬組成物
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WO1997001562A1 (en) * 1995-06-26 1997-01-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
EP1555267A1 (en) * 2002-10-11 2005-07-20 Otsuka Pharmaceutical Co., Ltd. 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES
EP1678185B1 (en) * 2003-10-31 2008-10-08 Otsuka Pharmaceutical Co., Ltd. 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compounds for the treatment of tuberculosis
CN101268084A (zh) * 2005-07-28 2008-09-17 沃泰克斯药物股份有限公司 天冬氨酸特异性半胱氨酸蛋白酶抑制剂前体药物

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Also Published As

Publication number Publication date
KR20120084714A (ko) 2012-07-30
RU2012107180A (ru) 2013-09-10
JP2013500997A (ja) 2013-01-10
AU2010278779A1 (en) 2012-03-08
EP2459570B1 (en) 2014-12-24
JP5685254B2 (ja) 2015-03-18
US8293734B2 (en) 2012-10-23
KR101738868B1 (ko) 2017-05-23
US20110028466A1 (en) 2011-02-03
CA2769263C (en) 2017-03-07
CA2769263A1 (en) 2011-02-03
EP2459570A1 (en) 2012-06-06
ZA201201259B (en) 2013-08-28
AU2010278779B2 (en) 2014-08-14
CN102741259A (zh) 2012-10-17
BR112012002214B1 (pt) 2022-01-25
WO2011014776A1 (en) 2011-02-03
RU2540860C2 (ru) 2015-02-10
NZ598165A (en) 2013-05-31
ES2530266T3 (es) 2015-02-27
BR112012002214A2 (pt) 2020-08-18

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