KR101738868B1 - 니트로이미다조옥사진 및 니트로이미다조옥사졸 동족체 및 이들의 용도 - Google Patents

니트로이미다조옥사진 및 니트로이미다조옥사졸 동족체 및 이들의 용도 Download PDF

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KR101738868B1
KR101738868B1 KR1020127005331A KR20127005331A KR101738868B1 KR 101738868 B1 KR101738868 B1 KR 101738868B1 KR 1020127005331 A KR1020127005331 A KR 1020127005331A KR 20127005331 A KR20127005331 A KR 20127005331A KR 101738868 B1 KR101738868 B1 KR 101738868B1
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methyl
nitro
dihydro
oxazine
imidazo
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KR20120084714A (ko
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앤드류 엠. 톰슨
윌리엄 알렉산더 데니
에드리언 블레이저
젠쿤 마
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글로벌 알리앙스 포 티비 드럭 디벨롭먼트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020127005331A 2009-07-31 2010-07-30 니트로이미다조옥사진 및 니트로이미다조옥사졸 동족체 및 이들의 용도 Expired - Fee Related KR101738868B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23042209P 2009-07-31 2009-07-31
US61/230,422 2009-07-31
PCT/US2010/043908 WO2011014776A1 (en) 2009-07-31 2010-07-30 Nitroimidazooxazine and nitroimidazooxazole analogues and their uses

Publications (2)

Publication Number Publication Date
KR20120084714A KR20120084714A (ko) 2012-07-30
KR101738868B1 true KR101738868B1 (ko) 2017-05-23

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KR1020127005331A Expired - Fee Related KR101738868B1 (ko) 2009-07-31 2010-07-30 니트로이미다조옥사진 및 니트로이미다조옥사졸 동족체 및 이들의 용도

Country Status (13)

Country Link
US (1) US8293734B2 (enExample)
EP (1) EP2459570B1 (enExample)
JP (1) JP5685254B2 (enExample)
KR (1) KR101738868B1 (enExample)
CN (1) CN102741259B (enExample)
AU (1) AU2010278779B2 (enExample)
BR (1) BR112012002214B1 (enExample)
CA (1) CA2769263C (enExample)
ES (1) ES2530266T3 (enExample)
NZ (1) NZ598165A (enExample)
RU (1) RU2540860C2 (enExample)
WO (1) WO2011014776A1 (enExample)
ZA (1) ZA201201259B (enExample)

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GB201012209D0 (en) * 2010-05-31 2010-09-08 Ge Healthcare Ltd In vivo imaging agent
US9051333B2 (en) 2011-04-15 2015-06-09 Otsuka Pharmaceutical Co., Ltd. 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides
JP2015006994A (ja) * 2011-10-28 2015-01-15 大正製薬株式会社 ジヒドロイミダゾオキサゾール誘導体
KR101918469B1 (ko) * 2012-06-04 2018-11-15 한국화학연구원 바이사이클릭 니트로이미다졸 유도체 또는 이들의 광학이성질체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약제학적 조성물
US10301294B2 (en) * 2013-03-13 2019-05-28 The Broad Institute Inc. Compounds for the treatment of tuberculosis
CN104059082B (zh) * 2013-03-21 2016-08-03 苏州迈泰生物技术有限公司 硝基咪唑杂环类化合物及其在制备治疗结核病药物中的应用
KR101564425B1 (ko) 2013-11-26 2015-10-30 한국화학연구원 신규한 바이사이클릭 니트로이미다졸 카바메이트 화합물, 이를 제조하는 방법 및 이를 유효성분으로 함유하는 결핵 질환의 예방 또는 치료용 약제학적 조성물
TWI687409B (zh) 2014-08-28 2020-03-11 日商大塚製藥股份有限公司 稠合雜環化合物
KR101682356B1 (ko) 2014-11-04 2016-12-06 한국화학연구원 이미다조 옥사진 유도체, 이의 약학적으로 허용 가능한 염 또는 이의 광학이성질체 및 이를 유효성분으로 함유하는 약제학적 조성물
BR112017015744A2 (pt) 2015-01-29 2018-03-13 Medshine Discovery Inc composto apresentando uma estrutura de fórmula (i), um sal farmaceuticamente aceitável do mesmo ou um isômero ótico do mesmo, composição farmacêutica e uso do composto de fórmula (i) para o tratamento e prevenção de mycobacterium tuberculosis ou outras infecções microbianas
GB201519054D0 (en) * 2015-10-28 2015-12-09 Univ Dundee Composition
JP6905506B2 (ja) 2016-02-26 2021-07-21 大塚製薬株式会社 ピペリジン誘導体
CN108727406B (zh) * 2017-03-28 2021-12-07 北京协和制药二厂 含氮杂环取代的苯并噁嗪噁唑烷酮类化合物及其制备方法和用途
CN113767095A (zh) * 2019-05-01 2021-12-07 勃林格殷格翰国际有限公司 (r)-4-溴苯磺酸(2-甲基环氧乙烷-2-基)甲酯
CA3236890A1 (en) 2021-12-14 2023-06-22 Boehringer Ingelheim International Gmbh Aldosterone synthase inhibitors for treating chronic kidney disease
CN114249747A (zh) * 2021-12-27 2022-03-29 苏州虞美景盛新药开发有限公司 一种用于治疗广泛耐药性结核病的硝基咪唑吡喃类药物的新合成工艺

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IL41744A0 (en) 1972-03-16 1973-05-31 Ciba Geigy Ag New aryl ether derivatives,their production and their use as pesticides
CH568715A5 (enExample) 1972-03-16 1975-11-14 Ciba Geigy Ag
FR2575158B1 (fr) 1984-12-20 1987-10-02 Pf Medicament Arylalcoyloxymethyl-2 morpholines, leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central
SU1271861A1 (ru) * 1985-05-07 1986-11-23 Иркутский институт органической химии СО АН СССР Способ получени 2,2-диметил-3-цианометилиденбензимидазо @ 2,1- @ -1,3-оксазолидина
US6087358A (en) 1995-06-26 2000-07-11 Pathogenesis Corporation Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof
US5668127A (en) 1995-06-26 1997-09-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
TWI347946B (en) 2002-10-11 2011-09-01 Otsuka Pharma Co Ltd 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound
BRPI0414909A (pt) 2003-10-31 2006-11-07 Otsuka Pharma Co Ltd composto, agente antituberculoso, e, método para produzir um composto
JP4787529B2 (ja) 2004-04-09 2011-10-05 大塚製薬株式会社 医薬組成物
JP4789966B2 (ja) 2004-04-09 2011-10-12 大塚製薬株式会社 医薬組成物
KR20060051371A (ko) 2004-09-17 2006-05-19 다이소 가부시키가이샤 이미다조피란 유도체의 제조방법
JP2009502922A (ja) * 2005-07-28 2009-01-29 バーテックス ファーマシューティカルズ インコーポレイテッド カスパーゼ阻害剤プロドラッグ
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Also Published As

Publication number Publication date
WO2011014776A1 (en) 2011-02-03
KR20120084714A (ko) 2012-07-30
CA2769263C (en) 2017-03-07
NZ598165A (en) 2013-05-31
ZA201201259B (en) 2013-08-28
JP5685254B2 (ja) 2015-03-18
CN102741259B (zh) 2016-04-13
CA2769263A1 (en) 2011-02-03
AU2010278779A1 (en) 2012-03-08
EP2459570B1 (en) 2014-12-24
US8293734B2 (en) 2012-10-23
BR112012002214A2 (pt) 2020-08-18
RU2540860C2 (ru) 2015-02-10
AU2010278779B2 (en) 2014-08-14
ES2530266T3 (es) 2015-02-27
US20110028466A1 (en) 2011-02-03
RU2012107180A (ru) 2013-09-10
JP2013500997A (ja) 2013-01-10
BR112012002214B1 (pt) 2022-01-25
EP2459570A1 (en) 2012-06-06
CN102741259A (zh) 2012-10-17

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