CN102740977B - 微芯片和微芯片制造方法 - Google Patents

微芯片和微芯片制造方法 Download PDF

Info

Publication number
CN102740977B
CN102740977B CN201180008428.5A CN201180008428A CN102740977B CN 102740977 B CN102740977 B CN 102740977B CN 201180008428 A CN201180008428 A CN 201180008428A CN 102740977 B CN102740977 B CN 102740977B
Authority
CN
China
Prior art keywords
base layer
microchip
sample solution
channel
fluid channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201180008428.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN102740977A (zh
Inventor
渡边英俊
濑川雄司
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sony Corp
Original Assignee
Sony Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sony Corp filed Critical Sony Corp
Publication of CN102740977A publication Critical patent/CN102740977A/zh
Application granted granted Critical
Publication of CN102740977B publication Critical patent/CN102740977B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN201180008428.5A 2010-02-10 2011-02-01 微芯片和微芯片制造方法 Active CN102740977B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2010-028241 2010-02-10
JP2010028241A JP5218443B2 (ja) 2010-02-10 2010-02-10 マイクロチップ及びマイクロチップの製造方法
PCT/JP2011/000535 WO2011099246A1 (en) 2010-02-10 2011-02-01 Microchip and method of producing microchip

Publications (2)

Publication Number Publication Date
CN102740977A CN102740977A (zh) 2012-10-17
CN102740977B true CN102740977B (zh) 2016-05-04

Family

ID=43902965

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180008428.5A Active CN102740977B (zh) 2010-02-10 2011-02-01 微芯片和微芯片制造方法

Country Status (6)

Country Link
US (2) US9132424B2 (enExample)
EP (1) EP2533902B1 (enExample)
JP (1) JP5218443B2 (enExample)
CN (1) CN102740977B (enExample)
SG (1) SG182707A1 (enExample)
WO (1) WO2011099246A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5218443B2 (ja) * 2010-02-10 2013-06-26 ソニー株式会社 マイクロチップ及びマイクロチップの製造方法
JP2013130396A (ja) * 2011-12-20 2013-07-04 Sony Corp マイクロチップ
JP6197263B2 (ja) * 2012-02-06 2017-09-20 ソニー株式会社 マイクロチップ
CN104303062A (zh) * 2012-05-24 2015-01-21 索尼公司 微芯片
US20150239217A1 (en) * 2012-07-09 2015-08-27 Sony Corporation Microchip and method for manufacturing the same
CN104949789B (zh) * 2014-03-26 2017-10-31 中国科学院理化技术研究所 一种微流道压力传感器
GB201418899D0 (en) 2014-10-23 2014-12-10 Univ Hull System for radiopharmaceutical production
GB201418897D0 (en) 2014-10-23 2014-12-10 Univ Hull Methods and apparatus for the analysis of compounds
GB201418893D0 (en) 2014-10-23 2014-12-10 Univ Hull Monolithic body
CN107249742B (zh) * 2014-12-08 2019-12-06 伯克利之光生命科技公司 微流体装置中定向流动的致动微流体结构及使用它的方法
JP6466774B2 (ja) * 2015-04-30 2019-02-06 栄研化学株式会社 マイクロチップ
CN105715865B (zh) * 2016-03-24 2018-04-27 中国科学院理化技术研究所 电磁微阀装置
JP6394651B2 (ja) * 2016-07-15 2018-09-26 ウシオ電機株式会社 基板の貼り合わせ方法およびマイクロチップの製造方法
WO2018109829A1 (ja) * 2016-12-13 2018-06-21 栄研化学株式会社 マイクロチップ
JP2017203776A (ja) * 2017-06-21 2017-11-16 ソニー株式会社 マイクロチップ
JP7167434B2 (ja) * 2017-12-13 2022-11-09 株式会社ニコン 流体デバイス、リザーバー供給システムおよび流路供給システム
USD878622S1 (en) * 2018-04-07 2020-03-17 Precision Nanosystems Inc. Microfluidic chip
JP6658857B2 (ja) * 2018-12-27 2020-03-04 ソニー株式会社 マイクロチップ
WO2020183938A1 (ja) * 2019-03-08 2020-09-17 株式会社フコク マイクロ流路チップ
CN111013676A (zh) * 2019-12-17 2020-04-17 江苏圣极基因科技有限公司 一种液滴制备方法及微流控芯片
CN119657250B (zh) * 2025-02-20 2025-05-27 至美时代生物智能科技(北京)有限公司 一种储液式微流控芯片及其工作方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1675536A (zh) * 2002-08-02 2005-09-28 日本电气株式会社 微芯片、制造微芯片的方法、以及检测成分的方法
EP1707267A1 (en) * 2005-03-30 2006-10-04 F. Hoffman-la Roche AG Device having a self sealing fluid port
EP1867733A1 (en) * 2006-06-16 2007-12-19 Hitachi Software Engineering Co., Ltd. Biological material preparation chip and preparation chip system and method for DNA extraction from biological materials

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6126899A (en) * 1996-04-03 2000-10-03 The Perkins-Elmer Corporation Device for multiple analyte detection
US20030196695A1 (en) * 2000-11-06 2003-10-23 Nanostream, Inc. Microfluidic flow control devices
US6521188B1 (en) * 2000-11-22 2003-02-18 Industrial Technology Research Institute Microfluidic actuator
US6802342B2 (en) * 2001-04-06 2004-10-12 Fluidigm Corporation Microfabricated fluidic circuit elements and applications
US20040132166A1 (en) * 2001-04-10 2004-07-08 Bioprocessors Corp. Determination and/or control of reactor environmental conditions
US20030040119A1 (en) * 2001-04-11 2003-02-27 The Regents Of The University Of Michigan Separation devices and methods for separating particles
US20030049659A1 (en) * 2001-05-29 2003-03-13 Lapidus Stanley N. Devices and methods for isolating samples into subsamples for analysis
US20020187564A1 (en) * 2001-06-08 2002-12-12 Caliper Technologies Corp. Microfluidic library analysis
EP1439910A2 (en) * 2001-07-26 2004-07-28 Motorola, Inc. System and methods for mixing within a microfluidic device
US20030138969A1 (en) 2002-01-24 2003-07-24 Jakobsen Mogens Havsteen Closed substrate platforms suitable for analysis of biomolecules
GB0128350D0 (en) * 2001-11-27 2002-01-16 Lab901 Ltd Non-rigid apparatus for microfluidic applications
JP2004150891A (ja) * 2002-10-29 2004-05-27 Starlite Co Ltd 化学マイクロデバイス
JP2004219199A (ja) 2003-01-14 2004-08-05 Teruo Fujii 化学マイクロデバイス
JP4399766B2 (ja) * 2003-07-04 2010-01-20 横河電機株式会社 化学反応用カートリッジ
US7111501B2 (en) * 2003-10-03 2006-09-26 Agilent Technologies, Inc. Devices and methods for separating constituents
JP2006029485A (ja) 2004-07-20 2006-02-02 Pentax Corp マイクロバルブ及び該バルブを有するマイクロ流体デバイス
JP2006053064A (ja) * 2004-08-12 2006-02-23 Pentax Corp マイクロ流体チップ及びその製造方法
JP4694945B2 (ja) 2005-01-26 2011-06-08 セイコーインスツル株式会社 反応器、マイクロリアクタチップ、及びマイクロリアクタシステム、並びに反応器の製造方法
JP2006246777A (ja) * 2005-03-10 2006-09-21 Canon Inc 生化学反応用カートリッジおよび生化学反応カートリッジ内での溶液の移動方法
US20070014695A1 (en) * 2005-04-26 2007-01-18 Applera Corporation Systems and Methods for Multiple Analyte Detection
JP2009042103A (ja) * 2007-08-09 2009-02-26 Sony Corp 基板、これを用いた反応処理装置並びに反応制御方法
US8192360B2 (en) * 2007-09-25 2012-06-05 Pacesetter, Inc. Implantable body fluid analyzer
JP5215712B2 (ja) 2008-04-08 2013-06-19 日立アロカメディカル株式会社 マイクロチップ
JP2009284769A (ja) 2008-05-27 2009-12-10 Sony Corp マイクロ基板
JP5071282B2 (ja) 2008-07-15 2012-11-14 ソニー株式会社 ビット選択回路
JP5218443B2 (ja) * 2010-02-10 2013-06-26 ソニー株式会社 マイクロチップ及びマイクロチップの製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1675536A (zh) * 2002-08-02 2005-09-28 日本电气株式会社 微芯片、制造微芯片的方法、以及检测成分的方法
EP1707267A1 (en) * 2005-03-30 2006-10-04 F. Hoffman-la Roche AG Device having a self sealing fluid port
EP1867733A1 (en) * 2006-06-16 2007-12-19 Hitachi Software Engineering Co., Ltd. Biological material preparation chip and preparation chip system and method for DNA extraction from biological materials

Also Published As

Publication number Publication date
US20160001287A1 (en) 2016-01-07
EP2533902B1 (en) 2019-04-03
JP5218443B2 (ja) 2013-06-26
CN102740977A (zh) 2012-10-17
US9132424B2 (en) 2015-09-15
WO2011099246A1 (en) 2011-08-18
US20120301372A1 (en) 2012-11-29
SG182707A1 (en) 2012-08-30
JP2011163984A (ja) 2011-08-25
US9597683B2 (en) 2017-03-21
EP2533902A1 (en) 2012-12-19

Similar Documents

Publication Publication Date Title
CN102740977B (zh) 微芯片和微芯片制造方法
US11440006B2 (en) Microfluidic detection chip for multi-channel rapid detection
US8314488B2 (en) Sample liquid supply container, sample liquid supply container set, and microchip set
CN105555406B (zh) 用于执行聚合酶链式反应的分析单元、用于运行以及用于制造这样的分析单元的方法
US20130153424A1 (en) Microchip
US9669407B2 (en) Microchip
US8691163B2 (en) Sample solution introduction kit and sample solution injector
JP2011163984A5 (enExample)
CN103908982A (zh) 液体注入用夹具套件
CN102621342A (zh) 样本液供给装置、样本液供给装置组以及微芯片组
EP2871482B1 (en) Microchip and method for producing microchip
US9101924B2 (en) Interface device for bio-chip
KR100889727B1 (ko) 모세관력을 이용한 개방형 혈장 분리 필터 소자
JP5708683B2 (ja) マイクロチップ及びマイクロチップの製造方法
JPWO2009034819A1 (ja) マイクロチップの製造方法、マイクロチップ、真空貼付装置
CN104160011A (zh) 用于核酸扩增反应的微芯片的制造方法
JP2013145217A (ja) マイクロチップ及びマイクロチップ内への液体の導入方法
US20140134077A1 (en) Sample liquid injection tool and sample liquid heat treatment apparatus
EP3556853A1 (en) Microchip
Uchida et al. Masaki Kanai¹², Tatsuya Munaka¹, Hirohisa Abe¹, Yoichi Fujiyama¹
JP2013101081A (ja) マイクロチップ

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant