CN102725297A - 头孢菌素衍生物的制造方法 - Google Patents

头孢菌素衍生物的制造方法 Download PDF

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Publication number
CN102725297A
CN102725297A CN2011800074870A CN201180007487A CN102725297A CN 102725297 A CN102725297 A CN 102725297A CN 2011800074870 A CN2011800074870 A CN 2011800074870A CN 201180007487 A CN201180007487 A CN 201180007487A CN 102725297 A CN102725297 A CN 102725297A
Authority
CN
China
Prior art keywords
formula
salt
carboxylic acid
cephem
methylthiazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800074870A
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English (en)
Chinese (zh)
Inventor
和久井淳
大原宣彦
田久保洋介
松本信夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemical Industrial Co Ltd
Original Assignee
Nippon Chemical Industrial Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemical Industrial Co Ltd filed Critical Nippon Chemical Industrial Co Ltd
Publication of CN102725297A publication Critical patent/CN102725297A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D501/06—Acylation of 7-aminocephalosporanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2011800074870A 2010-01-27 2011-01-26 头孢菌素衍生物的制造方法 Pending CN102725297A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2010016053 2010-01-27
JP2010-016053 2010-01-27
PCT/JP2011/051390 WO2011093294A1 (fr) 2010-01-27 2011-01-26 Procédé de préparation d'un dérivé de céphalosporine

Publications (1)

Publication Number Publication Date
CN102725297A true CN102725297A (zh) 2012-10-10

Family

ID=44319281

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800074870A Pending CN102725297A (zh) 2010-01-27 2011-01-26 头孢菌素衍生物的制造方法

Country Status (3)

Country Link
JP (1) JPWO2011093294A1 (fr)
CN (1) CN102725297A (fr)
WO (1) WO2011093294A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103665002A (zh) * 2013-12-18 2014-03-26 成都医路康医学技术服务有限公司 一种头孢妥仑匹酯的制备方法
CN106366097A (zh) * 2016-08-19 2017-02-01 陕西思尔生物科技有限公司 一种头孢妥仑匹脂的制备方法
CN109180704A (zh) * 2018-11-19 2019-01-11 齐鲁安替制药有限公司 一种头孢妥仑匹酯的合成方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013026553B1 (pt) 2011-04-15 2020-01-28 Biogenic Reagents LLC processos para produzir reagentes biogênicos ricos em carbono
JP6728051B2 (ja) * 2014-10-30 2020-07-22 三栄源エフ・エフ・アイ株式会社 ゲニポシド、ゲニピン、又はこれらの両方を除去する方法
BR112023022197A2 (pt) 2021-04-27 2024-02-06 Carbon Tech Holdings Llc Composições de biocarbono com carbono fixo otimizado e processos para produzir o mesmo
US11987763B2 (en) 2021-07-09 2024-05-21 Carbon Technology Holdings, LLC Processes for producing biocarbon pellets with high fixed-carbon content and optimized reactivity, and biocarbon pellets obtained therefrom

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN85106733A (zh) * 1985-07-18 1987-01-14 明治制果株式会社 新头孢菌素化合物的制备方法
US20010016581A1 (en) * 1993-11-17 2001-08-23 Johannes Ludescher Separation of cephalosporin isomers
WO2005003141A2 (fr) * 2003-07-04 2005-01-13 Orchid Chemicals & Pharmaceuticals Ltd Procede perfectionne pour la preparation de cefditoren
WO2005016936A2 (fr) * 2003-08-14 2005-02-24 Ranbaxy Laboratories Limited Procede de preparation selective de l'isomere z de cedfitorene et de ses sels et esters pharmaceutiquement acceptables
WO2005100369A1 (fr) * 2004-04-13 2005-10-27 Ranbaxy Laboratories Limited Depletion d'e-isomeres dans la preparation de cephalosporines (vinyle susbstitue en 2)-3 enrichies en z
CN1964981A (zh) * 2004-06-04 2007-05-16 大塚化学株式会社 3－链烯基头孢烯化合物的制造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61178991A (ja) * 1984-09-07 1986-08-11 Meiji Seika Kaisha Ltd 新規セフアロスポリン化合物

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN85106733A (zh) * 1985-07-18 1987-01-14 明治制果株式会社 新头孢菌素化合物的制备方法
US20010016581A1 (en) * 1993-11-17 2001-08-23 Johannes Ludescher Separation of cephalosporin isomers
WO2005003141A2 (fr) * 2003-07-04 2005-01-13 Orchid Chemicals & Pharmaceuticals Ltd Procede perfectionne pour la preparation de cefditoren
WO2005016936A2 (fr) * 2003-08-14 2005-02-24 Ranbaxy Laboratories Limited Procede de preparation selective de l'isomere z de cedfitorene et de ses sels et esters pharmaceutiquement acceptables
WO2005100369A1 (fr) * 2004-04-13 2005-10-27 Ranbaxy Laboratories Limited Depletion d'e-isomeres dans la preparation de cephalosporines (vinyle susbstitue en 2)-3 enrichies en z
CN1964981A (zh) * 2004-06-04 2007-05-16 大塚化学株式会社 3－链烯基头孢烯化合物的制造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
陈林，等: "头孢托仑酯合成路线图解", 《国外医药抗生素分册》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103665002A (zh) * 2013-12-18 2014-03-26 成都医路康医学技术服务有限公司 一种头孢妥仑匹酯的制备方法
CN103665002B (zh) * 2013-12-18 2016-02-03 成都医路康医学技术服务有限公司 一种头孢妥仑匹酯的制备方法
CN106366097A (zh) * 2016-08-19 2017-02-01 陕西思尔生物科技有限公司 一种头孢妥仑匹脂的制备方法
CN109180704A (zh) * 2018-11-19 2019-01-11 齐鲁安替制药有限公司 一种头孢妥仑匹酯的合成方法

Also Published As

Publication number Publication date
WO2011093294A1 (fr) 2011-08-04
JPWO2011093294A1 (ja) 2013-06-06

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Application publication date: 20121010