CN102725284A - 适用于治疗共核蛋白病的化合物 - Google Patents
适用于治疗共核蛋白病的化合物 Download PDFInfo
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- CN102725284A CN102725284A CN2010800568024A CN201080056802A CN102725284A CN 102725284 A CN102725284 A CN 102725284A CN 2010800568024 A CN2010800568024 A CN 2010800568024A CN 201080056802 A CN201080056802 A CN 201080056802A CN 102725284 A CN102725284 A CN 102725284A
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D473/00—Heterocyclic compounds containing purine ring systems
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Applications Claiming Priority (3)
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| US28708209P | 2009-12-16 | 2009-12-16 | |
| US61/287,082 | 2009-12-16 | ||
| PCT/US2010/060862 WO2011084642A1 (en) | 2009-12-16 | 2010-12-16 | Compound suitable for the treatment of synucleopathies |
Publications (1)
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| CN102725284A true CN102725284A (zh) | 2012-10-10 |
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| CN2010800568024A Pending CN102725284A (zh) | 2009-12-16 | 2010-12-16 | 适用于治疗共核蛋白病的化合物 |
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| EP (1) | EP2513090A1 (enExample) |
| JP (2) | JP5922031B2 (enExample) |
| KR (1) | KR20120112548A (enExample) |
| CN (1) | CN102725284A (enExample) |
| AU (1) | AU2010339841B2 (enExample) |
| BR (1) | BR112012014807A2 (enExample) |
| CA (1) | CA2784744A1 (enExample) |
| MX (1) | MX335989B (enExample) |
| NZ (1) | NZ600449A (enExample) |
| RU (1) | RU2012129882A (enExample) |
| WO (1) | WO2011084642A1 (enExample) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104530013A (zh) * | 2014-12-04 | 2015-04-22 | 中国农业大学 | 基于吲哚环的吡唑酰胺类化合物作为农用杀菌剂的用途 |
| CN106132960A (zh) * | 2014-01-29 | 2016-11-16 | 神经孔疗法股份有限公司 | 用作蛋白质聚集抑制剂的杂芳基酰胺 |
| CN110191885A (zh) * | 2017-01-26 | 2019-08-30 | Ucb生物制药私人有限公司 | 作为蛋白质聚集调节剂的烷氧基双-杂芳基衍生物 |
| CN110198938A (zh) * | 2017-01-26 | 2019-09-03 | Ucb生物制药私人有限公司 | 作为蛋白质聚集调节剂的双-杂芳基衍生物 |
| WO2023125376A1 (zh) * | 2021-12-27 | 2023-07-06 | 上海京新生物医药有限公司 | 作为蛋白质聚集抑制剂的稠合双环杂芳基酰胺化合物 |
| WO2025002040A1 (zh) * | 2023-06-25 | 2025-01-02 | 上海京新生物医药有限公司 | 双环杂芳基酰胺化合物的晶型及盐、制备方法和用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2830608B8 (en) * | 2012-03-28 | 2020-01-15 | UCB Biopharma SRL | Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation |
| US9284309B2 (en) * | 2012-07-16 | 2016-03-15 | Neuropore Therapies, Inc. | Di- and tri-heteroaryl derivatives as inhibitors of protein aggregation |
| WO2014179303A1 (en) * | 2013-04-29 | 2014-11-06 | The General Hospital Corporation | Amyloid precursor protein mrna blockers for treating down syndrome and alzheimer's disease |
| EP3328379B1 (en) * | 2015-07-29 | 2021-07-28 | UCB Biopharma SRL | Bis-heteroaryl derivatives as modulators of protein aggregation |
| KR20190112022A (ko) * | 2017-01-26 | 2019-10-02 | 유씨비 바이오파마 에스피알엘 | 단백질 응집의 조절제로서의 바이사이클릭 비스-헤테로아릴 유도체 |
| US12178805B2 (en) | 2017-05-11 | 2024-12-31 | Remynd N.V. | Inhibitors of PDE6Delta for use in the prevention and/or treatment of epilepsy and/or neurodegenerative disorders |
| WO2018206760A1 (en) | 2017-05-11 | 2018-11-15 | Remynd N.V. | Compounds for the treatment of epilepsy, neurodegenerative disorders and other cns disorders |
| TW202415651A (zh) | 2022-07-29 | 2024-04-16 | 日商住友製藥股份有限公司 | 含氮飽和雜環衍生物 |
| TW202412787A (zh) | 2022-07-29 | 2024-04-01 | 日商住友製藥股份有限公司 | 2(1h)-吡啶亞胺衍生物 |
| WO2024102758A2 (en) * | 2022-11-08 | 2024-05-16 | The General Hospital Corporation | N-(n-aminoalkyl)phenanthridiunium series of chloride-sensitive fluorophores and methods of use thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090054410A1 (en) * | 2006-02-07 | 2009-02-26 | Nv Remynd | Thiadiazole derivatives for the treatment of neurodegenerative diseases |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0726263A3 (en) | 1995-02-08 | 1996-10-09 | American Cyanamid Co | Herbicides (1,3,4) oxadiazoles and thiadiazoles |
| US5591695A (en) | 1995-02-08 | 1997-01-07 | American Cyanamid Co. | Herbicidal [1,3,4]oxadiazoles and thiadiazoles |
| WO1998027108A2 (en) | 1996-12-16 | 1998-06-25 | Fujisawa Pharmaceutical Co., Ltd. | New amide compounds and their use as nitric oxide synthase inhibitors |
| US6096688A (en) | 1996-12-27 | 2000-08-01 | American Cyanamid Company | Oxazole carboxamide herbicides |
| JP2007519753A (ja) | 2004-01-30 | 2007-07-19 | スミスクライン ビーチャム コーポレーション | 化合物 |
| CA2580767A1 (en) * | 2004-09-17 | 2006-03-30 | Whitehead Institute For Biomedical Research | Compounds, compositions and methods of inhibiting alpha-synuclein toxicity |
| DE102004051277A1 (de) | 2004-10-21 | 2006-04-27 | Merck Patent Gmbh | Heterocyclische Carbonylverbindungen |
| KR101394245B1 (ko) * | 2005-12-30 | 2014-05-14 | 에스케이바이오팜 주식회사 | 아이속사졸 유도체 및 이의 용도 |
| EP2007373A4 (en) * | 2006-03-29 | 2012-12-19 | Foldrx Pharmaceuticals Inc | INHIBITION OF ALPHA SYNUCLEINE TOXICITY |
| US8163953B2 (en) * | 2008-04-18 | 2012-04-24 | University Of Connecticut | Compounds for lysosomal modulation and methods of use |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
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2010
- 2010-12-16 BR BR112012014807A patent/BR112012014807A2/pt not_active IP Right Cessation
- 2010-12-16 US US13/516,543 patent/US8846682B2/en active Active
- 2010-12-16 NZ NZ600449A patent/NZ600449A/en not_active IP Right Cessation
- 2010-12-16 KR KR1020127018232A patent/KR20120112548A/ko not_active Ceased
- 2010-12-16 CN CN2010800568024A patent/CN102725284A/zh active Pending
- 2010-12-16 WO PCT/US2010/060862 patent/WO2011084642A1/en not_active Ceased
- 2010-12-16 RU RU2012129882/04A patent/RU2012129882A/ru not_active Application Discontinuation
- 2010-12-16 MX MX2012006740A patent/MX335989B/es unknown
- 2010-12-16 AU AU2010339841A patent/AU2010339841B2/en not_active Ceased
- 2010-12-16 CA CA2784744A patent/CA2784744A1/en not_active Abandoned
- 2010-12-16 JP JP2012544854A patent/JP5922031B2/ja not_active Expired - Fee Related
- 2010-12-16 EP EP10805668A patent/EP2513090A1/en not_active Withdrawn
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2014
- 2014-08-21 US US14/465,773 patent/US20140364610A1/en not_active Abandoned
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2015
- 2015-11-06 JP JP2015218140A patent/JP2016074679A/ja not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090054410A1 (en) * | 2006-02-07 | 2009-02-26 | Nv Remynd | Thiadiazole derivatives for the treatment of neurodegenerative diseases |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106132960A (zh) * | 2014-01-29 | 2016-11-16 | 神经孔疗法股份有限公司 | 用作蛋白质聚集抑制剂的杂芳基酰胺 |
| CN106132960B (zh) * | 2014-01-29 | 2019-12-17 | 优时比生物医药有限公司 | 用作蛋白质聚集抑制剂的杂芳基酰胺 |
| CN111039939A (zh) * | 2014-01-29 | 2020-04-21 | 优时比生物医药有限公司 | 用作蛋白质聚集抑制剂的杂芳基酰胺 |
| CN111039939B (zh) * | 2014-01-29 | 2023-09-19 | 优时比生物医药有限公司 | 用作蛋白质聚集抑制剂的杂芳基酰胺 |
| CN104530013A (zh) * | 2014-12-04 | 2015-04-22 | 中国农业大学 | 基于吲哚环的吡唑酰胺类化合物作为农用杀菌剂的用途 |
| CN104530013B (zh) * | 2014-12-04 | 2016-06-29 | 中国农业大学 | 基于吲哚环的吡唑酰胺类化合物作为农用杀菌剂的用途 |
| CN110191885A (zh) * | 2017-01-26 | 2019-08-30 | Ucb生物制药私人有限公司 | 作为蛋白质聚集调节剂的烷氧基双-杂芳基衍生物 |
| CN110198938A (zh) * | 2017-01-26 | 2019-09-03 | Ucb生物制药私人有限公司 | 作为蛋白质聚集调节剂的双-杂芳基衍生物 |
| CN110198938B (zh) * | 2017-01-26 | 2023-03-14 | Ucb生物制药私人有限公司 | 作为蛋白质聚集调节剂的双-杂芳基衍生物 |
| CN110191885B (zh) * | 2017-01-26 | 2023-05-16 | Ucb生物制药私人有限公司 | 作为蛋白质聚集调节剂的烷氧基双-杂芳基衍生物 |
| WO2023125376A1 (zh) * | 2021-12-27 | 2023-07-06 | 上海京新生物医药有限公司 | 作为蛋白质聚集抑制剂的稠合双环杂芳基酰胺化合物 |
| WO2025002040A1 (zh) * | 2023-06-25 | 2025-01-02 | 上海京新生物医药有限公司 | 双环杂芳基酰胺化合物的晶型及盐、制备方法和用途 |
Also Published As
| Publication number | Publication date |
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| US8846682B2 (en) | 2014-09-30 |
| AU2010339841B2 (en) | 2014-09-25 |
| NZ600449A (en) | 2014-10-31 |
| BR112012014807A2 (pt) | 2017-06-27 |
| RU2012129882A (ru) | 2014-01-27 |
| US20130035342A1 (en) | 2013-02-07 |
| KR20120112548A (ko) | 2012-10-11 |
| JP5922031B2 (ja) | 2016-05-24 |
| JP2013514980A (ja) | 2013-05-02 |
| JP2016074679A (ja) | 2016-05-12 |
| EP2513090A1 (en) | 2012-10-24 |
| US20140364610A1 (en) | 2014-12-11 |
| MX335989B (es) | 2016-01-07 |
| WO2011084642A1 (en) | 2011-07-14 |
| AU2010339841A1 (en) | 2012-07-05 |
| CA2784744A1 (en) | 2011-07-14 |
| MX2012006740A (es) | 2012-09-07 |
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