NZ600449A - Compound suitable for the treatment of synucleopathies - Google Patents
Compound suitable for the treatment of synucleopathiesInfo
- Publication number
- NZ600449A NZ600449A NZ600449A NZ60044910A NZ600449A NZ 600449 A NZ600449 A NZ 600449A NZ 600449 A NZ600449 A NZ 600449A NZ 60044910 A NZ60044910 A NZ 60044910A NZ 600449 A NZ600449 A NZ 600449A
- Authority
- NZ
- New Zealand
- Prior art keywords
- synucleopathies
- treatment
- disease
- compounds
- compound suitable
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 208000018737 Parkinson disease Diseases 0.000 abstract 2
- 206010012289 Dementia Diseases 0.000 abstract 1
- 206010067889 Dementia with Lewy bodies Diseases 0.000 abstract 1
- 201000010374 Down Syndrome Diseases 0.000 abstract 1
- 201000011240 Frontotemporal dementia Diseases 0.000 abstract 1
- 201000002832 Lewy body dementia Diseases 0.000 abstract 1
- 208000001089 Multiple system atrophy Diseases 0.000 abstract 1
- 208000000609 Pick Disease of the Brain Diseases 0.000 abstract 1
- 206010044688 Trisomy 21 Diseases 0.000 abstract 1
- -1 bicyclic heteroaromatic compounds Chemical class 0.000 abstract 1
- 201000010901 lateral sclerosis Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000005264 motor neuron disease Diseases 0.000 abstract 1
- 208000002593 pantothenate kinase-associated neurodegeneration Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28708209P | 2009-12-16 | 2009-12-16 | |
| PCT/US2010/060862 WO2011084642A1 (en) | 2009-12-16 | 2010-12-16 | Compound suitable for the treatment of synucleopathies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ600449A true NZ600449A (en) | 2014-10-31 |
Family
ID=43629477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ600449A NZ600449A (en) | 2009-12-16 | 2010-12-16 | Compound suitable for the treatment of synucleopathies |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8846682B2 (enExample) |
| EP (1) | EP2513090A1 (enExample) |
| JP (2) | JP5922031B2 (enExample) |
| KR (1) | KR20120112548A (enExample) |
| CN (1) | CN102725284A (enExample) |
| AU (1) | AU2010339841B2 (enExample) |
| BR (1) | BR112012014807A2 (enExample) |
| CA (1) | CA2784744A1 (enExample) |
| MX (1) | MX335989B (enExample) |
| NZ (1) | NZ600449A (enExample) |
| RU (1) | RU2012129882A (enExample) |
| WO (1) | WO2011084642A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1202452A1 (en) * | 2012-03-28 | 2015-10-02 | Neuropore Therapies, Inc. | Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation |
| EP2872143B1 (en) * | 2012-07-16 | 2017-12-13 | Neuropore Therapies, Inc. | Di-and tri-heteroaryl derivatives as inhibitors of protein aggregation |
| US10022357B2 (en) | 2013-04-29 | 2018-07-17 | The General Hospital Corporation | Amyloid precursor protein MRNA blockers for treating Down syndrome and Alzheimer's disease |
| EA032374B1 (ru) * | 2014-01-29 | 2019-05-31 | ЮСиБи БАЙОФАРМА СПРЛ | Гетероарильные амиды в качестве ингибиторов агрегации белков |
| CN104530013B (zh) * | 2014-12-04 | 2016-06-29 | 中国农业大学 | 基于吲哚环的吡唑酰胺类化合物作为农用杀菌剂的用途 |
| US10975066B2 (en) | 2015-07-29 | 2021-04-13 | UCB Biopharma SRL | Bis-heteroaryl derivatives as modulators of protein aggregation |
| US10889584B2 (en) | 2017-01-26 | 2021-01-12 | UCB Biopharma SRL | Bicyclic bis-heteroaryl derivatives as modulators of protein aggregation |
| CN110191885B (zh) * | 2017-01-26 | 2023-05-16 | Ucb生物制药私人有限公司 | 作为蛋白质聚集调节剂的烷氧基双-杂芳基衍生物 |
| RU2019126170A (ru) * | 2017-01-26 | 2021-02-26 | Юсб Байофарма Спрл | Бисгетероарильные производные в качестве модуляторов агрегации белков |
| US12178805B2 (en) | 2017-05-11 | 2024-12-31 | Remynd N.V. | Inhibitors of PDE6Delta for use in the prevention and/or treatment of epilepsy and/or neurodegenerative disorders |
| PL3621963T3 (pl) | 2017-05-11 | 2024-05-20 | Remynd N.V. | Związki do leczenia epilepsji, zaburzeń neurodegeneracyjnych i innych zaburzeń oun |
| US20250074902A1 (en) * | 2021-12-27 | 2025-03-06 | Shanghai Jingxin Biomedical Co., Ltd. | Fused bicyclic heteroaryl amide compound as protein aggregation inhibitor |
| TW202412787A (zh) | 2022-07-29 | 2024-04-01 | 日商住友製藥股份有限公司 | 2(1h)-吡啶亞胺衍生物 |
| TW202415651A (zh) | 2022-07-29 | 2024-04-16 | 日商住友製藥股份有限公司 | 含氮飽和雜環衍生物 |
| WO2024102758A2 (en) * | 2022-11-08 | 2024-05-16 | The General Hospital Corporation | N-(n-aminoalkyl)phenanthridiunium series of chloride-sensitive fluorophores and methods of use thereof |
| WO2025002040A1 (zh) * | 2023-06-25 | 2025-01-02 | 上海京新生物医药有限公司 | 双环杂芳基酰胺化合物的晶型及盐、制备方法和用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0726263A3 (en) * | 1995-02-08 | 1996-10-09 | American Cyanamid Co | Herbicides (1,3,4) oxadiazoles and thiadiazoles |
| US5591695A (en) * | 1995-02-08 | 1997-01-07 | American Cyanamid Co. | Herbicidal [1,3,4]oxadiazoles and thiadiazoles |
| EP0946587A2 (en) * | 1996-12-16 | 1999-10-06 | Fujisawa Pharmaceutical Co., Ltd. | New amide compounds |
| US6096688A (en) * | 1996-12-27 | 2000-08-01 | American Cyanamid Company | Oxazole carboxamide herbicides |
| US20080293716A1 (en) * | 2004-01-30 | 2008-11-27 | Smithkline Beecham Corporation | Chemical Compounds |
| ATE531367T1 (de) * | 2004-09-17 | 2011-11-15 | Whitehead Biomedical Inst | Verbindungen, zusammensetzungen und verfahren zur verhinderung einer a-synuklein-vergiftung |
| DE102004051277A1 (de) * | 2004-10-21 | 2006-04-27 | Merck Patent Gmbh | Heterocyclische Carbonylverbindungen |
| KR101394245B1 (ko) * | 2005-12-30 | 2014-05-14 | 에스케이바이오팜 주식회사 | 아이속사졸 유도체 및 이의 용도 |
| US8541406B2 (en) * | 2006-02-07 | 2013-09-24 | Nv Remynd | Thiadiazole derivatives for the treatment of neurodegenerative diseases |
| US20100273776A1 (en) * | 2006-03-29 | 2010-10-28 | FOLDRx PHARMACEUTICALS, INC | Inhibition of alpha-synuclein toxicity |
| WO2009129532A1 (en) * | 2008-04-18 | 2009-10-22 | University Of Connecticut | Compounds for lysosomal modulation and methods of use |
| GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
-
2010
- 2010-12-16 RU RU2012129882/04A patent/RU2012129882A/ru not_active Application Discontinuation
- 2010-12-16 BR BR112012014807A patent/BR112012014807A2/pt not_active IP Right Cessation
- 2010-12-16 MX MX2012006740A patent/MX335989B/es unknown
- 2010-12-16 AU AU2010339841A patent/AU2010339841B2/en not_active Ceased
- 2010-12-16 EP EP10805668A patent/EP2513090A1/en not_active Withdrawn
- 2010-12-16 CA CA2784744A patent/CA2784744A1/en not_active Abandoned
- 2010-12-16 US US13/516,543 patent/US8846682B2/en active Active
- 2010-12-16 WO PCT/US2010/060862 patent/WO2011084642A1/en not_active Ceased
- 2010-12-16 KR KR1020127018232A patent/KR20120112548A/ko not_active Ceased
- 2010-12-16 CN CN2010800568024A patent/CN102725284A/zh active Pending
- 2010-12-16 JP JP2012544854A patent/JP5922031B2/ja not_active Expired - Fee Related
- 2010-12-16 NZ NZ600449A patent/NZ600449A/en not_active IP Right Cessation
-
2014
- 2014-08-21 US US14/465,773 patent/US20140364610A1/en not_active Abandoned
-
2015
- 2015-11-06 JP JP2015218140A patent/JP2016074679A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US8846682B2 (en) | 2014-09-30 |
| MX335989B (es) | 2016-01-07 |
| EP2513090A1 (en) | 2012-10-24 |
| US20140364610A1 (en) | 2014-12-11 |
| AU2010339841A1 (en) | 2012-07-05 |
| US20130035342A1 (en) | 2013-02-07 |
| BR112012014807A2 (pt) | 2017-06-27 |
| AU2010339841B2 (en) | 2014-09-25 |
| CN102725284A (zh) | 2012-10-10 |
| RU2012129882A (ru) | 2014-01-27 |
| JP2013514980A (ja) | 2013-05-02 |
| JP5922031B2 (ja) | 2016-05-24 |
| KR20120112548A (ko) | 2012-10-11 |
| CA2784744A1 (en) | 2011-07-14 |
| WO2011084642A1 (en) | 2011-07-14 |
| MX2012006740A (es) | 2012-09-07 |
| JP2016074679A (ja) | 2016-05-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 16 DEC 2017 BY JAMES + WELLS Effective date: 20150907 |
|
| S38C | Proceedings under section 38 (amendment of specification with leave of commissioner): specification amended | ||
| S38C | Proceedings under section 38 (amendment of specification with leave of commissioner): specification amended | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2018 BY CPA GLOBAL Effective date: 20171102 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2019 BY CPA GLOBAL Effective date: 20181102 |
|
| LAPS | Patent lapsed |