BR112012014807A2 - "compostos adequados para o tratamento de sinucleopatias" - Google Patents
"compostos adequados para o tratamento de sinucleopatias"Info
- Publication number
- BR112012014807A2 BR112012014807A2 BR112012014807A BR112012014807A BR112012014807A2 BR 112012014807 A2 BR112012014807 A2 BR 112012014807A2 BR 112012014807 A BR112012014807 A BR 112012014807A BR 112012014807 A BR112012014807 A BR 112012014807A BR 112012014807 A2 BR112012014807 A2 BR 112012014807A2
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- group
- unsubstituted
- carbon atoms
- homocyclic
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000002723 alicyclic group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28708209P | 2009-12-16 | 2009-12-16 | |
| PCT/US2010/060862 WO2011084642A1 (en) | 2009-12-16 | 2010-12-16 | Compound suitable for the treatment of synucleopathies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012014807A2 true BR112012014807A2 (pt) | 2017-06-27 |
Family
ID=43629477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012014807A BR112012014807A2 (pt) | 2009-12-16 | 2010-12-16 | "compostos adequados para o tratamento de sinucleopatias" |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8846682B2 (enExample) |
| EP (1) | EP2513090A1 (enExample) |
| JP (2) | JP5922031B2 (enExample) |
| KR (1) | KR20120112548A (enExample) |
| CN (1) | CN102725284A (enExample) |
| AU (1) | AU2010339841B2 (enExample) |
| BR (1) | BR112012014807A2 (enExample) |
| CA (1) | CA2784744A1 (enExample) |
| MX (1) | MX335989B (enExample) |
| NZ (1) | NZ600449A (enExample) |
| RU (1) | RU2012129882A (enExample) |
| WO (1) | WO2011084642A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2830608B8 (en) * | 2012-03-28 | 2020-01-15 | UCB Biopharma SRL | Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation |
| US9284309B2 (en) * | 2012-07-16 | 2016-03-15 | Neuropore Therapies, Inc. | Di- and tri-heteroaryl derivatives as inhibitors of protein aggregation |
| WO2014179303A1 (en) * | 2013-04-29 | 2014-11-06 | The General Hospital Corporation | Amyloid precursor protein mrna blockers for treating down syndrome and alzheimer's disease |
| AU2015211119B2 (en) | 2014-01-29 | 2019-05-30 | Ucb Biopharma Sprl | Heteroaryl amides as inhibitors of protein aggregation |
| CN104530013B (zh) * | 2014-12-04 | 2016-06-29 | 中国农业大学 | 基于吲哚环的吡唑酰胺类化合物作为农用杀菌剂的用途 |
| EP3328379B1 (en) * | 2015-07-29 | 2021-07-28 | UCB Biopharma SRL | Bis-heteroaryl derivatives as modulators of protein aggregation |
| AU2018213886A1 (en) * | 2017-01-26 | 2019-07-25 | UCB Biopharma SRL | Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation |
| ES2882285T3 (es) * | 2017-01-26 | 2021-12-01 | Ucb Biopharma Sprl | Derivados de bis-heteroarilo como moduladores de la agregación de proteínas |
| KR20190112022A (ko) * | 2017-01-26 | 2019-10-02 | 유씨비 바이오파마 에스피알엘 | 단백질 응집의 조절제로서의 바이사이클릭 비스-헤테로아릴 유도체 |
| US12178805B2 (en) | 2017-05-11 | 2024-12-31 | Remynd N.V. | Inhibitors of PDE6Delta for use in the prevention and/or treatment of epilepsy and/or neurodegenerative disorders |
| WO2018206760A1 (en) | 2017-05-11 | 2018-11-15 | Remynd N.V. | Compounds for the treatment of epilepsy, neurodegenerative disorders and other cns disorders |
| US20250074902A1 (en) * | 2021-12-27 | 2025-03-06 | Shanghai Jingxin Biomedical Co., Ltd. | Fused bicyclic heteroaryl amide compound as protein aggregation inhibitor |
| TW202415651A (zh) | 2022-07-29 | 2024-04-16 | 日商住友製藥股份有限公司 | 含氮飽和雜環衍生物 |
| TW202412787A (zh) | 2022-07-29 | 2024-04-01 | 日商住友製藥股份有限公司 | 2(1h)-吡啶亞胺衍生物 |
| WO2024102758A2 (en) * | 2022-11-08 | 2024-05-16 | The General Hospital Corporation | N-(n-aminoalkyl)phenanthridiunium series of chloride-sensitive fluorophores and methods of use thereof |
| WO2025002040A1 (zh) * | 2023-06-25 | 2025-01-02 | 上海京新生物医药有限公司 | 双环杂芳基酰胺化合物的晶型及盐、制备方法和用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0726263A3 (en) | 1995-02-08 | 1996-10-09 | American Cyanamid Co | Herbicides (1,3,4) oxadiazoles and thiadiazoles |
| US5591695A (en) | 1995-02-08 | 1997-01-07 | American Cyanamid Co. | Herbicidal [1,3,4]oxadiazoles and thiadiazoles |
| WO1998027108A2 (en) | 1996-12-16 | 1998-06-25 | Fujisawa Pharmaceutical Co., Ltd. | New amide compounds and their use as nitric oxide synthase inhibitors |
| US6096688A (en) | 1996-12-27 | 2000-08-01 | American Cyanamid Company | Oxazole carboxamide herbicides |
| JP2007519753A (ja) | 2004-01-30 | 2007-07-19 | スミスクライン ビーチャム コーポレーション | 化合物 |
| CA2580767A1 (en) * | 2004-09-17 | 2006-03-30 | Whitehead Institute For Biomedical Research | Compounds, compositions and methods of inhibiting alpha-synuclein toxicity |
| DE102004051277A1 (de) | 2004-10-21 | 2006-04-27 | Merck Patent Gmbh | Heterocyclische Carbonylverbindungen |
| KR101394245B1 (ko) * | 2005-12-30 | 2014-05-14 | 에스케이바이오팜 주식회사 | 아이속사졸 유도체 및 이의 용도 |
| US8541406B2 (en) * | 2006-02-07 | 2013-09-24 | Nv Remynd | Thiadiazole derivatives for the treatment of neurodegenerative diseases |
| EP2007373A4 (en) * | 2006-03-29 | 2012-12-19 | Foldrx Pharmaceuticals Inc | INHIBITION OF ALPHA SYNUCLEINE TOXICITY |
| US8163953B2 (en) * | 2008-04-18 | 2012-04-24 | University Of Connecticut | Compounds for lysosomal modulation and methods of use |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
-
2010
- 2010-12-16 BR BR112012014807A patent/BR112012014807A2/pt not_active IP Right Cessation
- 2010-12-16 US US13/516,543 patent/US8846682B2/en active Active
- 2010-12-16 NZ NZ600449A patent/NZ600449A/en not_active IP Right Cessation
- 2010-12-16 KR KR1020127018232A patent/KR20120112548A/ko not_active Ceased
- 2010-12-16 CN CN2010800568024A patent/CN102725284A/zh active Pending
- 2010-12-16 WO PCT/US2010/060862 patent/WO2011084642A1/en not_active Ceased
- 2010-12-16 RU RU2012129882/04A patent/RU2012129882A/ru not_active Application Discontinuation
- 2010-12-16 MX MX2012006740A patent/MX335989B/es unknown
- 2010-12-16 AU AU2010339841A patent/AU2010339841B2/en not_active Ceased
- 2010-12-16 CA CA2784744A patent/CA2784744A1/en not_active Abandoned
- 2010-12-16 JP JP2012544854A patent/JP5922031B2/ja not_active Expired - Fee Related
- 2010-12-16 EP EP10805668A patent/EP2513090A1/en not_active Withdrawn
-
2014
- 2014-08-21 US US14/465,773 patent/US20140364610A1/en not_active Abandoned
-
2015
- 2015-11-06 JP JP2015218140A patent/JP2016074679A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US8846682B2 (en) | 2014-09-30 |
| AU2010339841B2 (en) | 2014-09-25 |
| NZ600449A (en) | 2014-10-31 |
| RU2012129882A (ru) | 2014-01-27 |
| US20130035342A1 (en) | 2013-02-07 |
| KR20120112548A (ko) | 2012-10-11 |
| JP5922031B2 (ja) | 2016-05-24 |
| JP2013514980A (ja) | 2013-05-02 |
| JP2016074679A (ja) | 2016-05-12 |
| EP2513090A1 (en) | 2012-10-24 |
| CN102725284A (zh) | 2012-10-10 |
| US20140364610A1 (en) | 2014-12-11 |
| MX335989B (es) | 2016-01-07 |
| WO2011084642A1 (en) | 2011-07-14 |
| AU2010339841A1 (en) | 2012-07-05 |
| CA2784744A1 (en) | 2011-07-14 |
| MX2012006740A (es) | 2012-09-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112012014807A2 (pt) | "compostos adequados para o tratamento de sinucleopatias" | |
| MX2009005449A (es) | Compuesto heteromonociclico y uso del mismo. | |
| MX2009010024A (es) | Nuevo compuesto de adenina. | |
| NZ608314A (en) | Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy | |
| BR112012003955A2 (pt) | compostos heterocíclicos tricíclicos como inibidores da fosfoinositídeos 3-quinase | |
| MX2012015023A (es) | Derivado novedoso de nicotinamida o sal del mismo. | |
| PE20090770A1 (es) | Derivados de benzoxazolona | |
| MX2010008818A (es) | Derivado de bicicloamina. | |
| BRPI0818193B8 (pt) | composto, composição farmacêutica, e, uso de um composto | |
| BRPI0809770B8 (pt) | Composto e composição para controlar uma praga de invertebrados | |
| MY161094A (en) | Anti-tumor effect potentiator | |
| NZ630259A (en) | Heterobicyclic compounds as beta-lactamase inhibitors | |
| TN2009000287A1 (en) | Cyclized derivatives as eg-5inhibitors | |
| AR039150A1 (es) | Piridinoilpiperidinas como agonistas de 5-ht1f | |
| NO20091858L (no) | Hydrobenzamid derivater som inhibitorer av HSP90 | |
| MY149180A (en) | Uracil compound having inhibitor activity on human deoxyuridine triphosphatase or salt thereof | |
| MA30315B1 (fr) | Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| PH12012500542A1 (en) | Substituted amide compound | |
| AR068115A1 (es) | Derivado del acido pirazolcarboxilico metodo de produccion del mismo y fungicida | |
| BR112015015275A2 (pt) | composto heterocíclico substituído por halogênio | |
| BR112013026116A2 (pt) | derivados etinílicos como moduladores alostéricos positivos de mglur5 | |
| BR112013021848A2 (pt) | 5-(fenil/piridinil-etinil)-2-piridina/2-pirimidina-carboxamidas como moduladores de mglur5 | |
| BR112013017416A2 (pt) | derivado de indola ou indazola ou sal do mesmo | |
| BR112013023480A8 (pt) | composto heterocíclico saturado contendo nitrogênio | |
| DOP2005000091A (es) | (4-metoxi-7-morfolin-4-il-benzotiazol-2-il) amida del acido 4-hidroxi-4-metil-piperidin-1-carboxilico |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES. |
|
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |