CN102716228A - Traditional Chinese medicine composition for treating acute and chronic viral hepatitis and preparation method for traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating acute and chronic viral hepatitis and preparation method for traditional Chinese medicine composition Download PDFInfo
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- CN102716228A CN102716228A CN201210227564XA CN201210227564A CN102716228A CN 102716228 A CN102716228 A CN 102716228A CN 201210227564X A CN201210227564X A CN 201210227564XA CN 201210227564 A CN201210227564 A CN 201210227564A CN 102716228 A CN102716228 A CN 102716228A
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- fructus schisandrae
- schisandrae chinensis
- herba hedyotidis
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Abstract
The invention discloses a traditional Chinese medicine composition for treating acute and chronic viral hepatitis and a preparation method for the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from 100-150g of Schisandra chinensis, 100-150g of Oldenlandia diffusa and 8-20g of Cordyceps sinensis. The traditional Chinese medicine composition has the effects of clearing heat and removing toxicity, supporting the healthy energy and simultaneously treating principal and subordinate symptoms, and is used for treating all kinds of acute and chronic viral hepatitis.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition of treating acute and chronic hepatitis, particularly relating to a kind of is the Chinese medicine composition of the treatment acute and chronic hepatitis of crude drug preparation with Chinese medicine.The invention still further relates to the method for preparing of this Chinese medicine composition.
Background technology
Viral hepatitis also belongs to disease categories such as " jaundice " in motherland's medical science, " epidemic febrile disease ", " purplish or white patches on the skin is long-pending ".Its pathogenesis is burnt in the damp-heat accumulation, the transporting and transforming function of the spleen and stomach imbalance, so that indigestion and loss of appetite, lack of appetite; Depression and stagnation of QI, stomach-QI being unable to descend normally, thereby nauseating abdominal distention; Spleen governing muscles, extremity, wet being stranded in spleen, temper is not transported, and then limbs are sleepy, fatigue and weak.Liver and gall are the exterior and the interior each other, and also with placed in the middle burnt, so damp-heat in the spleen and stomach whenever is prone to suffocating of liver and gall, defeated the letting out of bile do not followed Chang Dao; The dipping appearance is overflow in skin, thereby produces jaundice, and the appearance skin all shows resembling of jaundice; The liver master dredges and stagnates, damp-heat blocking in the body, and liver is lost bar and reaches; Depression and stagnation of QI, venation is become estranged, and alt-reducing and liver-protecting is a fundamentum.
Modern medicine study shows that viral hepatitis is to be caused by different hepatitis viruss, and being one group is the infectious disease of sign with liver inflammation, downright bad pathological changes, has characteristics such as strong, popular wide, the sickness rate height of infectiousness.The patient who suffers from viral hepatitis can be the performance of acute hepatitis or chronic hepatitis, and might develop into the possibility of liver cirrhosis and hepatocarcinoma.At present the treatment viral hepatitis in, though Western medicine has a lot, effect is not satisfactory, therefore also needs further to develop the medicine of new treatment viral hepatitis.
Summary of the invention
The purpose of this invention is to provide a kind of is the Chinese medicine composition of the treatment acute and chronic hepatitis of crude drug preparation with Chinese medicine; This Chinese medicine composition gets Fructus Schisandrae Chinensis extractum and Herba Hedyotidis Diffusae extractum through Fructus Schisandrae Chinensis and Herba Hedyotidis Diffusae are carried out extraction separation respectively; Two kinds of extractum and Cordyceps powder, dextrin are carried out scientific and reasonable combination by a certain percentage, thereby the effect of heat-clearing and toxic substances removing, strengthening the body resistance is provided.This Chinese medicine composition treating both the principal and the secondary aspects of a disease at the same time can be treated all kinds of acute and chronic hepatitis.
Simultaneously, another object of the present invention provides the method for preparing that the present invention treats the Chinese medicine composition of acute and chronic hepatitis.
The Chinese medicine composition that the present invention treats acute and chronic hepatitis is that crude drug prepares: Fructus Schisandrae Chinensis, Herba Hedyotidis Diffusae and Cordyceps by following Chinese medicine.
Preferably, the Chinese medicine composition of said treatment acute and chronic hepatitis is processed by Fructus Schisandrae Chinensis 100-200g, Herba Hedyotidis Diffusae 100-200g and Cordyceps 5-40g.
More preferably, the Chinese medicine composition of said treatment acute and chronic hepatitis is processed by Fructus Schisandrae Chinensis 100-150g, Herba Hedyotidis Diffusae 100-150g and Cordyceps 8-20g.
More preferably, the Chinese medicine composition of said treatment acute and chronic hepatitis is processed by Fructus Schisandrae Chinensis 100-120g, Herba Hedyotidis Diffusae 100-120g and Cordyceps 8-13g.
Most preferably, the Chinese medicine composition of said treatment acute and chronic hepatitis is processed by Fructus Schisandrae Chinensis 100g, Herba Hedyotidis Diffusae 100 and Cordyceps 8g.
More than the method for preparing step of the Chinese medicine composition of treatment acute and chronic hepatitis is following:
(1) Fructus Schisandrae Chinensis adds 50-80% alcohol reflux secondary, adds the 50-80% ethanol of 3-6 times of volume for the first time, adds the 50-80% ethanol of 4-5 times of volume for the second time; Each 1-1.5 hour, merge extractive liquid, filtered; Filtrate recycling ethanol; And the relative density that is concentrated into 50-80 ℃ is 0.5-2.8, Fructus Schisandrae Chinensis extractum, subsequent use;
(2) Herba Hedyotidis Diffusae adds water reflux, extract, secondary, adds the water of 3-6 times of volume for the first time, adds the water of 4-5 times of volume for the second time; Each 1-1.5 hour, merge extractive liquid, filtered; The relative density that is concentrated into 80-100 ℃ of filtrating is 1.0-2.0, gets Herba Hedyotidis Diffusae extractum, and is subsequent use;
(3) Cordyceps is pulverized, crossed the 60-80 mesh sieve, subsequent use;
(4) will be mixed by Fructus Schisandrae Chinensis extractum, Herba Hedyotidis Diffusae extractum, the Cordyceps powder that above-mentioned steps obtains, gained mixture and dextrin are pressed (2.5-3): 1 weight ratio stirs, and drying, pulverizing, dress zero capsule, check, packing promptly get.
Treat in the Chinese medicine composition of acute and chronic hepatitis in the present invention, the effect of each crude drug is following:
Fructus Schisandrae Chinensis is Magnoliacea plant [Schisandga Chinensis (Turcz.) Baill], and cause and effect has sweet, sour, hot, bitter, the salty five tastes in fact and gains the name.Fruit both can be used as medicine and also can be used for wine brewing, system juice preparation of drinks, have grow lung, arresting seminal emission, hidroschesis, antidiarrheal, promote the production of body fluid, Fructus Alpiniae Oxyphyllae, the effect of calming the nerves.
Herba Hedyotidis Diffusae; Be the herb of Rubiaceae cerastium plant Herba Hedyotidis Diffusae Hedyotis diffusa Willd. [Oldenlandia diffusa (Willd.) Roxb.], sweet in the mouth is light; Return stomach, lung, large intestine, urinary bladder channel, the effect of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, promoting urination to remove dampness is arranged.
Cordyceps, for wheat Cordycepps Cordyceps fungus colonizes in Stroma and the complex of polypide on the Hepialidae insect larvae, being linked to each other with the fungus Stroma that grows from the worm head by polypide forms.Cordyceps has curative effect preferably to diseases such as anti-curing oncoma, acute or chronic hepatitis, nephritis, bronchitis, cough with asthma, cytopenia, the raising immune function of human body is arranged in addition, health-care efficacies such as allaying tiredness and slow down aging.
In we, Herba Hedyotidis Diffusae has the heat-clearing and toxic substances removing dampness removing, and alt-reducing and liver-protecting is that substrate is got rid of, and helps the recovery of liver function; Cordyceps plays strong tonic, tonify deficiency profit and loss vital essence, protects the liver kidney tonifying, controls weakness, flat spleen reinforcing warp, the effect of ridging Rong Mu; Fructus Schisandrae Chinensis can increase the function of detoxification and the hepatocellular antagonism of liver, promotes glycogen and protein anabolism, helps hepatocellular reparation, to reducing serum glutamic pyruvic transminase significant curative effect is arranged.
The specific embodiment
Through embodiment the present invention is carried out detailed explanation below.
Embodiment 1:
Prepare the Chinese medicine composition that the present invention treats acute and chronic hepatitis according to following method:
Take by weighing Fructus Schisandrae Chinensis 100g, add 70% alcohol reflux secondary, add 70% ethanol of 4 times of volumes for the first time, add 75% ethanol of 4-5 times of volume for the second time; Each 1 hour, merge extractive liquid, filtered filtrate recycling ethanol; And the relative density that is concentrated into 60 ℃ is 2.0, Fructus Schisandrae Chinensis extractum, subsequent use;
Take by weighing Herba Hedyotidis Diffusae 100g, add water reflux, extract, secondary, add the water of 3 times of volumes for the first time, add the water of 4 times of volumes for the second time, each 1.5 hours, merge extractive liquid, filtered, and the relative density that is concentrated into 80 ℃ of filtrating is 1.0, gets Herba Hedyotidis Diffusae extractum, and is subsequent use;
Take by weighing Cordyceps 8g, pulverize, cross 60 mesh sieves, subsequent use;
To be mixed by Fructus Schisandrae Chinensis extractum, Herba Hedyotidis Diffusae extractum, the Cordyceps powder that above-mentioned steps obtains, gained mixture and dextrin stir by 3: 1 weight ratio, and drying, pulverizing, dress zero capsule, check, packing promptly get.
Embodiment 2:
Prepare the Chinese medicine composition that the present invention treats acute and chronic hepatitis according to following method:
Take by weighing Fructus Schisandrae Chinensis 150g, add 55% alcohol reflux secondary, add 55% ethanol of 6 times of volumes for the first time, add 55% ethanol of 4 times of volumes for the second time; Each 1 hour, merge extractive liquid, filtered filtrate recycling ethanol; And the relative density that is concentrated into 80 ℃ is 1.8, Fructus Schisandrae Chinensis extractum, subsequent use;
Take by weighing Herba Hedyotidis Diffusae 130g, add water reflux, extract, secondary, add the water of 6 times of volumes for the first time, add the water of 5 times of volumes for the second time, each 1 hour, merge extractive liquid, filtered, and the relative density that is concentrated into 100 ℃ of filtrating is 1.75, gets Herba Hedyotidis Diffusae extractum, and is subsequent use;
Take by weighing Cordyceps 12g, pulverize, cross 70 mesh sieves, subsequent use;
To be mixed by Fructus Schisandrae Chinensis extractum, Herba Hedyotidis Diffusae extractum, the Cordyceps powder that above-mentioned steps obtains, gained mixture and dextrin stir by 2.5: 1 weight ratio, and drying, pulverizing, dress zero capsule, check, packing promptly get.
Embodiment 3:
Prepare the Chinese medicine composition that the present invention treats acute and chronic hepatitis according to following method:
Take by weighing Fructus Schisandrae Chinensis 120g, add 80% alcohol reflux secondary, add 80% ethanol of 3 times of volumes for the first time, add 80% ethanol of 4 times of volumes for the second time; Each 1 hour, merge extractive liquid, filtered filtrate recycling ethanol; And the relative density that is concentrated into 60 ℃ is 2.4, Fructus Schisandrae Chinensis extractum, subsequent use;
Take by weighing Herba Hedyotidis Diffusae 140g, add water reflux, extract, secondary, add the water of 5 times of volumes for the first time, add the water of 4 times of volumes for the second time, each 1 hour, merge extractive liquid, filtered, and the relative density that is concentrated into 90 ℃ of filtrating is 1.5, gets Herba Hedyotidis Diffusae extractum, and is subsequent use;
Take by weighing Cordyceps 10g, pulverize, cross 80 mesh sieves, subsequent use;
To be mixed by Fructus Schisandrae Chinensis extractum, Herba Hedyotidis Diffusae extractum, the Cordyceps powder that above-mentioned steps obtains, gained mixture and dextrin stir by 2.8: 1 weight ratio, and drying, pulverizing, dress zero capsule, check, packing promptly get.
Clinical example:
1, diagnostic criteria: according to the diagnostic criteria of in November, 1978 China medical association whole nation viral hepatitis academic conference, confirm acute and chronic hepatitis patient totally 30 examples, age 20-50 year, the men and women does not limit.
2, Therapeutic Method: to this 30 routine patient's orally give embodiment of the invention 1 prepared Chinese medicine, take the 2-3 grain, every day three times, one month is a course of treatment at every turn.During with traditional Chinese medicine composition for treating of the present invention, all patients do not give other any medicine.
3, curative effect is judged: therapeutic effect is according to produce effects, effective and invalid classifications.Wherein, produce effects is that clinical symptoms and sign disappear or obviously improvement, and serum alanine aminotransferase (ALT) is reduced to normally, and serum total bilirubin (TBil) is reduced to normal range (promptly being lower than 17.1 μ mol/L); Effectively be that clinical symptoms takes a turn for the better to some extent, sign is more stable, ALT reduce to the treatment before below 50%; Invalid is that patient's sings and symptoms does not change after finishing the course of treatment, and perhaps the state of an illness increases the weight of.Produce effects is all listed effective percentage in effective case and is calculated.
4, therapeutic outcome:
(1), to the influence of liver function
The variation
of liver function before and after table 1 treatment
(Δ p＜0.01 before and after the treatment)
Measure the patient respectively with serum alanine aminotransferase (ALT), aspartic transaminase (AST), albumins/globulins (A/G) and serum total bilirubin (TBil) before and after the traditional Chinese medicine composition for treating of the present invention, to investigate the influence of Chinese medicine composition of the present invention to the patients with hepatic function.Experimental result is seen table 1.
The result shows that after traditional Chinese medicine composition for treating of the present invention, patient's ALT, AST, TBIL significantly descend, and A/G increases to some extent, explain the acute and chronic hepatitis patient liver function be improved significantly.
(2) influence of symptoms and sign
Observe various clinical symptoms and sign variation that the patient takes traditional Chinese medicine composition for treating of the present invention front and back, to investigate the influence of Chinese medicine composition of the present invention to the patients with hepatic function.Experimental result is seen table 2.
The variation of sings and symptoms before and after table 2 treatment
The result shows that after traditional Chinese medicine composition for treating of the present invention, patient's clinical symptoms and sign have clear improvement, and particularly abdominal distention and inappetence change obviously.
(3) untoward reaction
In the process that 30 routine patients are treated with this Chinese medicine composition, do not see that untoward reaction such as heating, erythra, skin itching, vomiting, diarrhoea appear in the patient, show that Chinese medicine composition side effect of the present invention is little, drug safety.
Claims (6)
1. Chinese medicine composition of treating acute and chronic hepatitis is characterized in that described Chinese medicine composition processed by Fructus Schisandrae Chinensis, Herba Hedyotidis Diffusae and Cordyceps.
2. a kind of Chinese medicine composition of treating acute and chronic hepatitis as claimed in claim 1 is characterized in that described Chinese medicine composition processed by Fructus Schisandrae Chinensis 100-200g, Herba Hedyotidis Diffusae 100-200g and Cordyceps 5-40g.
3. a kind of Chinese medicine composition of treating acute and chronic hepatitis as claimed in claim 2 is characterized in that described Chinese medicine composition processed by Fructus Schisandrae Chinensis 100-150g, Herba Hedyotidis Diffusae 100-150g and Cordyceps 8-20g.
4. a kind of Chinese medicine composition of treating acute and chronic hepatitis as claimed in claim 3 is characterized in that described Chinese medicine composition processed by Fructus Schisandrae Chinensis 100-120g, Herba Hedyotidis Diffusae 100-120g and Cordyceps 8-13g.
5. a kind of Chinese medicine composition of treating acute and chronic hepatitis as claimed in claim 4 is characterized in that described Chinese medicine composition processed by Fructus Schisandrae Chinensis 100g, Herba Hedyotidis Diffusae 100 and Cordyceps 8g.
6. like each described a kind of method for preparing of treating the Chinese medicine composition of acute and chronic hepatitis of claim 1-5, it is characterized in that preparation process is following:
(1) Fructus Schisandrae Chinensis adds 50-80% alcohol reflux secondary, adds the 50-80% ethanol of 3-6 times of volume for the first time, adds the 50-80% ethanol of 4-5 times of volume for the second time; Each 1-1.5 hour, merge extractive liquid, filtered; Filtrate recycling ethanol; And the relative density that is concentrated into 50-80 ℃ is 0.5-2.8, Fructus Schisandrae Chinensis extractum, subsequent use;
(2) Herba Hedyotidis Diffusae adds water reflux, extract, secondary, adds the water of 3-6 times of volume for the first time, adds the water of 4-5 times of volume for the second time; Each 1-1.5 hour, merge extractive liquid, filtered; The relative density that is concentrated into 80-100 ℃ of filtrating is 1.0-2.0, gets Herba Hedyotidis Diffusae extractum, and is subsequent use;
(3) Cordyceps is pulverized, crossed the 60-80 mesh sieve, subsequent use;
(4) will be mixed by Fructus Schisandrae Chinensis extractum, Herba Hedyotidis Diffusae extractum, the Cordyceps powder that above-mentioned steps obtains, gained mixture and dextrin are pressed (2.5-3): 1 weight ratio stirs, and drying, pulverizing, dress zero capsule, check, packing promptly get.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210227564.XA CN102716228B (en) | 2012-06-27 | 2012-06-27 | Traditional Chinese medicine composition for treating acute and chronic viral hepatitis and preparation method for traditional Chinese medicine composition |
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| CN201210227564.XA CN102716228B (en) | 2012-06-27 | 2012-06-27 | Traditional Chinese medicine composition for treating acute and chronic viral hepatitis and preparation method for traditional Chinese medicine composition |
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| CN102716228A true CN102716228A (en) | 2012-10-10 |
| CN102716228B CN102716228B (en) | 2014-01-15 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106110274A (en) * | 2016-08-18 | 2016-11-16 | 陈定潜 | A kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106110274A (en) * | 2016-08-18 | 2016-11-16 | 陈定潜 | A kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure and preparation method thereof |
| CN106110274B (en) * | 2016-08-18 | 2019-08-30 | 陈定潜 | It is a kind of for treating the Chinese medicine composition and preparation method thereof of chronic viral hepatitis or hepatic failure |
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| CN102716228B (en) | 2014-01-15 |
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