CN106110274B - It is a kind of for treating the Chinese medicine composition and preparation method thereof of chronic viral hepatitis or hepatic failure - Google Patents
It is a kind of for treating the Chinese medicine composition and preparation method thereof of chronic viral hepatitis or hepatic failure Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The present invention provides a kind of for treating the Chinese medicine composition and preparation method thereof of chronic viral hepatitis or hepatic failure, the Chinese medicine composition is the medicament made of bulk pharmaceutical chemicals, and raw material medicaments in part by weight number meter includes: 10-20 parts of ginseng, 15-30 parts of Radix Astragali, 15-18 parts of oriental wormwood, 10-15 parts of radix bupleuri, 17-20 parts of radix paeoniae rubra, 10-15 parts of the dried immature fruit of citron orange, 5-15 parts of rhizoma pinellinae praeparata, 15-20 parts of Poria cocos, 5-10 parts of radix aucklandiae, 5-15 parts of fructus amomi, 5-10 parts of safflower, 15-20 parts of jujube, 10-15 parts of ginger, 5-10 parts of Radix Glycyrrhizae.Preparation method is the decocting method of decoction.Curative effect of this Chinese medicine composition when with the treatment of combination of Chinese tradiational and Western medicine Combining Artificial Liver is fine, and reduces the number for needing artificial liver in treatment, has saved medical treatment cost.This Chinese medicine composition effectively can treat chronic viral hepatitis and hepatic failure in conjunction with doctor trained in Western medicine, be a kind of new departure safely, effectively, economic for treating chronic viral hepatitis or hepatic failure disease.
Description
Technical field
The present invention relates to the field of Chinese medicines, are used for chronic viral hepatitis or hepatic failure Chinese medicine group in particular to one kind
Close object and preparation method thereof.
Background technique
Chronic hepatitis B is pandemic communicable disease, if treatment can develop not in time as cirrhosis or liver cancer etc.
Major Liver disease generates serious threat to the life and health of patient.Clinical treatment mostly uses antiviral, immune adjust at present
Section improves the complex treatments such as liver function, but drug therapy toxicity is big, adverse reaction is more and medicine high price is expensive.More and more experts
A large amount of clinical observations and research have been carried out to TCM Treatment for Chronic Hepatitis B.
Hepatic failure is the low disease incidence caused by Hepadna Virus, the dangerous hepatitis of high mortality, and disease incidence accounts for about jaundice
The 3% of type hepatitis, is the serious disease for threatening hepatopath's life, and medical treatment case fatality rate is 30%~83.3%.In view of liver
The high mortality of failure, adopt various measures reduce hepatic failure patients the death rate be the treatment of current hepatic failure difficult point and heat
Point.
There are mainly three types for the treatment of methods for hepatic failure at present: medical treatment, artificial liver in treatment and liver transfer operation.In China due to taking
With it is expensive, for the reasons such as liver is in short supply, liver transfer operation is still difficult to commonly used, and most of severe viral hepatitis cannot be benefited.Internal medicine is controlled
Treatment method is identical, including general supportive treatment, protection liver cell, prevention and treatment complication etc., but therapeutic effect is not good enough, and the death rate is still
It is high.Artificial liver in treatment is the important means for treating hepatic failure in recent years.However, the curative effect of single artificial liver is usually with the time
Extend and disappear, clinically needs that artificial liver in treatment is repeated.In addition, artificial liver in treatment is expensive, to some disease
Ability to shoulder economically is also limited for people, especially needs multiple artificial liver in treatment person, therefore part patient misses
Best occasion for the treatment, it is last dead.
It is imperative instead of the cost-effective method of artificial liver in treatment to seek a kind of energy.Therefore, excellent by traditional medicine
Gesture, explores one kind safely, effectively and economic therapeutic scheme is particularly necessary.
Summary of the invention
The first object of the present invention is to provide a kind of for treating the Chinese traditional medicine composition of chronic viral hepatitis or hepatic failure
The principle of reatment of object, this traditional Chinese medicine composition for treating chronic viral hepatitis or hepatic failure is dispersing the stagnated liver-QI and dredging collateral, dehumidifying of being amusing, and is hited
The interpretation of the cause, onset and process of an illness of chronic viral hepatitis or hepatic failure is matched with fragrant sand erchen tangization sanction to get the drug of the Chinese medicine composition of this programme
Side.This Chinese medicine composition can be not only used for the treatment of hepatic failure acute stage, reduces mortality and liver function is promoted to restore,
And care for shield taste；It can also be used for the convalescence of hepatic failure；In addition, this Chinese medicine composition imitates the treatment of chronic viral hepatitis
Fruit is good, helps to improve the quality of life of patient.
The second object of the present invention is to provide the preparation method of Chinese medicine composition described in one kind, and the preparation method is simple
Easy, parameters are controllable, strong operability, easy to industrialized production under the premise of keeping drug effect.
In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:
It is a kind of for treating the Chinese medicine composition of chronic viral hepatitis or hepatic failure, Chinese medicine composition is by bulk pharmaceutical chemicals system
At medicament, raw material medicaments in part by weight number meter includes:
10-20 parts of ginseng, 15-30 parts of Radix Astragali, 15-18 parts of oriental wormwood, 10-15 parts of radix bupleuri, 17-20 parts of radix paeoniae rubra, the dried immature fruit of citron orange
10-15 parts, 5-15 parts of rhizoma pinellinae praeparata, 15-20 parts of Poria cocos, 5-10 parts of radix aucklandiae, 5-15 parts of fructus amomi, 5-10 parts of safflower, jujube
15-20 parts, 10-15 parts of ginger, 5-10 parts of Radix Glycyrrhizae.
It is a kind of for treating the preparation method of the Chinese medicine composition of chronic viral hepatitis or hepatic failure, will be in bulk pharmaceutical chemicals
Ginseng, Radix Astragali, oriental wormwood, radix bupleuri, radix paeoniae rubra, the dried immature fruit of citron orange, rhizoma pinellinae praeparata, Poria cocos, radix aucklandiae, safflower, jujube, ginger and Radix Glycyrrhizae and water are mixed
It closes, the volume of water is 9-11 times of bulk pharmaceutical chemicals gross mass, and heating decocts, and slightly boiled 20-40min is kept after boiling, and is filtered, medicine
Slag continues to decoct 1-2 times, merges and decocts resulting filtrate, fructus amomi is added after boiling, keeps slightly boiled 3-5min to get decoction.
" heavy type hepatitis " this name of disease is had no in traditional Chinese medicine, since jaundice runs through this disease always, and mostly with mind
Faint time, it is clinical and often show as that the state of an illness is critical, and patient's condition is urgent, Chinese medicine " acute febrile " scope can be belonged to, and infect because it has
Feature, therefore be referred to as " pest yellow ", " jaundice of day row ", whens merging bleeding, ascites, hepatic encephalopathy etc., then with " blood trouble ", " tympanites ",
Diseases such as " liver-syncope " are related.
Modern many doctors are distinguished by " damp and hot " controls chronic severe hepatitis, is mostly added and subtracted with Yinchenhao Tang, Oriental Wormwood Decoction；Some then lays particular emphasis on the " stasis of blood
Blood jaundice "；Also there is part doctor to think that weakened body resistance evil Sheng, (gas) deficiency of yang wet poison are important pathomechanism, advocate to chronic hepatitis
Cannot excessively use clearing heat and promoting diuresis and activating microcirculation and removing stasis medicinal, so not only can the impairment of the spleen again, symptom is further aggravated, and to weakened body resistance
Domination of pathogen person easily leads to bleeding etc., makes that sb.'s illness took a turn for the worse.
Compared with prior art, the invention has the benefit that
(1) inventor passes through the clinical practice of many years, and it is due to wet that discovery hepatic failure patients jaundice shows as " yin jaundice " more
Poison retardance, liver network pent-up cause.Therefore we, with fragrant sand erchen tangization sanction, are obtained for principle of reatment with dispersing the stagnated liver-QI and dredging collateral, dehumidifying of being amusing
Chinese medicine composition in case.
(2) this pharmaceutical composition is dim to hepatic failure patients mesh xanthochromia color, angel, it is out of strength, receive poor, pink tongue, thin lingual fur
The symptoms such as white greasy, wiry and rolling pulse have good relaxation effect, also have well when invalid to the improvement of liver function to artificial liver in treatment
Facilitation.
(3) Chinese medicine composition follows the principles of formulating prescriptions of Chinese medicine " monarch ", and wherein monarch drug in a prescription is radix bupleuri, reason that radix bupleuri is soothing the liver
Gas again can sending up the lucid YANG so that hot and suffocating outer.Ministerial drug is oriental wormwood and radix paeoniae rubra, and yin is held back in radix paeoniae rubra blood-nourishing, is matched with radix bupleuri, one liter one is held back, and is made
Strongly fragrant solution is without impairment of yin；Oriental wormwood normalizing gallbladder to cure jaundice, matching with radix bupleuri enhances its diathermanous choleretic effect.Adjutant is the dried immature fruit of citron orange, rhizoma pinellinae praeparata, Fu
Siberian cocklebur, costus root, fructus amomi, safflower, sun-dried ginseng and astragalus root, wherein the dried immature fruit of citron orange, rhizoma pinellinae praeparata, Poria cocos, costus root, fructus amomi, safflower are common
The monarch and his subjects' dampness elimination promoting the circulation of qi is assisted, vital energy regualting and blood circulation-promoting is in；Sun-dried ginseng, astragalus root energy QI invigorating training member, keep gas biochemistry active.Make medicine: Radix Glycyrrhizae,
Ginger, jujube, three's coordinating the drug actions of a prescription in ginger-red jujube stomach function regulating tune, promote all medicines to absorb.
(4) fructus amomi has the function of dampness elimination appetizing, ventilating, stomach strengthening and digestion promoting.Decoction is made in the Chinese medicine composition
In preparation method, fructus amomi is finally added in filtrate and decocts 3-5min, and this method both can ensure that the effective component in fructus amomi
Dissolution rate is maximum, and is avoided that the loss of armaticity effective component volatile in fructus amomi, to make the medicine of the Chinese medicine composition
Effect is best.
(5) curative effect of this Chinese medicine composition when with the treatment of combination of Chinese tradiational and Western medicine Combining Artificial Liver is fine, and reduces
The number for needing artificial liver in treatment, has saved medical treatment cost.This Chinese medicine composition can be treated effectively in conjunction with doctor trained in Western medicine
Hepatic failure is a kind of new departure safely, effectively, economic for treating hepatic failure.This Chinese medicine composition can be not only used for hepatic failure
The treatment of acute stage reduces mortality and liver function is promoted to restore；It can also be used for the convalescence of hepatic failure；In addition, right
Also there is good facilitation to the improvement of liver function when artificial liver in treatment is invalid.
(6) this Chinese medicine composition also has good therapeutic effect to chronic viral hepatitis, and patient takes the Chinese medicine group
After closing object continuous one month, symptom mitigates, and helps to improve the quality of life of patient.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
The present invention provides a kind of for treating the Chinese medicine composition of chronic viral hepatitis or hepatic failure, and Chinese medicine composition is
The medicament made of bulk pharmaceutical chemicals, raw material medicaments in part by weight number meter include:
10-20 parts of ginseng, 15-30 parts of Radix Astragali, 15-25 parts of oriental wormwood, 10-15 parts of radix bupleuri, 15-20 parts of radix paeoniae rubra, the dried immature fruit of citron orange
10-15 parts, 5-15 parts of rhizoma pinellinae praeparata, 15-20 parts of Poria cocos, 5-10 parts of radix aucklandiae, 5-15 parts of fructus amomi, 5-10 parts of safflower, jujube
15-20 parts, 10-15 parts of ginger, 5-10 parts of Radix Glycyrrhizae.
It is further preferred that above-mentioned ginseng is 13-20 parts, Radix Astragali is 19-30 parts, oriental wormwood is 17-18 parts, radix bupleuri is
11-15 parts, radix paeoniae rubra be 18-20 parts, the dried immature fruit of citron orange is 11-15 parts, rhizoma pinellinae praeparata is 7-15 parts, Poria cocos is 16-20 parts, radix aucklandiae is
6-10 parts, fructus amomi be 7-15 parts, safflower is 6-10 parts, jujube is 16-20 parts, ginger is 11-15 parts and Radix Glycyrrhizae is
6-10 parts.
Highly preferred, above-mentioned ginseng is 20 parts, Radix Astragali is 30 parts, oriental wormwood is 18 parts, radix bupleuri is 15 parts, radix paeoniae rubra 20
Part, the dried immature fruit of citron orange are 15 parts, rhizoma pinellinae praeparata is 15 parts, Poria cocos is 20 parts, radix aucklandiae is 10 parts, fructus amomi is 15 parts, safflower is 10 parts, jujube is
15 parts, ginger be 15 parts, Radix Glycyrrhizae is 5 parts.
Curative effect of this Chinese medicine composition when with the treatment of combination of Chinese tradiational and Western medicine Combining Artificial Liver is fine, and reduces needs
The number of artificial liver in treatment, has saved medical treatment cost.This Chinese medicine composition effectively can treat liver failure in conjunction with doctor trained in Western medicine
It exhausts, is a kind of new departure safely, effectively, economic for treating hepatic failure.
This Chinese medicine composition can be not only used for the treatment of hepatic failure acute stage, reduces mortality and promotes liver function
Restore；It can also be used for the convalescence of hepatic failure；In addition, also having good rush to the improvement of liver function when invalid to artificial liver in treatment
Into effect.
The Chinese medicine composition follows the principles of formulating prescriptions of Chinese medicine " monarch ", and wherein monarch drug in a prescription is radix bupleuri, radix bupleuri dispersing stagnated hepatoqi
Again can sending up the lucid YANG so that hot and suffocating outer.Ministerial drug is oriental wormwood and radix paeoniae rubra, and yin is held back in radix paeoniae rubra blood-nourishing, is matched with radix bupleuri, one liter one is held back, and is made strongly fragrant
Saturating solution is without impairment of yin；Oriental wormwood normalizing gallbladder to cure jaundice, matching with radix bupleuri enhances its diathermanous choleretic effect.Adjutant is the dried immature fruit of citron orange, rhizoma pinellinae praeparata, Fu
Siberian cocklebur, costus root, fructus amomi, safflower, sun-dried ginseng and astragalus root, wherein the dried immature fruit of citron orange, rhizoma pinellinae praeparata, Poria cocos, costus root, fructus amomi, safflower are common
The monarch and his subjects' dampness elimination promoting the circulation of qi is assisted, vital energy regualting and blood circulation-promoting is in；Sun-dried ginseng, astragalus root energy QI invigorating training member, keep gas biochemistry active.Make medicine: Radix Glycyrrhizae,
Ginger, jujube, three's coordinating the drug actions of a prescription in ginger-red jujube stomach function regulating tune, promote all medicines to absorb.
In the Chinese medicine composition:
Monarch drug in a prescription: radix bupleuri, can harmonizing Sharyang, relax liver stomach function regulating, yang invigorating, modern pharmacological research prompt radix bupleuri have solution
Heat is brought down a fever, anti-liver injury and antiviral effect.
Ministerial drug: oriental wormwood, can clearing heat and promoting diuresis, removing jaundice, modern pharmacological research prompts oriental wormwood to have cholagogue, refrigeration function
Effect；Radix paeoniae rubra, being capable of promoting blood circulation to remove blood stasis.Modern pharmacological research prompt radix paeoniae rubra have inhibit platelet aggregation, antithrombotic formation,
Reduce blood glucose and liver-protective effect.
Adjutant: the dried immature fruit of citron orange, can relieving stagnant Qi disperse accumulation, eliminating phlegm and dispersing mass；Rhizoma pinellinae praeparata, can eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, disappear ruffian
Dissipating bind；Poria cocos, being capable of eliminating dampness and diuresis, strengthening the spleen and stomach, antitoxic heart-soothing and sedative；Radix aucklandiae, can middle benefit gas promoting qi circulation and relieving pain, reinforcing spleen to promote digestion lead
It is stagnant；Fructus amomi, can dampness elimination appetizing, ventilating, stomach strengthening and digestion promoting；Safflower, being capable of blood circulation, removing blood stasis and acesodyne；Sun-dried ginseng,
It can reinforce vital energy, strengthening the spleen and tonifying the lung；Radix Astragali, being capable of invigorating qi for strengthening superficies.
Make medicine: Radix Glycyrrhizae is invigorated the spleen and benefited qi, relieving spasm to stop pain, coordinating the drug actions of a prescription；Ginger, being capable of inducing sweat and dispelling exogenous evils, warm stomach preventing or arresting vomiting；It is red
Jujube can strengthen the spleen and stomach, yin and blood nourishing, mental-tranquilization.
Inventor is according to the clinical experiences of many years, it is believed that hepatic failure is divided into liver and gallbladder damp-heat, water retention due to hypofunction of the spleen, stagnation in liver meridian and liver
Gas virtual loss four-stage, the course of disease later period is common " weight in wet base is in heat ", shows as " yin jaundice ", therefore focuses on " real spleen " this therapy, and " real
Spleen " is not limited to help, and based on " dehumidifying of being amusing, promoting blood circulation and removing obstruction in channels " of innovation.By a period of time medication, subtract to humidity hysteresis stasis blocking
After light, liver- qi invasion patient is added to answer its gas using sour-sweet herbs nourishing yin, burnt bitter Invigorating Qi and waits drugs to facilitate liver with replenishing qi to invigorate the spleen
The reparation and regeneration of cell, thus advantageously reduce case fatality rate.The traditional Chinese medicinal components in conjunction with doctor trained in Western medicine and are combined into artificial liver in treatment,
The liver function that hepatic failure patients can be improved, the death rate for reducing hepatic failure patients short-term (4 weekend), the generation for reducing complication.
In order to further increase the drug effect of this traditional Chinese medicine composition for treating chronic viral hepatitis or hepatic failure, above-mentioned ginseng
Preferably sun-dried ginseng.Sun-dried ginseng is after cleaning ginseng and scraping off rough bark, directly to dry to obtain, sun-dried ginseng is during processing
The loss reduction of effective component.Modern pharmacological research prompts sun-dried ginseng to have enhancing immune function of human body, inhibition thrombosis, resist
Anoxic improves microcirculation, promotes the functions such as body substance metabolism and the synthesis of protein and RNA, DNA.
It is further preferred that above-mentioned radix aucklandiae is that mica is fragrant.Mica perfume (or spice) middle benefit gas promoting qi circulation and relieving pain, the drug effect of reinforcing spleen to promote digestion promoting are more
It is good.Modern pharmacological research, which prompts costus root to have, improves cardiovascular function effect.In order to further improve this Chinese traditional medicine composition
Object treats the drug effect of hepatic failure, and above-mentioned Radix Astragali is preferably astragalus root, and the effect of astragalus root invigorating middle warmer and replenishing QI is more preferable, is conducive to QI invigorating training
Member keeps gas biochemistry active.
In preferred embodiments of the present invention, above-mentioned medicament is decoction, granule, pill, powder, tablet or capsule
Agent.Above-mentioned preparation is made in pharmaceutical composition, facilitates the storage of the Chinese medicine composition, transport and facilitate patients.Particle
These are all conventional pharmaceutical dosage forms for agent, pill, powder, tablet or capsule, and production technology is highly developed, this
Field technical staff can refer to conventional production process and prepare.
The present invention provides a kind of preparation method that above-mentioned Chinese medicine composition is made to decoction: by ginseng, the Huang in bulk pharmaceutical chemicals
Stilbene, oriental wormwood, radix bupleuri, radix paeoniae rubra, the dried immature fruit of citron orange, rhizoma pinellinae praeparata, Poria cocos, radix aucklandiae, safflower, jujube, ginger and Radix Glycyrrhizae mix with water, water
Volume is 9-11 times of bulk pharmaceutical chemicals gross mass, and heating decocts, and slightly boiled 20-40min is kept after boiling, and is filtered, and the dregs of a decoction continue
It decocts 1-2 times, merges and decoct resulting filtrate, fructus amomi is added after boiling, keeps slightly boiled 3-5min to get decoction.
Fructus amomi has the function of dampness elimination appetizing, ventilating, stomach strengthening and digestion promoting.The Chinese medicine composition is made to the preparation of decoction
In method, fructus amomi is finally added in filtrate and decocts 3-5min, and this method both can ensure that the effective component in fructus amomi dissolved out
Rate is maximum, and is avoided that the loss of armaticity effective component volatile in fructus amomi, to make the drug effect of the Chinese medicine composition most
It is good.
In order to endure out the effective substance in above-mentioned compound medicine to a greater extent, in preferred embodiments of the present invention,
Before water is mixed with bulk pharmaceutical chemicals, each medicinal material drying in bulk pharmaceutical chemicals is first crushed to 4-20 mesh.Smashed each medicinal material can be with water
It comes into full contact with, so that the dissolution rate of active principle is high.It is further preferred that bulk pharmaceutical chemicals soak after mixing with water before heating decocts
Steep 40-80min, be conducive to decoct when effective component being capable of Fast Stripping.
Embodiment 1
The present embodiment provides a kind of for treating the Chinese medicine composition of chronic viral hepatitis or hepatic failure, Chinese medicine composition
The medicament made of bulk pharmaceutical chemicals, raw material medicaments in part by weight number meter include:
Ginseng 10g, Radix Astragali 15g, oriental wormwood 15g, radix bupleuri 10g, radix paeoniae rubra 17g, dried immature fruit of citron orange 10g, rhizoma pinellinae praeparata 5g, Poria cocos 15g, radix aucklandiae
5g, fructus amomi 5g, safflower 5g, jujube 15g, ginger 10g and Radix Glycyrrhizae 5g.
Preparation method: by bulk pharmaceutical chemicals ginseng, Radix Astragali, oriental wormwood, radix bupleuri, radix paeoniae rubra, the dried immature fruit of citron orange, rhizoma pinellinae praeparata, Poria cocos, radix aucklandiae,
Safflower, jujube, ginger and Radix Glycyrrhizae mix with water, and the volume of water is 9 times of bulk pharmaceutical chemicals gross mass, and heating decocts, after boiling
Slightly boiled 40min is kept, is filtered, the dregs of a decoction continue to decoct 2 times, merge and decoct resulting filtrate, and fructus amomi is added after boiling, and keep slightly boiled
3min is to get decoction.
Embodiment 2
The present embodiment provides a kind of for treating the Chinese medicine composition of chronic viral hepatitis or hepatic failure, Chinese medicine composition
The medicament made of bulk pharmaceutical chemicals, raw material medicaments in part by weight number meter include:
Ginseng 13g, Radix Astragali 19g, oriental wormwood 17g, radix bupleuri 11g, radix paeoniae rubra 18g, dried immature fruit of citron orange 11g, rhizoma pinellinae praeparata 7g, Poria cocos 16g, radix aucklandiae
6g, fructus amomi 7g, safflower 6g, jujube 16g, ginger 11g, Radix Glycyrrhizae 6g.
Preparation method: by bulk pharmaceutical chemicals ginseng, Radix Astragali, oriental wormwood, radix bupleuri, radix paeoniae rubra, the dried immature fruit of citron orange, rhizoma pinellinae praeparata, Poria cocos, radix aucklandiae,
Safflower, jujube, ginger and Radix Glycyrrhizae mix with water, and the volume of water is 11 times of bulk pharmaceutical chemicals gross mass, and heating decocts, wait boil
After keep slightly boiled 20min, filter, the dregs of a decoction continue to decoct 1 time, merge and decoct resulting filtrate, and fructus amomi is added after boiling, and keep micro-
5min is boiled to get decoction.
Embodiment 3
The present embodiment provides a kind of for treating the Chinese medicine composition of chronic viral hepatitis or hepatic failure, Chinese medicine composition
The medicament made of bulk pharmaceutical chemicals, raw material medicaments in part by weight number meter include:
Sun-dried ginseng 20g, astragalus root 30g, oriental wormwood 18g, radix bupleuri 15g, radix paeoniae rubra 20g, dried immature fruit of citron orange 15g, rhizoma pinellinae praeparata 15g, Poria cocos
20g, Aplotaxis auriculata 10g, fructus amomi 15g, safflower 10g, jujube 15g, ginger 15g and Radix Glycyrrhizae 5g.
Preparation method: by sun-dried ginseng, astragalus root, oriental wormwood, radix bupleuri, radix paeoniae rubra, the dried immature fruit of citron orange, rhizoma pinellinae praeparata, Poria cocos, the cloud in bulk pharmaceutical chemicals
Radix aucklandiae, safflower, jujube, ginger and Radix Glycyrrhizae mix with water, and the volume of water is 10 times of bulk pharmaceutical chemicals gross mass, and heating decocts, to
Slightly boiled 30min is kept after boiling, is filtered, and the dregs of a decoction continue to decoct 2 times, merge and decoct resulting filtrate, fructus amomi is added after boiling, and protect
Slightly boiled 4min is held to get decoction.
Embodiment 4
The present embodiment provides a kind of for treating the Chinese medicine composition of chronic viral hepatitis or hepatic failure, Chinese medicine composition
The medicament made of bulk pharmaceutical chemicals, raw material medicaments in part by weight number meter include:
Sun-dried ginseng 17g, astragalus root 26g, oriental wormwood 18g, radix bupleuri 14g, radix paeoniae rubra 19g, dried immature fruit of citron orange 14g, rhizoma pinellinae praeparata 13g, Poria cocos
19g, radix aucklandiae 9g, fructus amomi 13g, safflower 9g, jujube 19g, ginger 14g, Radix Glycyrrhizae 9g.
Preparation method: by sun-dried ginseng, astragalus root, oriental wormwood, radix bupleuri, radix paeoniae rubra, the dried immature fruit of citron orange, rhizoma pinellinae praeparata, Poria cocos, the wood in bulk pharmaceutical chemicals
Perfume, safflower, jujube, ginger and Radix Glycyrrhizae mix with water, and the volume of water is 10 times of bulk pharmaceutical chemicals gross mass, after immersion 40min again
Heating decocts, and slightly boiled 30min is kept after boiling, and filters, and the dregs of a decoction continue to decoct 2 times, merges and decocts resulting filtrate, after boiling
Fructus amomi is added, keeps slightly boiled 4min to get decoction.
Embodiment 5
The present embodiment provides a kind of for treating the Chinese medicine composition of chronic viral hepatitis or hepatic failure, Chinese medicine composition
The medicament made of bulk pharmaceutical chemicals, raw material medicaments in part by weight number meter include:
Ginseng 20g, Radix Astragali 30g, oriental wormwood 18g, radix bupleuri 15g, radix paeoniae rubra 20g, dried immature fruit of citron orange 15g, rhizoma pinellinae praeparata 15g, Poria cocos 20g, wood
Fragrant 10g, fructus amomi 15g, safflower 10g, jujube 20g, ginger 15g and Radix Glycyrrhizae 10g.
Preparation method: by bulk pharmaceutical chemicals ginseng, Radix Astragali, oriental wormwood, radix bupleuri, radix paeoniae rubra, the dried immature fruit of citron orange, rhizoma pinellinae praeparata, Poria cocos, radix aucklandiae,
Safflower, jujube, ginger and Radix Glycyrrhizae mix with water, and the volume of water is 10 times of bulk pharmaceutical chemicals gross mass, add again after impregnating 80min
Heat decoction, keeps slightly boiled 30min after boiling, and filters, and the dregs of a decoction continue to decoct 2 times, merge and decoct resulting filtrate, adds after boiling
Enter fructus amomi, keeps slightly boiled 4min to get decoction.
Embodiment 6
The present embodiment provides a kind of for treating the Chinese medicine composition of chronic viral hepatitis or hepatic failure, in the present embodiment
Bulk pharmaceutical chemicals composition and embodiment 3 it is consistent, the difference is that:
Preparation method: respectively by sun-dried ginseng, astragalus root, oriental wormwood, radix bupleuri, radix paeoniae rubra, the dried immature fruit of citron orange, rhizoma pinellinae praeparata, the Fu in bulk pharmaceutical chemicals
After Siberian cocklebur, Aplotaxis auriculata, safflower, jujube, ginger and Radix Glycyrrhizae are crushed to 20 mesh, above-mentioned medicinal material is mixed with water, the volume of water is former
10 times for expecting medicine gross mass, heating decoct, and slightly boiled 30min is kept after boiling, and filter, and the dregs of a decoction continue to decoct 1-2 times, merge
Resulting filtrate is decocted, fructus amomi is added after boiling, keeps slightly boiled 4min to get decoction.
Embodiment 7
The present embodiment provides a kind of for treating the Chinese medicine composition of chronic viral hepatitis or hepatic failure, in the present embodiment
Bulk pharmaceutical chemicals composition and embodiment 3 it is consistent, the difference is that:
Preparation method: respectively by sun-dried ginseng, astragalus root, oriental wormwood, radix bupleuri, radix paeoniae rubra, the dried immature fruit of citron orange, rhizoma pinellinae praeparata, the Fu in bulk pharmaceutical chemicals
After Siberian cocklebur, Aplotaxis auriculata, safflower, jujube, ginger and Radix Glycyrrhizae are crushed to 4 mesh, above-mentioned medicinal material is mixed with water, the volume of water is former
10 times for expecting medicine gross mass reheat decoction after impregnating 60min, slightly boiled 30min are kept after boiling, filter, and the dregs of a decoction continue to decoct
It boils 1-2 times, merges and decoct resulting filtrate, fructus amomi is added after boiling, keeps slightly boiled 4min to get decoction.
Comparative example 1
This comparative example provides one kind for Chinese medicine composition, which is the medicament made of bulk pharmaceutical chemicals, raw material
Medicine includes: according to parts by weight
Sun-dried ginseng 10g, astragalus root 20g, oriental wormwood 20g, radix bupleuri 15g, radix paeoniae rubra 15g, dried immature fruit of citron orange 15g, rhizoma pinellinae praeparata 15g, Poria cocos
20g, Aplotaxis auriculata 10g, fructus amomi 15g, safflower 10g, Radix Notoginseng 6g, ginger 15g and Radix Glycyrrhizae 5g.
The method and embodiment 3 that decoction is made in the Chinese medicine composition are unanimously.
Test example 1
Clinical test of the Chinese medicine composition to patients with chronic viral hepatitis:
One, testing program
1. case selection 1
Case derives from Chengdu public health clinical treatment center, is divided into two groups of patients for the treatment of group and control group and meets
" viral hepatitis prevention program " standard that 10th national virus hepatitis academic conference is formulated.In 38 patients for the treatment of group,
It is male 20, women 18, the age 33~62 years old, average age 44.6 years old, the course of disease 1 year~17 years, 9.7 years average.Control group
It is male 22, women 16, the age 28~68 years old, average age 45.2 years old, the course of disease 1 year~15 years, 8.4 years average.Two groups of trouble
No significant difference (P > 0.05) of the person in terms of gender, age and the course of disease
2. therapeutic scheme
Two groups of patients are all made of conventional anti-viral, liver protection treatment.Treatment group on this basis, takes obtained by embodiment 3
Decoction, embodiment 3 decocts using thickener of boiling medicine is unified, one dose per day, every dose decoct after be concentrated into 60mL, take orally 20mL,
Three times a day, it continuously takes 8 weeks.And control group is only with conventional anti-viral, liver protection treatment.
3. statistical method
For statistical analysis to data using SPSS16.0 software, wherein measurement data is examined with t, and comparison among groups use x2
It examines, P < 0.05 is that difference is statistically significant.
Two, treatment results
Clinical efficacy compares between 1 two groups of table
Note: * comparison among groups P < 0.05
As shown in table 1, treatment group's total effective rate 89.5%, is significantly higher than the 71.1% of control group, and two groups of treatments are always effective
Difference between rate is statistically significant (P < 0.05).Thus illustrate, Chinese medicine composition provided by the invention is to chronic viral
Hepatitis has treatment curative effect well.
Test example 2
Clinical test of the Chinese medicine composition to hepatic failure patients:
1. case selection 2
This group of case derives from 45 hepatic failure patients that Meishan City hospital of traditional Chinese hospital 2013.09-2014.09 is accepted for medical treatment, symbol
Conjunction is included in, exclusion criteria, the age 19-60 years old, 42.7 years old average, and male 27 accounts for the 60.0% of total number of persons；Female 18, Zhan Zongren
Several 40.0%.Infecting sick credit according to Chinese Medical Association in 2006 can hepatic failure and artificial liver Xue Zu Chinese Medical Association hepatopathy
The standard diagnostics of " hepatic failure practice guidelines " that branch's Sever Hepatitis and artificial liver group are formulated and by stages.It is ground standard compliant
Study carefully object and is randomly divided into 2 groups, every group 15 of experimental group, 1 group of control and control.
It is included in standard: 1. meeting the diagnostic criteria person of 2006 " hepatic failure practice guidelines "；2. Serum Markers of Hepatitis B Virus positive；
3. age 18-60 year person；4. this research of voluntary participation simultaneously signs informed consent form.
2. therapeutic scheme
Three groups in addition to regular western medicine treatment, the treatment of an artificial liver must be at least carried out to all selected patients.Experiment
Group takes decoction obtained by embodiment 3 while using regular western medicine treatment, and 1 group of control is using regular western medicine treatment
While, take decoction obtained by comparative example 1.It is unified to be all made of thickener of boiling medicine for decoction in embodiment 3 and comparative example 1
It decocts, one dose per day, is concentrated into 60mL after every dose of decoction, oral 20mL three times a day continuously takes 8 weeks.
Using whole body digitized color ultrasonic doppler diagnostic system, when entering group, treatment the 4th week, respectively inspection 1 in the 8th week
It is secondary, Glisson's capsule and substantive echo vena portae hepatica trunk diameter, splenic vein diameter and thickness of spleen are compared
3. statistical method
Each group applies unified Neuroscore application form and investigation and assessment mode.Statistical procedures method: all numbers
It according to computer is inputted, is analyzed with 17.0 editions statistical softwares of SPSS, measurement data is examined using t, and enumeration data uses χ2
It examines, ranked data compare to be analyzed using Radit, and all measurement datas are all made of X ± S (mean ± standard deviation) expression.P is double
Side is examined, and P < 0.05 is to have significant difference, and P > 0.05 is that there was no significant difference.
Two, treatment results
2 groups are compareed in therapeutic process to fall off 2.The general information comparing difference such as three groups gender, age is anticipated without statistics
Adopted (P > 0.05), is comparable.
1. two groups of pretherapy and post-treatment Glisson's capsules and substantive echo acoustic image compare, 1 the results are shown in Table:
The pretherapy and post-treatment Glisson's capsule of table 1 and substantive echo acoustic image compare
As shown in Table 1, after treating 4 weeks, the Glisson's capsule of 2 groups of 1 group of control and control, substantive echo compared with pre-treatment,
There was no significant difference (P > 0.05).And experimental group and the Glisson's capsule of 2 groups of control, substantive echo are compared with pre-treatment, have significant
Sex differernce (P < 0.05) thus illustrates that the Chinese medicine composition of embodiment 3 in experimental group is rapid-action to the treatment of hepatic failure patients,
The Glisson's capsule of patient and substantive echo compared with pre-treatment, can there is apparent change in very short treatment cycle.
When compareing 2 groups of treatments 8 weeks, compared with pre-treatment, there was no significant difference (P > 0.05) for Glisson's capsule, substantive echo.It is right
According to 1 group and experimental group when treating 8 weeks, Glisson's capsule compared with pre-treatment, there is significant difference (P=0.45, P=0.12),
Illustrate that the Chinese medicine composition of this programme has the therapeutic effect of conspicuousness to hepatic failure；Compared with pre-treatment, nothing is significant for substantive echo
Sex differernce (P > 0.05).At treatment 4 weeks, experimental group has significant difference (P=0.031) compared with 1 group of control of Glisson's capsule,
Illustrate on the basis of doctor trained in Western medicine Primary Care, increases the Chinese medicine composition taken in this programme, can significantly improve liver function.
2. main portal vein diameter, splenic vein width and spleen thickness compare under three groups of pretherapy and post-treatment B ultrasound, it the results are shown in Table 2.
Main portal vein diameter, splenic vein width, spleen thickness compare (mm, X ± S) under 2 two groups of pretherapy and post-treatment B ultrasound of table
As known to table 2, when treating 8 weeks, experimental group is compared with 1 group of control, main portal vein diameter, splenic vein width and spleen
Thickness has significant difference (t=2.23,2.15,1.95, equal P < 0.05)；Experimental group is compared with 1 group of control, portal vein master
Dry diameter and splenic vein width have significant difference (t=2.27,2.25, equal P < 0.05), spleen thickness there was no significant difference (t
=0.39, P > 0.05).It can be seen that increase the Chinese medicine composition taken in this programme on the basis of doctor trained in Western medicine Primary Care, it can
Significantly improve liver function.
In conclusion curative effect of this Chinese medicine composition when with the treatment of combination of Chinese tradiational and Western medicine Combining Artificial Liver is fine, and
Reduce the number for needing artificial liver in treatment, saves medical treatment cost.This Chinese medicine composition can be effectively in conjunction with doctor trained in Western medicine
Hepatic failure is treated, is a kind of new departure safely, effectively, economic for treating hepatic failure.This Chinese medicine composition can be not only used for
The treatment of hepatic failure acute stage reduces mortality and liver function is promoted to restore；It can also be used for the convalescence of hepatic failure；This
Outside, also there is good facilitation to the improvement of liver function when invalid to artificial liver in treatment.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from of the invention
Many other change and modification can be made in the case where spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of for treating the Chinese medicine composition of chronic viral hepatitis or hepatic failure, which is characterized in that the Chinese traditional medicine composition
Object is the medicament made of bulk pharmaceutical chemicals, and the raw material medicaments in part by weight number meter includes:
10-20 parts of ginseng, 15-30 parts of Radix Astragali, 15-18 parts of oriental wormwood, 10-15 parts of radix bupleuri, 17-20 parts of radix paeoniae rubra, dried immature fruit of citron orange 10-
15 parts, 5-15 parts of rhizoma pinellinae praeparata, 15-20 parts of Poria cocos, 5-10 parts of radix aucklandiae, 5-15 parts of fructus amomi, 5-10 parts of safflower, jujube 15-
20 parts, 10-15 parts of ginger and 5-10 parts of Radix Glycyrrhizae.
2. according to claim 1 for treating the Chinese medicine composition of chronic viral hepatitis or hepatic failure, feature exists
In the ginseng is 13-20 parts, the Radix Astragali is 19-30 parts, the oriental wormwood is 17-18 parts, the radix bupleuri is 11-15
Part, the radix paeoniae rubra are 18-20 parts, the dried immature fruit of citron orange is 11-15 parts, the rhizoma pinellinae praeparata is 7-15 parts, the Poria cocos is 16-20
Part, the radix aucklandiae be 6-10 parts, the fructus amomi is 7-15 parts, the safflower is 6-10 parts, the jujube is 16-20 parts,
The ginger is 11-15 parts and the Radix Glycyrrhizae is 6-10 parts.
3. according to claim 1 for treating the Chinese medicine composition of chronic viral hepatitis or hepatic failure, feature exists
In the ginseng is 20 parts, the Radix Astragali is 30 parts, the oriental wormwood is 18 parts, the radix bupleuri is 15 parts, the radix paeoniae rubra is 20
Part, the dried immature fruit of citron orange are 15 parts, the rhizoma pinellinae praeparata is 15 parts, the Poria cocos is 20 parts, the radix aucklandiae is 10 parts, the fructus amomi is 15
Part, the safflower are 10 parts, the jujube is 15 parts, the ginger is 15 parts and the Radix Glycyrrhizae is 5 parts.
4. according to claim 1 for treating the Chinese medicine composition of chronic viral hepatitis or hepatic failure, feature exists
In the ginseng is sun-dried ginseng.
5. the Chinese medicine composition according to claim 1 for being used for chronic viral hepatitis or hepatic failure, which is characterized in that institute
Stating radix aucklandiae is Aplotaxis auriculata.
6. the Chinese medicine composition according to claim 1 for being used for chronic viral hepatitis or hepatic failure, which is characterized in that institute
Stating Radix Astragali is astragalus root.
7. according to claim 1 for treating the Chinese medicine composition of chronic viral hepatitis or hepatic failure, feature exists
In the medicament is decoction, granule, pill, powder, tablet or capsule.
8. a kind of according to claim 7 for treating the preparation of the Chinese medicine composition of chronic viral hepatitis or hepatic failure
Method, which is characterized in that by the bulk pharmaceutical chemicals the ginseng, the Radix Astragali, the oriental wormwood, the radix bupleuri, the radix paeoniae rubra,
The dried immature fruit of citron orange, the rhizoma pinellinae praeparata, the Poria cocos, the radix aucklandiae, the safflower, the jujube, the ginger and the Radix Glycyrrhizae
It is mixed with water, the volume of the water is 9-11 times of the bulk pharmaceutical chemicals gross mass, and heating decocts, and keeps slightly boiled after boiling
20-40min, filtering, the dregs of a decoction continue to decoct 1-2 times, merge and decoct resulting filtrate, and fructus amomi is added after boiling, keeps slightly boiled
3-5min is to get the decoction.
9. according to claim 8 for treating the preparation side of the Chinese medicine composition of chronic viral hepatitis or hepatic failure
Method, which is characterized in that before the water is mixed with the bulk pharmaceutical chemicals, be first crushed to each medicinal material drying in the bulk pharmaceutical chemicals
4-20 mesh.
10. according to claim 8 for treating the preparation side of the Chinese medicine composition of chronic viral hepatitis or hepatic failure
Method, which is characterized in that before heating decoction, the bulk pharmaceutical chemicals impregnate 40-80min after mixing with the water.
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