CN106110274A - A kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure and preparation method thereof Download PDFInfo
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Abstract
The invention provides a kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure and preparation method thereof, this Chinese medicine composition is the medicament being made up of crude drug, and raw material medicaments in part by weight number meter includes: Radix Ginseng 10-20 part, Radix Astragali 15-30 part, Herba Artemisiae Scopariae 15-18 part, Radix Bupleuri 10-15 part, Radix Paeoniae Rubra 17-20 part, Fructus Aurantii Immaturus 10-15 part, Rhizoma Pinelliae Preparatum 5-15 part, Poria 15-20 part, Radix Aucklandiae 5-10 part, Fructus Amomi 5-15 part, Flos Carthami 5-10 part, Fructus Jujubae 15-20 part, Rhizoma Zingiberis Recens 10-15 part, Radix Glycyrrhizae 5-10 part.Its preparation method is the decocting method of decoction.This Chinese medicine composition curative effect when using the treatment of combination of Chinese and Western medicine Combining Artificial Liver very well, and decreases the number of times needing artificial liver in treatment, has saved medical treatment cost.This Chinese medicine composition effectively can be combined with doctor trained in Western medicine and treat chronic viral hepatitis and liver failure, be a kind of treat chronic viral hepatitis or liver failure disease safely, effectively, economic new departure.
Description
Technical field
The present invention relates to the field of Chinese medicines, in particular to one for chronic viral hepatitis or liver failure Chinese drug-treated group
Compound and preparation method thereof.
Background technology
Chronic hepatitis B is pandemic infectious disease, if treatment can develop into liver cirrhosis or hepatocarcinoma etc. not in time
Major Liver disease, produces serious threat to the life and health of patient.Clinical treatment many employings antiviral, immunity at present is adjusted
Save, improve the Comprehensive Treatments such as liver function, but Drug therapy toxicity is big, untoward reaction is many and medicine high price is expensive.Increasing expert
TCM Treatment for Chronic Hepatitis B a large amount of clinical observation and research have been carried out.
Liver failure is low sickness rate, the dangerous hepatitis of high mortality caused by Hepadna Virus, and its sickness rate accounts for jaundice
The 3% of type hepatitis, is the serious disease threatening hepatopath's life, and medical treatment case fatality rate is 30%～83.3%.In view of liver
The high mortality of exhaustion, the mortality rate of reduction hepatic failure patients of adopting various measures is difficult point and the heat of the treatment of current liver failure
Point.
At present liver failure mainly has three kinds of Therapeutic Method: medical treatment, artificial liver in treatment and liver transplantation.In China owing to taking
With expensive, for reasons such as liver are in short supply, liver transplantation is still difficult to commonly used, and most of severe viral hepatitis can not be benefited.Internal medicine is controlled
Treatment method is identical, including general Supporting Therapy, protects hepatocyte, prevents and treats complication etc., but therapeutic effect is not good enough, and mortality rate is still
High.Artificial liver in treatment is the important means treating liver failure in recent years.But, the curative effect of single artificial liver is the most over time
Extend and disappear, need clinically artificial liver in treatment is repeated.Additionally, artificial liver in treatment is expensive, sick to some
Ability to shoulder economically or limited for people, especially needs repeatedly artificial liver in treatment person, and partly therefore patient misses
Best occasion for the treatment, finally dead.
Seek a kind of cost-effective method that can replace artificial liver in treatment imperative.Therefore, excellent by traditional medicine
Gesture, explore a kind of safely, effectively and the therapeutic scheme of economy is particularly necessary.
Summary of the invention
The first object of the present invention is to provide a kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure
Thing, the Therapeutic Principle of this traditional Chinese medicine composition for treating chronic viral hepatitis or liver failure is dispersing the stagnated liver-QI and dredging collateral, dehumidifying of being amusing, and hits
Chronic viral hepatitis or the pathogenesis of liver failure, cut out with fragrant sand ERCHEN TANGization, and the medicine of the Chinese medicine composition obtaining this programme is joined
Side.This Chinese medicine composition can be not only used for the treatment of liver failure acute stage, reduces mortality and promotes that liver function recovers,
And Gu protects taste；Can also be used for the convalescent period of liver failure；Additionally, the treatment of chronic viral hepatitis is imitated by this Chinese medicine composition
The best, it is favorably improved the quality of life of patient..
The second object of the present invention is to provide the preparation method of a kind of described Chinese medicine composition, and this preparation method is simple
Easy, parameters is controlled, workable, on the premise of keeping drug effect, it is easy to industrialized production.
In order to realize the above-mentioned purpose of the present invention, spy by the following technical solutions:
A kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure, Chinese medicine composition is by crude drug system
The medicament become, raw material medicaments in part by weight number meter includes:
Radix Ginseng 10-20 part, Radix Astragali 15-30 part, Herba Artemisiae Scopariae 15-18 part, Radix Bupleuri 10-15 part, Radix Paeoniae Rubra 17-20 part, Fructus Aurantii Immaturus
10-15 part, Rhizoma Pinelliae Preparatum 5-15 part, Poria 15-20 part, Radix Aucklandiae 5-10 part, Fructus Amomi 5-15 part, Flos Carthami 5-10 part, Fructus Jujubae
15-20 part, Rhizoma Zingiberis Recens 10-15 part, Radix Glycyrrhizae 5-10 part.
The preparation method of a kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure, by crude drug
Radix Ginseng, the Radix Astragali, Herba Artemisiae Scopariae, Radix Bupleuri, Radix Paeoniae Rubra, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Poria, the Radix Aucklandiae, Flos Carthami, Fructus Jujubae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae mix with water
Closing, the volume of water is 9-11 times of crude drug gross mass, and heating decocts, and keeps micro-boiling 20-40min after boiling, and filters, medicine
Slag continues to decoct 1-2 time, merges the filtrate decocting gained, adds Fructus Amomi, keep micro-boiling 3-5min, obtain decoction after boiling.
Chinese medicine there is no " hepatitis gravis " this name of disease, owing to jaundice runs through primary disease all the time and many with mind
The time of unconsciousness, it is critical that clinic the most often shows as the state of an illness, and patient's condition is urgent, can belong to the traditional Chinese medical science " acute jaundice " category, have infection because of it again
Feature, therefore referred to as " fulminant jaundice ", " jaundice of sky row ", when merging hemorrhage, ascites, hepatic encephalopathy etc., then with " blood disorder ", " tympanites ",
Diseases such as " syncope due to disorder of the liver " is relevant.
Modern many doctors are distinguished by " damp and hot " and control chronic severe hepatitis, how to add and subtract with Herba Artemisiae Scopariae Decoction；Have then lays particular emphasis on " the stasis of blood
Blood turns to be yellow "；Also positive exogenous pathogen is contained, (gas) yang deficiency noxious dampness is important pathomechanism to have part doctor to think, advocates chronic hepatitis
Can not use clearing away heat-damp and promoting diuresis and blood circulation promoting and blood stasis dispelling excessively, the most not only can imapirment of the spleen and stomach again, make symptom increase the weight of further, and to weakened body resistance
Domination of pathogen person is easily caused hemorrhage etc., makes that sb.'s illness took a turn for the worse.
Compared with prior art, the invention have the benefit that
(1) inventor is through clinical practice for many years, finds that hepatic failure patients jaundice shows as " YIN jaundice " more, is due to wet
Poison retardance, liver network pent-up cause.Therefore with dispersing the stagnated liver-QI and dredging collateral, dehumidifying of being amusing as Therapeutic Principle, cut out with fragrant sand ERCHEN TANGization, obtain we
Chinese medicine composition in case.
(2) this pharmaceutical composition is to hepatic failure patients icteric sclera dim, the angel of dyeing, weak, poor appetite, light red tongue, thin lingual fur
The symptoms such as the most greasy, stringy and rolling pulse have good mitigation, to artificial liver in treatment time invalid improvement to liver function also have well
Facilitation.
(3) this Chinese medicine composition follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", and wherein monarch drug is Radix Bupleuri, reason that Radix Bupleuri is soothing the liver
Gas again can sending up the lucid YANG so that hot and suffocating passing through inside.Ministerial drug is Herba Artemisiae Scopariae and Radix Paeoniae Rubra, and Radix Paeoniae Rubra nourishes blood yin fluid astringing, matches with Radix Bupleuri, holds back, make for one liter one
Strongly fragrant solution and non-impairment of YIN；Herba Artemisiae Scopariae promoting the function of the gallbladder to alleviate jaundice, matches with Radix Bupleuri and strengthens its diathermanous choleretic effect.Adjuvant drug is Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Fu
Siberian cocklebur, Radix Aucklandiae (Radix Vladimiriae), Fructus Amomi, Flos Carthami, Radix Ginseng and Radix Astragali Preparata, wherein Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Poria, Radix Aucklandiae (Radix Vladimiriae), Fructus Amomi, Flos Carthami are common
Assist a ruler in governing a country the monarch and his subjects' removing dampness circulation of qi promoting, vital energy regualting and blood circulation-promoting and in；The training of Radix Ginseng, Radix Astragali Preparata energy QI invigorating is first, makes gas biochemistry active.Make medicine: Radix Glycyrrhizae,
Rhizoma Zingiberis Recens, Fructus Jujubae, three's coordinating the actions of various ingredients in a prescription, during ginger-red jujube stomach function regulating is adjusted, promote that all medicines absorb.
(4) Fructus Amomi has the effect of removing dampness appetizing, promoting the circulation of QI to alleviate the stagnation in middle-JIAO, invigorating the stomach and promoting digestion.This Chinese medicine composition is made decoction
In preparation method, Fructus Amomi is finally added in filtrate and decocts 3-5min, and this method both can ensure that the effective ingredient in Fructus Amomi
Dissolution rate is maximum, is avoided that again the loss of volatile armaticity effective ingredient in Fructus Amomi, so that the medicine of this Chinese medicine composition
Effect is optimal.
(5) this Chinese medicine composition curative effect when using the treatment of combination of Chinese and Western medicine Combining Artificial Liver is very well, and decreases
Need the number of times of artificial liver in treatment, save medical treatment cost.This Chinese medicine composition effectively can be combined with doctor trained in Western medicine and treat
Liver failure, be a kind of treat liver failure safely, effectively, economic new departure.This Chinese medicine composition can be not only used for liver failure
The treatment of acute stage, reduces mortality and promotes that liver function recovers；Can also be used for the convalescent period of liver failure；Additionally, it is right
When artificial liver in treatment is invalid, the improvement to liver function also has good facilitation.
(6) this Chinese medicine composition also has good therapeutic effect to chronic viral hepatitis, and patient takes this Chinese drug-treated group
After continuous one month of compound, symptom alleviates, and is favorably improved the quality of life of patient.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but those skilled in the art will
Understanding, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.In embodiment unreceipted specifically
Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument unreceipted production firm person, be
Can be by the commercially available conventional products bought and obtain.
The present invention provides a kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure, and Chinese medicine composition is
The medicament being made up of crude drug, raw material medicaments in part by weight number meter includes:
Radix Ginseng 10-20 part, Radix Astragali 15-30 part, Herba Artemisiae Scopariae 15-25 part, Radix Bupleuri 10-15 part, Radix Paeoniae Rubra 15-20 part, Fructus Aurantii Immaturus
10-15 part, Rhizoma Pinelliae Preparatum 5-15 part, Poria 15-20 part, Radix Aucklandiae 5-10 part, Fructus Amomi 5-15 part, Flos Carthami 5-10 part, Fructus Jujubae
15-20 part, Rhizoma Zingiberis Recens 10-15 part, Radix Glycyrrhizae 5-10 part.
It is further preferred that above-mentioned Radix Ginseng is 13-20 part, the Radix Astragali be 19-30 part, Herba Artemisiae Scopariae be that 17-18 part, Radix Bupleuri are
11-15 part, Radix Paeoniae Rubra be 18-20 part, Fructus Aurantii Immaturus be 11-15 part, Rhizoma Pinelliae Preparatum be 7-15 part, Poria be that 16-20 part, the Radix Aucklandiae are
6-10 part, Fructus Amomi be 7-15 part, Flos Carthami be 6-10 part, Fructus Jujubae be that 16-20 part, Rhizoma Zingiberis Recens are 11-15 part and Radix Glycyrrhizae is
6-10 part.
Highly preferred, above-mentioned Radix Ginseng is 20 parts, the Radix Astragali is 30 parts, Herba Artemisiae Scopariae is 18 parts, Radix Bupleuri is 15 parts, Radix Paeoniae Rubra is 20
Part, Fructus Aurantii Immaturus be 15 parts, Rhizoma Pinelliae Preparatum be 15 parts, Poria be 20 parts, the Radix Aucklandiae be 10 parts, Fructus Amomi be 15 parts, Flos Carthami be 10 parts, Fructus Jujubae be
15 parts, Rhizoma Zingiberis Recens be 15 parts, Radix Glycyrrhizae be 5 parts.
This Chinese medicine composition curative effect when using the treatment of combination of Chinese and Western medicine Combining Artificial Liver very well, and decreases needs
The number of times of artificial liver in treatment, has saved medical treatment cost.This Chinese medicine composition can effectively be combined with doctor trained in Western medicine treats liver and declines
Exhaust, be a kind of treat liver failure safely, effectively, economic new departure.
This Chinese medicine composition can be not only used for the treatment of liver failure acute stage, reduces mortality and promotes liver function
Recover；Can also be used for the convalescent period of liver failure；Additionally, to artificial liver in treatment time invalid improvement to liver function also have well rush
Enter effect.
This Chinese medicine composition follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", and wherein monarch drug is Radix Bupleuri, Radix Bupleuri depressed liver-energy dispersing and QI regulating
Again can sending up the lucid YANG so that hot and suffocating passing through inside.Ministerial drug is Herba Artemisiae Scopariae and Radix Paeoniae Rubra, and Radix Paeoniae Rubra nourishes blood yin fluid astringing, matches with Radix Bupleuri, holds back for one liter one, make strongly fragrant
Thoroughly solve and not impairment of YIN；Herba Artemisiae Scopariae promoting the function of the gallbladder to alleviate jaundice, matches with Radix Bupleuri and strengthens its diathermanous choleretic effect.Adjuvant drug is Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Fu
Siberian cocklebur, Radix Aucklandiae (Radix Vladimiriae), Fructus Amomi, Flos Carthami, Radix Ginseng and Radix Astragali Preparata, wherein Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Poria, Radix Aucklandiae (Radix Vladimiriae), Fructus Amomi, Flos Carthami are common
Assist a ruler in governing a country the monarch and his subjects' removing dampness circulation of qi promoting, vital energy regualting and blood circulation-promoting and in；The training of Radix Ginseng, Radix Astragali Preparata energy QI invigorating is first, makes gas biochemistry active.Make medicine: Radix Glycyrrhizae,
Rhizoma Zingiberis Recens, Fructus Jujubae, three's coordinating the actions of various ingredients in a prescription, during ginger-red jujube stomach function regulating is adjusted, promote that all medicines absorb.
In this Chinese medicine composition:
Monarch drug: Radix Bupleuri, its can treating SHAO YANG disease by mediation, soothing liver-QI stomach function regulating, ascending up spleen-Qi and Yang, modern pharmacological research prompting Radix Bupleuri there is solution
Heat, bring down a fever, anti-liver injury and the effect of antiviral.
Ministerial drug: Herba Artemisiae Scopariae, its can clearing away heat-damp and promoting diuresis, jaundice eliminating, modern pharmacological research prompting Herba Artemisiae Scopariae has function of gallbladder promoting, refrigeration function
Effect；Radix Paeoniae Rubra, it can promoting blood circulation to remove blood stasis.Modern pharmacological research prompting Radix Paeoniae Rubra have suppression platelet aggregation, antithrombotic formation,
Reduce blood glucose and liver-protective effect.
Adjuvant drug: Fructus Aurantii Immaturus, its can dispelling the stagnated QI removing food stagnancy, scattered painful abdominal mass of reducing phlegm；Rhizoma Pinelliae Preparatum, its can drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, disappear painful abdominal mass
Eliminating stagnation；Poria, it can eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming；The Radix Aucklandiae, it can warming middle-JIAO to promote flow of QI pain relieving, strengthening the spleen to promote digestion be led
Stagnant；Fructus Amomi, its can removing dampness appetizing, promoting the circulation of QI to alleviate the stagnation in middle-JIAO, invigorating the stomach and promoting digestion；Flos Carthami, it can promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain；Radix Ginseng,
It can strongly invigorating primordial QI, strengthening the spleen and tonifying the lung；The Radix Astragali, it can invigorating QI to consolidate the body surface resistance.
Make medicine: Radix Glycyrrhizae, invigorating the spleen and replenishing QI, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription；Rhizoma Zingiberis Recens, it can relieving the exterior syndrome by diaphoresis, stomach warming preventing or arresting vomiting；Red
Fructus Jujubae, it can strengthen the spleen and stomach, yin and blood nourishing, tranquilizing by nourishing the heart.
Inventor is according to clinical experience for many years, it is believed that liver failure is divided into dampness-heat in the liver and gallbladder, stagnation of dampness due to deficiency of the spleen, stagnation in liver meridian regulating liver-QI
Gas virtual loss four-stage, in the course of disease later stage common " weight in wet base is in heat ", shows as " YIN jaundice ", therefore focuses on " tonifying the spleen " this method for the treatment of, and " real
Spleen " it is not limited to tonification, and based on " be amusing dehumidifying, the promoting blood circulation to remove obstruction in the collateral " of innovation.By a period of time medication, treat that humidity hysteresis stasis blocking subtracts
After Qing, use sour and sweet drugs can transforme into YIN, burnt bitter Invigorating Qi with its gas multiple for deficiency of liver-QI patient, add and contribute to liver with medicines such as replenishing QI to invigorate the spleen
The reparation of cell and regeneration, thus advantageously reduce case fatality rate.This Chinese medicinal components is combined with doctor trained in Western medicine and combines artificial liver in treatment,
The liver function that can improve hepatic failure patients, the mortality rate reducing hepatic failure patients short-term (4 weekend), the generation of minimizing complication.
In order to improve this traditional Chinese medicine composition for treating chronic viral hepatitis or the drug effect of liver failure, above-mentioned Radix Ginseng further
It is preferably Radix Ginseng.Radix Ginseng be Radix Ginseng is cleaned and is scraped off rough bark after, directly dry and obtain, Radix Ginseng concoct during
The loss reduction of effective ingredient.Modern pharmacological research prompting Radix Ginseng has enhancing immune function of human body, inhibition thrombosis, resists
Anoxia, improve microcirculation, promote the function such as synthesis of body substance metabolism and protein and RNA, DNA.
It is further preferred that the above-mentioned Radix Aucklandiae is Muscovitum perfume.Muscovitum perfume (or spice) warming middle-JIAO to promote flow of QI pain relieving, strengthening the spleen to promote digestion intestinal stasis relieving drug effect more
Good.Modern pharmacological research prompting Radix Aucklandiae (Radix Vladimiriae) has improves cardiovascular function effect.In order to further improve this Chinese medicine composition
The drug effect of thing treatment liver failure, the above-mentioned Radix Astragali is preferably Radix Astragali Preparata, and the effect of Radix Astragali Preparata QI invigorating invigorating middle warmer is more preferable, beneficially QI invigorating training
Unit, makes gas biochemistry active.
In preferred embodiment of the present invention, above-mentioned medicament is decoction, granule, pill, powder, tablet or capsule
Agent.Pharmaceutical composition is made above-mentioned preparation, facilitates the storage of this Chinese medicine composition, transport and facilitate patients.Granule
Agent, pill, powder, tablet or capsule these be all conventional pharmaceutical dosage form, its production technology is the most highly developed, this
Skilled person can refer to conventional production process and is prepared.
The present invention provides a kind of preparation method that above-mentioned Chinese medicine composition is made decoction: by the Radix Ginseng in crude drug, Huang
Stilbene, Herba Artemisiae Scopariae, Radix Bupleuri, Radix Paeoniae Rubra, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Poria, the Radix Aucklandiae, Flos Carthami, Fructus Jujubae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae mix with water, water
Volume is 9-11 times of crude drug gross mass, and heating decocts, and keeps micro-boiling 20-40min after boiling, and filters, and medicinal residues continue
Decoct 1-2 time, merge the filtrate decocting gained, add Fructus Amomi after boiling, keep micro-boiling 3-5min, obtain decoction.
Fructus Amomi has the effect of removing dampness appetizing, promoting the circulation of QI to alleviate the stagnation in middle-JIAO, invigorating the stomach and promoting digestion.This Chinese medicine composition is made the preparation of decoction
In method, Fructus Amomi is finally added in filtrate and decocts 3-5min, and this method both can ensure that the effective ingredient dissolution in Fructus Amomi
Rate is maximum, is avoided that again the loss of volatile armaticity effective ingredient in Fructus Amomi, so that the drug effect of this Chinese medicine composition is
Good.
In order to endure out the effective substance in above-mentioned compound medicine to a greater extent, in preferred embodiment of the present invention,
Before water mixes with crude drug, first each medicinal material drying in crude drug is crushed to 4-20 mesh.Each medical material after pulverizing can be with water
It is fully contacted, thus the dissolution rate of active substance is high.It is further preferred that before heating decocts, crude drug soaks after mixing with water
Bubble 40-80min, beneficially decocting when, effective ingredient can Fast Stripping.
Embodiment 1
The present embodiment provides a kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure, Chinese medicine composition
The medicament being made up of crude drug, raw material medicaments in part by weight number meter includes:
Radix Ginseng 10g, Radix Astragali 15g, Herba Artemisiae Scopariae 15g, Radix Bupleuri 10g, Radix Paeoniae Rubra 17g, Fructus Aurantii Immaturus 10g, Rhizoma Pinelliae Preparatum 5g, Poria 15g, the Radix Aucklandiae
5g, Fructus Amomi 5g, Flos Carthami 5g, Fructus Jujubae 15g, Rhizoma Zingiberis Recens 10g and Radix Glycyrrhizae 5g.
Preparation method: by the Radix Ginseng in crude drug, the Radix Astragali, Herba Artemisiae Scopariae, Radix Bupleuri, Radix Paeoniae Rubra, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Poria, the Radix Aucklandiae,
Flos Carthami, Fructus Jujubae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae mix with water, and the volume of water is 9 times of crude drug gross mass, and heating decocts, after boiling
Keeping micro-boiling 40min, filter, medicinal residues continue to decoct 2 times, merge the filtrate decocting gained, add Fructus Amomi, keep micro-boiling after boiling
3min, obtains decoction.
Embodiment 2
The present embodiment provides a kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure, Chinese medicine composition
The medicament being made up of crude drug, raw material medicaments in part by weight number meter includes:
Radix Ginseng 13g, Radix Astragali 19g, Herba Artemisiae Scopariae 17g, Radix Bupleuri 11g, Radix Paeoniae Rubra 18g, Fructus Aurantii Immaturus 11g, Rhizoma Pinelliae Preparatum 7g, Poria 16g, the Radix Aucklandiae
6g, Fructus Amomi 7g, Flos Carthami 6g, Fructus Jujubae 16g, Rhizoma Zingiberis Recens 11g, Radix Glycyrrhizae 6g.
Preparation method: by the Radix Ginseng in crude drug, the Radix Astragali, Herba Artemisiae Scopariae, Radix Bupleuri, Radix Paeoniae Rubra, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Poria, the Radix Aucklandiae,
Flos Carthami, Fructus Jujubae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae mix with water, and the volume of water is 11 times of crude drug gross mass, and heating decocts, and waits to boil
Rear holding micro-boiling 20min, filters, and medicinal residues continue to decoct 1 time, merge the filtrate decocting gained, adds Fructus Amomi, keep micro-after boiling
Boiling 5min, obtains decoction.
Embodiment 3
The present embodiment provides a kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure, Chinese medicine composition
The medicament being made up of crude drug, raw material medicaments in part by weight number meter includes:
Radix Ginseng 20g, Radix Astragali Preparata 30g, Herba Artemisiae Scopariae 18g, Radix Bupleuri 15g, Radix Paeoniae Rubra 20g, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae Preparatum 15g, Poria
20g, Saussurea lappa Clarke 10g, Fructus Amomi 15g, Flos Carthami 10g, Fructus Jujubae 15g, Rhizoma Zingiberis Recens 15g and Radix Glycyrrhizae 5g.
Preparation method: by the Radix Ginseng in crude drug, Radix Astragali Preparata, Herba Artemisiae Scopariae, Radix Bupleuri, Radix Paeoniae Rubra, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Poria, cloud
The Radix Aucklandiae, Flos Carthami, Fructus Jujubae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae mix with water, and the volume of water is 10 times of crude drug gross mass, and heating decocts, and treats
Keeping micro-boiling 30min after boiling, filter, medicinal residues continue to decoct 2 times, merge the filtrate decocting gained, add Fructus Amomi, protect after boiling
Hold micro-boiling 4min, obtain decoction.
Embodiment 4
The present embodiment provides a kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure, Chinese medicine composition
The medicament being made up of crude drug, raw material medicaments in part by weight number meter includes:
Radix Ginseng 17g, Radix Astragali Preparata 26g, Herba Artemisiae Scopariae 18g, Radix Bupleuri 14g, Radix Paeoniae Rubra 19g, Fructus Aurantii Immaturus 14g, Rhizoma Pinelliae Preparatum 13g, Poria
19g, Radix Aucklandiae 9g, Fructus Amomi 13g, Flos Carthami 9g, Fructus Jujubae 19g, Rhizoma Zingiberis Recens 14g, Radix Glycyrrhizae 9g.
Preparation method: by the Radix Ginseng in crude drug, Radix Astragali Preparata, Herba Artemisiae Scopariae, Radix Bupleuri, Radix Paeoniae Rubra, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Poria, wood
Perfume, Flos Carthami, Fructus Jujubae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae mix with water, and the volume of water is 10 times of crude drug gross mass, after immersion 40min again
Heating decocts, and keeps micro-boiling 30min after boiling, and filters, and medicinal residues continue to decoct 2 times, merge the filtrate decocting gained, after boiling
Add Fructus Amomi, keep micro-boiling 4min, obtain decoction.
Embodiment 5
The present embodiment provides a kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure, Chinese medicine composition
The medicament being made up of crude drug, raw material medicaments in part by weight number meter includes:
Radix Ginseng 20g, Radix Astragali 30g, Herba Artemisiae Scopariae 18g, Radix Bupleuri 15g, Radix Paeoniae Rubra 20g, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae Preparatum 15g, Poria 20g, wood
Fragrant 10g, Fructus Amomi 15g, Flos Carthami 10g, Fructus Jujubae 20g, Rhizoma Zingiberis Recens 15g and Radix Glycyrrhizae 10g.
Preparation method: by the Radix Ginseng in crude drug, the Radix Astragali, Herba Artemisiae Scopariae, Radix Bupleuri, Radix Paeoniae Rubra, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Poria, the Radix Aucklandiae,
Flos Carthami, Fructus Jujubae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae mix with water, and the volume of water is 10 times of crude drug gross mass, add after soaking 80min again
Heat decocts, and keeps micro-boiling 30min after boiling, and filters, and medicinal residues continue to decoct 2 times, merge the filtrate decocting gained, add after boiling
Enter Fructus Amomi, keep micro-boiling 4min, obtain decoction.
Embodiment 6
The present embodiment provides a kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure, in the present embodiment
The composition of crude drug consistent with embodiment 3, difference is:
Preparation method: respectively by the Radix Ginseng in crude drug, Radix Astragali Preparata, Herba Artemisiae Scopariae, Radix Bupleuri, Radix Paeoniae Rubra, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Fu
After Siberian cocklebur, Saussurea lappa Clarke, Flos Carthami, Fructus Jujubae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae powder are broken to 20 mesh, being mixed with water by above-mentioned medical material, the volume of water is former
10 times of material medicine gross mass, heating decocts, and keeps micro-boiling 30min after boiling, and filters, and medicinal residues continue to decoct 1-2 time, merge
Decoct the filtrate of gained, add Fructus Amomi after boiling, keep micro-boiling 4min, obtain decoction.
Embodiment 7
The present embodiment provides a kind of Chinese medicine composition for treating chronic viral hepatitis or liver failure, in the present embodiment
The composition of crude drug consistent with embodiment 3, difference is:
Preparation method: respectively by the Radix Ginseng in crude drug, Radix Astragali Preparata, Herba Artemisiae Scopariae, Radix Bupleuri, Radix Paeoniae Rubra, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Fu
After Siberian cocklebur, Saussurea lappa Clarke, Flos Carthami, Fructus Jujubae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae powder are broken to 4 mesh, being mixed with water by above-mentioned medical material, the volume of water is former
10 times of material medicine gross mass, reheat after soaking 60min and decoct, keep micro-boiling 30min, filter after boiling, and medicinal residues continue to decoct
Boil 1-2 time, merge the filtrate decocting gained, add Fructus Amomi after boiling, keep micro-boiling 4min, obtain decoction.
Comparative example 1
This comparative example provides one for Chinese medicine composition, the medicament that this Chinese medicine composition is made up of crude drug, raw material
Medicine is counted by weight and is included:
Radix Ginseng 10g, Radix Astragali Preparata 20g, Herba Artemisiae Scopariae 20g, Radix Bupleuri 15g, Radix Paeoniae Rubra 15g, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae Preparatum 15g, Poria
20g, Saussurea lappa Clarke 10g, Fructus Amomi 15g, Flos Carthami 10g, Radix Notoginseng 6g, Rhizoma Zingiberis Recens 15g and Radix Glycyrrhizae 5g.
The method that this Chinese medicine composition makes decoction is consistent with embodiment 3.
Test example 1
The clinical trial to patients with chronic viral hepatitis of this Chinese medicine composition:
One, testing program
1. case selection 1
Case derives from public health clinical treatment center, Chengdu, is divided into two groups of patients for the treatment of group and matched group all to meet
" viral hepatitis control prece " standard that 10th national viral hepatitis academic conference is formulated.In treatment group 38 example patient,
Male 20 example, women 18 example, age 33～62 years old, 44.6 years old mean age, the course of disease 1 year～17 years, average 9.7 years.Matched group
Male 22 example, women 16 example, age 28～68 years old, 45.2 years old mean age, the course of disease 1 year～15 years, average 8.4 years.Two groups of trouble
Person's no significant difference (P ＞ 0.05) in terms of sex, age and the course of disease
2. therapeutic scheme
Two groups of patients all use conventional anti-viral, liver protection treatment.Treatment group on this basis, is taken obtained by embodiment 3
Decoction, embodiment 3 uses that thickener of boiling medicine is unified to be decocted, every day potion, every dose decoct after be concentrated into 60mL, oral 20mL,
Three times a day, 8 weeks are taken continuously.And matched group is only with conventional anti-viral, liver protection treatment.
3. statistical method
Using SPSS16.0 software that data carry out statistical analysis, wherein measurement data t checks, and compares employing x between group2
Inspection, P ＜ 0.05 is that difference is statistically significant.
Two, therapeutic outcome
Clinical efficacy contrast between 1 liang of group of table
Note: compare P ＜ 0.05 between * group
As shown in table 1, treatment group total effective rate 89.5%, it is significantly higher than the 71.1% of matched group, two groups of treatments are total effectively
Difference between rate is statistically significant (P ＜ 0.05).Thus illustrating, the Chinese medicine composition that the present invention provides is to chronic viral
Hepatitis has well treats curative effect.
Test example 2
The clinical trial to hepatic failure patients of this Chinese medicine composition:
1. case selection 2
This group case derives from the 45 example hepatic failure patients that Meishan City hospital of traditional Chinese hospital 2013.09-2014.09 accepts for medical treatment, symbol
Conjunction is included in, exclusion standard, age 19-60 year, average 42.7 years old, and male 27 examples account for the 60.0% of total number of persons；Female 18 example, accounts for total people
The 40.0% of number.Infecting sick credit according to Chinese Medical Association in 2006 can liver failures and artificial liver Xue Zu Chinese Medical Association hepatopathy
The standard diagnostics of " liver failure practice guidelines " that branch's Sever Hepatitis and artificial liver group are formulated and by stages.Grind standard compliant
Study carefully object to be randomly divided into experimental group, compare 1 group and comparison 2 groups, often organize 15 examples.
Inclusive criteria: 1. meet the diagnostic criteria person of 2006 " liver failure practice guidelines "；2. Serum Markers of Hepatitis B Virus positive；
3. 18-60 age, person year；4. this research of voluntary participation sign Informed Consent Form.
2. therapeutic scheme
Three groups, in addition to regular western medicine treatment, must at least carry out the treatment of an artificial liver to all selected patients.Experiment
Group, while using regular western medicine treatment, takes the decoction obtained by embodiment 3, compares 1 group and is using regular western medicine treatment
While, take the decoction obtained by comparative example 1.Decoction in embodiment 3 and comparative example 1, all uses thickener of boiling medicine unified
Decocting, every day, potion, was concentrated into 60mL after every dose of decoction, and oral 20mL three times a day, takes 8 weeks continuously.
Use whole body digitized color ultrasonic doppler diagnostic system, when entering to organize, treat the 4th week, respectively inspection 1 in the 8th week
Secondary, Glisson's capsule and essence echo hepatic portal vein trunk diameter, Dsv and thickness of spleen are contrasted
3. statistical method
Each group applies unified Neuroscore application form and investigation and assessment mode.Statistical procedures method: all numbers
According to all inputting computer, being analyzed with 17.0 editions statistical softwares of SPSS, measurement data uses t inspection, and enumeration data uses χ2
Inspection, ranked data compare employing Radit and analyze, and all measurement datas all use X ± S (mean ± standard deviation) to represent.P is double
Side is checked, and P ＜ 0.05 is for there being significant difference, and P ＞ 0.05 is for there was no significant difference.
Two, therapeutic outcome
Therapeutic process compares 2 groups of 2 examples that come off.The physical data comparing differences such as the sex of three groups, age are anticipated without statistics
Justice (P ＞ 0.05), has comparability.
1. liang before and after group treatment, Glisson's capsule and essence echo acoustic image compare, and the results are shown in Table 1:
Before and after table 1 treatment, Glisson's capsule and essence echo acoustic image compare
As shown in Table 1, after treating 4 weeks, compare 1 group with the Glisson's capsule of comparison 2 groups, essence echo compared with before treatment, all
There was no significant difference (P ＞ 0.05).And compared with before experimental group and the Glisson's capsule of comparison 2 groups, essence echo and treatment, all have notable
Sex differernce (P ＜ 0.05), thus in explanation experimental group, the Chinese medicine composition of embodiment 3 is rapid-action to the treatment of hepatic failure patients,
The Glisson's capsule of patient in the shortest treatment cycle and essence echo compared with before treatment, can there is significantly change.
Compare 2 groups treatment 8 weeks time, Glisson's capsule, essence echo and treat before compared with, there was no significant difference (P ＞ 0.05).Right
According to 1 group and experimental group when treating 8 weeks, Glisson's capsule with treat before compared with, all have significant difference (P=0.45, P=0.12),
Illustrate that the Chinese medicine composition of this programme has the therapeutic effect of significance to liver failure；Essence echo is compared with before treatment, without notable
Sex differernce (P ＞ 0.05).When treating 4 weeks, experimental group compares with the Glisson's capsule compareing 1 group, has significant difference (P=0.031),
Illustrate on the basis of doctor trained in Western medicine Primary Care, increase and take the Chinese medicine composition in this programme, it is possible to significantly improve liver function.
2. before and after three groups of treatments, under B ultrasonic, main portal vein diameter, splenic vein width and spleen thickness compare, and the results are shown in Table 2.
Before and after the group treatment of 2 liang of table, under B ultrasonic, main portal vein diameter, splenic vein width, spleen thickness compare (mm, X ± S)
Known to table 2, when treating 8 weeks, experimental group compares with compareing 1 group, main portal vein diameter, splenic vein width and spleen
Thickness all has significant difference (t=2.23,2.15,1.95, equal P ＜ 0.05)；Experimental group compares with compareing 1 group, portal vein master
Dry diameter and splenic vein width all have significant difference (t=2.27,2.25, equal P ＜ 0.05), and spleen thickness there was no significant difference (t
=0.39, P ＞ 0.05).As can be seen here, on the basis of doctor trained in Western medicine Primary Care, increase and take the Chinese medicine composition in this programme, it is possible to
Significantly improve liver function.
In sum, this Chinese medicine composition curative effect when using combination of Chinese and Western medicine Combining Artificial Liver to treat is fine, and
Decrease the number of times needing artificial liver in treatment, save medical treatment cost.This Chinese medicine composition can effectively be combined with doctor trained in Western medicine
Treat liver failure, be a kind of treat liver failure safely, effectively, economic new departure.This Chinese medicine composition can be not only used for
The treatment of liver failure acute stage, reduces mortality and promotes that liver function recovers；Can also be used for the convalescent period of liver failure；This
Outward, to artificial liver in treatment time invalid improvement to liver function also have good facilitation.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's
May be made that in the case of spirit and scope many other change and amendment.It is, therefore, intended that in the following claims
Including all such changes and modifications belonged in the scope of the invention.
Claims (10)
1. the Chinese medicine composition being used for treating chronic viral hepatitis or liver failure, it is characterised in that described Chinese medicine composition
Thing is the medicament being made up of crude drug, and described raw material medicaments in part by weight number meter includes:
Radix Ginseng 10-20 part, Radix Astragali 15-30 part, Herba Artemisiae Scopariae 15-18 part, Radix Bupleuri 10-15 part, Radix Paeoniae Rubra 17-20 part, Fructus Aurantii Immaturus 10-
15 parts, Rhizoma Pinelliae Preparatum 5-15 part, Poria 15-20 part, Radix Aucklandiae 5-10 part, Fructus Amomi 5-15 part, Flos Carthami 5-10 part, Fructus Jujubae 15-
20 parts, Rhizoma Zingiberis Recens 10-15 part and Radix Glycyrrhizae 5-10 part.
Chinese medicine composition for treating chronic viral hepatitis or liver failure the most according to claim 1, its feature exists
In, described Radix Ginseng be 13-20 part, the described Radix Astragali be 19-30 part, described Herba Artemisiae Scopariae be 17-18 part, described Radix Bupleuri be 11-15
Part, described Radix Paeoniae Rubra be 18-20 part, described Fructus Aurantii Immaturus be 11-15 part, described Rhizoma Pinelliae Preparatum be 7-15 part, described Poria be 16-20
Part, the described Radix Aucklandiae be 6-10 part, described Fructus Amomi be 7-15 part, described Flos Carthami be 6-10 part, described Fructus Jujubae be 16-20 part,
Described Rhizoma Zingiberis Recens is 11-15 part and described Radix Glycyrrhizae is 6-10 part.
The most according to claim 1 for chronic viral hepatitis or the Chinese medicine composition of liver failure, it is characterised in that institute
State Radix Ginseng be 20 parts, the described Radix Astragali be 30 parts, described Herba Artemisiae Scopariae be 18 parts, described Radix Bupleuri be 15 parts, described Radix Paeoniae Rubra be 20 parts, described
Fructus Aurantii Immaturus is 15 parts, described Rhizoma Pinelliae Preparatum is 15 parts, described Poria is 20 parts, the described Radix Aucklandiae is 10 parts, described Fructus Amomi is 15 parts, described
Flos Carthami is 10 parts, described Fructus Jujubae is 15 parts, described Rhizoma Zingiberis Recens is 15 parts and described Radix Glycyrrhizae is 5 parts.
The most according to claim 1 for chronic viral hepatitis or the Chinese medicine composition of liver failure, it is characterised in that institute
Stating Radix Ginseng is Radix Ginseng.
The most according to claim 1 for chronic viral hepatitis or the Chinese medicine composition of liver failure, it is characterised in that institute
Stating the Radix Aucklandiae is Saussurea lappa Clarke.
The most according to claim 1 for chronic viral hepatitis or the Chinese medicine composition of liver failure, it is characterised in that institute
Stating the Radix Astragali is Radix Astragali Preparata.
The most according to claim 1 for chronic viral hepatitis or the Chinese medicine composition of liver failure, it is characterised in that institute
Stating medicament is decoction, granule, pill, powder, tablet or capsule.
8. one kind according to claim 7 for chronic viral hepatitis or the preparation side of the Chinese medicine composition of liver failure
Method, it is characterised in that by the described Radix Ginseng in described crude drug, the described Radix Astragali, described Herba Artemisiae Scopariae, described Radix Bupleuri, described Radix Paeoniae Rubra, institute
State Fructus Aurantii Immaturus, described Rhizoma Pinelliae Preparatum, described Poria, the described Radix Aucklandiae, described Flos Carthami, described Fructus Jujubae, described Rhizoma Zingiberis Recens and described Radix Glycyrrhizae with
Water mixes, and the volume of described water is 9-11 times of described crude drug gross mass, and heating decocts, and keeps micro-boiling 20-after boiling
40min, filters, and medicinal residues continue to decoct 1-2 time, merge the filtrate decocting gained, adds Fructus Amomi, keep micro-boiling 3-after boiling
5min, obtains described decoction.
The most according to claim 8 for chronic viral hepatitis or the preparation method of the Chinese medicine composition of liver failure, its
It is characterised by, before described water mixes with described crude drug, first each medicinal material drying in described crude drug is crushed to 4-20
Mesh.
The most according to claim 8 for chronic viral hepatitis or the preparation method of the Chinese medicine composition of liver failure, its
Being characterised by, before described heating decocts, described crude drug soaks 40-80min after mixing with described water.
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