CN105535827A

CN105535827A - Traditional Chinese medicine formula for treating infantile chronic viral hepatitis

Info

Publication number: CN105535827A
Application number: CN201511026152.XA
Authority: CN
Inventors: 王珍丽; 李雷
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-12-30
Filing date: 2015-12-30
Publication date: 2016-05-04

Abstract

The invention discloses a traditional Chinese medicine formula for treating infantile chronic viral hepatitis. The traditional Chinese medicine formula is prepared from the following traditional Chinese medicine raw materials in parts by weight: 3-5 parts of radix bupleuri, 5-8 parts of angelica sinensis, 3-5 parts of radix curcumae, 3-5 parts of fructus aurantii, 5-8 parts of herba epimedii, 3-5 parts of herba artemisiae capillariae, 3-5 parts of longhairy antenoron herb, 5-8 parts of radix puerariae, 5-8 parts of semen cuscutae, 3-5 parts of Yuke, 5-8 parts of radix ophiopogonis, 3-5 parts of cortex moutan, 3-5 parts of salvia miltiorrhiza, 3-5 parts of radix aucklandiae and 3-5 parts of white chloe benevolence. Through traditional Chinese medicine conditioning, the traditional Chinese medicine formula disclosed by the invention has the functions of soothing the liver and invigorating the spleen, clearing heat and draining dampness, nourishing the liver and kidneys and promoting qi and activating blood, and can be used for effectively treating infantile viral hepatitis.

Description

A kind of Chinese medicine formula for the treatment of children's chronic viral hepatitis

Technical field

The invention belongs to field of traditional Chinese medicine technology, particularly a kind of Chinese medicine formula for the treatment of children's chronic viral hepatitis.

Background technology

Viral hepatitis is a kind of infectious disease based on hepatic lesions caused by multiple hepatitis virus.Clinically with loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, weak for main manifestations.Some patients can have jaundice heating and hepatomegaly with liver function injury.Some patient can chronicity, and even develop into liver cirrhosis, minority can develop into hepatocarcinoma.

Chronic viral hepatitis, the B-mode or non-a, non-b type acute hepatitis protracted course of disease of polyphyly, divides a word with a hyphen at the end of a line and forms.The general course of disease, more than 6 months, mainly comprises chronic persistent hepatitis and chronic active hepatitis two class.Its reason is got clear not yet completely, may and patient age, nutrition and immune state, treatment is incured loss through delay, and movable too early, the factors such as secondary infection are relevant.A few days ago, modern medicine to primary disease still based on symptomatic treatment.

The traditional Chinese medical science of primary disease is discussed, and belongs to the disease such as " hypochondriac pain ", " blood stasis syndrome ".About the understanding to primary disease pathogenesis syndrome, namely on the books in Huangdi's Internal Classics.As " hypochondriac pain " is demonstrate,proved, " Plain Questions " is pointed out: " liver-heat patient, urine is first yellow ... fullness and pain in the hypochondrium." Qing Dynasty's You Zaijing says in " the golden deficient wing " book: " and hypochondriac pain due to stagnation of liverQI person, grieved angry, strongly fragrantly hinder irritability." have recognized that hypochondriac pain and liver have certain relation, and think that exopathogen invasion and attack are the reason that hypochondriac pain is fallen ill.

On specifically dialectical, bright clear doctor have accumulated certain experience.Zhang Jingyue is pointed out: primary disease " but is examined to it is tangible invisible, can be known.Lid blood is then tangible and do not move, or hard and tenderness; Gas is then popular and without mark, or suddenly poly-and suddenly fall apart." think and should belong to blood according to tangible invisible genus gas of differentiating.Woods qin point hypochondriac pain in " Lei Zheng Zhi Cai " of soughing is stagnation of liver-QI, the liver stasis of blood, phlegm retention, food stagnation, all classes of deficiency of the liver, is all shown to be the key of primary disease.In medicine for treatment, Xiayuxue Tang, Decoction for Dischanging Blood clots, Taohe Chengqi decoction, Didang Tang, biejiajian pills etc. that Zhang Zhongjing is worked out, set up model for applying stasis primary disease later age.And YE Tian shi belongs to for a long time pain people network person to hypochondriac pain, be good at pungent fragrant dredging collateral, sweet slow reason is empty, pungent method for the treatment of such as declaring the stasis of blood of letting out, and cube selects medicine, has much clever thought, still has a certain impact so far.

The cause of disease mainly positive QI-insufficiency of primary disease, evil poison invasion and attack, delay mistake is controlled.Secondly be eating and drinking without temperance, work and rest mistake degree, the factor such as abnormal emotion and drug intoxication.Diseased region is mainly dirty at liver, spleen (stomach), kidney three.

Summary of the invention

The invention provides a kind of Chinese medicine formula for the treatment of child virus hepatitis, soothing liver and strengthening spleen, clearing away heat-damp and promoting diuresis, nourishing the liver and kidney, promoting flow of QI and blood, effectively treatment child virus hepatitis.

The Chinese medicine formula for the treatment of children's chronic viral hepatitis of the present invention, is characterized in that by the raw material of Chinese medicine of following parts by weight formulated:

Radix Bupleuri 3-5 part, Radix Angelicae Sinensis 5-8 part, Radix Curcumae 3-5 part, Fructus Aurantii 3-5 part, Herba Epimedii 5-8 part, Herba Artemisiae Scopariae 3-5 part, Herba Lysimachiae 3-5 part, Radix Puerariae 5-8 part, Semen Cuscutae 5-8 part, beautiful gram 3-5 part, Radix Ophiopogonis 5-8 part, Cortex Moutan 3-5 part, Radix Salviae Miltiorrhizae 3-5 part, Radix Aucklandiae 3-5 part, roud cardamon seed 3-5 part.

As preferably, prepare by following parts by weight:

Radix Bupleuri 3 parts, Radix Angelicae Sinensis 5 parts, Radix Curcumae 5 parts, Fructus Aurantii 3 parts, Herba Epimedii 5 parts, Herba Artemisiae Scopariae 3 parts, Herba Lysimachiae 3 parts, Radix Puerariae 8 parts, Semen Cuscutae 6 parts, beautiful gram 5 parts, Radix Ophiopogonis 6 parts, Cortex Moutan 3 parts, Radix Salviae Miltiorrhizae 3 parts, the Radix Aucklandiae 3 parts, roud cardamon seed 3 parts.

Chinese medicine of the present invention, prepare in the steps below:

Take each Chinese crude drug by above-mentioned parts by weight, clean and dry, the reflux, extract, that adds water 3 times, each 2-3 hour, extracting solution concentrates, and spraying dry, mixes with appropriate amount of starch, must treat the Chinese medicinal granule of children's chronic viral hepatitis.

Each serving with 5g, every day 3 times, one after each meal.

Pharmacology analysis:

Radix Bupleuri: acrid in the mouth, hardship, cold nature.Return liver, gallbladder, lung meridian.Reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang, preventing the attack (or recurrence) of malaria of bringing down a fever.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.

Radix Angelicae Sinensis: sweet, pungent, warm; Return liver, the heart, spleen channel.Enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.

Radix Curcumae: pungent, bitter, cold.Return liver, the heart, lung meridian.Promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clear away heart-fire removing heat from blood, promoting the function of the gallbladder to alleviate jaundice.

Fructus Aurantii: bitter, pungent, sour, warm, has effect of regulating the flow of QI to ease the stomach, the stagnant relieving distension of row, and cure mainly the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, the diseases such as sub-official's prolapsus.

Herba Epimedii: pungent, warm, nontoxic.There is kidney invigorating and YANG supporting, bone and muscle strengthening, invigorate vital energy and reinforce the heart, effect of expelling wind and removing dampness, be applicable to the soft disease such as unable for the treatment of sexual impotence, seminal emission, premature ejaculation, sexual disorder, menoxenia, climacteric syndrome, hypertension, rheumatalgia, hemiplegia, numb limbs and tense tendons, knee joint.

Herba Artemisiae Scopariae: bitter, pungent, is slightly cold.Return spleen, stomach, liver, gallbladder meridian.Herba Artemisiae Scopariae clearing away heat-damp and promoting diuresis; Jaundice eliminating.Cure mainly: jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis etc.

Herba Lysimachiae: sweet in the mouth, micro-hardship, cool in nature.Return liver, gallbladder, kidney, urinary bladder channel.Relieving stranguria by diuresis, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, eliminating damp-heat, Sha Lin, urine is puckery has a pain, jaundice dark coloured urine, carbuncle furuncle.

Radix Puerariae: sweet, pungent, cool.There is expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, the merit of yang invigorating antidiarrheal.Be usually used in exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, and the deficiency of YIN is quenched one's thirst, diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen.

Semen Cuscutae: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.Suffer from a deficiency of the kidney rush down for impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen kidney vaginal bleeding during pregnancy, frequent fetal movement, spleen; Externally treating leucoderma.

Beautiful gram: Semen Arecae, bitter in the mouth; Pungent; Warm in nature.Return stomach; Large intestine channel.Parasite killing, removing mass, sending down the abnormal ascending QI is capable stagnant, and row aquation wets.Cure mainly rapid digestion of food to relieve oedema or abdominal distension through diuresis or purgation, kill Enterozoa, volt corpse, proglottid of tapeworm; Except dampness, get round by bribery, sharp nine orifices, relieving restlessness, caking in broken abdomen; Also can control beriberi, edema, chest pain, dysentery, abdominal distention is suffered from abdominal pain, defecation is unfavorable, mental disorder dyspnea with rapid respiration, treat pernicious malaria, resist communicable subtropical diseases.

Radix Ophiopogonis: sweet, micro-hardship, is slightly cold.Lung moistening clears away heart-fire, purge heat and promote the production of body fluid, the preventing or arresting vomiting that reduces phlegm, control row water of coughing, and has nourishing YIN and moistening the lung, reinforcing stomach reg fluid, the effect of the relieving restlessness that clears away heart-fire, for dryness of the lung dry cough, the disease such as deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, Tianjin wound are thirsty, interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.

Cortex Moutan: cold in nature, bitter in the mouth; Cool; Be slightly cold.GUIXIN; Liver; Kidney; Lung meridian.Clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The pathogenic bacteria later stage brimful of tears, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; Beriberoid pyretic arthralgia.

Radix Salviae Miltiorrhizae: bitter in the mouth, is slightly cold.GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, abdominal mass abdominal mass is gathered, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, and dysmenorrhea amenorrhea, skin infection swells and ache.

The Radix Aucklandiae: acrid in the mouth, temperature.Enter the heart, lung, liver, spleen, stomach, bladder the six channels.Circulation of qi promoting, pain relieving, spleen invigorating, helps digestion; Promoting the circulation of QI to relieve pain; Intestinal stasis relieving in tune.Main born of the same parents coerce distension foot; Abdominal distention; Tell and have loose bowels; Heavy after dysentery.For weighing after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia; Middle gas is not economized; Sudden deafness; Snake bite and insect sting; Toothache.

Roud cardamon seed: property and flavor of peppery and warm.There is regulating the flow of QI to ease the stomach, dry cold-damp, effect of alcoholic intoxication.Can to treat for stomachache the disease such as abdominal distention, eructation regurgitation.

In Chinese medicine formula of the present invention, Radix Bupleuri, Radix Angelicae Sinensis, Radix Curcumae, Fructus Aurantii, Herba Epimedii are in order to soothing liver and strengthening spleen; Herba Artemisiae Scopariae, Herba Lysimachiae, Radix Puerariae clearing away heat-damp and promoting diuresis; Semen Cuscutae, Radix Ophiopogonis, Cortex Moutan nourishing the liver and kidney; Radix Salviae Miltiorrhizae, the Radix Aucklandiae, roud cardamon seed fragrance are invigorated blood circulation, regulating the flow of QI to ease the stomach, all medicine compatibilities, treatment children's chronic viral hepatitis.

Clinical case:

1, sex

Observation group: male 13 example, women 17 example.

Matched group: male 15 example, women 15 example.

2, the age

Observation group: 1-3 year 6 example, 4-6 year 17 example, 7-9 year 7 example.

Matched group: 1-3 year 5 example, 4-6 year 19 example, 7-9 year 6 example.

Two, case selection standard

(1) the dialectical standard of tcm diagnosis

The symptom main manifestations of hepatitis is heating, Nausea and vomiting, loss of appetite, weak, hepatomegaly, liver pain, jaundice, malnutrition etc.

(2) Western medicine diagnose

1. Liver function grade

(1) serum enzyme detection alanine aminotransferase (ALT) the concentration ratio serum in hepatocyte is high 104 times, as long as there is 1% hepatic necrosis that serum-concentration can be made to raise 1 times, acute hepatitis positive rate reaches 80% ~ 100%.AST (AST) concentration in cardiac muscle is the highest, therefore when judging the affecting of liver function, first should get rid of the impact of heart disease.AST80% is in liver cell mitochondria, and generally, hepatic injury is based on ALT rising, if serum AST obviously increases, and normal expression hepatocyte severe necrosis.In mitochondrion, AST is released into blood, and the degree that serum transaminase increases roughly parallels with lesion severity, but during hepatitis gravis, can occur that bilirubin constantly increases, and transaminase declines on the contrary, and namely gallbladder enzyme is separated, and prompting hepatic necrosis is serious.

(2) serum albumin detects clinically often using the biochemical indicator of serum albumin as liver protein metabolism, during chronic hepatitis liver cirrhosis, often has serum albumin to decline, and globulin levels raises, and based on gamma globulin rising.

(3) serum bilirubin detects liver picked-up transhipment in bilirubin metabolism, and in conjunction with the function of excretion, liver function damage causes bilirubin level and raises, and except cholestatic hepatitis, bilirubin level is directly proportional to the hepatic injury order of severity.

(4) prothrombin time (PT) can sensitivity response liver synthesis factor Ⅱ, VII, Ⅸ, the situation of Ⅹ, during hepatopathy, PT length and hepatic injury degree are proportionate.

2. mark of hepatitis virus detects

(1) hepatitis A acute hepatitis patient, the serum Anti-HAV IgM positive can be diagnosed as HAV recent infection, and the anti-HAV-IgG positive points out previous infection and existing immunity.

(2) hepatitis B 1. HBsAg and Anti-HBs antibody: the HBsAg positive shows that HBV is in infective stage at present, Anti-HBs antibody is that the immunoprotective antibody positive shows the immunity produced HBV.The diagnosis basis of chronic HBsAg carriers is normal without any clinical symptoms and sign, liver function, HBsAg lasting masculin more than 6 months persons.2. the index that HBeAg and the anti-HBe:HBeAg positive copies for HBV enlivens and infectiousness is strong, tested serum is that the anti-HBe positive represents that disease has alleviation infectivity to weaken from HBeAg positive shift.3. HBcAg and the anti-HBc:HBcAg positive is pointed out and be there is complete HBV granule direct reaction, and HBV is active to be copied because detection method complex clinical is used less.Anti-HBc is the mark of HBV infection, and the prompting of the anti-HBc IgM positive is in be infected in early days, has virus replication in body.In chronic mild hepatitis B and HBsAg carrier, HBsAg, HBeAg and anti-HBc tri-equal positives have hyperinfection index and are difficult to cloudy turning.

Mark of molecular biology: detect by molecular hybridization or PCR method, serum HBV DNA is positive, active the copying of direct reaction HBV has infectiousness.

(3) hepatitis C cannot be measured very little due to antigen amount in blood, therefore can only to detect antibody anti-HCV be HCV infection labelling, is not protection antibody.Detect by shell type reverse transcriptional PCR method, the serum HCV-RNA positive shows that active the copying of virus has infectiousness.

(4) hepatitis D HDV is defective virus, rely on HBsAg just reproducible, HDV-HBV can be shown as infect simultaneously, only in blood, there is a couple of days in HDAg, occur that the anti-HD of IgM type, the anti-HDIgG of chronic HDV infection continue to raise thereupon, detect in serum HDV-RNA be then more directly, more special diagnostic method.

(5) hepatitis E acute hepatitis patient, anti-HEVIgM antibody is detected in serum, in convalescent serum, IgG antibody titre is very low, and antiHEV IgG persistent period in serum is shorter than 1 year, therefore anti-HEVIgM, antiHEV IgG all can be used as HEV recent infection index.

(6) hepatitis G RT-PCR technology can detect HGVRNA, is the effective ways of HGV early diagnosis and monitoring viremia, and the IgM of anti-HGV and IgG antibody are not yet ripe at present, exist recall rate low and with the feature such as RT-PCR result does not conform to.

3. liver wears biopsy

Being the leading indicator of diagnosis Various Types of Hepatitis, is also the conclusive evidence of diagnosis early stage liver cirrhosis, but because is that traumatic examination still can not be popularized also not as first-selected.

Three, Therapeutic Method:

(1) observation group: 30 examples take Chinese medicinal granule of the present invention, each 5g, every day 3 times one week is a course for the treatment of.

(2) matched group: 30 examples, takes silybin, each a slice, every day 3 times.

Four, curative effect statistics:

	Total number of cases	Invalid	Effective	Cure	Effective percentage %	Cure rate %
							Observation group	30	3	9	18	90	60％
Matched group	30	9	11	10	70	33％

Above-mentioned therapeutic outcome shows, Chinese medicinal granule treatment children's chronic viral hepatitis of the present invention, cure rate and effective percentage comparatively matched group are high, have better therapeutic effect.

Detailed description of the invention

Embodiment 1

Each serving with 5g, every day 3 times, one after each meal.

Case 1:

Zhang: 6 years old, man; Acute infective anicteric hepatitis is suffered from March, 2015 first visit, and control for a long time endlessly, prolong as chronic, Chinese and western medicine is treated simultaneously.Disease feelings are slightly improved, still lassitude, and brains dusk is swollen, fatigue and weak, hepatic region tenderness, abdominal distention loose stool, weak digestive function of the spleen and stomach, and two lower limbs are micro-swollen, micro-ly cough.In JIUYUE, 2015 is to our hospital, examines deep-thready pulse, and tongue white matter is partially light.The fluctuation of chemical examination liver function is indefinite, the fashion time difference; The ultrasound investigation liver upper bound the 6th rib, lower 5 centimetres of sword, lower 1 centimetre of rib; Lower 3 centimetres of spleen rib, liver ripple four type.Take Chinese medicinal granule of the present invention, after first quarter moon, spirit is improved, and appetite increases, and loose stool is improved.Continue to take first quarter moon, ultrasound investigation liver function is normal.Follow up a case by regular visits to one month without recurrence.

Case 2:

Liu, man, 8 years old, first visit in February, 2015.Main suit: heating, yellow urine more than ten sky.Heating is started before infant more than ten sky, local clinic is treated, but heating recurrent exerbation, inappetence; yellow urine, last night vomits, and looks into abnormal liver function (total bilirubin 47umol/L); glutamate pyruvate transaminase > 200u/L), hepatitis B surface antigen ().In July, 2015 goes to a doctor in here, and infant is weak, lassitude, is off one's feed, and feels sick, yellow sclera, yellow urine, and tongue fur is sliding, and soft pulse owes neat, body temperature 38 DEG C.Be diagnosed as: viral hepatitis, acute icteric.Give Chinese medicinal granule of the present invention, every day 3 times, each 5g, takes 1 month.Result: check abnormal liver function August and alleviate (total red pigment 27umol/L, glutamate pyruvate transaminase > 150u/L), heating stops, continue to take first quarter moon, check liver function normal (total bilirubin 12.7umol/L, glutamate pyruvate transaminase 23u/L), clinical cure.

Claims

1. treat a Chinese medicine formula for children's chronic viral hepatitis, it is characterized in that by the raw material of Chinese medicine of following parts by weight formulated: Radix Bupleuri 3-5 part, Radix Angelicae Sinensis 5-8 part, Radix Curcumae 3-5 part, Fructus Aurantii 3-5 part, Herba Epimedii 5-8 part, Herba Artemisiae Scopariae 3-5 part, Herba Lysimachiae 3-5 part, Radix Puerariae 5-8 part, Semen Cuscutae 5-8 part, beautiful gram 3-5 part, Radix Ophiopogonis 5-8 part, Cortex Moutan 3-5 part, Radix Salviae Miltiorrhizae 3-5 part, Radix Aucklandiae 3-5 part, roud cardamon seed 3-5 part.

2. the Chinese medicine formula for the treatment of children's chronic viral hepatitis according to claim 1, is characterized in that by the raw material of Chinese medicine of following parts by weight formulated: Radix Bupleuri 3 parts, Radix Angelicae Sinensis 5 parts, Radix Curcumae 5 parts, Fructus Aurantii 3 parts, Herba Epimedii 5 parts, Herba Artemisiae Scopariae 3 parts, Herba Lysimachiae 3 parts, Radix Puerariae 8 parts, Semen Cuscutae 6 parts, beautiful gram 5 parts, Radix Ophiopogonis 6 parts, Cortex Moutan 3 parts, Radix Salviae Miltiorrhizae 3 parts, the Radix Aucklandiae 3 parts, roud cardamon seed 3 parts.