CN105535571A - Detoxifying, dehumidifying, liver-protecting and cholagogic plantain seed oral liquid and preparation method thereof - Google Patents

Abstract

The invention provides a detoxifying, dehumidifying, liver-protecting and cholagogic plantain seed oral liquid, which comprises the following raw materials by weight: 10-50 parts of plantain seed, 10-20 parts of Rabdosia serra, 10-20 parts of Gynostemma pentaphyllum, 10-20 parts of purslane, 10-20 parts of prunella vulgaris, 10-20 parts of rhizoma atractylodis, 10-20 parts of goosegrass herb, 10-20 parts of dried orange peel, 10-20 parts of chicken's gizzard-membrane, 10-20 parts of scutellaria baicalensis, 10-20 parts of cape jasmine, 10-20 parts of rhizoma imperatae, 10-20 parts of Verbena officinalis, 10-20 parts of Lobelia chinensis, 10-20 parts of polyporus, 10-20 parts of dandelion, 10-20 parts of corn stigma, 10-20 parts of Taxillus sutchuenensis, and 10-20 parts of Lysimachia christinae Hance. Plantain seed is sweet and cold, can go deep into kidney and urinary bladder meridians, and has the main efficacy of promoting urination, clearing heat, improving eyesight and eliminating phlegm. The plantain seed oral liquid provided by the invention selects fire-clearing and dehumidifying traditional Chinese medicines to dispel and resolve dampness so as to achieve heat dissipating, toxin removal and weight reduction.

Description

A toxin expelling dehumidifying, Semen Plantaginis oral liquid of hepatic cholagogic and preparation method thereof

Technical field

The present invention relates to the medical health product containing deriving from plant, animal or raw mineral materials, particularly a kind of toxin expelling dehumidifies, Semen Plantaginis oral liquid of hepatic cholagogic and preparation method thereof.

Background technology

Sub-health state is more common in damp-heat constitution especially.Symptoms: the type body characteristics of damp and hot matter people: body is partially fat or become thin; Often have performance: dirty face is glossy, have acne, often feel dry mouth with bitter taste more, eyes red red, vexed slack, heavy sensation of the body is sleepy, red urine is short, constipation due to dry stool or viscid, male have dampness of scrotum, women often to have leukorrhagia to increase more.Time sick, above-mentioned sign is increased the weight of; Picture of the tongue: the partially red idle Huang of body of the tongue is greasy; Pulse condition: common sliding number; Psychological peculiarity: irascible temperament, easy on the trigger; Adaptive capacity: can not hygrothermal environment be tolerated.Common dermatosis: acne, eczema, psoriasis, pompholyx, exudative dermatitis, seborrheic dermatitis, acne rosacea etc.

Take good care of rule: adjust body method: divide the turbid damp that disappears, let out clearly volt fire.Adjust body main points: one, a surname dredges removing dampness with heat radiation: the traditional Chinese medical science is thought " dispersing fire for treating depression of fire ", in other words pathogenic fire stasis in body, and fire be tried every possible means to send, and can add eliminating fire and detoxication, declares the composition dredging Qinghua in formula.Two, tonneau removing dampness to expel the heat-evil, according to the reason of eliminating dampness by diuresis to separate it from pathogenic heat, make damp and hot from two just excrete.Help with the Rhizoma Imperatae of tonneau, Herba Lophatheri, Semen Coicis, Semen Cassiae at soothing the liver dampness removing simultaneously, heat is let out from down.

When registering the department of Chinese medicine, we often can listen doctor to say " damp and hot ".So, what is damp and hot, and damp and hot have which to show, what problem should be noted? understand damp and hot, first should be appreciated that what cries wet, what is heat.So-called wet, namely usually said water wets, and it has the differentiation of exogenous damp and endogenous dampness.Exogenous damp is drenched with rain owing to having a humid climate or paddling or room humidity, makes secondary water wet invasion human body and cause; Endogenous dampness is a kind of pathological product, normal relevant with digestive function.The traditional Chinese medical science thinks the function that spleen has " transmitting and distributing the fluids ", if the empty dyspepsia of body or eating and drinking too much at one meal, eats too much greasy, sweet food, then spleen just can not normal transporting and make " retention of water-damp in the body "; And insufficiency of the spleen people also easily causes the invasion of exogenous damp, exogenous damp is also normal to be made wet from interior life, so both are not only independent but also associate because hindering taste.So-called heat is then a kind of thermal image.And damp and hot in heat be with wet simultaneous, or because of the hot weight in wet base in summer and autumn sky, wetly invade human body with heat seal, or because of wet stay for a long time not except and heat-transformation, or make to wet " heat being transformed from excessive YANG " because of " positive hot body matter ", therefore, wet and hot to exist be very common simultaneously.Damp-heat constitution is facial and nose is always glossy shinny, easy fecula thorn, furuncle, and often feel bitter taste, halitosis or have abnormal flavour in the mouth, often stool viscous is not well, urine has heating to feel, and the jaundice of urine color, the normal leucorrhea with yellow discharge of women, males scrotum is moist hyperhidrosis always.Morbidity tendency: the people of damp-heat constitution easily suffers from furuncle, jaundice, burning hot disease etc. and levies.

Damp and hot generally shows as: limbs are heavy, and heating is many obviously afternoon, does not alleviate because of perspiration; Yellowish fur, rapid pulse.Concrete manifestation has difference because of different position, damp and hot place: be then eczema or furuncle bleb at skin and flesh; At joint muscle arteries and veins then partial gall.But usually said damp and hot finger damp and hotly gos deep into internal organs more, and particularly taste is damp and hot, the vexed abdominal distention of visible gastral cavity, anorexia of feeling sick, and loose stool is rare, and short urination is red, soft and rapid pulse; Other shows as liver pain as dampness-heat in the liver and gallbladder, and bitter taste appetite is poor, or the jaundice of body order, or heating is afraid of cold alternately, wiry and frequent pulse; Damp-heat in the urinary bladder is shown in frequent micturition, urgent micturition, less puckery and pain, yellow skin is turbid; Damp-heat in the large intestine is shown in abdominal pain diarrhea, even tenesmus, rushes down defecation with blood and pus just, burning sensation of the anus, thirsty.

Damp and hot treatment, generally will divide weight in wet base or thermogravimetric.The removing dampness of weight in wet base is main, can select LIUYI SAN, sanren decoction, Pingwei San; Thermogravimetric, based on heat clearing away, can select lianpu drink, Herba Artemisiae Scopariae Decoction, GEGEN QINLIAN TANG.Under this principle, then select corresponding medicine according to some Special Manifestations, as eczema, furuncle bleb, add Flos Chrysanthemi Indici, Herba Violae, Radix Sophorae Flavescentis, Cortex Dictamni; Arthralgia adds Ramulus Cinnamomi, Caulis Lonicerae, Ramulus Mori etc.; Even dysentery of suffering from diarrhoea adds Radix Pulsatillae Decoction, Radix Sanguisorbae, Semen Plantaginis etc.; Eczema scrotum, distending pain of the testis, leucorrhea are yellow smellyly adds Radix Gentianae, Radix Sophorae Flavescentis etc.; Hematuria can add HERBA CIRSII, Rhizoma Imperatae, Folium Pyrrosiae, Herba Polygoni Avicularis etc.In addition, exist because heat often depends on wet, so, improvement and the dietetic regulation of habitat environment should be noted, unsuitable eating and drinking too much at one meal, excessive drinking, eat sweet food less.

Semen Plantaginis is sweet, cold.Enter kidney, urinary bladder channel.Function cures mainly diuretic, heat clearing away, and improving eyesight is eliminated the phlegm.Control urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view." herbal classic ": " main stranguria due to disorder of QI, pain relieving, dredging water passages urine, except arthralgia chiefly caused by damp pathogen." Collective Notes to the Canon of Materia medica: " main asthenia." " not Lu ": " man's damaging the spleen and stomach, woman drenches drop, loss of appetite.Support lung reinforcing YIN-essence benefit essence.Swelling pain is treated in improving eyesight." " property of medicine opinion ": " can remove pathogenic wind toxic, and the liver affected by pathogenic wind heat, malicious wind dotting punch order, swelling pain is hidden from view, and headache lacrimation, removes irritable feverish sensation of chest and heart." " Japan hanako materia medica ": " diuresis drenches puckery, tonifying YANG.Control de-essence, vexed.The therapeutic method to keep the adverse QI flowing downwards." " medicine origin ": " main urinary obstruction, leads little pathogenic heat in the bowels." " Thunder God concocts property of medicine solution ": " main pouring drop difficulty in urination, penis swells and ache, eczema, has loose bowels, and also leucorrhea is turbid, and blood closes difficult labour.″

" book on Chinese herbal medicine is newly organized ": Semen Plantaginis, sweet in the mouth, one-tenth, feeble QI is trembled with fear, nontoxic.Enter bladder, spleen, kidney three warp.Merit patent water, logical urinary catheter is the most refreshing, only drenches drop and has loose bowels, can close orifice for discharging seminal fluid, heat of dispeling the wind, and the kind Akamu that disappears, expedites the emergence of meritorious.But property is sliding, and diuretic can be multiplex, also not flat with it.Rush down and be suitable for few use, with its too sliding profit also.Person of modern times claims its power energy seed, then miss pole.Husband's WUZIYANZONG WAN uses Semen Plantaginis person, because of Fructus Lycii, covers the too dynamic sun of basin, Herba cuscutae, Fructus Schisandrae Chinensis too arresting seminal emission, thus with Herba Plantaginis with minor benefit it.With leading among closing, with rushing down within benefit, beginning can diuretic and do not consume gas.Water key is opened, and orifice for discharging seminal fluid closes, and natural spirit is healthy and vigorous, and enter room and begin raw sub, the self energy seed of non-Herba Plantaginis also.Among the tonic of about use, then with group's mutual aid, there is outstanding service more.Not credible is the medicine of seed, too also multiplex.

Semen Plantaginis compatibility Rhizoma Imperatae: Semen Plantaginis clearing away heat with drugs sweet in flavor and cold in nature relieving stranguria by diuresis; Rhizoma Imperatae cooling blood for hemostasis, clearing away heat and promoting diuresis. the two 5 with the card such as the dysuria having relieving stranguria by diuresis, effect of cooling blood for hemostasis is used for the treatment of retention of water-damp in the body, lower limbs edema and oliguria, dysurea, hematuria because of person caused by damp-heat in lower-JIAO.

The Semen Plantaginis compatibility Rhizoma Atractylodis Macrocephalae: Semen Plantaginis diuretic and antidiarrheal; Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI and dampness. Papillary has effect of invigorating the spleen to arrest diarrhea to be used for the treatment of diarrhea due to hypofunction of the spleen, oliguria person.

Semen Plantaginis compatibility Rhizoma Atractylodis: Semen Plantaginis eliminating damp-heat; Rhizoma Atractylodis dispelling the damp pathogen with bitter and warm drugs. the two is 5 with having effect of the spleen strengthening and damp drying to be used for the treatment of women's leukorrhagia or having loose bowels because of person caused by damp.

Semen Plantaginis compatibility Spora Lygodii: Semen Plantaginis eliminating damp-heat; Spora Lygodii Tonglin Paishi. two medicines share the effect that can strengthen clearing away heat-damp and promoting diuresis and are used for the treatment of the puckery pain of urine leaching caused by damp-heat accumulation bladder or damp and hot caused calculus.

Semen Plantaginis compatibility Radix Rehmanniae Preparata: Semen Plantaginis lets out liver-heat and improving eyesight; Radix Rehmanniae Preparata liver and kidney tonifying. two medicines share liver and kidney tonifying, the effect of the improving eyesight that expels the heat-evil is used for the treatment of the disease such as the dark cataracta of order, blurring of vision, visual deterioration, oliguria that the hepatic and renal YIN deficiency causes.

Liver and gall diseases is the commonly encountered diseases frequently-occurring disease of serious harm human health, promotes liver cell regeneration at present and prevent hepatic necrosis without specific medicament.Take good care of rule: adjust body method: divide the turbid damp that disappears, let out clearly volt fire.Adjust body main points: one, a surname dredges removing dampness with heat radiation: the traditional Chinese medical science is thought " dispersing fire for treating depression of fire ", in other words pathogenic fire stasis in body, and fire be tried every possible means to send, and can add eliminating fire and detoxication, declares the composition dredging Qinghua in formula.Two, tonneau removing dampness to expel the heat-evil, according to the reason of eliminating dampness by diuresis to separate it from pathogenic heat, make damp and hot from two just excrete.Help with the Rhizoma Imperatae of tonneau, Herba Lophatheri, Semen Coicis, Semen Cassiae at soothing the liver dampness removing simultaneously, heat is let out from down.

Summary of the invention

Technical problem to be solved by this invention is, liver and gall diseases is the commonly encountered diseases frequently-occurring disease of serious harm human health, promotes liver cell regeneration at present and prevent hepatic necrosis without specific medicament.Damp and hotly contain in human body, row does not go out, and will cause courage overflow, bitter taste xerostomia, being irritable and getting angry easily.Damp-heat blocking in the body, yang-energy is held back, because this person panesthesia heavy sensation of the body is sleepy.The present invention chooses the Chinese medicine of dehumidifying of relieving inflammation or internal heat, and a surname dredges removing dampness with toxin expelling fat-reducing of dispelling the heat.And it is cumbersome to take Chinese medicine, mouthfeel is not good, unsuitable long-term taking, and effect is also not necessarily desirable.Be medicine three points of poison, Chinese medicine health care product must control dosage well, its toxicity is dropped to minimum.The present invention improves Chinese medicine extraction technology greatly, the toxic component of Chinese medicine is dropped to minimum, can make absorption of human body, greatly improves its utilization rate.

For solving the problems of the technologies described above, the invention provides the dehumidifying of a kind of toxin expelling, the Semen Plantaginis oral liquid of hepatic cholagogic, described in it, Semen Plantaginis oral liquid comprises the raw material of following parts by weight: Semen Plantaginis 10 ~ 50 parts, Herba Rabdosiae Lophanthoidis 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Herba Portulacae 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Rhizoma Atractylodis 10 ~ 20 parts, Herba Eleusines Indicae 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Endothelium Corneum Gigeriae Galli 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Rhizoma Imperatae 10 ~ 20 parts, Herba Verbenae 10 ~ 20 parts, Herba Lobeliae Chinensis 10 ~ 20 parts, Polyporus 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Herba Lysimachiae 10 ~ 20 parts.

Described toxin expelling dehumidifying, the Semen Plantaginis oral liquid of hepatic cholagogic, described in it, Semen Plantaginis oral liquid can comprise the raw material of following parts by weight: Semen Plantaginis 10 ~ 30 parts, Herba Rabdosiae Lophanthoidis 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 10 ~ 15 parts, Herba Portulacae 10 ~ 15 parts, Spica Prunellae 10 ~ 15 parts, Rhizoma Atractylodis 10 ~ 15 parts, Herba Eleusines Indicae 10 ~ 15 parts, Pericarpium Citri Reticulatae 10 ~ 15 parts, Endothelium Corneum Gigeriae Galli 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Fructus Gardeniae 10 ~ 20 parts, Rhizoma Imperatae 10 ~ 20 parts, Herba Verbenae 10 ~ 20 parts, Herba Lobeliae Chinensis 10 ~ 20 parts, Polyporus 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Herba Lysimachiae 10 ~ 20 parts.

Described toxin expelling dehumidifying, the Semen Plantaginis oral liquid of hepatic cholagogic, described in it, Semen Plantaginis oral liquid can also comprise the raw material of following parts by weight: Semen Plantaginis 10 ~ 40 parts, Herba Rabdosiae Lophanthoidis 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Herba Portulacae 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Rhizoma Atractylodis 10 ~ 20 parts, Herba Eleusines Indicae 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Endothelium Corneum Gigeriae Galli 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Fructus Gardeniae 10 ~ 15 parts, Rhizoma Imperatae 10 ~ 15 parts, Herba Verbenae 10 ~ 15 parts, Herba Lobeliae Chinensis 10 ~ 15 parts, Polyporus 10 ~ 15 parts, Herba Taraxaci 10 ~ 15 parts, Stigma Maydis 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, Herba Lysimachiae 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of described toxin expelling dehumidifying, the preparation method of the Semen Plantaginis oral liquid of hepatic cholagogic, and described in it, the preparation process of Semen Plantaginis oral liquid comprises:

A, by Semen Plantaginis gather rear alcohol extraction;

B, all the other raw materials are put into ethanol soak, heat is extracted 2 times, and becoming paste, is component 2;

C, component 1 and component 2 to be mixed, add dextrin after concentrated and make oral liquid.

In described step a, the Semen Plantaginis roguing that can collect, is equipped with in lid stainless steel cask, is added 70% ethanol, and quality is 0.8-1 times of coarse powder, and stir, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Being merged by percolate and leave standstill, is component 1.

In described step b, all the other raw materials can be added soak with ethanol 1 hour; Heating extraction 2 times, each 1-2 hour, merge extractive liquid, remove supernatant after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, becoming component, is component 2.

In described step c, component 1 and component 2 can be inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.36, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, adds dextrin and make oral liquid.

For solving the problems of the technologies described above, the present invention also provides a kind of described toxin expelling dehumidifying, the preparation method of the Semen Plantaginis oral liquid of hepatic cholagogic, and described preparation method can also be:

A, Semen Strychni of picking up the car are put into ethanol and are soaked, and heat is extracted 2 times, and becoming paste, is component 1;

B, to be shredded by all the other raw materials, sieve, according to percolation, with 70% ethanol for solvent percolation, liquid less than 70 DEG C of filtering concentrates, and becoming paste, for component is paste, is component 2;

C, above-mentioned two kinds of pastes to be merged, then add Mel and make granule, pack.

In described step a, the Semen Plantaginis that can will collect, adds soak with ethanol 1 hour; Heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, and then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, become component 1; In described step b, the chopping of all the other raw materials can be beaten powder and sieve, be equipped with by medicated powder in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, and stir, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Percolate is merged and leaves standstill, as component 2.

In described step c, component 1 can be mixed with component 2 and insert in economic benefits and social benefits vacuum concentrator, decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.36; The extractum of temperature to 60 DEG C-70 DEG C, adds dextrin oral liquid.

Semen Plantaginis is sweet, cold.Enter kidney, urinary bladder channel.Function cures mainly diuretic, heat clearing away, and improving eyesight is eliminated the phlegm.Control urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.The technique effect that the present invention is useful is, the present invention truly has choleretic effect in pharmacology and clinical confirmation, and choleretic effect may be to promote hepatocytes secrete bile, and bile in liver and gall is increased, and intrinsic pressurely increases, and Oddi's sphincter relaxes, and causes bile excretion to increase.Damp and hotly contain in human body, row does not go out, and will cause courage overflow, bitter taste xerostomia, being irritable and getting angry easily.Damp-heat blocking in the body, yang-energy is held back, because this person panesthesia heavy sensation of the body is sleepy.The present invention chooses the Chinese medicine of dehumidifying of relieving inflammation or internal heat, and a surname dredges removing dampness with toxin expelling fat-reducing of dispelling the heat.And it is cumbersome to take Chinese medicine, mouthfeel is not good, unsuitable long-term taking, and effect is also not necessarily desirable.The present invention reduces SGOT effect selectively, and heavy dose makes liver index reduce, and also illustrates that this medicine has good hepatic cholagogic, the effect of dehumidification slimming toxin expelling.

Detailed description of the invention

Have a class fat person, ancients are called " meat people ", and we are called the obesity of firm type, contrary with puffiness due to deficiency.Their personality is irritable, is easily moved to anger.In fact, the being irritable and getting angry easily of this kind of fat person is not born, but because has damp and hot in their body.Wet is exactly stagnant water in health, stagnant water is combined with expectorant, has just become phlegm-damp, stagnant water and thermal, just becomes damp and hot.The people in rural area knows, after wheat harvest, straw can be built into one and pile up neatly by peasant, after a burst of thunderstorm, straw has been drenched, and at this moment hands puts in wheat buttress by you, will feel the inside not only tide, not only wet but also hot, thisly damply, hottish feel to be exactly damp and hot.Damp and hotly contain in wheat buttress, the time one is long, and wheat buttress will rot, ferment, and peasant makees fertilizer with it; Damp and hotly contain in human body, row does not go out, and will cause courage overflow, bitter taste xerostomia, being irritable and getting angry easily.Damp-heat blocking in the body, yang-energy is held back, because this person panesthesia heavy sensation of the body is sleepy.Feel have like one deck oil.In addition, also often can grow some acnes, acne on the face, a lot of situation of acne is because of accumulation of damp-heat in body, and row does not go out, and finally ejecting on the face, this is also the small pox that we say at ordinary times.See that a fat person has and do not have damp and hot, also should see his appetite.People's all honey stomaches of damp-heat type, are good at eating, but can eat and do not represent that spleen and stomach function is normal, are the pathological state being in " the strong spleen of stomach is weak " on the contrary.Have damp and hot meeting to have influence on stomach in body, stomach has damp and hot, and the traditional Chinese medical science is called " gastric heat dampness ", and after stomach is heated, its function will be hyperfunction, and at this moment the appetite of people will increase, and easily will feel hungry.But stomach was received prosperous, just certainly will increase the weight of the burden of spleen transporting, the effect that spleen has " transmitting and distributing the fluids ", over-burden easily causes " retention of water-damp in the body " for spleen.So this kind of fat person is called " stomach-heat moisture resistance type obesity " again by the traditional Chinese medical science.

Differentiate damp-heat type fat person, also will see tongue.The partially red tongue of damp-heat type fat person body of the tongue, yellow and greasy fur, the heat in body is more contained, and tongue fur is more yellow, just look like when cooking fire too large, meal just boils Jiao, and become the rice crust of coke yellow, if or else close fire, rice crust will burn till black.So the color of tongue fur is darker, what prove in your body is damp and hot more serious.We can also to judge whether oneself has damp and hot by observing defecation, stool too dry or too wet, is all performance damp and hot in body.If health interior-heat overweights wet, then constipation due to dry stool; Weight in wet base in heat, is then defecated viscid, oliguria with reddish urine.The people of damp-heat constitution, is afraid of that wet To Be Protected from Heat, to wet environment or temperature higher, especially damp and hot friendship steam at the beginning of autumn late summer is waited and is difficult to adapt to.Whether a fat person body in have damp and hot, also should see his eyes, retention of damp-heat in the interior if seeing, heat is burnt blood network, and at this moment two ophthalmic of people just have the red red blood streak, superficial, and doctor trained in Western medicine says that this is immune reaction.In fact, damp and hot performance is had in Here it is body.Generally speaking, red red, the stool too dry of glossy, the long pox of dirty face, yellowish fur, short-tempered, eyes or too wet be all the performance of damp-heat type fat person.Damp and hot treatment, generally will divide weight in wet base or thermogravimetric.The removing dampness of weight in wet base is main, can select LIUYI SAN, sanren decoction, Pingwei San; Thermogravimetric, based on heat clearing away, can select lianpu drink, Herba Artemisiae Scopariae Decoction, GEGEN QINLIAN TANG.Under this principle, then select corresponding medicine according to some Special Manifestations, as eczema, furuncle bleb, add Flos Chrysanthemi Indici, Herba Violae, Radix Sophorae Flavescentis, Cortex Dictamni; Arthralgia adds Ramulus Cinnamomi, Caulis Lonicerae, Ramulus Mori etc.; Even dysentery of suffering from diarrhoea adds Radix Pulsatillae Decoction, Radix Sanguisorbae, Semen Plantaginis etc.; Eczema scrotum, distending pain of the testis, leucorrhea are yellow smellyly adds Radix Gentianae, Radix Sophorae Flavescentis etc.; Hematuria can add HERBA CIRSII, Rhizoma Imperatae, Folium Pyrrosiae, Herba Polygoni Avicularis etc.In addition, exist because heat often depends on wet, so, improvement and the dietetic regulation of habitat environment should be noted, unsuitable eating and drinking too much at one meal, excessive drinking, eat sweet food less.Semen Plantaginis is sweet, cold.Enter kidney, urinary bladder channel.Function cures mainly diuretic, heat clearing away, and improving eyesight is eliminated the phlegm.Control urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view." herbal classic ": " main stranguria due to disorder of QI, pain relieving, dredging water passages urine, except arthralgia chiefly caused by damp pathogen." Collective Notes to the Canon of Materia medica: " main asthenia." " not Lu ": " man's damaging the spleen and stomach, woman drenches drop, loss of appetite.Support lung reinforcing YIN-essence benefit essence.Swelling pain is treated in improving eyesight." " property of medicine opinion ": " can remove pathogenic wind toxic, and the liver affected by pathogenic wind heat, malicious wind dotting punch order, swelling pain is hidden from view, and headache lacrimation, removes irritable feverish sensation of chest and heart." " Japan hanako materia medica ": " diuresis drenches puckery, tonifying YANG.Control de-essence, vexed.The therapeutic method to keep the adverse QI flowing downwards." " medicine origin ": " main urinary obstruction, leads little pathogenic heat in the bowels." " Thunder God concocts property of medicine solution ": " main pouring drop difficulty in urination, penis swells and ache, eczema, has loose bowels, and also leucorrhea is turbid, and blood closes difficult labour.″

" book on Chinese herbal medicine newly organized ": Semen Plantaginis, sweet in the mouth, salty, feeble QI is trembled with fear, nontoxic.Enter bladder, spleen, kidney three warp.Merit patent water, logical urinary catheter is the most refreshing, only drenches drop and has loose bowels, can close orifice for discharging seminal fluid, heat of dispeling the wind, and the kind Akamu that disappears, expedites the emergence of meritorious.But property is sliding, and diuretic can be multiplex, also not flat with it.Rush down and be suitable for few use, with its too sliding profit also.Person of modern times claims its power energy seed, then miss pole.Husband's WUZIYANZONG WAN uses Semen Plantaginis person, because of Fructus Lycii, covers the too dynamic sun of basin, Herba cuscutae, Fructus Schisandrae Chinensis too arresting seminal emission, thus with Herba Plantaginis with minor benefit it.With leading among closing, with rushing down within benefit, beginning can diuretic and do not consume gas.Water key is opened, and orifice for discharging seminal fluid closes, and natural spirit is healthy and vigorous, and enter room and begin raw sub, the self energy seed of non-Herba Plantaginis also.Among the tonic of about use, then with group's mutual aid, there is outstanding service more.Not credible is the medicine of seed, too also multiplex.

Semen Plantaginis compatibility Rhizoma Imperatae: Semen Plantaginis clearing away heat with drugs sweet in flavor and cold in nature relieving stranguria by diuresis; Rhizoma Imperatae cooling blood for hemostasis, clearing away heat and promoting diuresis. the two 5 with the card such as the dysuria having relieving stranguria by diuresis, effect of cooling blood for hemostasis is used for the treatment of retention of water-damp in the body, lower limbs edema and oliguria, dysurea, hematuria because of person caused by damp-heat in lower-JIAO.

The Semen Plantaginis compatibility Rhizoma Atractylodis Macrocephalae: Semen Plantaginis diuretic and antidiarrheal; Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI and dampness. Papillary has effect of invigorating the spleen to arrest diarrhea to be used for the treatment of diarrhea due to hypofunction of the spleen, oliguria person.

Semen Plantaginis compatibility Rhizoma Atractylodis: Semen Plantaginis eliminating damp-heat; Rhizoma Atractylodis dispelling the damp pathogen with bitter and warm drugs. the two is 5 with having effect of the spleen strengthening and damp drying to be used for the treatment of women's leukorrhagia or having loose bowels because of person caused by damp.

Semen Plantaginis compatibility Spora Lygodii: Semen Plantaginis eliminating damp-heat; Spora Lygodii Tonglin Paishi. two medicines share the effect that can strengthen clearing away heat-damp and promoting diuresis and are used for the treatment of the puckery pain of urine leaching caused by damp-heat accumulation bladder or damp and hot caused calculus.

Semen Plantaginis compatibility Radix Rehmanniae Preparata: Semen Plantaginis lets out liver-heat and improving eyesight; Radix Rehmanniae Preparata liver and kidney tonifying. two medicines share liver and kidney tonifying, the effect of the improving eyesight that expels the heat-evil is used for the treatment of the disease such as the dark cataracta of order, blurring of vision, visual deterioration, oliguria that the hepatic and renal YIN deficiency causes.

Result shows, the present invention significantly can suppress the gallstone formation rate of rat, significantly improves large mouse with renal calculs Kidney coefficients, significantly reduces kidney calcium content, serum BUN and Cr level; Have obvious diuresis to Normal saline loading rat, can increase urine volume, anion and the calcium ion concentrations such as diluted urine mesoxalic acid ion, reduce lithogenous chance.Ureteral peristalsis experimental result shows, and this medicine can significantly suppress ureteral tension force, and the reduction of ureter mean tension, ureter caliber can be made to expand, be conducive to the unobstructed gentle solution spasmic pain of pipeline, add strong diuresis simultaneously, calculus can be impelled to discharge with urine.The present invention simultaneously also has antiinflammatory action, avoids damage factor directly or indirectly to cause the destruction of tissue and cell.

Endothelium Corneum Gigeriae Galli returns spleen, stomach, small intestinal, urinary bladder channel.Effect invigorating the stomach and promoting digestion, arresting seminal emission, treating stranguria fossil.Cure mainly and do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission, the puckery pain of stranguria caused by urinary stone, gallbladder-distention hypochondriac pain.Compendium of Material Medica: the wine that disappears amasss, and takes with Semen Glycines powder ball." the southern regions of the Yunnan Province book on Chinese herbal medicine ": alleviating distention in middle-JIAO spleen invigorating, help digestion mill stomach.Control children's's breast food knot stagnant, the large muscle of tripe is blue or green, mass in the abdomen infantile malnutrition.

Herba Lobeliae Chinensis, (formal name used at school: LobeliachinensisLour.) English name: (HERBALOBELIAECHINENSIS) belongs to campanulaceae lobelia.All herbal medicine, possesses inducing diuresis to remove edema, the effects such as heat-clearing and toxic substances removing, can treat extensive abdominal edema, face foot edema, carbuncle furuncle, snake bite and insect sting etc.Heat-clearing and toxic substances removing; Inducing diuresis to remove edema.For carbuncle furuncle, snakeworm flood dragon hinders, expansion edema, jaundice due to damp-heat, eczema eczema." detailed outline ": " control Serpentis a poisonous snake mentioned in ancient books wound, smash juice drink, enclose painting with dregs." [" the SHENGCAO property of medicine is standby to be wanted ": " applies skin ulcer, detumescence poison.″

Herba Taxilli hardship is sweet, flat.Enter liver, kidney channel.Function cures mainly invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, and the meridian dredging, beneficial blood, antiabortive.Control soreness of waist and knee joint, muscles and bones flaccidity is weak, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.Control chronic cough, protrusion of the tongue is dizzy." herbal classic ": main lumbago, children's's stiffback, carbuncle, antiabortive, fill skin, hard, tooth, long man." not Lu ": main incised wound, goes numbness, woman's metrorrhagia, and internal injury is not enough, puerperal She's disease, lower milk.

Herba Portulacae Classification system: PortulacaoleraceaL is Portulacaceae annual herb plant.Plump succulence, without hair, high 10 ~ 30cm, is born in the area without shade such as roadside, field and ruins, flower garden.Herb hyoscine, has clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, antiinflammatory, quenches the thirst, diuresis; Seed improving eyesight.Modern study, Herba Portulacae is also containing abundant SL3 fatty acid and vitamin A sample material.SL3 fatty acid forms cell membrane, especially brain cell membrane and the necessary material of eye cell membrane; Vitamin A sample substance maintains epithelial tissue as skin, cornea and conjunctival normal function, participates in the synthesis of rhodopsin, strengthens retinal photoreceptor performance, also participates in many oxidizing processs in body.

Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant, there are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Herba Taraxaci, simultaneously containing protein, fat, carbohydrate, trace element and vitamin etc., has abundant nutritive value, raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant, there are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Herba Taraxaci containing protein, fat, carbohydrate, trace element and vitamin etc., has abundant nutritive value simultaneously.The carotene wherein contained and C and mineral, to the effect that dyspepsia, constipation are all improved.Leaf is also improved eczema in addition, the effect of dermatitis of releiving, and root then has antiinflammation, and flower decocts into medicine juice can remove freckle

Herba Lysimachiae is used for sore carbuncle, acute mastitis, erysipelas, venom and traumatic injury.Herba Lysimachiae has removing toxic substances dissipating blood stasis, the merit of reducing swelling and alleviating pain, and conventional fresh goods is taken orally or external application, can smash juice drink by alone fresh grass, or smash deposited affected part, also can be equal to strengthen antipyretic and antidote functions with wild Flos Lonicerae, Herba Taraxaci, Rohdea japonica Roth.In addition, Herba Lysimachiae is used for edema, tympanites, and merit for oral administration, external application all has inducing diuresis to remove edema, for cough due to lung-heat, infantile hyperpyrexia gets its antipyretic and antidote functions

Polyporus sweet in the mouth, light, flat.Enter the heart, spleen, stomach, lung, kidney, warp.Promoting diuresis to eliminate damp pathogen.Control dysuria, edema, to have loose bowels, stranguria with turbid discharge, leukorrhagia.Polyporus is long at China's applicating history.As far back as " village " in book " pig zero " by name; Shennong's Herbal is classified as middle product.Collective Notes to the Canon of Materia medica note has: " maple Siberian cocklebur, its skin de-black makes block like pig dung, thus with name it.Meat Bai Ershi person is good, with it casting skin of pruning." amplification on Canon of Materia Medica carries: " Polyporus, the merit spirit of row water, clothes must damage kidney qi for a long time, enter order dusk "." book on Chinese herbal medicine is looked for the truth " carries: " Polyporus, the side such as all four Siberian cockleburs, five Siberian cockleburs, and all with this, though property has class Rhizoma Imperatae, with entering bladder kidney channel, antipyretic dehumidifying, row key diuretic, right water disappears then spleen must be dry, and water to the greatest extent then gas must be walked.

The Radix Rehmanniae (Classification system: RehmanniaglutinosaLibosch), another name Radix Rehmanniae, wild country Huang, mountain cigarette root etc. are the tuber of scrophulariaceae rehmannia glutinosa plant.There is clearing away heat and cooling blood, effect that tonifying YIN promotes the production of body fluid.To join the army blood for warm febrile disease, high fever coma, xerostomia crimson tongue, as qingying decoction.The evaluation of Li Shizhen (1518-1593 A.D.) to Radix Rehmanniae is: one hundred days of clothes are rosy cheeks, within 3 years, makes light of one's life by commiting suicide not old.For goatweed, its root is one of Chinese medicine, and the source of an allusion is in Shennong's Herbal the earliest.Shennong's Herbal: sweet in the mouth, cold.Cure mainly folding to fall, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fill out bone marrow, longue meat.Make soup except cold and heat and gather, eliminating impediment.Survivor is especially good.

Rhizoma Imperatae return through: enter kidney, urinary bladder channel.Effect: diuretic, eliminating dampness by diuresis, expels the heat-evil.Control dysuria, edema distension, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria." herbal classic ": main anemofrigid-damp arthralgia, breast is difficult, and disappear water, supports the five internal organs, physical strength profiting, fertile strong." not Lu ": tonifying deficiency five kinds of over strain, except the five internal organs feeling of fullness, plays cloudy gas, stopping leak essence, quenches one's thirst, drenches drop, cuts off the water by bladder, three Jiao." property of medicine opinion ": main essence of suffering from a deficiency of the kidney, from going out, controls five types of stranguria, sharp bladder heat, straight through water passage.

Herba Verbenae: the dry aerial parts " Bencao Jingshu " of Verbenaceae Herba Verbenae VerbenaofficinalisL.: Herba Verbenae are originally the medicines of removing heat from blood removing blood stasis.Bottom abscess person, the pole of heat in blood, furthermore damp and hot, therefore blood stains are turbid forms skin ulcer, and have worm also.The cool pyrolysis of blood, the broken and row of dirty person, waste and be not recovered.CHEN Zang-Qi calls its removing blood stasis parasite killing, also this meaning ear." China's book on Chinese herbal medicine " cures mainly cold, fever; Laryngopharynx swelling and pain; Gingival swelling and pain; Jaundice; Dysentery; Blood stasis amenorrhea; Dysmenorrhea; Lump in the abdomen; Edema; Dysuria; Malaria; Carbuncle pyogenic infections from tumour or sore; Traumatic injury.Venbenalin is excited in a small amount to SNE, suppresses in a large number; Galactopoiesis can be promoted to mammal.Heat and toxic materials clearing away medicine; Promoting blood circulation to restore menstrual flow medicine; Edema-alleviating diuretic; Preventing the attack (or recurrence) of malaria medicine; Promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, removing toxic substances, inducing diuresis to remove edema.For lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria.

Herba Eleusines Indicae, the sub-section Finger-millet of grass family Herba Eragrostidis pilosae belongs to Herba Eleusines Indicae.Classification system Eleusineindica (L.) Gaertn. cures mainly heat clearing away, dampness removing.The summer-heat that can cure the wound generates heat, acute infantile convulsion, jaundice, dysentery, gonorrhea, dysuria; And can encephalitis b be prevented and treated.Water decocted by this grass, and informal dress takes in a large number, has epidemic prevention, anti-pestilence seasonal noxious pathogen special effect according to legend from ancient times.Since Wei Jin, the among the people and traditional Chinese medical science passes for a long time and does not wane, and steps on because it is called as thousand people usually, and juvenile is funny cricket grass with it.Informal dress is coordinated with Flos Lonicerae preparation with this grass, can flu-prevention and other popular epidemic diseases.Effect is better than Radix Isatidis greatly, Radix Isatidis granules to common cold or influenza all substantially invalid, just a kind of medicine of psychological comfort.

Spica Prunellae is the dry fruit ear of labiate Spica Prunellae PrunellavulgarisL..All parts of the country are all produced, main product in Jiangsu, Zhejiang, Anhui, the ground such as Henan.Gather when summer, fruit ear was brownish red, removing impurity, dries.Raw use.Its property is pungent, bitter, cold.Return liver, gallbladder meridian.There is clearing away heat-fire, improving eyesight, effect of mass dissipating and swelling eliminating.Treatment conjunctival congestion and swelling pain, dizzy, order pearl nyctalgia of having a headache.Spica Prunellae bitter cold master enters Liver Channel, and kind removing fire from the liver is with improving eyesight.With controlling flaming up of liver-fire, conjunctival congestion and swelling pain, it is medicinal to join Folium Mori, Flos Chrysanthemi, Semen Cassiae etc.Among this product liver heat removing and eyesight improving, nourishing the liver of slightly holding concurrently, joins Radix Angelicae Sinensis, Fructus Lycii, can be used for deficiecny of liver-YIN, ophthalmalgia, to night more particularly; Also can accessory stick up, Radix Glycyrrhizae use, as loose in Spica Prunellae (" Zhang Shi doctor is logical ")

Herb Gynostemmae Pentaphylli returns lung; Spleen; Kidney channel, also known as: Herba Gynostemmatis, Pentapanax and gynostemma pentaphyllum makino etc., Latin literary fame: Gynostemmapentaphyllum (Thunb.) Makino Cucurbitaceae, Gynostemma herbaceous stem Climbing Plant; Arrange in pairs or groups to boil water with Herb Gynostemmae Pentaphylli and Ganoderma or brew up, hypertension, hyperlipidemia, hyperglycemia can be treated, the diseases such as fatty liver.There is effect of protecting liver and detoxication, blood pressure lowering, blood fat reducing blood glucose.It is gypenoside, Herb Gynostemmae Pentaphylli glucoside (polysaccharide), water-soluble amino acid, flavonoid, multivitamin, trace element, mineral etc. that Herb Gynostemmae Pentaphylli mainly contains effective constituent.Cure mainly: body void is weak; Nephrasthenia emission; Leukopenia; Hyperlipemia; Viral hepatitis; Chronic gastroenteritis; Chronic tracheitis.

Herba Rabdosiae Lophanthoidis is the herb of Labiatae spray nose tea Lepidium plant Rabdosia lophanthoides.Classification system Rabdosiaserra (Maxim.) Hara, Herba Rabdosiae Lophanthoidis is traditional herbal medicine, be commonly called as Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) etc., there is effect of clearing away heat-damp and promoting diuresis, jaundice eliminating damp eliminating, cool the blood dissipate blood stasis, be used for the treatment of the diseases such as acute icterohepatitis, acute cholecystitis, dysentery, enteritis, traumatic injury stasis of blood pain.The diseases such as Herba Rabdosiae Lophanthoidis has effect of clearing away heat-damp and promoting diuresis, jaundice eliminating damp eliminating, cool the blood dissipate blood stasis, is used for the treatment of acute icterohepatitis, acute cholecystitis, dysentery, enteritis, the difficulty in urination, traumatic injury stasis of blood pain.Herba Rabdosiae Lophanthoidis can not treat chronic hepatitis in fact, if the icteric hepatitis B of samples can do acute treatment with Herba Rabdosiae Lophanthoidis, chronic viral hepatitis B or will arrive regular hospital does and treat targetedly, otherwise likely delay treatment, and then increase the difficulty of curing.Chinese herbal medicine Herba Rabdosiae Lophanthoidis has certain effect to hepatitis, but treatment small three positive effect is but very limited.

Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, in tune, dampness, reduces phlegm.Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach.Abdominal distention uncomfortable in chest in turbid damp resistance, indigestion and loss of appetite loose stool.Phlegm-damp stops up the cough and asthma of lung.Therefore Pericarpium Citri Reticulatae has three major types effect, one is lead cold-evil in the heart, two broken stagnant gas, three strengthening the spleen stomaches.This three large on, Main Function is row QI of the spleen and stomach.The main transmitting and distributing the fluids of taste, therefore QI of the spleen and stomach is capable, can dry, spleen invigorating, reduce phlegm, therefore can say again, Pericarpium Citri Reticulatae temperature can support spleen, pungently can be amusing, bitter can spleen invigorating.Due to the main row QI of the spleen and stomach of Pericarpium Citri Reticulatae, taste are located in middle Jiao, and the gas of middle Jiao passes through, and the gas of three Jiao is also sprung up thereupon.Three Jiao are the organ in charge of water circulation, and current water liquid, accompanies with wetting phase; Again for hiding mansion outside mansion, upper and the heart, lung, lower and liver, kidney.So the effect of Pericarpium Citri Reticulatae can wide and all Zang Fu, wet throughout whole body.Say from lung, then pungent loose lung qi, hardship lets out lung qi, temperatureization cold, can control abundant expectoration cough with asthma, and gas is stopped up food and stopped; Say from the heart, then pungent happy gas, hardship lets out heart-fire, and warm removing dampness is turbid, can control irritable feverish sensation in the chest, and the implication sound of vomiting is smelly; Say from liver, then pungent loose stagnation of liver-QI, liver-fire falls in hardship, warming for eliminaring cold-damp, so its can treating the liver be strongly fragrant heat, drink is stopped eating stagnant; Say from kidney, then pungent profit kidney is dry, and hardship is let out kidney and wet, gentle kidney qi, so it can control life fire deficiency, and indigestion.Certainly, all explanations are all relevant with spleen with wet, so its property of medicine effect performance leeway is larger, all can use in general activating QI to eliminate phlegm side.As Li Shizhen (1518-1593 A.D.) is said: " Pericarpium Citri tangerinae hardship can be let out can be dry, pungent energy loose can and, it controls all kinds of diseases and ailments, always gets the merit of its dampness of regulating the flow of vital energy.Then mending with tonic, then rush down with cathartic, then rise with Hydrargyri Oxydum Rubrum, then falling with falling medicine." as with the Rhizoma Atractylodis Macrocephalae with using; then having the effect of tonifying the spleen and stomach; with Radix Ginseng, Radix Glycyrrhizae with the effect then having tonifying the lung gas; with Semen Armeniacae Amarum with then there being logical effect of falling large intestine constipation due to disorder of QI, logical moisten the secret effect of large intestine blood with Semen Persicae with then having, with the Rhizoma Pinelliae with the effect then having dampness; with Poria with the effect then having damp eliminating; with Pericarpium Citri Reticulatae with the effect then having sending down the abnormal ascending QI preventing or arresting vomiting, with Rhizoma Zingiberis with can warming for resolving cold-phlegm, drink with Rhizoma Coptidis is same treat gastrointestinal disease better efficacy with heat-phlegm can be removed or directly take gastrointestinal.

Rhizoma Atractylodis acrid in the mouth; Bitter; Warm in nature.It is pungent strong that amplification on Canon of Materia Medica records abnormal smells from the patient; " pearl sac " is recorded sweet pungent; " brilliant converge with essence will " records bitter but sweet flavor, warm in nature, nontoxic.Cure mainly drying damp and strengthening spleen; Wind-damp dispelling; Improving eyesight.Main the spleen and stomach being stranded by dampness; Asthenia drowsiness; Born of the same parents' painful abdominal mass abdominal distention; Inappetence; Tell and have loose bowels; Phlegm retention; Damp-edema; Exterior syndrome folder is wet; Head heavy sensation of the body pain; Arthromyodynia warm nature; Podomere is ached and is weighed; Flaccidity folds in a garment; Nyctalopia.Liu Wansu: improving eyesight, warming the kidney." pearl sac ": stomach invigorating can pacify spleen, non-this of all damp-edema can not remove.Li Gao: dehumidifying diaphoresis, stomach invigorating peace spleen, controls flaccidity key medicine." detailed outline ": control damp-phlegm prolonged fluid-retention, or hold blood stasis under the arm and become nest capsule, and spleen wets dirty, turbid drop leukorrhagia, slidingly rushes down hemorrhoidal hamorrhage.

The fruit of Fructus Gardeniae is Chinese medicine, belongs to the 1st batch of medicine-food two-purpose resource that Ministry of Public Health is promulgated, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence.The diseases such as treatment icterohepatitis, bruise, hypertension, diabetes are usually used at tcm clinical practice.The system of Fructus Gardeniae rushes down deacetylasperulosidic acid methyl ester discharge function, and the median effective dose of mice is 0.53g/kg, starts diarrhoea after taking 6 hours.Gardenoside also has catharsis effect, and the median effective dose of Mouse oral is 1.2g/kg, takes latter 3 hours and starts effect.The catharsis effect median effective dose of gardenoside is 300mg/kg, takes medicine and works for latter 3 hours.The catharsis effect median effective dose > 800mg/kg of geniposidic acid.

Stigma Maydis sweet in the mouth, light, property is put down.There is inducing diuresis to remove edema; Effect of liver heat removing function of gallbladder promoting.Main edema, dribbling urination, jaundice, cholecystitis, cholelithiasis, hypertension, diabetes, galactostasis." the southern regions of the Yunnan Province book on Chinese herbal medicine ": the wide intestinal therapeutic method to keep the adverse QI flowing downwards.Control married woman's breast knot, galactostasis, congestion and swelling pain, heating of being afraid of cold, headache body is stranded." south of the Five Ridges gather medicinal herbs record ": decoct soup with Carnis Sus domestica and control diabetes.Control again dribbling urination sandstone, bitter unbearably painful, decoct soup and be taken in small doses at short intervals.

The specific embodiment of the invention

Specific embodiment 1

To gather when summer, autumn two season seed maturity fruit ear, and to dry, rub seed, about 5000g, put into water and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, remove supernatant after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, become component 1.By all the other raw material Herba Rabdosiae Lophanthoidiss 1500g, Herb Gynostemmae Pentaphylli 1500g, Herba Portulacae 1500g, Spica Prunellae 1500g, Rhizoma Atractylodis 1500g, Herba Eleusines Indicae 1500g, Pericarpium Citri Reticulatae 1500g, Endothelium Corneum Gigeriae Galli 1500g, Radix Scutellariae 1500g, Fructus Gardeniae 1500g, Rhizoma Imperatae 1500g, Herba Verbenae 1500g, Herba Lobeliae Chinensis 1500g, Polyporus 1500g, Herba Taraxaci 1500g, Stigma Maydis 1500g, Herba Taxilli 1500g, Herba Lysimachiae 1500g, mixing breaks into coarse powder, sieve, medicated powder is equipped with in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, stir, moistening airtight placement more than 1 hour, make abundant expansion, drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator, medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol, air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container, being merged by percolate and leave standstill, is component 2.Honor is divided 1, component 2 mixes, decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.36; The extractum of temperature to 60 DEG C-70 DEG C, adds dextrin and is in harmonious proportion and makes oral liquid.

Specific embodiment 2

The fruit ear of gathering when summer, autumn two season seed maturity of results, dries, rubs seed, about 4500g, put into water and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, remove supernatant after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, become component 1; By all the other raw material Herba Rabdosiae Lophanthoidiss 1200g, Herb Gynostemmae Pentaphylli 1100g, Herba Portulacae 1200g, Spica Prunellae 1100g, Rhizoma Atractylodis 1100g, Herba Eleusines Indicae 1200g, Pericarpium Citri Reticulatae 1100g, Endothelium Corneum Gigeriae Galli 1100g, Radix Scutellariae 1100g, Fructus Gardeniae 1200g, Rhizoma Imperatae 1200g, Herba Verbenae 1200g, Herba Lobeliae Chinensis 1100g, Polyporus 1200g, Herba Taraxaci 1100g, Stigma Maydis 1200g, Herba Taxilli 1200g, Herba Lysimachiae 1100g, soak 1 hour; Soaked raw material is put in multi-function extractor and decocts with water secondary; Add up the water of medical material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; Leave standstill as component 2, component 1 filtrate with component 2 inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Then add Mel mediation and make oral liquid.

Specific embodiment 3

The preparation of oral solutions of the present invention:

The fruit ear of gathering when summer, autumn two season seed maturity of results, dries, rubs seed, about 4500g, put into soak with ethanol 1-2 hour, heating extraction 2 times, each 1-2 hour, decoct to the rear to the greatest extent merge extractive liquid, of taste, remove supernatant after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, become component 1.By all the other raw material Herba Rabdosiae Lophanthoidiss 1200g, Herb Gynostemmae Pentaphylli 1100g, Herba Portulacae 1200g, Spica Prunellae 1100g, Rhizoma Atractylodis 1100g, Herba Eleusines Indicae 1200g, Pericarpium Citri Reticulatae 1100g, Endothelium Corneum Gigeriae Galli 1100g, Radix Scutellariae 1100g, Fructus Gardeniae 1200g, Rhizoma Imperatae 1200g, Herba Verbenae 1200g, Herba Lobeliae Chinensis 1100g, Polyporus 1200g, Herba Taraxaci 1100g, Stigma Maydis 1200g, Herba Taxilli 1200g, Herba Lysimachiae 1100g, put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then concentrating under reduced pressure tank is put into, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06 extractum, become component 2.By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds dextrin and reconciles into oral liquid, bottles after ultraviolet sterilization.

Specific embodiment 4

The fruit ear of gathering when summer, autumn two season seed maturity of results, dries, rubs seed, about 4500g, put into soak with ethanol 1-2 hour, heating extraction 2 times, each 1-2 hour, decoct to the rear to the greatest extent merge extractive liquid, of taste, remove supernatant after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, become component 1.By all the other raw material Herba Rabdosiae Lophanthoidiss 1200g, Herb Gynostemmae Pentaphylli 1100g, Herba Portulacae 1200g, Spica Prunellae 1100g, Rhizoma Atractylodis 1100g, Herba Eleusines Indicae 1200g, Pericarpium Citri Reticulatae 1100g, Endothelium Corneum Gigeriae Galli 1100g, Radix Scutellariae 1100g, Fructus Gardeniae 1200g, Rhizoma Imperatae 1200g, Herba Verbenae 1200g, Herba Lobeliae Chinensis 1100g, Polyporus 1200g, Herba Taraxaci 1100g, Stigma Maydis 1200g, Herba Taxilli 1200g, Herba Lysimachiae 1100g.By the roguing of described component crude drug, dry, be ground into granule, soak 1 hour; Soaked raw material is put in multi-function extractor and decocts with water secondary; Add up the water of medical material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; For component 1; Medicinal residues are added 10 times amount ethanol again, heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; Decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08; The extractum of temperature to 60 DEG C-70 DEG C, stand for standby use, becomes component 2.Component 1 and component 2 are inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, adds Mel and reconcile into oral liquid.

Pharmacological toxicity is tested

One, test material:

(1) laboratory animal: mouse NIH, body weight 25-28g, male and female half and half; Rats Wistar body weight 130-160g, male and female half and half, the feedstuff of rat, mice is provided by Shandong medical college animal experimental center.

(2) test medicine:

1, medicine of the present invention: the oral liquid that embodiment 2 is made, applies with distilled water diluting during three batch equal amount of mixture experiments.

2, positive control medicine: JINGUI SHENQI WAN, commercially available.

Two, test method and result:

(1) get the healthy mice 80 of body weight 25-28g, female, hero half and half, is divided into four groups respectively by sex and body weight, often organizes 20.1, take medicine of the present invention for 2,3 groups, dosage is respectively 8.6g crude drug/kg/d, 6.4g crude drug/kg/d, 4.2g crude drug/kg/d, and take positive control drug JINGUI SHENQI WAN for the 4th group, dosage is 6g crude drug/kg/d, is used in conjunction 15 days.

Result of the test: 1,2,3 groups of mices obviously strengthen than 4 groups of mice sexual excitation degree, the number of copulations of 1,2,3 group of mice average every day increases by 3 times than the number of copulations of 4 groups of mices.

Result of the test shows that medicine of the present invention has obvious excitation to central nervous system, thus medicine of the present invention for adjustment human body function equilibrium, QI invigorating, enrich blood, slow down aging strengthens metabolism, neurolysis, sexual hypofunction has treatment foundation.

Animal acute toxicity test of the present invention

One, test material

(1) animal mouse NIH kind male and female half and half, body weight 20-22g, are provided by Shandong medical college Animal Lab..

(2) test medicine: the oral liquid that the present invention is made, is diluted with distilled water into suspension.

Two, test method and result:

Mice maximum tolerance determination: get healthy mice 32, male and female half and half, divided three groups within 24 hours, and only, gross weight 1.8ml, is equivalent to crude drug in whole 4.0g to each 0.6ml/ of gavage intestinal, i.e. 100g crude drug/kg/d, is equivalent to 857 times of clinical 65 kilograms of people.After mice administration routinely feedstuff within 12 days, have no animal dead and do not go out, existing toxic reaction.Therefore prove, medicine of the present invention has no side effect, and clinical practice is safe and reliable.

The long-term toxicity test for animals of pharmaceutical composition of the present invention

One, test material and method

(1) test medicine: the oral liquid that the embodiment of the present invention is made.

(2) laboratory animal, healthy rat Wistar, body weight 100-130g, 140 male and female half and half, by sex and body weight random packet, four groups, often organize 35.1, take test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/d.4 groups contrast to the distilled water of respective volume amount, the equal gavage enteral administration of rat, often organize and be once used in conjunction 6 months, put to death half, and under She, all death in 12 days is observed in 1/2 drug withdrawal.

Two, test index

(1) general status comprises body weight, diet, emotion, movable energy.

(2) hemogram checking: red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin counts.

(3) biochemical analysis, serum albumin quantitatively, cholesterol, blood sugar quantitative.

(4) pathologic diagnosis: get half animal after experimental result and weigh, sacrificed by decapitation, gets blood, solution is treated others for earnest simultaneously, liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.

Three, result of the test: show through rat chronic toxicity test, with the heavy dose of coloclysis of the present invention six months, increases the growth of rat, body weight, all has no side effect to brain, Liver and kidney function.Do not find that infringement changes to each histoorgan of rat, blood circulation, medication group compares no significant difference with matched group.Illustrate that medicine of the present invention has warming and recuperating the kidney-YANG, QI invigorating, enriches blood, slow down aging strengthens the drug effects such as metabolism, avirulence.

Medicine and clinical experiment

Pharmacological experiment:

1, materials and methods

Medicine: the present invention proposes the preparation of alcohol deposit fluid: get a certain amount of crude drug of the present invention, decocting twice, adds 95% alcohol settling impurity after water-bath being concentrated into certain volume, cross liquid, filtrate recycling ethanol.Be made into 100% concentration.

Matched group is White Cloud Mountain XIAOYAN LIDAN PIAN, the accurate word Z44022243 of traditional Chinese medicines.Ursodesoxycholic acid is that Mitsubishi changes into production.

Animal ICR mice, SD rat provides by zooscopy room, the court.

The protective effect of the mouse liver injury that the 1.1 pairs of carbon tetrachloride cause: male mice 78, body weight 18-23g, is divided into six groups by body weight random stratified, often organizes 13.The present invention 3 dosage group 2.5g/kg, 5.0g/kg, 10.0g/kg, positive control drug White Cloud Mountain XIAOYAN LIDAN PIAN 10g/kg, model group, water matched group gastric infusion every day once, continuous 6d, after administration in the 6th day, 1h dewaters, and all the other respectively organize carbon tetrachloride vegetable oil 5ml/kg of equal subcutaneous injection 0.15 to matched group outward.Pluck eyeball after 16h and get kit measurement serum SGPT, SGOT of producing blood Beijing Chemical Plant.Solution cuts liver and weighs, and calculates the liver body ratio of every mice, data represent with average scholar standard deviation, carry out t inspection between group according to body weight when putting to death.

1.2 affect 1.2.1 to normal rat bile flow

The mensuration of bile flow: get rat 60, male, body weight 250 ~ 350g, weighs and is divided into five groups at random, often organizes 12, and fasting 12h before experiment, can't help water.Experiment is with 10% urethane 1.0g/kg intraperitoneal injection of anesthesia, face upward position and be fixed on operating-table, along abdomen median line open abdomen, find out duodenum, the gallbladder pipe finding white flexible in portion's mesentery is falling, two rhizoid lines are worn under it, ligation pars papillaris, " V " shape otch is made to liver direction, insert plastic conduit, ligation is fixed, namely pistac gallbladder antiperspirant is had to flow out as seen, gallbladder juice collected by test tube, postoperative with saline gauze covering abdominal cavity, after stable 1h, first collect the gallbladder juice of 30min, as the basic value before administration, then to divide into groups administration (through duodenum).The present invention 3 dosage group 2.5g/kg, 5.0g/kg, 10.0g/kg, water matched group, positive drug ursodesoxycholic acid 0.5g/kg.Measurement 1 bile is collected every 30min after administration.4h altogether.

1.2.2 the mensuration of bile component: before administration, the bile that after administration, 4h collects measures bilirubin (health Bioisystech Co., Ltd of Erie produces, caffeine method).The test kit that Determination of Cholesterol Content is produced with Eastern Europe bio-engineering corporation, enzymatic assays.

2 experimental results

The protective effect of the mouse liver injury that the 2.1 pairs of carbon tetrachloride cause: SGPT, SGOT that carbon tetrachloride causes significantly raise P < 0.01, illustrates moulding success.The present invention makes SGOT significantly reduce by three equal P < of dosage group O.05, and the present invention has no significant effect SGPT.White Cloud Mountain XIAOYAN LIDAN PIAN makes SGPT, SGOT significantly reduce (P-~ O.05).Herba Lycopi 10g/kg group makes liver body than significantly lower than carbon tetrachloride model group.Refer to table 1.

Table 1 the present invention is on the impact (X ± S) of carbon tetrachloride poisoning mice serum transaminase

Note: carry out t inspection between group, with carbon tetrachloride group than * P < 0.05, * * P < 0.01

2.2 impacts on normal rat bile flow: 2.5g/kg group of the present invention makes normal rat bile flow increase, continue 2h, increase the most remarkable < 0.05 with the 30min after administration).The each phase of 5.0g/kg group administration 2h all significantly to increase after the administration of < 0.05.10.0g/kg group all remarkable than the matched group rising (P < 0.01, P < 0.05) of each phase in 90min.Positive drug ursodesoxycholic acid also makes flow increase, and continues 1h.P < 0.05 refers to table 2.

Table 2 the present invention is on the impact (X ± S) of anesthetized rat bile flow

Note t with flow before administration for 100%, group is asked and is carried out t inspection, determine bile mesobilirubin with matched group than tiny stream before * P < 0.05, * * P < 0.01. administration of the present invention, after administration and have no significant difference with alcohol content with gallbladder compared with matched group.Refer to table 3.

Table 3 the present invention is on cholesterol, the impact of bilirubin output (X ± S) in rat bile

Discuss:

Traditional medicine think the inflammation of liver and gall system, calculus mainly toxic dampness and heat broadcast in body and cause. the liver that someone analyzes 100 routine hepatitis patients is worn pathological examination and show that acute Jaundice Jaundice 100% belongs to the damp and hot conclusion of the traditional Chinese medical science in conjunction with Syndrome Differentiation of Traditional Chinese Medicine, under so clear away the dampness and heat, evil poison purging FU-organs rushes down, eliminating damp, detoxifying is the normal rule for the treatment of.

Clinical trial

From year June in August, 2012 to 2015, adopt from intending liver heat removing dampness removing Jiangzhitang treatment fatty liver 90 example, obtain significant curative effect, the out-patient for health check-up finder and unit of going together in 90 examples originally organized by clinical data, 35 ~ 55 years old age, average 44 years old; 1 ~ 6 year course for the treatment of is not etc.Two groups of data are checked through Ridit, and the aspect such as age, the course of disease is all without the significance difference opposite sex.There is comparability.Diagnosis basis clinical manifestation and iconography and lab testing, all meet fatty liver feature.Treatment group and each 45 examples of matched group are divided at random by medical order.Diagnostic criteria: State Administration of Traditional Chinese Medicine Liver of TCM sick Pivot Subjects writing group chief editor " traditional Chinese medical science hepatopathy conventional treatment " October in 2005 the 1st edition.

Therapeutic Method

Treatment group: oral liquid of the present invention, square medicine composition: Semen Plantaginis 30g, Herba Rabdosiae Lophanthoidis 12g, Herb Gynostemmae Pentaphylli 11g, Herba Portulacae 11g, Spica Prunellae 12g, Rhizoma Atractylodis 13g, Herba Eleusines Indicae 12g, Pericarpium Citri Reticulatae 12g, Endothelium Corneum Gigeriae Galli 11g, Radix Scutellariae 12g, Fructus Gardeniae 12g, Rhizoma Imperatae 12g, Herba Verbenae 12g, Herba Lobeliae Chinensis 12g, Polyporus 12g, Herba Taraxaci 12g, Stigma Maydis 13g, Herba Taxilli 12g, Herba Lysimachiae 12g, prepare by embodiment method 2, every day 3 bottles, after serveing on 2 months, withdraw 1 week, then to take 1 month be 1 course for the treatment of.

Matched group: liver-strengthening capsule (Shijiazhuang Dongfang Pharmaceutical Co., Ltd.'s production) the accurate word of traditional Chinese medicines: ZL0980012,1 time 5,1d3 time.Two months 1 courses for the treatment of.Treatments period withdraws any medicine.

Criterion of therapeutical effect: clinical cure: symptom, sign disappear completely, liver function is normal, and blood fat is normal, and B ultrasonic prompting liver acoustic image recovers normal.Effective: symptom and sign disappears, glutamate pyruvate transaminase and blood fat raised portion decline more than 50%, and B ultrasonic prompting fatty liver ultrasonogram alleviates.Invalid: not reach above standard person.Therapeutic outcome is in table 1.

The comparitive study of table 1 treatment group and matched group

Group	Number of cases	Recovery from illness	Effectively	Invalid	Total effective rate *
						Treatment group	45	18	15	7	84.44％
Matched group	45	12	18	15	66.67％

* clinical cure be effectively considered as effective number of cases, comparing through statistical procedures two groups has notable difference (P < 0.05), and treatment group is obviously better than matched group.

Discuss: fatty liver is the adipose metabolism disorder disease just causing medical circle to pay much attention in recent years.Modern medicine think primary disease primarily of lipid take the photograph people too much, fat or poisonous substance (ethanol), or heredity and metabolic factor to cause excessive fat to pile up in liver pathogenic.Consult allusion, though motherland's medical science does not have the name of disease of fatty liver, in successive dynasties doctor nationality, have the record of some similar primary disease." Ling Shu Miraculous Pivot or Divine Axis. disorder of defensive QI " namely point out in human body, there is " fat, " and have " cream " to have "flesh" (nonproductive construction) and be divided into " fat people ", " cream people, " " meat people " according to the difference of human body body.Its cloud: " cream person, many gas and skin are vertical slow, therefore it is vertical fertile indulge abdomen.Meat person, health holds large.Fat person, its body zooms in." Zhang Zhi's acute hearing " Ling Shu Miraculous Pivot or Divine Axis variorum " cloud: " and the gas of middle Jiao steams body fluid. and its Tianjin is micro-overflows in outer then skin and flesh cream fertilizer.She is in meat, then cream fat is plentiful." Zhang Jingyue Systematic Compilation of Internal Classic also cloud: " seminal fluid and combined into cream, to fill up among bone sky, then for brain is marrow, for essence is blood." as can be seen here, the cream fat of description above and the lipid material of modern medicine similar.Also illustrate that cream fat is one of physiology constituent of human body in fact, belong to the category of seminal fluid, and mutually can transform with other compositions of body fluid, Tianjin is cream from turbidity simultaneously, solidifying then be fat.Normal fat with the operation nutrition vital organs of the human body of blood, the white bones of the body of extremity and brains.If innate deficiency, eating and drinking without temperance, taste are lacked of proper care, feelings will internal injury, and liver and gall are lacked of proper care, old, the empty reason such as not enough of body, and cause hyperphagia or transmission, utilization, excretion are abnormal, all in blood, fat is piled up, too much fat turbidity.And become turbid damp, phlegm retention, invade excessive tunnel, make QI-blood circulation obstacle, the essence of blood stasis is in particular in microcirculation disturbance, the kinetics exception of blood flow and Abnormal Blood Rheology.And the turbid pathological product being both body visceral dysfunction with blood stasis of expectorant, finally form Liver Channel expectorant to coagulate the stasis of blood stagnant, the pathological change that the intrahepatic fat stasis of blood is long-pending, and occur the card such as " phlegm syndrome ", " blood stasis syndrome ", " BI-syndrome involved the blood vessels ".

Comprehensively it seems that the category such as surely belong to liver painful abdominal mass, hypochondriac pain, lump in the abdomen, gather is based on above-mentioned cognition, follow soothing the liver and blood fat reducing, dampness removing and doublely to reduce phlegm, invigorate blood circulation and the rule for the treatment of of blood stasis dispelling, adopt the Chinese medicine of soothing the liver blood fat reducing, dispelling phlegm and eliminating dampness, blood circulation promoting and dispersing pathogen accumulation, softening the hard mass removing food stagnancy.

Claims (10)

1. a toxin expelling dehumidifying, the Semen Plantaginis oral liquid of hepatic cholagogic, it is characterized in that, described Semen Plantaginis oral liquid comprises the raw material of following parts by weight: Semen Plantaginis 10 ~ 50 parts, Herba Rabdosiae Lophanthoidis 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Herba Portulacae 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Rhizoma Atractylodis 10 ~ 20 parts, Herba Eleusines Indicae 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Endothelium Corneum Gigeriae Galli 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Rhizoma Imperatae 10 ~ 20 parts, Herba Verbenae 10 ~ 20 parts, Herba Lobeliae Chinensis 10 ~ 20 parts, Polyporus 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Herba Lysimachiae 10 ~ 20 parts.

2. toxin expelling dehumidifying according to claim 1, the Semen Plantaginis oral liquid of hepatic cholagogic, it is characterized in that, described Semen Plantaginis oral liquid comprises the raw material of following parts by weight: Semen Plantaginis 10 ~ 30 parts, Herba Rabdosiae Lophanthoidis 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 10 ~ 15 parts, Herba Portulacae 10 ~ 15 parts, Spica Prunellae 10 ~ 15 parts, Rhizoma Atractylodis 10 ~ 15 parts, Herba Eleusines Indicae 10 ~ 15 parts, Pericarpium Citri Reticulatae 10 ~ 15 parts, Endothelium Corneum Gigeriae Galli 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Fructus Gardeniae 10 ~ 20 parts, Rhizoma Imperatae 10 ~ 20 parts, Herba Verbenae 10 ~ 20 parts, Herba Lobeliae Chinensis 10 ~ 20 parts, Polyporus 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Herba Lysimachiae 10 ~ 20 parts.

3. toxin expelling dehumidifying according to claim 1, the Semen Plantaginis oral liquid of hepatic cholagogic, it is characterized in that, described Semen Plantaginis oral liquid comprises the raw material of following parts by weight: Semen Plantaginis 10 ~ 40 parts, Herba Rabdosiae Lophanthoidis 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Herba Portulacae 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Rhizoma Atractylodis 10 ~ 20 parts, Herba Eleusines Indicae 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Endothelium Corneum Gigeriae Galli 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Fructus Gardeniae 10 ~ 15 parts, Rhizoma Imperatae 10 ~ 15 parts, Herba Verbenae 10 ~ 15 parts, Herba Lobeliae Chinensis 10 ~ 15 parts, Polyporus 10 ~ 15 parts, Herba Taraxaci 10 ~ 15 parts, Stigma Maydis 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, Herba Lysimachiae 10 ~ 15 parts.

4. a toxin expelling dehumidifying according to any one of claims 1 to 3, the preparation method of the Semen Plantaginis oral liquid of hepatic cholagogic, is characterized in that, the preparation process of described Semen Plantaginis oral liquid comprises:

A, by Semen Plantaginis gather rear alcohol extraction;

B, all the other raw materials are put into ethanol soak, heat is extracted 2 times, and becoming paste, is component 2;

C, component 1 and component 2 to be mixed, add dextrin after concentrated and make oral liquid.

5. toxin expelling dehumidifying according to claim 4, the preparation method of the Semen Plantaginis oral liquid of hepatic cholagogic, it is characterized in that, in described step a, by the Semen Plantaginis roguing of collecting, be equipped with in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, stirs, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Being merged by percolate and leave standstill, is component 1.

6. toxin expelling dehumidifying according to claim 4, the preparation method of the Semen Plantaginis oral liquid of hepatic cholagogic, is characterized in that, in described step b, all the other raw materials is added soak with ethanol 1 hour; Heating extraction 2 times, each 1-2 hour, merge extractive liquid, remove supernatant after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, becoming component, is component 2.

7. toxin expelling dehumidifying according to claim 4, the preparation method of the Semen Plantaginis oral liquid of hepatic cholagogic, is characterized in that, in described step c, component 1 and component 2 are inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.36, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, adds dextrin and make oral liquid.

8. a toxin expelling dehumidifying according to any one of claims 1 to 3, the preparation method of the Semen Plantaginis oral liquid of hepatic cholagogic, is characterized in that, described preparation method can also be:

A, Semen Strychni of picking up the car are put into ethanol and are soaked, and heat is extracted 2 times, and becoming paste, is component 1;

B, to be shredded by all the other raw materials, sieve, according to percolation, with 70% ethanol for solvent percolation, liquid less than 70 DEG C of filtering concentrates, and becoming paste, for component is paste, is component 2;

C, above-mentioned two kinds of pastes to be merged, then add Mel and make granule, pack.

9. toxin expelling dehumidifying according to claim 8, the preparation method of the Semen Plantaginis oral liquid of hepatic cholagogic, is characterized in that, in described step a, by the Semen Plantaginis of collecting, adds soak with ethanol 1 hour; Heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, and then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, become component 1; In described step b, powder is beaten in the chopping of all the other raw materials and sieves, be equipped with by medicated powder in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, and stir, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Percolate is merged and leaves standstill, as component 2.

10. toxin expelling dehumidifying according to claim 8, the preparation method of the Semen Plantaginis oral liquid of hepatic cholagogic, it is characterized in that, in described step c, component 1 being mixed with component 2 inserts in economic benefits and social benefits vacuum concentrator, decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.36; The extractum of temperature to 60 DEG C-70 DEG C, adds dextrin oral liquid.