CN102715178A - Sterilization combination containing pyraclostrobin and oxadixyl and application thereof - Google Patents
Sterilization combination containing pyraclostrobin and oxadixyl and application thereof Download PDFInfo
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- CN102715178A CN102715178A CN2012102187193A CN201210218719A CN102715178A CN 102715178 A CN102715178 A CN 102715178A CN 2012102187193 A CN2012102187193 A CN 2012102187193A CN 201210218719 A CN201210218719 A CN 201210218719A CN 102715178 A CN102715178 A CN 102715178A
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- pyraclostrobin
- oxadixyl
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- wakil
- bactericidal composition
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Abstract
The invention relates to a sterilization combination in the field of pesticide combination. The sterilization combination comprises active ingredients which are pyraclostrobin and oxadixyl, and the balance auxiliary ingredients allowed to be used and accepted in pesticides. The weight percentage between pyraclostrobin and oxadixyl is (80:1)-(1:80), preferably (20:1)-(1:20). Through a method known in the field, the sterilization combination can be made into wettable powder, a suspending agent, water aqua and water dispersible granules. The sterilization combination can be used for controlling fungal disease of crops.
Description
Technical field
The invention belongs to the compounded technology field of agricultural chemicals, be specifically related to a kind ofly contain pyraclostrobin and Wakil carries out composite bactericidal composition, and the application aspect control farm crop fungus disease.
Background technology
Pyraclostrobin (Pyraclostrobin) is claimed pyraclostrobin again, chemical name N-[2-[[1-(4-chlorphenyl) pyrazole-3-yl] oxygen methyl] phenyl]-N-methoxyl group methyl carbamate; Belong to the methoxy acrylic bactericide that has the pyrazoles structure concurrently; Be the mitochondrial respiratory inhibitor, the electronics transmission suppresses mitochondrial breathing between thin race pigment b and C1 through stoping, and the interference cell energy is supplied with; Make cell death, thus the performance bactericidal action.Pyraclostrobin has excellent protection, treatment, interior suction conduction and resistance of rainwater washing against performance, and the sterilization wide spectrum, and nearly all Mycophyta (Ascomycetes, Basidiomycetes, Oomycete and Fungi Imperfecti) disease is all demonstrated good active; Simultaneously can be to making the positive physiological regulatory action of deposits yields.Not only toxicity is low for it, to non-target organism safety, and also friendly to user and Environmental security.
Wakil (Oxadixyl), chemical name 2-methoxyl group-N-(2-oxo-1,3-oxazoles alkane-3-yl) acetyl-2 '; 6 '-dimethylaniline; Being heterocycle compound, is a kind of efficient systemic fungicide, has protection and therapeutic action; The Peronosporales pathogen is had very high preventive effect, and the lasting period is long.Can prevent and treat the downy mildew, eqpidemic disease of Peronosporales pathogen such as tobacco, cucumber, grape, vegetables etc., and Secondary cases disease such as brown spot, black rot etc. are planted by the Zhiduo County of holding concurrently.
Above-mentioned two kinds of medicaments, long-term use separately causes drug-fast generation of germ and development easily, causes dosage to strengthen, and preventive effect reduces, and the lasting period shortens, and is unfavorable for environment sustainable development.The inventor proves that by series of studies pyraclostrobin and Wakil be composite use in the certain proportion scope, and synergistic effect is comparatively obvious, can effectively improve preventive effect, reduces the medicament use amount, thereby accomplishes the present invention.Composite research about pyraclostrobin and Wakil does not at home and abroad appear in the newspapers at present as yet.
Summary of the invention
The object of the present invention is to provide and a kind ofly carry out composite bactericidal composition and application thereof by pyraclostrobin and Wakil; Said composition plays synergistic effect by composite; Reduce drug cost, improve actual preventive effect; Can be used to prevent and treat the fungal disease on the crop, simultaneously drug-fast generation and the development that delays pathogen had better action.
Among the present invention, the weight of the pyraclostrobin of being mentioned, the weight of Wakil, active ingredient etc. all refer to the weight of rolling over after hundred, i.e. the weight of active principle.
The present invention containing pyraclostrobin and oxadixyl bactericidal composition of active ingredients of pyraclostrobin and oxadixyl, said pyraclostrobin and oxadixyl weight ratio, pyraclostrobin Ester: oxadixyl = 80:1 ~ 1:80.
Advantageously, said of pyraclostrobin and oxadixyl weight ratio, pyraclostrobin: oxadixyl = 20:1 to 1:20.
Wherein, the weight percentage of active ingredient is 1%～90% in the said composition.
The said composition formulation comprises wetting powder, suspending agent, aqua, water dispersible granules, adds auxiliary agent and excipient, and the production technology of all knowing according to those skilled in the art can be made into required formulation.
This bactericidal composition is used to prevent and treat the fungal disease on the crop, is particularly useful for preventing and treating downy mildew, the eqpidemic disease that the Peronosporales pathogen causes on fruits and vegetables.
Beneficial effect of the present invention is: pyraclostrobin and two kinds of bactericide of Wakil are carried out composite, because the structure between the two differs bigger, the mechanism of action is different, and the application of complex preparation can delay generation and the development of germ to single agent resistance.The two composite composition shows synergistic effect preferably in certain ratio range simultaneously; The more single agent of the bactericidal effect of mixed composition is significantly improved; Thereby reduce the medicament usage amount, reduced peasant household's drug cost, reduced harmful effect environment.
Studied the indoor virulence of the composite mixture Phytophthora infestans of pyraclostrobin and the different proportionings of Wakil with the mycelial growth rate method; Experimental technique adopts the abundant method calculating co-toxicity coefficient of Sun Yun (CTC) to estimate and uses effect with; The CTC value has synergistic effect greater than 120 o'clock mixtures; Less than 80 o'clock be antagonism, have summation action in the time of between 80～120.
Concrete grammar is following:
Get the soup for preparing and place 100ml 50-60 ℃ of PDA sterilising medium; Shake up, pour in the sterilization culture dish of diameter 60mm, after the cooled and solidified; Moving respectively delivers a child grows unanimity, diameter is the bacterium cake of 4mm; As blank, all operations all carries out sterile working at superclean bench with the sterilising medium that adds the equivalent coordinative solvent, and 3 repetitions are established in every processing.Put into 27 ℃ of constant incubators and cultivate after 3-8 days, adopt the right-angled intersection method to measure colony diameter, calculate bacteriostasis rate, EC
50, relevant parameter such as CTC, the relevant calculation formula is following:
Pure amount of growth=bacterium colony average diameter-bacterium cake diameter (0.4cm)
Bacteriostasis rate=[the pure amount of growth of (contrast pure amount of growth-handle pure amount of growth) * 100/ contrast] * 100%
The EC50*100 of the EC50/B agent of toxicity index TI (B)=standard agent A
The EC50*100 of the EC50/AB of actual toxicity index ATI (AB)=A
Theoretical toxicity index TTI (AB)=percentage+TI (B) * B the percentage in mixture of TI (A) * A in mixture
Co-toxicity coefficient CTC=ATI (AB)/TTI (AB) * 100
The toxicity test table of table 1 pyraclostrobin and Wakil list mixture Phytophthora infestans
Visible by table 1; Pyraclostrobin and Wakil are composite; Phytophthora infestans has good indoor virulence, and the CTC value of nine proportionings shows that all above 120 these two bactericide have good synergistic effects under this proportioning; Can find out also simultaneously that in composition different its synergistic effects along with kasugarnycin and the white azoles ratio of cyanogen also are different, mixed ratio synergy between 20: 1～1: 20 is particularly remarkable.
Embodiment
Below in conjunction with embodiment the present invention is described further, but the present invention is not limited thereto, the formulation preparation method among the embodiment is conventional method.
Embodiment 1:10% pyraclostrobin Wakil suspending agent comprises following component by weight:
With whole mixing of materials, the back that stirs joins sand mill to material and carries out sand milling, makes material reach 2～5 μ m fineness, makes 10% pyraclostrobin Wakil suspending agent.
Embodiment 2:20% pyraclostrobin Wakil water dispersible granules comprises following component by weight:
Above-mentioned mixed by prescription is even, be ground into wettable powder through air-flow, add the granulation of a certain amount of water extrusion again, after dry screened, obtain 20% pyraclostrobin Wakil water dispersible granules.
Embodiment 3:42% pyraclostrobin Wakil wettable powder comprises following component by weight:
Said components is carried out air-flow pulverize, make 41% pyraclostrobin Wakil wettable powder.
Embodiment 4:85% pyraclostrobin Wakil wettable powder comprises following component by weight:
Said components is carried out air-flow pulverize, make 85% pyraclostrobin Wakil wettable powder.
Embodiment 5:24% pyraclostrobin Wakil aqua comprises following component by weight:
Said components is carried out mixed dissolution, make 24% pyraclostrobin Wakil aqua.
Test Example: the test of pesticide effectiveness of the mixture control cucumber downy mildew of pyraclostrobin and the different proportionings of Wakil
5 kinds of mixtures that the embodiment of the invention is obtained carry out the test of pesticide effectiveness, adopt the greenhouse pot culture cucumber seedling, measure the prevention effect of single mixture of pyraclostrobin and Wakil to cucumber downy mildew.When cucumber grows to 3～4 leaves, select the blade of growing way uniformity to adopt manual sprayer to carry out the foliar spray processing, inoculate pathogen after 24 hours, preserve moisture and cultivate 7d " Invest, Then Investigate " result, the result sees table 2.
The control efficiency table of table 2 pair cucumber downy mildew
As can be seen from Table 2, the mixture preparation of pyraclostrobin and Wakil can effectively be prevented and treated cucumber downy mildew, and obviously is better than the prevention effect of single agent.
Claims (6)
1 containing pyraclostrobin and oxadixyl bactericidal composition of active ingredients of pyraclostrobin and oxadixyl, said pyraclostrobin and oxadixyl weight ratio, azole bacteria amine ester: oxadixyl = 80:1 ~ one eighty.
(2) as claimed in claim 1, wherein the fungicidal composition, characterized in that said pyraclostrobin and oxadixyl weight ratio, pyraclostrobin: oxadixyl = 20:1 to 1:20.
3. bactericidal composition according to claim 1 and 2 is characterized in that, the weight percentage of described active ingredient is 1%～90%.
4. bactericidal composition according to claim 1 is characterized in that the said composition formulation comprises wetting powder, suspending agent, aqua, water dispersible granules.
5. like the described bactericidal composition of claim 1-4, it is characterized in that said composition is used to prevent and treat the farm crop fungus disease.
6. like the described bactericidal composition of claim 1-5, it is characterized in that said composition is used to prevent and treat downy mildew, the eqpidemic disease that the Peronosporales pathogen causes on fruits and vegetables.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102187193A CN102715178A (en) | 2012-06-29 | 2012-06-29 | Sterilization combination containing pyraclostrobin and oxadixyl and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102187193A CN102715178A (en) | 2012-06-29 | 2012-06-29 | Sterilization combination containing pyraclostrobin and oxadixyl and application thereof |
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| Publication Number | Publication Date |
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| CN102715178A true CN102715178A (en) | 2012-10-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012102187193A Pending CN102715178A (en) | 2012-06-29 | 2012-06-29 | Sterilization combination containing pyraclostrobin and oxadixyl and application thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6365614B1 (en) * | 1997-06-19 | 2002-04-02 | Basf Aktiengesellschaft | Fungicides mixtures |
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2012
- 2012-06-29 CN CN2012102187193A patent/CN102715178A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6365614B1 (en) * | 1997-06-19 | 2002-04-02 | Basf Aktiengesellschaft | Fungicides mixtures |
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Application publication date: 20121010 |