CN102712691A - 蛋白质纯化中提高病毒去除的方法 - Google Patents

蛋白质纯化中提高病毒去除的方法 Download PDF

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Publication number
CN102712691A
CN102712691A CN2010800447903A CN201080044790A CN102712691A CN 102712691 A CN102712691 A CN 102712691A CN 2010800447903 A CN2010800447903 A CN 2010800447903A CN 201080044790 A CN201080044790 A CN 201080044790A CN 102712691 A CN102712691 A CN 102712691A
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China
Prior art keywords
antibody
antibodies
protein
filtration
cells
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Pending
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CN2010800447903A
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English (en)
Chinese (zh)
Inventor
A·梅塔
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42985499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102712691(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to CN201710110829.0A priority Critical patent/CN106905413A/zh
Publication of CN102712691A publication Critical patent/CN102712691A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN2010800447903A 2009-08-06 2010-08-06 蛋白质纯化中提高病毒去除的方法 Pending CN102712691A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710110829.0A CN106905413A (zh) 2009-08-06 2010-08-06 蛋白质纯化中提高病毒去除的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23181109P 2009-08-06 2009-08-06
US61/231,811 2009-08-06
PCT/US2010/044760 WO2011031397A1 (en) 2009-08-06 2010-08-06 Method to improve virus removal in protein purification

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201710110829.0A Division CN106905413A (zh) 2009-08-06 2010-08-06 蛋白质纯化中提高病毒去除的方法

Publications (1)

Publication Number Publication Date
CN102712691A true CN102712691A (zh) 2012-10-03

Family

ID=42985499

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2010800447903A Pending CN102712691A (zh) 2009-08-06 2010-08-06 蛋白质纯化中提高病毒去除的方法
CN201710110829.0A Pending CN106905413A (zh) 2009-08-06 2010-08-06 蛋白质纯化中提高病毒去除的方法

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CN201710110829.0A Pending CN106905413A (zh) 2009-08-06 2010-08-06 蛋白质纯化中提高病毒去除的方法

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US (5) US10662237B2 (enExample)
EP (3) EP4559926A3 (enExample)
JP (6) JP2013501075A (enExample)
KR (3) KR20180035936A (enExample)
CN (2) CN102712691A (enExample)
AU (1) AU2010292897B2 (enExample)
BR (1) BR112012002574A2 (enExample)
CA (1) CA2770235C (enExample)
DK (1) DK2462158T3 (enExample)
ES (1) ES2662529T3 (enExample)
HR (1) HRP20180309T1 (enExample)
HU (1) HUE038451T2 (enExample)
IL (3) IL217740B (enExample)
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MX (1) MX346115B (enExample)
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PT (1) PT2462158T (enExample)
RU (1) RU2573894C2 (enExample)
SG (1) SG178276A1 (enExample)
SI (1) SI2462158T1 (enExample)
WO (1) WO2011031397A1 (enExample)
ZA (1) ZA201200626B (enExample)

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TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
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WO2013028330A2 (en) 2011-08-19 2013-02-28 Emd Millipore Corporation Methods of reducing level of one of more impurities in a sample during protein purification
HRP20181846T1 (hr) 2011-12-22 2018-12-28 Genentech, Inc. Kromatografija membranom za ionsku izmjenu
KR102260855B1 (ko) 2013-09-13 2021-06-04 제넨테크, 인크. 세포주에서 숙주 세포 단백질 및 재조합 폴리펩티드 생성물을 검출 및 정량화하기 위한 조성물 및 방법
NZ756749A (en) 2013-09-13 2022-05-27 Genentech Inc Methods and compositions comprising purified recombinant polypeptides
AU2015334455B2 (en) * 2014-10-21 2020-05-21 Gennova Biopharmaceuticals Limited A novel purification process for isolation and commercial production of recombinant TNK-tPA (Tenecteplase)
EP3274359B1 (en) * 2015-03-23 2022-11-02 Alexion Pharmaceuticals, Inc. Virus filtration
EP3639911B1 (en) * 2017-06-12 2024-07-31 Asahi Kasei Medical Co., Ltd. Filtration method for protein-containing liquid
KR102753090B1 (ko) * 2017-12-21 2025-01-14 젠자임 코포레이션 단백질 a 크로마토그래피 동안 불순물의 향상된 제거를 위한 방법
TWI871300B (zh) * 2019-01-28 2025-02-01 美商安進公司 藉由將藥物物質和藥物產品過程整體化的生物製劑製造之連續製造過程

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PL2462158T3 (pl) 2018-05-30
IL273486A (en) 2020-05-31
EP4559926A3 (en) 2025-08-06
JP2023029853A (ja) 2023-03-07
HUE038451T2 (hu) 2018-10-29
MX346115B (es) 2017-03-08
IL273486B (en) 2022-04-01
RU2012108318A (ru) 2013-09-20
US10662237B2 (en) 2020-05-26
LT2462158T (lt) 2018-03-26
AU2010292897B2 (en) 2016-01-07
EP2462158B1 (en) 2018-01-10
CN106905413A (zh) 2017-06-30
JP2025003999A (ja) 2025-01-14
KR20130051431A (ko) 2013-05-20
IL217740B (en) 2020-04-30
EP3309168A1 (en) 2018-04-18
ES2662529T3 (es) 2018-04-06
JP2013501075A (ja) 2013-01-10
KR20190018041A (ko) 2019-02-20
IL287431A (en) 2021-12-01
EP4559926A2 (en) 2025-05-28
JP2017206529A (ja) 2017-11-24
CA2770235C (en) 2021-06-29
MX2012001659A (es) 2012-04-30
NO2462158T3 (enExample) 2018-06-09
IL217740A0 (en) 2012-03-29
US20220306726A1 (en) 2022-09-29
US20240083980A1 (en) 2024-03-14
PT2462158T (pt) 2018-02-23
EP2462158A1 (en) 2012-06-13
CA2770235A1 (en) 2011-03-17
MY188566A (en) 2021-12-22
WO2011031397A1 (en) 2011-03-17
NZ597809A (en) 2014-05-30
SG178276A1 (en) 2012-03-29
US11225513B2 (en) 2022-01-18
US20110034674A1 (en) 2011-02-10
KR101844859B1 (ko) 2018-05-18
SI2462158T1 (en) 2018-04-30
KR20180035936A (ko) 2018-04-06
JP2020023491A (ja) 2020-02-13
HRP20180309T1 (hr) 2018-03-23
ZA201200626B (en) 2013-06-26
DK2462158T3 (en) 2018-03-05
AU2010292897A1 (en) 2012-02-16
US20250282850A1 (en) 2025-09-11
JP2016106096A (ja) 2016-06-16
US20200347118A1 (en) 2020-11-05
RU2573894C2 (ru) 2016-01-27
BR112012002574A2 (pt) 2020-11-03

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