CN102686579A - 作为gpr119活性调节剂的化合物和组合物 - Google Patents
作为gpr119活性调节剂的化合物和组合物 Download PDFInfo
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- CN102686579A CN102686579A CN2010800453177A CN201080045317A CN102686579A CN 102686579 A CN102686579 A CN 102686579A CN 2010800453177 A CN2010800453177 A CN 2010800453177A CN 201080045317 A CN201080045317 A CN 201080045317A CN 102686579 A CN102686579 A CN 102686579A
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- bases
- methyl
- fluoro
- phenyl
- trifluoromethyl
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| PCT/US2010/051186 WO2011044001A1 (en) | 2009-10-09 | 2010-10-01 | Compounds and compositions as modulators of gpr119 activity |
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| AR083904A1 (es) | 2010-11-18 | 2013-04-10 | Prosidion Ltd | Derivados de 1,4-pirrolidinas disustituidos y 3-il-aminas y sus usos en el tratamiento de desordenes metabolicos |
| GB201114389D0 (en) | 2011-08-22 | 2011-10-05 | Prosidion Ltd | Novel compounds |
| WO2012170867A1 (en) | 2011-06-09 | 2012-12-13 | Rhizen Pharmaceuticals Sa | Novel compounds as modulators of gpr-119 |
| EP2872127A1 (en) | 2012-07-11 | 2015-05-20 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| WO2014019967A1 (en) | 2012-08-02 | 2014-02-06 | Boehringer Ingelheim International Gmbh | N-cyclopropyl-n-piperidinyl-amides, pharmaceutical compositions containing them and uses thereof |
| WO2014052619A1 (en) * | 2012-09-27 | 2014-04-03 | Irm Llc | Piperidine derivatives and compositions as modulators of gpr119 activity |
| AU2013344603B2 (en) * | 2012-11-16 | 2017-07-06 | Bristol-Myers Squibb Company | Pyrrolidine GPR40 modulators |
| CN107257793A (zh) * | 2015-01-20 | 2017-10-17 | 梅里亚股份有限公司 | 抗蠕虫化合物、组合物及其使用方法 |
| CN109311848B (zh) | 2016-06-07 | 2022-02-01 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| WO2018153849A1 (en) * | 2017-02-21 | 2018-08-30 | Sanofi | Azetidine compounds as gpr119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders |
| SMT202400385T1 (it) | 2017-03-23 | 2024-11-15 | Jacobio Pharmaceuticals Co Ltd | Nuovi derivati eterociclici utili come inibitori di shp2 |
| HRP20220991T1 (hr) | 2017-10-27 | 2022-11-11 | Boehringer Ingelheim International Gmbh | Derivati piridina i njihova terapeutska uporaba kao inhibitora trpc6 |
| US20210393623A1 (en) | 2018-09-26 | 2021-12-23 | Jacobio Pharmaceuticals Co., Ltd. | Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors |
| TW202140440A (zh) | 2020-02-28 | 2021-11-01 | 美商克力歐普股份有限公司 | Gpr40激動劑 |
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| US4613610A (en) | 1984-06-22 | 1986-09-23 | Sandoz Pharmaceuticals Corp. | Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives |
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| US4668794A (en) | 1985-05-22 | 1987-05-26 | Sandoz Pharm. Corp. | Intermediate imidazole acrolein analogs |
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2010
- 2010-10-01 JP JP2012533226A patent/JP2013507366A/ja active Pending
- 2010-10-01 BR BR112012008004A patent/BR112012008004A2/pt not_active IP Right Cessation
- 2010-10-01 CA CA2774573A patent/CA2774573A1/en not_active Abandoned
- 2010-10-01 IN IN2471DEN2012 patent/IN2012DN02471A/en unknown
- 2010-10-01 EP EP10763952A patent/EP2486033A1/en not_active Withdrawn
- 2010-10-01 US US12/896,735 patent/US8575168B2/en not_active Expired - Fee Related
- 2010-10-01 CN CN2010800453177A patent/CN102686579A/zh active Pending
- 2010-10-01 AU AU2010303780A patent/AU2010303780B2/en not_active Ceased
- 2010-10-01 EA EA201200570A patent/EA201200570A1/ru unknown
- 2010-10-01 WO PCT/US2010/051186 patent/WO2011044001A1/en not_active Ceased
- 2010-10-01 MX MX2012004078A patent/MX2012004078A/es active IP Right Grant
- 2010-10-01 KR KR1020127011865A patent/KR20120092629A/ko not_active Abandoned
- 2010-10-07 AR ARP100103648A patent/AR078550A1/es unknown
- 2010-10-08 TW TW099134498A patent/TW201124400A/zh unknown
- 2010-10-08 UY UY0001032937A patent/UY32937A/es not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2007003964A1 (en) * | 2005-06-30 | 2007-01-11 | Prosidion Limited | G-protein coupled receptor agonists |
| WO2009038974A1 (en) * | 2007-09-20 | 2009-03-26 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013507366A (ja) | 2013-03-04 |
| BR112012008004A2 (pt) | 2016-03-29 |
| US8575168B2 (en) | 2013-11-05 |
| AU2010303780B2 (en) | 2014-02-20 |
| AR078550A1 (es) | 2011-11-16 |
| KR20120092629A (ko) | 2012-08-21 |
| US20110245220A1 (en) | 2011-10-06 |
| EA201200570A1 (ru) | 2012-11-30 |
| AU2010303780A1 (en) | 2012-04-12 |
| TW201124400A (en) | 2011-07-16 |
| MX2012004078A (es) | 2012-07-25 |
| WO2011044001A1 (en) | 2011-04-14 |
| EP2486033A1 (en) | 2012-08-15 |
| UY32937A (es) | 2011-05-31 |
| CA2774573A1 (en) | 2011-04-14 |
| IN2012DN02471A (enExample) | 2015-08-21 |
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