CN102666873A - 用于高效率蛋白质表达的分泌蛋白质生物标记物 - Google Patents

用于高效率蛋白质表达的分泌蛋白质生物标记物 Download PDF

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CN102666873A
CN102666873A CN2010800503369A CN201080050336A CN102666873A CN 102666873 A CN102666873 A CN 102666873A CN 2010800503369 A CN2010800503369 A CN 2010800503369A CN 201080050336 A CN201080050336 A CN 201080050336A CN 102666873 A CN102666873 A CN 102666873A
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protein
subunit
cell
precursor
biomarker
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CN2010800503369A
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Chinese (zh)
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P.霍斯勒
I.R.科雷亚
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AbbVie Inc
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Abbott GmbH and Co KG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN2010800503369A 2009-11-09 2010-11-09 用于高效率蛋白质表达的分泌蛋白质生物标记物 Pending CN102666873A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25952709P 2009-11-09 2009-11-09
US61/259527 2009-11-09
US12/941347 2010-11-08
US12/941,347 US8524458B2 (en) 2009-11-09 2010-11-08 Secretory protein biomarkers for high efficiency protein expression
PCT/US2010/055953 WO2011057239A2 (en) 2009-11-09 2010-11-09 Secretory protein biomarkers for high efficiency protein expression

Publications (1)

Publication Number Publication Date
CN102666873A true CN102666873A (zh) 2012-09-12

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CN2010800503369A Pending CN102666873A (zh) 2009-11-09 2010-11-09 用于高效率蛋白质表达的分泌蛋白质生物标记物

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US (2) US8524458B2 (enExample)
EP (1) EP2499254A2 (enExample)
JP (1) JP2013510324A (enExample)
KR (1) KR20120115494A (enExample)
CN (1) CN102666873A (enExample)
AU (1) AU2010314922A1 (enExample)
BR (1) BR112012010976A2 (enExample)
CA (1) CA2778254A1 (enExample)
IL (1) IL219518A0 (enExample)
IN (1) IN2012DN03358A (enExample)
MX (1) MX2012005380A (enExample)
RU (1) RU2012124114A (enExample)
WO (1) WO2011057239A2 (enExample)
ZA (1) ZA201202966B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108467890A (zh) * 2018-05-02 2018-08-31 首都医科大学附属北京天坛医院 Vat1基因及vat1基因的干扰物的应用和应用vat1基因的产品
CN109470756A (zh) * 2018-10-11 2019-03-15 昆明理工大学 测定14-3-3蛋白与质膜H+-ATPase蛋白互作的电化学方法
JP2019527815A (ja) * 2016-06-06 2019-10-03 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ 生体高分子複合体の精製のための方法
CN117099743A (zh) * 2023-07-11 2023-11-24 吉林大学 一种snx6基因不表达的异种移植供体及制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6507542B2 (ja) * 2014-09-22 2019-05-08 東洋紡株式会社 バイオマーカーを用いた組換えタンパク質生産量の予測方法

Citations (1)

* Cited by examiner, † Cited by third party
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WO2008054514A2 (en) * 2006-04-21 2008-05-08 Wyeth Differential expression profiling analysis of cell culture phenotypes and the uses thereof

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USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
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US5302517A (en) * 1987-06-16 1994-04-12 The Board Of Regents Of The University Of Nebraska Method of controlling the expression of a gene in a cell culture, cell culture vector used in the method and method of making the vector
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US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
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JP2011522265A (ja) * 2008-06-04 2011-07-28 プロテオシス アクチエンゲゼルシャフト 化学物質の発生毒性及び胚性毒性のｉｎｖｉｔｒｏ試験のためのタンパク質バイオマーカー

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Publication number Priority date Publication date Assignee Title
WO2008054514A2 (en) * 2006-04-21 2008-05-08 Wyeth Differential expression profiling analysis of cell culture phenotypes and the uses thereof

Non-Patent Citations (1)

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Title
王巧侠等: "热休克蛋白70和糖调节蛋白94 在人胃癌细胞BGC-823中的表达", 《陕西医学杂志》 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019527815A (ja) * 2016-06-06 2019-10-03 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ 生体高分子複合体の精製のための方法
US11401301B2 (en) 2016-06-06 2022-08-02 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Method for the purification of biological macromolecular complexes
CN108467890A (zh) * 2018-05-02 2018-08-31 首都医科大学附属北京天坛医院 Vat1基因及vat1基因的干扰物的应用和应用vat1基因的产品
CN109470756A (zh) * 2018-10-11 2019-03-15 昆明理工大学 测定14-3-3蛋白与质膜H+-ATPase蛋白互作的电化学方法
CN109470756B (zh) * 2018-10-11 2020-08-25 昆明理工大学 测定14-3-3蛋白与质膜H+-ATPase蛋白互作的电化学方法
CN117099743A (zh) * 2023-07-11 2023-11-24 吉林大学 一种snx6基因不表达的异种移植供体及制备方法

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Publication number Publication date
US8524458B2 (en) 2013-09-03
MX2012005380A (es) 2012-05-29
AU2010314922A1 (en) 2012-05-31
WO2011057239A3 (en) 2011-06-30
JP2013510324A (ja) 2013-03-21
KR20120115494A (ko) 2012-10-18
BR112012010976A2 (pt) 2016-08-16
WO2011057239A2 (en) 2011-05-12
US20140004531A1 (en) 2014-01-02
RU2012124114A (ru) 2013-12-20
IN2012DN03358A (enExample) 2015-10-23
EP2499254A2 (en) 2012-09-19
IL219518A0 (en) 2012-06-28
CA2778254A1 (en) 2011-05-12
US20110236906A1 (en) 2011-09-29
ZA201202966B (en) 2012-12-27

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Application publication date: 20120912